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Article ; Online: Visualization of the Internal Thoracic Arteries in Giant Cell Arteritis on 18 F-FDG Semiconductor PET/CT.

Maki, Takashi / Matsusaka, Yohji / Egi, Ryota / Seto, Akira / Kuji, Ichiei

2024 Volume 49, Issue 5, Page(s) 484–485

Abstract: Abstract: A 72-year-old woman presented with the fever and the pain of skull and face for 2 weeks. 18 F-FDG PET/CT equipped with semiconductor detectors revealed strong uptake not only in the temporal, cervical, subclavian arteries, and aorta, but also ... ...

Abstract	Abstract: A 72-year-old woman presented with the fever and the pain of skull and face for 2 weeks. 18 F-FDG PET/CT equipped with semiconductor detectors revealed strong uptake not only in the temporal, cervical, subclavian arteries, and aorta, but also in the bilateral internal thoracic arteries. The diagnosis of giant cell arteritis was made. Semiconductor PET can visualize small arteries such as the internal thoracic artery. The patients with giant cell arteritis are at a high risk of ischemic heart disease, and inflammatory involvement of the internal thoracic arteries may affect the outcome of coronary artery bypass grafting.
MeSH term(s)	Female ; Humans ; Aged ; Giant Cell Arteritis/diagnostic imaging ; Fluorodeoxyglucose F18 ; Positron Emission Tomography Computed Tomography ; Mammary Arteries/diagnostic imaging ; Radiopharmaceuticals
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000005158
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Article: Diffuse FDG uptake in the bilateral lungs: hypersensitivity pneumonitis supported by low-dose CT findings.

Goto, Shun / Matsusaka, Yohji / Yamane, Tomohiko / Hoshino, Yuki / Kuji, Ichiei

Asia Oceania journal of nuclear medicine & biology

2022 Volume 10, Issue 1, Page(s) 43–46

Abstract: Hypersensitivity pneumonitis (HP) is an interstitial lung disease resulting from an immune-mediated response in susceptible and sensitized individuals to various inhaled antigens in the environment. Imaging diagnosis is usually based on high-resolution ... ...

Abstract	Hypersensitivity pneumonitis (HP) is an interstitial lung disease resulting from an immune-mediated response in susceptible and sensitized individuals to various inhaled antigens in the environment. Imaging diagnosis is usually based on high-resolution CT findings. Here, we present a 49-year-old man with a history of diffuse large B-cell lymphoma presented with fever and occasional cough.
Language	English
Publishing date	2022-01-17
Publishing country	Iran
Document type	Case Reports
ZDB-ID	2724313-8
ISSN	2322-5726 ; 2322-5718
ISSN (online)	2322-5726
ISSN	2322-5718
DOI	10.22038/AOJNMB.2021.56000.1393
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Article ; Online: Development and Initial Characterization of the First

Spatz, Philipp / Chen, Xinyu / Reichau, Kora / Huber, Max E / Mühlig, Saskia / Matsusaka, Yohji / Schiedel, Matthias / Higuchi, Takahiro / Decker, Michael

Journal of medicinal chemistry

2024 Volume 67, Issue 8, Page(s) 6327–6343

Abstract: The interleukin-8 receptor beta (CXCR2) is a highly promising target for molecular imaging of inflammation and inflammatory diseases. This is due to its almost exclusive expression on neutrophils. Modified fluorinated ligands were designed based on a ... ...

Abstract	The interleukin-8 receptor beta (CXCR2) is a highly promising target for molecular imaging of inflammation and inflammatory diseases. This is due to its almost exclusive expression on neutrophils. Modified fluorinated ligands were designed based on a squaramide template, with different modification sites and synthetic strategies explored. Promising candidates were then tested for affinity to CXCR2 in a NanoBRET competition assay, resulting in tracer candidate
MeSH term(s)	Receptors, Interleukin-8B/metabolism ; Humans ; Fluorine Radioisotopes/chemistry ; Neutrophils/metabolism ; Positron-Emission Tomography/methods ; Radiopharmaceuticals/chemistry ; Radiopharmaceuticals/chemical synthesis ; Radiopharmaceuticals/pharmacokinetics ; HEK293 Cells
Chemical Substances	Receptors, Interleukin-8B ; Fluorine Radioisotopes ; Radiopharmaceuticals ; CXCR2 protein, human ; Fluorine-18 (GZ5I74KB8G)
Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.3c02285
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Article ; Online: Evaluating the Patterns of FAPI Uptake in the Shoulder Joint: a Preliminary Study Comparing with FDG Uptake in Oncological Studies.

