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Article ; Online: International comparison of Hodgkin and non-Hodgkin lymphoma incidence.

Saito, Eiko / Matsuoka, Junko

2019 Volume 50, Issue 1, Page(s) 96–97

Language	English
Publishing date	2019-12-21
Publishing country	England
Document type	Journal Article
ZDB-ID	190978-2
ISSN	1465-3621 ; 0368-2811
ISSN (online)	1465-3621
ISSN	0368-2811
DOI	10.1093/jjco/hyz202
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Article ; Online: Incidence rates of thyroid cancer in the world from the Cancer Incidence in Five Continents XI.

Katanoda, Kota / Matsuoka, Junko

Japanese journal of clinical oncology

2019 Volume 49, Issue 6, Page(s) 587–588

Language	English
Publishing date	2019-05-20
Publishing country	England
Document type	Journal Article
ZDB-ID	190978-2
ISSN	1465-3621 ; 0368-2811
ISSN (online)	1465-3621
ISSN	0368-2811
DOI	10.1093/jjco/hyz082
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Article ; Online: Kidney cancer incidence rates in the world from the Cancer Incidence in Five Continents XI.

Hori, Megumi / Matsuoka, Junko

Japanese journal of clinical oncology

2019 Volume 49, Issue 3, Page(s) 295–296

Language	English
Publishing date	2019-03-29
Publishing country	England
Document type	Journal Article
ZDB-ID	190978-2
ISSN	1465-3621 ; 0368-2811
ISSN (online)	1465-3621
ISSN	0368-2811
DOI	10.1093/jjco/hyz021
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Article ; Online: Incidence rates of malignant lymphoma in the world from the Cancer Incidence in Five Continents XI.

Matsuoka, Junko / Katanoda, Kota

Japanese journal of clinical oncology

2019 Volume 49, Issue 4, Page(s) 393–394

Language	English
Publishing date	2019-03-14
Publishing country	England
Document type	Journal Article
ZDB-ID	190978-2
ISSN	1465-3621 ; 0368-2811
ISSN (online)	1465-3621
ISSN	0368-2811
DOI	10.1093/jjco/hyz043
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Article ; Online: Factors Related to Sleeping Disorder Due to Pruritus in Patients with Chronic Liver Disease.

Internal medicine (Tokyo, Japan)

2021 Volume 60, Issue 20, Page(s) 3195–3203

Abstract: Objective This study evaluated cases of pruritus, which is known to be associated with sleep disorder, in chronic liver disease (CLD) patients. Methods Questionnaires were given to 339 enrolled CLD outpatients in winter (November 2019 to March 2020) and ... ...

Abstract	Objective This study evaluated cases of pruritus, which is known to be associated with sleep disorder, in chronic liver disease (CLD) patients. Methods Questionnaires were given to 339 enrolled CLD outpatients in winter (November 2019 to March 2020) and again in summer (April to October 2020) (median interval: 104 days). Relative changes in symptoms shown by a visual analogue scale (VAS) and Kawashima's pruritus score between winter and summer were evaluated in Study 1 (n=199), while Study 2 examined the clinical features of patients with sleep disorder based on the results of the second questionnaire (n=235, median age 70 years old; 141 men, liver cirrhosis 37%). Results Study 1. There was a significant relationship in VAS between daytime and nighttime for each season, as well as between winter and summer for each time period (p<0.001). A comparison of Kawashima's pruritus scores for the daytime and nighttime showed no significant seasonal differences (p=0.436 and 0.828, respectively). When Kawashima's score increased, so did the average VAS for both daytime (0:1:2:3:4=0.4±0.2:1.4±0.9:3.0±1.8:5.9±2.1:6.2±2.3) and nighttime (0:1:2:3:4=0.3±0.1:1.4±1.5:3.5±2.3:6.7±2.6:6.9±1.8) (p<0.001 for both). Study 2. Twenty subjects (8.5%) complained of sleep disorder. An elevated FIB-4 index (≥3.07) showed a good predictive value for sleep disorder (p<0.01). The cut-off for the daytime and nighttime VAS values for existing sleep disorder were 1.6 [area under the curve (AUC) 0.901] and 3.4 (AUC 0.931). The respective sensitivity, specificity, and positive and negative predictive values for sleep disorder based on Kawashima's score (≥2) were 0.85, 0.28, 0.10, and 0.95 for the daytime and 1.00, 0.29, 0.12, and 1.00 for the nighttime. Conclusion Intervention against pruritus is recommended in CLD patients with a high Kawashima's score (≥2) in any season, especially with an elevated FIB-4 index.
MeSH term(s)	Aged ; Humans ; Liver Diseases/complications ; Liver Diseases/epidemiology ; Male ; Pain Measurement ; Pruritus/diagnosis ; Pruritus/epidemiology ; Pruritus/etiology ; Sleep Wake Disorders/diagnosis ; Sleep Wake Disorders/epidemiology ; Sleep Wake Disorders/etiology ; Surveys and Questionnaires
Language	English
Publishing date	2021-10-15
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.7129-21
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Article ; Online: Easy clinical predictor for low BCAA to tyrosine ratio in chronic liver disease patients with hepatocellular carcinoma: Usefulness of ALBI score as nutritional prognostic marker.

