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  1. AU="Matsuo, Kazuya"
  2. AU="Yaniv, Ziv"
  3. AU="Robertson, Anne"
  4. AU="Davis, Rebecca"
  5. AU="Joy, Tisha R"
  6. AU="Özil, Musa"
  7. AU="Franci, Lorenzo"
  8. AU="Khoobdel, Mehdi"
  9. AU="Ian B Wilkinson"
  10. AU="Sarpün, I.H."
  11. AU="Gums, Jeremiah J"
  12. AU="Petsalaki, Eleni"
  13. AU="Yu, Weichao"
  14. AU="Mertens, Anne Wiebke"
  15. AU="Roitershtein, Alexander"
  16. AU="Deppen, Stephen"
  17. AU="Goliath, Rene"
  18. AU="Emons, Günter"
  19. AU="Sarah S. Barnett"

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  1. Artikel ; Online: [Photopharmacological Tools for Mitotic Cell Division].

    Matsuo, Kazuya

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2022  Band 142, Heft 5, Seite(n) 513–519

    Abstract: Genetic information is replicated and transmitted from a parent cell to two identical daughter cells through mitotic cell division. To accomplish this dynamic process with high accuracy and precision, various motor proteins work in a concerted manner. ... ...

    Abstract Genetic information is replicated and transmitted from a parent cell to two identical daughter cells through mitotic cell division. To accomplish this dynamic process with high accuracy and precision, various motor proteins work in a concerted manner. Especially in the metaphase, mitotic chromosomes are delivered by the motor protein of centromere-associated protein E (CENP-E) to the cell equatorial plane (metaphase plate) along mitotic spindles. However, the critical functional failure of CENP-E can activate the spindle assembly checkpoint through the misalignment of chromosomes at the metaphase plate. In this symposium review, the reversibly photoswitchable CENP-E inhibitor PCEI-HU (5) is reported. Compound 5 exhibited almost quantitative trans-cis photoisomerization of the arylazopyrazole photoswitch by illuminating light at 365 nm and 510 nm. Depending on the photoisomerization, CENP-E activity was regulated not only in vitro but also in cells. We successfully established a novel technique using 5 to dynamically photocontrol the CENP-E-dependent chromosome movement and mitotic progression in a living cell.
    Mesh-Begriff(e) Cell Division ; Metaphase ; Spindle Apparatus
    Sprache Japanisch
    Erscheinungsdatum 2022-03-30
    Erscheinungsland Japan
    Dokumenttyp Journal Article
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.21-00203-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: In-cell chemical construction of a photoswitchable CENP-E using a photochromic covalent inhibitor.

    Matsuo, Kazuya / Yamaoka, Shusuke / Waku, Tomonori / Kobori, Akio

    Organic & biomolecular chemistry

    2024  

    Abstract: An arylazopyrazole-based covalent inhibitor targeting the mitotic motor protein of centromere-associated protein E (CENP-E) was developed. Using this photoswitchable inhibitor, a photoswitchable CENP-E was chemically constructed in cells, which enabled ... ...

    Abstract An arylazopyrazole-based covalent inhibitor targeting the mitotic motor protein of centromere-associated protein E (CENP-E) was developed. Using this photoswitchable inhibitor, a photoswitchable CENP-E was chemically constructed in cells, which enabled to local control of mitotic cell division with light illumination.
    Sprache Englisch
    Erscheinungsdatum 2024-05-24
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d4ob00647j
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Rational design and development of a lit-active photoswitchable inhibitor targeting CENP-E.

    Matsuo, Kazuya / Tamaoki, Nobuyuki

    Organic & biomolecular chemistry

    2021  Band 19, Heft 32, Seite(n) 6979–6984

    Abstract: In the emerging field of photopharmacology, synthetic photoswitches based on reversible photochemical reactions are fused to bioactive molecules. Azobenzene derivatives, which can undergo trans-cis photoisomerization, are typical photoswitches. Most ... ...

    Abstract In the emerging field of photopharmacology, synthetic photoswitches based on reversible photochemical reactions are fused to bioactive molecules. Azobenzene derivatives, which can undergo trans-cis photoisomerization, are typical photoswitches. Most azobenzene-based photochemical tools are active in the thermodynamically stable trans, but not cis, form. cis-Active photochemical tools would be ideal because they can be "initially inactive and active after light illumination" in a reversible mode only by light illumination. However, only a few rational strategies for constructing such "lit-active" photopharmacological tools has been developed. Herein, we report a rationally designed lit-active photoswitchable inhibitor targeting centromere-associated protein E (CENP-E). Using the lit-active inhibitor, we were able to photoregulate CENP-E-dependent mitotic chromosome location in cells. This study provides a framework to facilitate further progress in the development of photopharmacological tools.
    Sprache Englisch
    Erscheinungsdatum 2021-08-04
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d1ob01332g
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Comparison of the tidal volume by the recruitment maneuver combined with positive end-expiratory pressure for mechanically ventilated children.

