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  1. AU="Matsumura, Sosuke"
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  1. Article: A case of epidermal growth factor receptor tyrosine kinase inhibitor effectiveness in epidermal growth factor receptor mutation-positive squamous cell carcinoma.

    Matsumura, Sosuke / Ano, Satoshi / Kikuchi, Norihiro / Masuda, Michiko / Osawa, Hajime / Kondo, Yuzuru / Ishii, Yukio / Hizawa, Nobuyuki

    SAGE open medical case reports

    2023  Volume 11, Page(s) 2050313X231159504

    Abstract: A 71-year-old non-smoker woman was admitted to our hospital because of left front chest pain. A computed tomography scan showed a large mass of >7.0 cm in the lower left part of the lung and multiple organ metastases in the liver, brain, bone, and left ... ...

    Abstract A 71-year-old non-smoker woman was admitted to our hospital because of left front chest pain. A computed tomography scan showed a large mass of >7.0 cm in the lower left part of the lung and multiple organ metastases in the liver, brain, bone, and left adrenal gland. Pathological analysis of a resected specimen obtained by bronchoscopy revealed keratinization. In addition, p40 was positive and thyroid transcription factor-1, synaptophysin, CD56, and chromogranin A were negative by immunohistochemistry. Programmed cell death ligand 1 expression was 1%-10%, and exon 19 deletion was detected. We diagnosed the patient with stage IVB lung squamous cell carcinoma and administered osimertinib. Osimertinib was later replaced with afatinib because of grade 3 skin rash. Overall, the size of the cancer was decreased. Furthermore, her symptoms, laboratory data, and computer tomographic findings markedly improved. In summary, we experienced a case of epidermal growth factor receptor-positive lung squamous cell carcinoma that was responsive to epidermal growth factor receptor tyrosine kinase inhibitors.
    Language English
    Publishing date 2023-02-28
    Publishing country England
    Document type Case Reports
    ZDB-ID 2736953-5
    ISSN 2050-313X
    ISSN 2050-313X
    DOI 10.1177/2050313X231159504
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Risk factors for clinical progression in patients with pulmonary Mycobacterium avium complex disease without culture-positive sputum: a single-center, retrospective study.

    Nonaka, Mizu / Matsuyama, Masashi / Sakai, Chio / Matsumura, Sosuke / Arai, Naoki / Nakajima, Masayuki / Saito, Takefumi / Hizawa, Nobuyuki

    European journal of medical research

    2023  Volume 28, Issue 1, Page(s) 186

    Abstract: Objectives: Limited data are available on the progression of pulmonary Mycobacterium avium complex (MAC) disease without culture-positive sputum. The aim of this study was to identify the risk factors associated with clinical progression of pulmonary ... ...

    Abstract Objectives: Limited data are available on the progression of pulmonary Mycobacterium avium complex (MAC) disease without culture-positive sputum. The aim of this study was to identify the risk factors associated with clinical progression of pulmonary MAC disease diagnosed by bronchoscopy.
    Methods: A single-center, retrospective, observational study was conducted. Pulmonary MAC patients diagnosed by bronchoscopy without culture-positive sputum from January 1, 2013, to December 31, 2017 were analyzed. Clinical progression after diagnosis was defined as having culture-positive sputum at least once or initiation of guideline-based therapy. Then, clinical characteristics were compared between clinically progressed patients and stable patients.
    Results: Ninety-three pulmonary MAC patients diagnosed by bronchoscopy were included in the analysis. During the 4-year period after diagnosis, 38 patients (40.9%) started treatment, and 35 patients (37.6%) had new culture-positive sputum. Consequently, 52 patients (55.9%) were classified into the progressed group, and 41 patients (44.1%) were classified into the stable group. There were no significant differences between the progressed and the stable groups in age, body mass index, smoking status, comorbidities, symptoms, or species isolated from bronchoscopy. On multivariate analysis, male sex, monocyte to lymphocyte ratio (MLR) ≥ 0.17, and the presence of combined lesions in the middle (lingula) and lower lobes were risk factors for clinical progression.
    Conclusions: Some patients with pulmonary MAC disease without culture-positive sputum progress within 4 years. Therefore, pulmonary MAC patients, especially male patients, having higher MLR or lesions in the middle (lingula) and lower lobes might need careful follow-up for a longer time.
    MeSH term(s) Humans ; Male ; Mycobacterium avium Complex ; Retrospective Studies ; Mycobacterium avium-intracellulare Infection/diagnosis ; Mycobacterium avium-intracellulare Infection/drug therapy ; Mycobacterium avium-intracellulare Infection/microbiology ; Sputum/microbiology ; Lung Diseases/drug therapy ; Risk Factors ; Disease Progression
    Language English
    Publishing date 2023-06-08
    Publishing country England
    Document type Observational Study ; Letter
    ZDB-ID 1329381-3
    ISSN 2047-783X ; 0949-2321
    ISSN (online) 2047-783X
    ISSN 0949-2321
    DOI 10.1186/s40001-023-01152-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4636: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Pathophysiology of pulmonary nontuberculous mycobacterial (NTM) disease.

