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Article ; Online: Development of an Imaging Technique for Boron Neutron Capture Therapy.

Fukumitsu, Nobuyoshi / Matsumoto, Yoshitaka

2021 Volume 10, Issue 8

Abstract: The development of 4- ...

Abstract	The development of 4-
MeSH term(s)	Animals ; Boron Neutron Capture Therapy/methods ; Humans ; Positron-Emission Tomography
Language	English
Publishing date	2021-08-19
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells10082135
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Article ; Online: Strategies for Preclinical Studies Evaluating the Biological Effects of an Accelerator-Based Boron Neutron Capture Therapy System.

Kondo, Natsuko / Masutani, Mitsuko / Imamichi, Shoji / Matsumoto, Yoshitaka / Nakai, Kei

Cancer biotherapy & radiopharmaceuticals

2022 Volume 38, Issue 3, Page(s) 173–183

Abstract: This review discusses the strategies of preclinical studies intended for accelerator-based (AB)-boron neutron capture therapy (BNCT) clinical trials, which were presented at the National Cancer Institute (NCI) Workshop on Neutron Capture Therapy held ... ...

Abstract	This review discusses the strategies of preclinical studies intended for accelerator-based (AB)-boron neutron capture therapy (BNCT) clinical trials, which were presented at the National Cancer Institute (NCI) Workshop on Neutron Capture Therapy held from April 20 to 22, 2022. Clinical studies of BNCT have been conducted worldwide using reactor neutron sources, with most targeting malignant brain tumors, melanoma, or head and neck cancer. Recently, small accelerator-based neutron sources that can be installed in hospitals have been developed. AB-BNCT clinical trials for recurrent malignant glioma, head and neck cancers, high-grade meningioma, melanoma, and angiosarcoma have all been conducted in Japan. The necessary methods, equipment, and facilities for preclinical studies to evaluate the biological effects of AB-BNCT systems in terms of safety and efficacy are described, with reference to two examples from Japan. The first is the National Cancer Center, which is equipped with a vertical downward neutron beam, and the other is the University of Tsukuba, which has a horizontal neutron beam. The preclinical studies discussed include cell-based assays to evaluate cytotoxicity and genotoxicity,
MeSH term(s)	Humans ; Boron Neutron Capture Therapy/methods ; Brain Neoplasms/radiotherapy ; Glioma ; Head and Neck Neoplasms ; Melanoma
Language	English
Publishing date	2022-09-26
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1315649-4
ISSN	1557-8852 ; 1084-9785
ISSN (online)	1557-8852
ISSN	1084-9785
DOI	10.1089/cbr.2022.0057
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Article: A Critical Review of Radiation Therapy: From Particle Beam Therapy (Proton, Carbon, and BNCT) to Beyond.

Matsumoto, Yoshitaka / Fukumitsu, Nobuyoshi / Ishikawa, Hitoshi / Nakai, Kei / Sakurai, Hideyuki

Journal of personalized medicine

2021 Volume 11, Issue 8

Abstract: In this paper, we discuss the role of particle therapy-a novel radiation therapy (RT) that has shown rapid progress and widespread use in recent years-in multidisciplinary treatment. Three types of particle therapies are currently used for cancer ... ...

Abstract	In this paper, we discuss the role of particle therapy-a novel radiation therapy (RT) that has shown rapid progress and widespread use in recent years-in multidisciplinary treatment. Three types of particle therapies are currently used for cancer treatment: proton beam therapy (PBT), carbon-ion beam therapy (CIBT), and boron neutron capture therapy (BNCT). PBT and CIBT have been reported to have excellent therapeutic results owing to the physical characteristics of their Bragg peaks. Variable drug therapies, such as chemotherapy, hormone therapy, and immunotherapy, are combined in various treatment strategies, and treatment effects have been improved. BNCT has a high dose concentration for cancer in terms of nuclear reactions with boron. BNCT is a next-generation RT that can achieve cancer cell-selective therapeutic effects, and its effectiveness strongly depends on the selective
Language	English
Publishing date	2021-08-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm11080825
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Article: Smart Nanofiber Mesh with Locally Sustained Drug Release Enabled Synergistic Combination Therapy for Glioblastoma.