    Tsukamoto, Masanori / Goto, Maho / Hitosugi, Takashi / Matsuo, Kazuya / Yokoyama, Takeshi

    Scientific reports

    2023  Band 13, Heft 1, Seite(n) 18690

    Abstract: The recruitment maneuver (RM) combined with PEEP to prevent atelectasis have beneficial effects. However, the change in tidal volume ( ... ...

    Abstract The recruitment maneuver (RM) combined with PEEP to prevent atelectasis have beneficial effects. However, the change in tidal volume (V
    Mesh-Begriff(e) Humans ; Child ; Tidal Volume ; Respiration, Artificial/methods ; Positive-Pressure Respiration/methods ; Anesthesia, General
    Sprache Englisch
    Erscheinungsdatum 2023-10-31
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-45441-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Transcriptome Analysis in Hippocampus of Rats Prenatally Exposed to Valproic Acid and Effects of Intranasal Treatment of Oxytocin.

    Matsuo, Kazuya / Shinoda, Yasuharu / Abolhassani, Nona / Nakabeppu, Yusaku / Fukunaga, Kohji

    Frontiers in psychiatry

    2022  Band 13, Seite(n) 859198

    Abstract: Autism spectrum disorder (ASD) is a heterogeneous disorder characterized by repetitive behaviors and social impairments, often accompanied by learning disabilities. It has been documented that the neuropeptide oxytocin (OXT) ameliorates core symptoms in ... ...

    Abstract Autism spectrum disorder (ASD) is a heterogeneous disorder characterized by repetitive behaviors and social impairments, often accompanied by learning disabilities. It has been documented that the neuropeptide oxytocin (OXT) ameliorates core symptoms in patients with ASD. We recently reported that chronic administration of intranasal OXT reversed social and learning impairments in prenatally valproic acid (VPA)-exposed rats. However, the underlying molecular mechanisms remain unclear. Here, we explored molecular alterations in the hippocampus of rats and the effects of chronic administration of intranasal OXT (12 μg/kg/d). Microarray analyses revealed that prenatal VPA exposure altered gene expression, a part of which is suggested as a candidate in ASD and is involved in key features including memory, developmental processes, and epilepsy. OXT partly improved the expression of these genes, which were predicted to interact with those involved in social behaviors and hippocampal-dependent memory. Collectively, the present study documented molecular profiling in the hippocampus related to ASD and improvement by chronic treatment with OXT.
    Sprache Englisch
    Erscheinungsdatum 2022-03-30
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2022.859198
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Structural polymorphism of the nucleic acids in pentanucleotide repeats associated with the neurological disorder CANVAS.

    Kudo, Kenta / Hori, Karin / Asamitsu, Sefan / Maeda, Kohei / Aida, Yukari / Hokimoto, Mei / Matsuo, Kazuya / Yabuki, Yasushi / Shioda, Norifumi

    The Journal of biological chemistry

    2024  Band 300, Heft 4, Seite(n) 107138

    Abstract: Short tandem repeats are inherently unstable during DNA replication depending on repeat length, and the expansion of the repeat length in the human genome is responsible for repeat expansion disorders. Pentanucleotide AAGGG and ACAGG repeat expansions in ...