    Matsuyama, Masashi / Matsumura, Sosuke / Nonaka, Mizu / Nakajima, Masayuki / Sakai, Chio / Arai, Naoki / Ueda, Kodai / Hizawa, Nobuyuki

    Respiratory investigation

    2023  Volume 61, Issue 2, Page(s) 135–148

    Abstract: In recent years, the incidence and prevalence of pulmonary nontuberculous mycobacterial (NTM) disease have increased worldwide. Although the reasons for this increase are unclear, dealing with this disease is essential. Pulmonary NTM disease is a chronic ...

    Abstract In recent years, the incidence and prevalence of pulmonary nontuberculous mycobacterial (NTM) disease have increased worldwide. Although the reasons for this increase are unclear, dealing with this disease is essential. Pulmonary NTM disease is a chronic pulmonary infection caused by NTM bacteria, which are ubiquitous in various environments. In Japan, Mycobacterium avium-intracellulare complex (MAC) accounts for approximately 90% of the causative organisms of pulmonary NTM disease, which is also called pulmonary MAC disease or pulmonary MAI disease. It is important to elucidate the pathophysiology of this disease, which occurs frequently in postmenopausal women despite the absence of obvious immunodeficiency. The pathophysiology of this disease has not been fully elucidated; however, it can largely be divided into bacterial (environmental) and host-side problems. The host factors can be further divided into immune and airway problems. The authors suggest that the triangular relationship between bacteria, immunity, and the airway is important in the pathophysiology of this disease. The latest findings on the pathophysiology of pulmonary NTM disease are reviewed.
    MeSH term(s) Humans ; Female ; Mycobacterium Infections, Nontuberculous/epidemiology ; Mycobacterium avium Complex ; Nontuberculous Mycobacteria ; Lung Diseases/epidemiology ; Lung
    Language English
    Publishing date 2023-01-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2660821-2
    ISSN 2212-5353 ; 2212-5345
    ISSN (online) 2212-5353
    ISSN 2212-5345
    DOI 10.1016/j.resinv.2022.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Blood eosinophil phenotype during treatment with mepolizumab in patients with severe eosinophilic asthma.

    Sakai, Chio / Matsuyama, Masashi / Nakajima, Masayuki / Matsumura, Sosuke / Nonaka, Mizu / Arai, Naoki / Kuramoto, Kenya / Yoshida, Kazufumi / Morishima, Yuko / Muratani, Masafumi / Hizawa, Nobuyuki

    Allergology international : official journal of the Japanese Society of Allergology

    2024  

    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Letter
    ZDB-ID 1336498-4
    ISSN 1440-1592 ; 1323-8930
    ISSN (online) 1440-1592
    ISSN 1323-8930
    DOI 10.1016/j.alit.2024.03.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5248: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article: A case of

    Yabuuchi, Yuki / Matsuyama, Masashi / Matsumura, Sosuke / Nakajima, Masayuki / Kiyasu, Yoshihiko / Takeuchi, Yuto / Murata, Yoshihiko / Matsuoka, Ryota / Noguchi, Masayuki / Hizawa, Nobuyuki

    Multidisciplinary respiratory medicine

    2022  Volume 17, Issue 2, Page(s) 802

    Abstract: Pneumocystis ... ...

    Abstract Pneumocystis jirovecii
    Language English
    Publishing date 2022-01-12
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2677839-7
    ISSN 2049-6958 ; 1828-695X
    ISSN (online) 2049-6958
    ISSN 1828-695X
    DOI 10.4081/mrm.2022.802
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Variations in

    Arai, Naoki / Nakajima, Masayuki / Matsuyama, Masashi / Matsumura, Sosuke / Yazaki, Kai / Sakai, Chio / Nonaka, Mizu / Yanai, Hidetoshi / Numata, Takeshi / Yamamoto, Yusuke / Akatsu, Yoshibumi / Iijima, Hiroaki / Morishima, Yuko / Matsuno, Yosuke / Endo, Takeo / Muratani, Masafumi / Ishii, Yukio / Saito, Takefumi / Hizawa, Nobuyuki

    American journal of respiratory cell and molecular biology

    2023  Volume 69, Issue 2, Page(s) 242–246

    MeSH term(s) Humans ; Idiopathic Pulmonary Fibrosis/drug therapy ; Idiopathic Pulmonary Fibrosis/genetics ; Idiopathic Pulmonary Fibrosis/metabolism ; Indoles/pharmacology ; Indoles/therapeutic use ; Gene Expression ; Treatment Outcome
    Chemical Substances nintedanib (G6HRD2P839) ; Indoles
    Language English
    Publishing date 2023-08-01
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2023-0054LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2851: Show issues Location:
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  7. Article ; Online: Depletion of PD-1 or PD-L1 did not affect the mortality of mice infected with Mycobacterium avium.