Li, Yinuo / Matsumoto, Yoshitaka / Chen, Lili / Sugawara, Yu / Oe, Emiho / Fujisawa, Nanami / Ebara, Mitsuhiro / Sakurai, Hideyuki

Nanomaterials (Basel, Switzerland)

2023 Volume 13, Issue 3

Abstract: This study aims to propose a new treatment model for glioblastoma (GBM). The combination of chemotherapy, molecular targeted therapy and radiotherapy has been achieved in a highly simultaneous manner through the application of a safe, non-toxic, locally ... ...

Abstract	This study aims to propose a new treatment model for glioblastoma (GBM). The combination of chemotherapy, molecular targeted therapy and radiotherapy has been achieved in a highly simultaneous manner through the application of a safe, non-toxic, locally sustained drug-releasing composite Nanofiber mesh (NFM). The NFM consisted of biodegradable poly(ε-caprolactone) with temozolomide (TMZ) and 17-allylamino-17-demethoxygeldanamycin (17AAG), which was used in radiation treatment. TMZ and 17AAG combination showed a synergistic cytotoxicity effect in the T98G cell model. TMZ and 17AAG induced a radiation-sensitization effect, respectively. The NFM containing 17AAG or TMZ, known as 17AAG-NFM and TMZ-NFM, enabled cumulative drug release of 34.1% and 39.7% within 35 days. Moreover, 17AAG+TMZ-NFM containing both drugs revealed a synergistic effect in relation to the NFM of a single agent. When combined with radiation, 17AAG+TMZ-NFM induced in an extremely powerful cytotoxic effect. These results confirmed the application of NFM can simultaneously allow multiple treatments to T98G cells. Each modality achieved a significant synergistic effect with the other, leading to a cascading amplification of the therapeutic effect. Due to the superior advantage of sustained drug release over a long period of time, NFM has the promise of clinically addressing the challenge of high recurrence of GBM post-operatively.
Language	English
Publishing date	2023-01-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano13030414
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Article: [Two Cases of Penoscrotal Strangulation].

Matsumoto, Yoshitaka / Endo, Keisuke / Omori, Yohei / Komine, Manabu / Kikuchi, Koji

Hinyokika kiyo. Acta urologica Japonica

2020 Volume 66, Issue 4, Page(s) 131–135

Abstract: Case 1 (42-year-old man) : The patient was examined for penoscrotal swelling that had continued for 1 month. An annular erosive skin ulcer was observed at the penoscrotal base, with distal swelling. Asking the patient about the history of his condition ... ...

Abstract	Case 1 (42-year-old man) : The patient was examined for penoscrotal swelling that had continued for 1 month. An annular erosive skin ulcer was observed at the penoscrotal base, with distal swelling. Asking the patient about the history of his condition was difficult due to a history of mental illness. We suspected his symptoms were due to an embedded foreign object. As computed tomography indicated the presence of a subcutaneous foreign object, surgery was performed to remove it. A rubber band was found wrapped twice around the area. After releasing the strangulation, penoscrotal swelling improved. Case 2 (72-year-old man) : Penoscrotal swelling appeared after having an automobile tow hook attached to the penoscrotal base for 2 weeks. The patient was examined at the emergency room because he could not remove it on his own. A rescue squad was called, and they cut the strangulating object with an electric saw. After releasing the strangulation, penoscrotal swelling improved. Although we experienced 2 cases of penoscrotal strangulation involving strangulating objects with different characteristics, improvement was achieved in both by releasing the strangulation. The cases of penoscrotal strangulation reported in Japan with known strangulation type are reviewed.
MeSH term(s)	Child, Preschool ; Foreign Bodies ; Humans ; Infant ; Japan ; Male ; Tomography, X-Ray Computed
Language	Japanese
Publishing date	2020-06-01
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	604331-8
ISSN	0018-1994
ISSN	0018-1994
DOI	10.14989/ActaUrolJap_66_4_131
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Article ; Online: Non-isotope enriched phenylboronic acid-decorated dual-functional nano-assembles for an actively targeting BNCT drug.