    Abstract Short tandem repeats are inherently unstable during DNA replication depending on repeat length, and the expansion of the repeat length in the human genome is responsible for repeat expansion disorders. Pentanucleotide AAGGG and ACAGG repeat expansions in intron 2 of the gene encoding replication factor C subunit 1 (RFC1) cause cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS) and other phenotypes of late-onset cerebellar ataxia. Herein, we reveal the structural polymorphism of the RFC1 repeats associated with CANVAS in vitro. Single-stranded AAGGG repeat DNA formed a hybrid-type G-quadruplex, whereas its RNA formed a parallel-type G-quadruplex with three layers. The RNA of the ACAGG repeat formed hairpin structure comprising C-G and G-C base pairs with A:A and GA:AG mismatched repeats. Furthermore, both pathogenic repeat RNAs formed more rigid structures than those of the nonpathogenic repeat RNAs. These findings provide novel insights into the structural polymorphism of the RFC1 repeats, which may be closely related to the disease mechanism of CANVAS.
    Mesh-Begriff(e) Humans ; Cerebellar Ataxia/genetics ; Cerebellar Ataxia/metabolism ; DNA Repeat Expansion ; G-Quadruplexes ; Microsatellite Repeats ; Polymorphism, Genetic ; Replication Protein C/genetics ; Replication Protein C/metabolism ; Replication Protein C/chemistry ; RNA/chemistry ; RNA/genetics ; RNA/metabolism ; Peripheral Nervous System Diseases/genetics ; Peripheral Nervous System Diseases/metabolism ; Vestibular Diseases/genetics ; Vestibular Diseases/metabolism
    Chemische Substanzen Replication Protein C (EC 3.6.4.-) ; RFC1 protein, human ; RNA (63231-63-0) ; CANVAS syndrome
    Sprache Englisch
    Erscheinungsdatum 2024-03-05
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2024.107138
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Transarterial Onyx embolization with targeted balloon-assisted sinus protection for treatment of dural arteriovenous fistula of the lateral tentorial sinus.

    Matsuo, Kazuya / Fujita, Atsushi / Kohta, Masaaki / Kohmura, Eiji

    Radiology case reports

    2020  Band 15, Heft 4, Seite(n) 405–410

    Abstract: We present a unique sinus protection technique that uses a short-length supercompliant balloon during the transarterial Onyx embolization for the dural arteriovenous fistula (DAVF) of the lateral tentorial sinus. With this technique, we temporarily ... ...

    Abstract We present a unique sinus protection technique that uses a short-length supercompliant balloon during the transarterial Onyx embolization for the dural arteriovenous fistula (DAVF) of the lateral tentorial sinus. With this technique, we temporarily change the Borden classification from type II to type III, avoiding venous compromise and reducing the risk of Onyx migration into the patent sinus. A 54-year-old man presented with left persistent tinnitus of 4 months' duration. Cerebral angiography revealed a Borden type II left lateral tentorial sinus-DAVF associated with retrograde cortical venous reflux draining into the vein of Labbé. In the venous phase, the ipsilateral transverse-sigmoid sinus was recognized as a functional sinus and the posterior temporal vein drained into the transverse sinus near the drainage channel. We planned to perform transarterial Onyx embolization using a short-length sinus protection balloon to protect against Onyx migration. During transarterial Onyx injection, a 7 × 7-mm HyperForm balloon was navigated into the affected sinus and positioned to cover the drainage channel from the shunt. After confirming the change in Borden classification with angiography, transarterial Onyx embolization was performed via the middle meningeal artery. This procedure resulted in complete obliteration of the fistula with good patency of both the transverse-sigmoid sinus and neighboring normal cortical veins. No procedure-related complications were observed and the patient remained free of recurrence during the 24-month follow-up period. Short-length balloon-protected Onyx embolization can be safe and effective for the treatment of Borden type II DAVF.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-02-07
    Erscheinungsland Netherlands
    Dokumenttyp Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2020.01.018
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: 5-aminolevulinic acid inhibits oxidative stress and ameliorates autistic-like behaviors in prenatal valproic acid-exposed rats.

    Matsuo, Kazuya / Yabuki, Yasushi / Fukunaga, Kohji

    Neuropharmacology

    2020  Band 168, Seite(n) 107975

    Abstract: Autism spectrum disorders (ASDs) constitute a neurodevelopmental disorder characterized by social deficits, repetitive behaviors, and learning disability. Oxidative stress and mitochondrial dysfunction are associated with ASD brain pathology. Here, we ... ...