Cancer medicine

2021 Volume 10, Issue 11, Page(s) 3584–3592

Abstract: Background/aim: Low branched-chain amino acid (BCAA) to tyrosine ratio (BTR) is known as an indicator of amino acid imbalance. We elucidated usefulness of newly developed albumin-bilirubin (ALBI) score as alternative methods of BTR in patients with ... ...

Abstract	Background/aim: Low branched-chain amino acid (BCAA) to tyrosine ratio (BTR) is known as an indicator of amino acid imbalance. We elucidated usefulness of newly developed albumin-bilirubin (ALBI) score as alternative methods of BTR in patients with naïve hepatocellular carcinoma (HCC) retrospectively. Materials/methods: In 842 patients with HCC and without BCAA supplementation (71 years, male 614, Child-Pugh A:B:C = 689:116:37), relationships among BTR and clinical features were evaluated. Of those, 438 patients, with Milan criteria HCC, treated curatively were divided into the high-BTR (>4.4) (n = 293) and low-BTR (≤4.4) (n = 145) groups. The prognostic value of BTR was evaluated using inverse probability weighting (IPW) with propensity score. Results: The low-BTR group showed worse prognosis than the other (3-, 5-, 10-year overall survival rates: 88.9% vs. 86.3%/70.5% vs. 78.1%/38.1% vs. 52.3%, respectively; p < 0.001). Multivariate Cox-hazard analysis adjusted for IPW showed elderly (≥65 years) HR 2.314, p = 0.001), female gender (HR 0.422, p < 0.001), ECOG PS ≥2 (HR 3.032, p = 0.002), low platelet count (HR 1.757, p = 0.010), and low BTR (≤4.4) (HR 1.852, p = 0.005) to be significant prognostic factors. Both serum albumin level (r = 0.370, p < 0.001) and ALBI score (r = -0.389, p < 0.001) showed a significant relationship with BTR. Child-Pugh class B, modified ALBI grade (mALBI) 2a, and mALBI 2b predictive values for BTR were 3.589, 4.509, and 4.155 (AUC range: 0.735-0.770), respectively, while the predictive value of ALBI score for low-BTR (≤4.4) was -2.588 (AUC 0.790). Conclusion: ALBI score -2.588 was a predictor for low-BTR (≤4.4), which was prognostic factors for early HCC patients, and at least patients with mALBI 2b might have an amino acid imbalance.
MeSH term(s)	Aged ; Amino Acids, Branched-Chain/blood ; Bilirubin/blood ; Biomarkers/blood ; Carcinoma, Hepatocellular/blood ; Carcinoma, Hepatocellular/mortality ; Chronic Disease ; Epidemiologic Methods ; Female ; Humans ; Liver Diseases/blood ; Liver Diseases/complications ; Liver Diseases/mortality ; Liver Neoplasms/blood ; Liver Neoplasms/mortality ; Male ; Nutritional Status ; Prognosis ; Protein-Energy Malnutrition/blood ; Protein-Energy Malnutrition/diagnosis ; Serum Albumin/analysis ; Tyrosine/blood
Chemical Substances	Amino Acids, Branched-Chain ; Biomarkers ; Serum Albumin ; Tyrosine (42HK56048U) ; Bilirubin (RFM9X3LJ49)
Language	English
Publishing date	2021-05-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.3908
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Article: [Synchronous gastrointestinal stromal tumors of the rectum and duodenum: a case report].

Minoda, Yosuke / Itaba, Soichi / Kaku, Toyoma / Makihara, Kosuke / Matsuoka, Junko / Murao, Hiroyuki / Hamada, Tetsuo / Nakamura, Kazuhiko

Nihon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology

2015 Volume 112, Issue 11, Page(s) 1991–1997

Abstract: An 85-year-old woman with anemia underwent colonoscopy, which revealed a 25-mm submucosal tumor with ulceration in the lower rectum. Histological examination of a biopsy showed that the lesion was a gastrointestinal stromal tumor (GIST). Subsequent ... ...