Kim, Ahram / Suzuki, Minoru / Matsumoto, Yoshitaka / Fukumitsu, Nobuyoshi / Nagasaki, Yukio

Biomaterials

2020 Volume 268, Page(s) 120551

Abstract: The feasibility of boron neutron capture therapy (BNCT) greatly depends on the selective accumulation ... ...

Abstract	The feasibility of boron neutron capture therapy (BNCT) greatly depends on the selective accumulation of
MeSH term(s)	Animals ; Boron Compounds ; Boron Neutron Capture Therapy ; Boronic Acids ; Humans ; Melanoma, Experimental ; Mice ; Pharmaceutical Preparations
Chemical Substances	Boron Compounds ; Boronic Acids ; Pharmaceutical Preparations ; benzeneboronic acid (L12H7B02G5)
Language	English
Publishing date	2020-11-24
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603079-8
ISSN	1878-5905 ; 0142-9612
ISSN (online)	1878-5905
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2020.120551
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Article: A Diels-Alder polymer platform for thermally enhanced drug release toward efficient local cancer chemotherapy.

Fujisawa, Nanami / Takanohashi, Masato / Chen, Lili / Uto, Koichiro / Matsumoto, Yoshitaka / Takeuchi, Masayuki / Ebara, Mitsuhiro

Science and technology of advanced materials

2021 Volume 22, Issue 1, Page(s) 522–531

Abstract: We reports a novel thermally enhanced drug release system synthesized via a dynamic Diels-Alder (DA) reaction to develop chemotherapy for pancreatic cancer. The anticancer prodrug was designed by tethering gemcitabine (GEM) to poly(furfuryl methacrylate) ...

Abstract	We reports a novel thermally enhanced drug release system synthesized via a dynamic Diels-Alder (DA) reaction to develop chemotherapy for pancreatic cancer. The anticancer prodrug was designed by tethering gemcitabine (GEM) to poly(furfuryl methacrylate) (PFMA) via
Language	English
Publishing date	2021-06-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2027985-1
ISSN	1878-5514 ; 1468-6996
ISSN (online)	1878-5514
ISSN	1468-6996
DOI	10.1080/14686996.2021.1939152
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Article: Study of zinc pollution in river water: Average mass balance based on irrigation schedule

Andarani, Pertiwi / Yokota, Kuriko / Saga, Makoto / Inoue, Takanobu / Matsumoto, Yoshitaka

River research and applications. 2020 Sept., v. 36, no. 7

2020

Abstract: Aichi Prefecture, which has a dense industrial area, is one of the sites in Japan where the levels of zinc are elevated. However, currently, there is no clear evidence of the source of zinc in this prefecture. This study aims to assess zinc concentration ...

Abstract	Aichi Prefecture, which has a dense industrial area, is one of the sites in Japan where the levels of zinc are elevated. However, currently, there is no clear evidence of the source of zinc in this prefecture. This study aims to assess zinc concentration and load in a river and identify the main sources of zinc pollution. We conducted a 20‐month survey to identify the temporal and spatial variation of zinc in river water, particularly in the Aizumame River. Using Flame Atomic Absorption Spectrometry, the total fraction of zinc concentrations was determined for nine sampling stations (five points in the mainstream and four points in the tributaries). The results show that the average of zinc concentration was lower during the irrigation period than in the non‐irrigation period. However, the load during the irrigation period was higher. During irrigation, the river discharges were higher resulting in a lower concentration. The highest zinc concentration was 0.139 mg/L in June 2017. Based on this study, the main zinc source was identified from industrial areas which on average contributed about 3,400 g/day into the mainstream. These results became more evident during the non‐irrigation period when only industrial discharges contributed zinc load into the mainstream.
Keywords	Japan ; atomic absorption spectrometry ; irrigation scheduling ; pollution ; research ; river water ; rivers ; surveys ; zinc
Language	English
Dates of publication	2020-09
Size	p. 1286-1295.
Publishing place	John Wiley & Sons, Ltd.
Document type	Article
Note	NAL-AP-2-clean ; JOURNAL ARTICLE
ZDB-ID	2072626-0
ISSN	1535-1459
ISSN	1535-1459
DOI	10.1002/rra.3632
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Efficient neutron capture therapy of glioblastoma with pteroyl-closo-dodecaborate-conjugated 4-(p-iodophenyl)butyric acid (PBC-IP).

