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  1. Article ; Online: Time course of tumorigenesis of a newly developed sporadic hemangioblastoma in an elderly patient: illustrative case.

    Sugiyama, Yu / Kuramitsu, Shunichiro / Eguchi, Kaoru / Ito, Masashi / Ando, Ryo / Matsuno, Hiroki / Suzaki, Noriyuki / Maesawa, Satoshi

    Journal of neurosurgery. Case lessons

    2024  Volume 7, Issue 15

    Abstract: Background: von Hippel-Lindau disease-associated hemangioblastomas (HBs) account for 20%-30% of all HB cases, with the appearance of new lesions often observed in the natural course of the disease. By comparison, the development of new lesions is rare ... ...

    Abstract Background: von Hippel-Lindau disease-associated hemangioblastomas (HBs) account for 20%-30% of all HB cases, with the appearance of new lesions often observed in the natural course of the disease. By comparison, the development of new lesions is rare in patients with sporadic HB.
    Observations: A 65-year-old man underwent clipping for an unruptured aneurysm of the anterior communicating artery. Fourteen years later, follow-up magnetic resonance imaging (MRI) revealed a strongly enhanced mass in the right cerebellar hemisphere, diagnosed as a sporadic HB. A retrospective review of MRI studies obtained over the follow-up period revealed the gradual development of peritumoral edema and vascularization before mass formation.
    Lessons: Newly appearing high-intensity T2 lesions in the cerebellum may represent a preliminary stage of tumorigenesis. Careful monitoring of these patients would be indicated, which could provide options for early treatment to improve patient outcomes.
    Language English
    Publishing date 2024-04-08
    Publishing country United States
    Document type Journal Article
    ISSN 2694-1902
    ISSN (online) 2694-1902
    DOI 10.3171/CASE23757
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Difference of coil distribution made by finishing coils in large size aneurysm model with radiolucent coils.

    Matsuno, Hiroki / Izumi, Takashi / Nishihori, Masahiro / Goto, Shunsaku / Araki, Yoshio / Yokoyama, Kinya / Uda, Kenji / Saito, Ryuta

    Nagoya journal of medical science

    2023  Volume 85, Issue 4, Page(s) 725–732

    Abstract: We conducted a study to understand the characteristics of the finishing coils to select the appropriate coil for the final stage of embolization. Consequently, experimental embolization was performed on a 10 mm spherical silicone aneurysm filled with ... ...

    Abstract We conducted a study to understand the characteristics of the finishing coils to select the appropriate coil for the final stage of embolization. Consequently, experimental embolization was performed on a 10 mm spherical silicone aneurysm filled with radiolucent coils, which simulated a volume embolization ratio of 20%. Nine different coils (i-ED complex ∞ SilkySoft, SilkySoft, ExtraSoft, V-Trak HyperSoft helical, Barricade 10 complex finishing, Optima complex 10 soft, Target 360 Ultra, Galaxy G3 mini, and Axium prime 3D ExtraSoft) were analyzed six times at random. After each coil insertion, indices that include area, Feret diameter, circularity, and centroid center of mass were calculated using biplane x-ray images. Furthermore, these data were analyzed using the spring constant k, which represents the stiffness of the coil. In multiple comparisons, a significant difference was observed in the area analysis. The i-ED complex ∞ SilkySoft was more widespread than Target 360 Ultra (
    MeSH term(s) Humans ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/therapy ; Embolization, Therapeutic/methods
    Language English
    Publishing date 2023-12-18
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 193148-9
    ISSN 2186-3326 ; 0027-7622
    ISSN (online) 2186-3326
    ISSN 0027-7622
    DOI 10.18999/nagjms.85.4.725
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.181: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Usefulness of Neuromelanin Sensitive MRI for En Plaque Meningeal Melanocytoma Involving the Cavernous Sinus: A Case Report.

    Matsuno, Hiroki / Takasu, Syuntaro / Seki, Yukio

    NMC case report journal

    2019  Volume 6, Issue 2, Page(s) 43–46

    Abstract: Intracranial meningeal melanocytoma is a rare tumor. Here, we report a case of pathologically diagnosed en plaque meningeal melanocytoma involving the cavernous sinus along with a review of the pertinent literature. A 35-year-old female presented with ... ...

    Abstract Intracranial meningeal melanocytoma is a rare tumor. Here, we report a case of pathologically diagnosed en plaque meningeal melanocytoma involving the cavernous sinus along with a review of the pertinent literature. A 35-year-old female presented with progressing left oculomotor nerve palsy and melanosis oculi. Radiological examinations revealed a lesion spreading in an en plaque fashion and involving the left cavernous sinus, which was hyperintense on T
    Language English
    Publishing date 2019-03-21
    Publishing country Japan
    Document type Case Reports
    ISSN 2188-4226
    ISSN 2188-4226
    DOI 10.2176/nmccrj.cr.2018-0211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A new chromosome 14-based human artificial chromosome (HAC) vector system for efficient transgene expression in human primary cells

    Kakeda, Minoru / Nagata, Keiko / Osawa, Kanako / Matsuno, Hiroki / Hiratsuka, Masaharu / Sano, Akiko / Okazaki, Akiyo / Shitara, Shingo / Nishikawa, Satoshi / Masuya, Anri / Hata, Toshihiro / Wako, Shun / Osaki, Mitsuhiko / Kazuki, Yasuhiro / Oshimura, Mitsuo / Tomizuka, Kazuma

    Biochemical and biophysical research communications. 2011 Nov. 25, v. 415, no. 3

    2011  

    Abstract: The use of non-integrating human artificial chromosomes (HACs) in gene therapy possibly allows for safe and reliable genetic modification of human cells without insertional mutagenesis and/or unexpected oncogene activations. Although we previously ... ...