Abstract	An 85-year-old woman with anemia underwent colonoscopy, which revealed a 25-mm submucosal tumor with ulceration in the lower rectum. Histological examination of a biopsy showed that the lesion was a gastrointestinal stromal tumor (GIST). Subsequent esophagogastroduodenoscopy revealed a submucosal tumor in the duodenum, and examination of a biopsy obtained by endoscopic ultrasound-guided fine-needle aspiration also confirmed that this lesion was a GIST. The rectal lesion was surgically resected to control bleeding and was confirmed as a GIST histologically. Simultaneous development of GISTs in the rectum and duodenum is extremely rare.
MeSH term(s)	Aged, 80 and over ; Duodenal Neoplasms/pathology ; Female ; Gastrointestinal Stromal Tumors/pathology ; Humans ; Neoplasms, Multiple Primary/pathology ; Rectal Neoplasms/pathology
Language	Japanese
Publishing date	2015-09-25
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	708695-7
ISSN	1349-7693 ; 0446-6586
ISSN (online)	1349-7693
ISSN	0446-6586
DOI	10.11405/nisshoshi.112.1991
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Article: [Three cases of pedunculated gastric hamartomatous inverted polyps resected endoscopically].

Matsuoka, Junko / Itaba, Soichi / Makihara, Yasuaki / Murao, Hiroyuki / Umeno, Naruhiro / Minoda, Yosuke / Kaku, Toyoma / Kuniyoshi, Masami / Hamada, Tetsuo / Nakamura, Kazuhiko

Nihon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology

2015 Volume 112, Issue 6, Page(s) 1030–1036

Abstract: We report three cases of pedunculated gastric hamartomatous inverted polyps (HIPs) that were successfully treated by endoscopic polypectomy. The first case involved an 87-year-old woman with mild anemia. Esophagogastroduodenoscopy (EGD) revealed a ... ...

Abstract	We report three cases of pedunculated gastric hamartomatous inverted polyps (HIPs) that were successfully treated by endoscopic polypectomy. The first case involved an 87-year-old woman with mild anemia. Esophagogastroduodenoscopy (EGD) revealed a pedunculated, reddish polyp located at the greater curvature of the upper stomach. The second case involved a 34-year-old woman in whom a pedunculated polyp was found at the gastric fundus during routine EGD. The third patient was a 59-year-old woman with epigastric discomfort. EGD revealed a pedunculated polyp in the gastric fundus. Polypectomy was successfully performed in all three cases. Histological examination revealed that the tumors comprised submucosal proliferation of cystically dilated gastric glands and hyperplastic glands;thus, we diagnosed gastric HIPs, which are rare and typically difficult to diagnose. Gastric HIPs should be considered in the differential diagnosis of elevated gastric lesions.
MeSH term(s)	Adult ; Aged, 80 and over ; Female ; Gastroscopy ; Hamartoma/pathology ; Hamartoma/surgery ; Humans ; Middle Aged ; Polyps/pathology ; Polyps/surgery ; Stomach Diseases/pathology ; Stomach Diseases/surgery
Language	Japanese
Publishing date	2015-06-06
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	708695-7
ISSN	1349-7693 ; 0446-6586
ISSN (online)	1349-7693
ISSN	0446-6586
DOI	10.11405/nisshoshi.112.1030
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Article ; Online: Cancer-associated orthotopic myofibroblasts stimulates the motility of gastric carcinoma cells.

Fuyuhiro, Yuhiko / Yashiro, Masakazu / Noda, Satoru / Matsuoka, Junko / Hasegawa, Tsuyoshi / Kato, Yukihiro / Sawada, Tetsuji / Hirakawa, Kosei

Cancer science

2012 Volume 103, Issue 4, Page(s) 797–805

Abstract: Tumor progression has been recognized as the product of evolving crosstalk between cancer cells and the surrounding stromal cells. Cancer-associated orthotopic myofibroblasts may be linked to the progression of gastric carcinomas. To understand the ... ...