Nishimura, Kai / Kashiwagi, Hideki / Morita, Taiki / Fukuo, Yusuke / Okada, Satoshi / Miura, Kazuki / Matsumoto, Yoshitaka / Sugawara, Yu / Enomoto, Takayuki / Suzuki, Minoru / Nakai, Kei / Kawabata, Shinji / Nakamura, Hiroyuki

Journal of controlled release : official journal of the Controlled Release Society

2023 Volume 360, Page(s) 249–259

Abstract: Boron neutron capture therapy (BNCT) has been applied for clinical trials on glioblastoma patients since 1950s, however, the low survival rate under the treatments has hampered the widespread use of BNCT. In this study, we developed a novel boron agent, ... ...

Abstract	Boron neutron capture therapy (BNCT) has been applied for clinical trials on glioblastoma patients since 1950s, however, the low survival rate under the treatments has hampered the widespread use of BNCT. In this study, we developed a novel boron agent, PBC-IP, which consists of three functional groups: FRα-targeting,
MeSH term(s)	Humans ; Rats ; Animals ; Glioblastoma/drug therapy ; Glioblastoma/radiotherapy ; Butyric Acid/therapeutic use ; Rats, Inbred F344 ; Boron/therapeutic use ; Glioma/drug therapy ; Glioma/radiotherapy ; Glioma/metabolism ; Brain Neoplasms/drug therapy ; Brain Neoplasms/radiotherapy ; Brain Neoplasms/metabolism ; Boron Compounds/chemistry ; Boron Neutron Capture Therapy
Chemical Substances	Butyric Acid (107-92-6) ; dodecaborate (12008-78-5) ; Boron (N9E3X5056Q) ; Boron Compounds
Language	English
Publishing date	2023-06-29
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2023.06.022
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Article: Chronoradiation Therapy for Prostate Cancer: Morning Proton Beam Therapy Ameliorates Worsening Lower Urinary Tract Symptoms.

Negoro, Hiromitsu / Iizumi, Takashi / Mori, Yutaro / Matsumoto, Yoshitaka / Chihara, Ichiro / Hoshi, Akio / Sakurai, Hideyuki / Nishiyama, Hiroyuki / Ishikawa, Hitoshi

Journal of clinical medicine

2020 Volume 9, Issue 7

Abstract: Background and purpose: Worsening lower urinary tract symptoms (LUTS) are a frequent adverse event following proton beam therapy (PBT) for localized prostate cancer. We investigated the differences in worsening LUTS among patients who received PBT at ... ...

Abstract	Background and purpose: Worsening lower urinary tract symptoms (LUTS) are a frequent adverse event following proton beam therapy (PBT) for localized prostate cancer. We investigated the differences in worsening LUTS among patients who received PBT at different times of day. Participants and methods: Among 173 patients who underwent PBT for prostate cancer, 168 patients (median age 68.5 years) completed international prostate symptom score (IPSS) questionnaires and were included. Changes in the IPSS from baseline to the end of PBT were assessed by multiple linear regression analysis for age, National Comprehensive Cancer Network risk classification, androgen deprivation therapy, fractional PBT dose, clinical target volume, severity of IPSS, diabetes, LUTS medication use before PBT, anti-coagulant therapy and radiation time of day (morning (08:30-10:30), around noon (10:31-14:30), and late afternoon (14:31-16:30)). Results: IPSS total score and IPSS-Quality of Life (QoL) score (12 patients were excluded due to missing IPSS-QoL score) increased from eight to 14.9 ( Conclusions: Morning PBT for localized prostate cancer significantly ameliorated worsening LUTS and improved QoL compared with treatment around noon or late afternoon. Chronoradiation therapy for localized prostate cancer may be effective and further research to elucidate the underlying mechanism is warranted.
Language	English
Publishing date	2020-07-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm9072263
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