    Abstract The use of non-integrating human artificial chromosomes (HACs) in gene therapy possibly allows for safe and reliable genetic modification of human cells without insertional mutagenesis and/or unexpected oncogene activations. Although we previously demonstrated that the HAC provides long-term therapeutic erythropoietin (EPO) production in normal human primary fibroblasts (hPFs), the expression level of EPO was too low to provide medical benefits for human therapy. Thus, the next challenge for the application of this system in therapeutic purposes is to improve the transgene expression on HACs. Here, we newly constructed chromosome 14-based HACs and examined the effects of the telomere and promoter regions on the expression level of the tansgene in hPFs. We showed that the use of natural telomere/sub-telomere and enhancers within the 5′ untranslated region of the human ubiquitin C gene greatly increased (over 1000-fold) the EPO production in hPFs. Furthermore, we demonstrated the reprogramming of mouse embryonic fibroblasts by HAC-mediated introduction of four transcription factors, and established induced pluripotent stem cells with no trace of the HACs carrying multiple expression cassettes with large genome fragments. These results indicate that this HAC system could allow us to manipulate multiple transgenes efficiently in human primary cells, providing a promising tool not only for gene therapy but also for investigating genome functions in drug discoveries.
    Keywords drugs ; erythropoietin ; fibroblasts ; gene expression ; gene therapy ; genetic engineering ; humans ; induced pluripotent stem cells ; insertional mutagenesis ; mice ; oncogenes ; promoter regions ; telomeres ; transcription (genetics) ; transcription factors ; transgenes ; ubiquitin
    Language English
    Dates of publication 2011-1125
    Size p. 439-444.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 205723-2
    ISSN 0006-291X ; 0006-291X
    ISSN (online) 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2011.10.088
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 71/706: Show issues
    Z 3.8: Show issues

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  5. Article ; Online: A new chromosome 14-based human artificial chromosome (HAC) vector system for efficient transgene expression in human primary cells.

    Kakeda, Minoru / Nagata, Keiko / Osawa, Kanako / Matsuno, Hiroki / Hiratsuka, Masaharu / Sano, Akiko / Okazaki, Akiyo / Shitara, Shingo / Nishikawa, Satoshi / Masuya, Anri / Hata, Toshihiro / Wako, Shun / Osaki, Mitsuhiko / Kazuki, Yasuhiro / Oshimura, Mitsuo / Tomizuka, Kazuma

    Biochemical and biophysical research communications

    2011  Volume 415, Issue 3, Page(s) 439–444

    Abstract: The use of non-integrating human artificial chromosomes (HACs) in gene therapy possibly allows for safe and reliable genetic modification of human cells without insertional mutagenesis and/or unexpected oncogene activations. Although we previously ... ...

    Abstract The use of non-integrating human artificial chromosomes (HACs) in gene therapy possibly allows for safe and reliable genetic modification of human cells without insertional mutagenesis and/or unexpected oncogene activations. Although we previously demonstrated that the HAC provides long-term therapeutic erythropoietin (EPO) production in normal human primary fibroblasts (hPFs), the expression level of EPO was too low to provide medical benefits for human therapy. Thus, the next challenge for the application of this system in therapeutic purposes is to improve the transgene expression on HACs. Here, we newly constructed chromosome 14-based HACs and examined the effects of the telomere and promoter regions on the expression level of the tansgene in hPFs. We showed that the use of natural telomere/sub-telomere and enhancers within the 5' untranslated region of the human ubiquitin C gene greatly increased (over 1000-fold) the EPO production in hPFs. Furthermore, we demonstrated the reprogramming of mouse embryonic fibroblasts by HAC-mediated introduction of four transcription factors, and established induced pluripotent stem cells with no trace of the HACs carrying multiple expression cassettes with large genome fragments. These results indicate that this HAC system could allow us to manipulate multiple transgenes efficiently in human primary cells, providing a promising tool not only for gene therapy but also for investigating genome functions in drug discoveries.
    MeSH term(s) Animals ; Cell Line ; Cellular Reprogramming ; Chromosomes, Artificial, Human/genetics ; Chromosomes, Human, Pair 14/genetics ; Enhancer Elements, Genetic/genetics ; Erythropoietin/genetics ; Fibroblasts ; Gene Expression ; Gene Transfer Techniques ; Genetic Therapy ; Genetic Vectors ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Mice ; Promoter Regions, Genetic/genetics ; Telomere/genetics ; Transgenes
    Chemical Substances Erythropoietin (11096-26-7)
    Language English
    Publishing date 2011-11-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2011.10.088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 116: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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