Abstract	Tumor progression has been recognized as the product of evolving crosstalk between cancer cells and the surrounding stromal cells. Cancer-associated orthotopic myofibroblasts may be linked to the progression of gastric carcinomas. To understand the significance of orthotopic myofibroblasts, we examined the effects of cancer-associated orthotopic myofibroblasts on the malignant phenotype of gastric cancer cells. Three human gastric cancer cell lines (OCUM-2MD3, OCUM-12, MKN-45) and four human gastric fibroblast cell lines (cancer-associated orthotopic fibroblast [CaF]-29, CaF-33, normal orthotopic fibroblast [NF]-29, NF-33) were used. The cancer-associated orthotopic fibroblast cell lines CaF-29 and CaF-33 were established from a tumoral gastric wall, and normal orthotopic fibroblast NF-29 and NF-33 were established from a non-tumoral gastric wall. Fibroblasts that were α-smooth muscle actin-positive were defined as myofibroblasts. We examined the effects of cancer-associated orthotopic myofibroblasts on the aggressiveness of gastric cancer cells by wound-healing assay, invasion assay, and RT-PCR. The ratios of myofibroblasts in CaF-29 (33%) and CaF-33 (46%) were significantly (P < 0.001) greater than those in NF-29 (11%) or NF-33 (13%). Although all four orthotopic fibroblast lines increased the motility of gastric cancer cells, including migration and invasion ability, the motility-stimulating activity of cancer-associated fibroblasts (CaF-29 and CaF-33) was significantly higher than that of normal fibroblasts (NF-29 and NF-33). These motility-stimulating activities of cancer-associated orthotopic fibroblasts were downregulated by Smad2 siRNA treatment and anti-transforming growth factor-β neutralizing antibody. These findings suggest that cancer-associated orthotopic myofibroblasts may play an important role in the progression of gastric cancers and that transforming growth factor-β produced by myofibroblasts may be one of the factors associated with the aggressiveness of gastric carcinoma cells.
MeSH term(s)	Cadherins/metabolism ; Cell Line ; Cell Line, Tumor ; Cell Movement ; Fibroblasts/physiology ; Humans ; Myofibroblasts/physiology ; Stomach Neoplasms/pathology ; Transforming Growth Factor beta/metabolism ; Vimentin/metabolism
Chemical Substances	Cadherins ; Transforming Growth Factor beta ; Vimentin
Language	English
Publishing date	2012-02-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2115647-5
ISSN	1349-7006 ; 1347-9032
ISSN (online)	1349-7006
ISSN	1347-9032
DOI	10.1111/j.1349-7006.2012.02209.x
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Article ; Online: Role of the stemness factors sox2, oct3/4, and nanog in gastric carcinoma.

Matsuoka, Junko / Yashiro, Masakazu / Sakurai, Katsunobu / Kubo, Naoshi / Tanaka, Hiroaki / Muguruma, Kazuya / Sawada, Tetsuji / Ohira, Masaichi / Hirakawa, Kosei

The Journal of surgical research

2012 Volume 174, Issue 1, Page(s) 130–135

Abstract: Background: Cancer stem cells have been proposed to be responsible for cancer tumorigenicity, and then to persist in tumors as a distinct population and cause relapse and metastasis. Recently, the stemness factors Sox2, Oct3/4, and Nanog were associated ...

Abstract	Background: Cancer stem cells have been proposed to be responsible for cancer tumorigenicity, and then to persist in tumors as a distinct population and cause relapse and metastasis. Recently, the stemness factors Sox2, Oct3/4, and Nanog were associated with induced pluripotent stem cells, suggesting a correlation between these stemness factors and cancer stem cells. We therefore investigated the role of stemness factors in the tumorigenesis of human gastric cancer. Materials and methods: A total of 290 patients who had undergone resection of a primary gastric cancer at our institute were enrolled. A curative R0 resection was performed for 253 of 290 patients, and the remaining 37 patients were treated with a palliative resection. The expression levels of Sox2, Oct3/4, and Nanog were analyzed by immunohistochemistry. Results: Sox2, Oct3/4, and Nanog expression were positive in 159 (55%), 129 (44%), and 28 (10%) of 290 gastric cancers, respectively. There was a statistically significant correlation between Sox2-positive or Oct3/4-negative expression and invasion depth, lymph node metastasis, or lymphatic invasion. In 253 patients with a curative resection, the prognosis of patients with Sox2-positive tumors or Oct3/4-negative tumors was significantly (P < 0.01 or P = 0.04, log-rank) worse than that of patients with Sox2-negative or Oct3/4-positive tumors, respectively. A multivariate analysis revealed the expression of Sox2 or Oct3/4 to be an independent prognostic factor (P = 0.01 or P = 0.04). Conclusions: Sox2-positive expression or Oct3/4-negative expression might be associated with invasion of gastric cancer. Sox2 and Oct3/4 might be independent prognostic factors for patients with gastric cancer.
MeSH term(s)	Homeodomain Proteins/analysis ; Homeodomain Proteins/physiology ; Humans ; Immunohistochemistry ; Nanog Homeobox Protein ; Neoplasm Invasiveness ; Octamer Transcription Factor-3/analysis ; Octamer Transcription Factor-3/physiology ; Prognosis ; SOXB1 Transcription Factors/analysis ; SOXB1 Transcription Factors/physiology ; Stomach Neoplasms/etiology ; Stomach Neoplasms/mortality ; Stomach Neoplasms/pathology
Chemical Substances	Homeodomain Proteins ; NANOG protein, human ; Nanog Homeobox Protein ; Octamer Transcription Factor-3 ; POU5F1 protein, human ; SOX2 protein, human ; SOXB1 Transcription Factors
Language	English
Publishing date	2012-05-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80170-7
ISSN	1095-8673 ; 0022-4804
ISSN (online)	1095-8673
ISSN	0022-4804
DOI	10.1016/j.jss.2010.11.903
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