    Nakajima, Masayuki / Matsuyama, Masashi / Kawaguchi, Mio / Matsumura, Sosuke / Kiwamoto, Takumi / Matsuno, Yosuke / Morishima, Yuko / Yoshida, Kazufumi / Sherpa, Mingma Thsering / Yazaki, Kai / Tanaka, Ryota / Okiyama, Naoko / Muratani, Masafumi / Ishii, Yukio / Hizawa, Nobuyuki

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 18008

    Abstract: The programmed cell death-1 (PD-1) and programmed cell death-ligand 1 (PD-L1) pathway could affect antimicrobial immune responses by suppressing T cell activity. Several recent studies demonstrated that blocking of the PD-1/PD-L1 pathway exacerbated ... ...

    Abstract The programmed cell death-1 (PD-1) and programmed cell death-ligand 1 (PD-L1) pathway could affect antimicrobial immune responses by suppressing T cell activity. Several recent studies demonstrated that blocking of the PD-1/PD-L1 pathway exacerbated Mycobacterium tuberculosis infection. However, the effect of blocking this pathway in pulmonary Mycobacterium avium-intracellulare complex (MAC) infection is not fully understood. Wild-type, PD-1-deficient mice, and PD-L1-deficient mice were intranasally infected with Mycobacterium avium bacteria. Depletion of PD-1 or PD-L1 did not affect mortality and bacterial burden in MAC-infected mice. However, marked infiltration of CD8-positive T lymphocytes was observed in the lungs of PD-1 and PD-L1-deficient mice compared to wild-type mice. Comprehensive transcriptome analysis showed that levels of gene expressions related to Th1 immunity did not differ according to the genotypes. However, genes related to the activity of CD8-positive T cells and related chemokine activity were upregulated in the infected lungs of PD-1 and PD-L1-deficient mice. Thus, the lack of change in susceptibility to MAC infection in PD-1 and PD-L1-deficient mice might be explained by the absence of obvious changes in the Th1 immune response. Furthermore, activated CD8-positive cells in response to MAC infection in these mice seemed to not be relevant in the control of MAC infection.
    MeSH term(s) Animals ; B7-H1 Antigen/deficiency ; B7-H1 Antigen/genetics ; B7-H1 Antigen/immunology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/microbiology ; Cell Movement ; Female ; Gene Expression Profiling ; Gene Expression Regulation ; Genotype ; Lung/immunology ; Lung/microbiology ; Lung/pathology ; Lymphocyte Activation ; Mice ; Mice, Knockout ; Mycobacterium avium/immunology ; Mycobacterium avium/pathogenicity ; Programmed Cell Death 1 Receptor/deficiency ; Programmed Cell Death 1 Receptor/genetics ; Programmed Cell Death 1 Receptor/immunology ; Survival Analysis ; Th1 Cells/immunology ; Th1 Cells/microbiology ; Transcriptome ; Tuberculosis/genetics ; Tuberculosis/immunology ; Tuberculosis/microbiology ; Tuberculosis/mortality
    Chemical Substances B7-H1 Antigen ; Cd274 protein, mouse ; Pdcd1 protein, mouse ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2021-09-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-97391-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Negative-pressure pulmonary Hemorrhaging Due to Severe Obstructive Sleep Apnea.

    Kuramoto, Kenya / Matsuyama, Masashi / Nonaka, Mizu / Takeishi, Takahiro / Oshima, Hisayuki / Matsumura, Sosuke / Nakajima, Masayuki / Sakai, Chio / Shiozawa, Toshihiro / Kiwamoto, Takumi / Tsukahara, Yuko / Takayashiki, Norio / Ogawa, Ryoko / Morishima, Yuko / Noguchi, Masayuki / Hizawa, Nobuyuki

    Internal medicine (Tokyo, Japan)

    2021  Volume 60, Issue 14, Page(s) 2291–2296

    Abstract: A 24-year-old man with a history of bloody sputum for 6 months was referred to our hospital with suspected alveolar hemorrhaging due to vasculitis. Chest computed tomography showed ground-glass opacities in both lungs, and an examination of his ... ...

    Abstract A 24-year-old man with a history of bloody sputum for 6 months was referred to our hospital with suspected alveolar hemorrhaging due to vasculitis. Chest computed tomography showed ground-glass opacities in both lungs, and an examination of his bronchoalveolar lavage fluid showed alveolar hemorrhaging. However, no evidence of vasculitis was found, and subsequent polysomnographic testing confirmed that he had severe obstructive sleep apnea (OSA). Since the alveolar hemorrhaging improved after the initiation of continuous positive airway pressure treatment, the diagnosis was negative-pressure alveolar hemorrhaging due to severe OSA.
    MeSH term(s) Adult ; Continuous Positive Airway Pressure ; Hemorrhage/etiology ; Humans ; Infant, Newborn ; Lung Diseases ; Male ; Polysomnography ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/diagnosis ; Young Adult
    Language English
    Publishing date 2021-02-22
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.6206-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 240: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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