    Abstract Autism spectrum disorders (ASDs) constitute a neurodevelopmental disorder characterized by social deficits, repetitive behaviors, and learning disability. Oxidative stress and mitochondrial dysfunction are associated with ASD brain pathology. Here, we used oxidative stress in prenatal valproic acid (VPA)-exposed rats as an ASD model. After maternal VPA exposure (600 mg/kg, p.o.) on embryonic day (E) 12.5, temporal analyses of oxidative stress in the brain using an anti-4-hydroxy-2-nonenal antibody revealed that oxidative stress was increased in the hippocampus after birth. This was accompanied by aberrant enzymatic activity in the mitochondrial electron transport chain and reduced adenosine triphosphate (ATP) levels in the hippocampus. VPA-exposed rats exhibited impaired spatial reference and object recognition memory alongside impaired social behaviors and repetitive behaviors. ASD-like behaviors including learning and memory were rescued by chronic oral administration of 5-aminolevulinic acid (5-ALA; 30 mg/kg/day) and intranasal administration of oxytocin (OXT; 12 μg/kg/day), a neuropeptide that improves social behavior in ASD patients. 5-ALA but not OXT treatment ameliorated oxidative stress and mitochondrial dysfunction in the hippocampus of VPA-exposed rats. Fewer parvalbumin-positive interneurons were observed in VPA-exposed rats. Both 5-ALA and OXT treatments augmented the number of parvalbumin-positive interneurons. Collectively, our results indicate that oral 5-ALA administration ameliorated oxidative stress and mitochondrial dysfunction, suggesting that 5-ALA administration improves ASD-like neuropathology and behaviors via mechanisms different to those of OXT.
    Mesh-Begriff(e) Aminolevulinic Acid/pharmacology ; Aminolevulinic Acid/therapeutic use ; Animals ; Anticonvulsants/toxicity ; Autistic Disorder/chemically induced ; Autistic Disorder/drug therapy ; Autistic Disorder/metabolism ; Dose-Response Relationship, Drug ; Drug Repositioning/methods ; Exploratory Behavior/drug effects ; Exploratory Behavior/physiology ; Female ; Male ; Maze Learning/drug effects ; Maze Learning/physiology ; Oxidative Stress/drug effects ; Oxidative Stress/physiology ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/therapeutic use ; Pregnancy ; Prenatal Exposure Delayed Effects/chemically induced ; Prenatal Exposure Delayed Effects/drug therapy ; Prenatal Exposure Delayed Effects/metabolism ; Rats ; Rats, Sprague-Dawley ; Valproic Acid/toxicity
    Chemische Substanzen Anticonvulsants ; Photosensitizing Agents ; Valproic Acid (614OI1Z5WI) ; Aminolevulinic Acid (88755TAZ87)
    Sprache Englisch
    Erscheinungsdatum 2020-01-25
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218272-5
    ISSN 1873-7064 ; 0028-3908
    ISSN (online) 1873-7064
    ISSN 0028-3908
    DOI 10.1016/j.neuropharm.2020.107975
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: A visible light-controllable Rho kinase inhibitor based on a photochromic phenylazothiazole.

    Matsuo, Kazuya / Thayyil, Sampreeth / Kawaguchi, Mitsuyasu / Nakagawa, Hidehiko / Tamaoki, Nobuyuki

    Chemical communications (Cambridge, England)

    2021  Band 57, Heft 93, Seite(n) 12500–12503

    Abstract: Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine-threonine kinase whose inhibitors are useful for the regulation of the actomyosin system. Here, we developed a photoswitchable ROCK inhibitor based on a phenylazothiazole scaffold. ... ...

    Abstract Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine-threonine kinase whose inhibitors are useful for the regulation of the actomyosin system. Here, we developed a photoswitchable ROCK inhibitor based on a phenylazothiazole scaffold. The reversible
    Mesh-Begriff(e) 3T3 Cells ; Animals ; Isomerism ; Light ; Mice ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/metabolism ; Thiazoles/chemistry ; Thiazoles/metabolism ; rho-Associated Kinases/antagonists & inhibitors ; rho-Associated Kinases/metabolism
    Chemische Substanzen Protein Kinase Inhibitors ; Thiazoles ; Rock1 protein, mouse (EC 2.7.11.1) ; rho-Associated Kinases (EC 2.7.11.1)
    Sprache Englisch
    Erscheinungsdatum 2021-11-23
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d1cc04905d
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: A visible light-controllable Rho kinase inhibitor based on a photochromic phenylazothiazole

    Matsuo, Kazuya / Thayyil, Sampreeth / Kawaguchi, Mitsuyasu / Nakagawa, Hidehiko / Tamaoki, Nobuyuki

    Chemical communications. 2021 Nov. 23, v. 57, no. 93

    2021  

    Abstract: Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine–threonine kinase whose inhibitors are useful for the regulation of the actomyosin system. Here, we developed a photoswitchable ROCK inhibitor based on a phenylazothiazole scaffold. ... ...

    Abstract Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine–threonine kinase whose inhibitors are useful for the regulation of the actomyosin system. Here, we developed a photoswitchable ROCK inhibitor based on a phenylazothiazole scaffold. The reversible trans–cis isomerization by visible light stimuli enabled us to manipulate ROCK activities in vitro and in cells.
    Schlagwörter isomerization ; light ; protein kinases
    Sprache Englisch
    Erscheinungsverlauf 2021-1123
    Umfang p. 12500-12503.
    Erscheinungsort The Royal Society of Chemistry
    Dokumenttyp Artikel
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d1cc04905d
    Datenquelle NAL Katalog (AGRICOLA)

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