Matsusaka, Yohji / Werner, Rudolf A / Serfling, Sebastian E / Buck, Andreas K / Kosmala, Aleksander / Sasaki, Takanori / Weich, Alexander / Higuchi, Takahiro

Molecular imaging and biology

2024 Volume 26, Issue 2, Page(s) 294–300

Abstract: Background: Fibroblast activation protein inhibitor (FAPI) targeting PET has been introduced as a novel molecular imaging modality for visualizing cancer-associated fibroblasts. There have also been reports suggesting incidental findings of localized ... ...

Abstract	Background: Fibroblast activation protein inhibitor (FAPI) targeting PET has been introduced as a novel molecular imaging modality for visualizing cancer-associated fibroblasts. There have also been reports suggesting incidental findings of localized accumulation in the shoulder joints. However, further characterization in a larger patient cohort is still lacking. Methods: 77 consecutive patients (28 females; mean age, 63.1 ± 11.6) who underwent Ga-68 FAPI-04 PET/CT for diagnosis of solid tumors were included. The incidence and localization of tracer uptake in shoulder joints were investigated and compared with available F-18 FDG scans serving as reference. Results: Ga-68 FAPI-04 uptake was evaluated in 77 patients (154 shoulder joints), of whom 54 subjects (108 shoulder joints) also had available F-18 FDG scans for head-to-head comparison. On FAPI-targeted imaging, 67/154 shoulders (43.5%) demonstrated increased radiotracer accumulation in target lesions, which were distributed as follows: acromioclavicular (AC) joints in 25/67 (37.3%), followed by glenohumeral and subacromial (GH + SA) joints in 23/67 (34.3%), or both (AC and GH + SA joints) in the remaining 19/67 (28.4%). Ga-68 FAPI-04 correlated with quantified F-18 FDG uptake (r = 0.69, p < 0.0001). Relative to the latter radiotracer, however, in-vivo FAP expression in the shoulders was significantly increased (Ga-68 FAPI-04, 4.7 ± 3.2 vs F-18 FDG, 3.6 ± 1.3, p < 0.001). Conclusion: Our study revealed focal accumulation of Ga-68 FAPI-04 in the shoulders, particularly in the AC joints, with higher uptake compared to the inflammatory-directed PET radiotracer F-18 FDG in oncological studies. As a result, further trials are warranted to investigate the potential of FAPI-directed molecular imaging in identifying chronic remodeling in shoulder joints. This could have implications for initiating anti-FAP targeted photodynamic therapy based on PET signal strength.
MeSH term(s)	Female ; Humans ; Middle Aged ; Aged ; Shoulder Joint ; Fluorodeoxyglucose F18 ; Gallium Radioisotopes ; Positron Emission Tomography Computed Tomography ; Quinolines
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Gallium-68 (98B30EPP5S) ; Gallium Radioisotopes ; Quinolines
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2079160-4
ISSN	1860-2002 ; 1536-1632
ISSN (online)	1860-2002
ISSN	1536-1632
DOI	10.1007/s11307-023-01893-8
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Zs.A 6468: Show issues

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Article ; Online: Atlas of non-pathological solitary or asymmetrical skeletal muscle uptake in [

Yamane, Tomohiko / Matsusaka, Yohji / Fukushima, Kenji / Seto, Akira / Matsunari, Ichiro / Kuji, Ichiei

Japanese journal of radiology

2022 Volume 40, Issue 8, Page(s) 755–767

Abstract: Positron emission tomography (PET) using 2-deoxy-2-[ ...

Abstract	Positron emission tomography (PET) using 2-deoxy-2-[
MeSH term(s)	Fluorodeoxyglucose F18 ; Humans ; Muscle, Skeletal/diagnostic imaging ; Positron-Emission Tomography ; Radiopharmaceuticals
Chemical Substances	Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2022-03-28
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2488907-6
ISSN	1867-108X ; 1867-1071
ISSN (online)	1867-108X
ISSN	1867-1071
DOI	10.1007/s11604-022-01264-3
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Zs.A 2249: Show issues

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Article: Can the function of the tubarial glands be evaluated using [

Matsusaka, Yohji / Yamane, Tomohiko / Fukushima, Kenji / Seto, Akira / Matsunari, Ichiro / Kuji, Ichiei

EJNMMI research

2021 Volume 11, Issue 1, Page(s) 34

Abstract: Background: The tubarial glands (TGs) are recently reported as newly found salivary gland structures that can be organs at risk predominantly localized in the tori tubarius in the nasopharynx using prostate-specific membrane antigen positron emission ... ...

Abstract	Background: The tubarial glands (TGs) are recently reported as newly found salivary gland structures that can be organs at risk predominantly localized in the tori tubarius in the nasopharynx using prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT). The aims of this study were to analyze uptake in the TGs compared with that in the other salivary glands and palatine tonsils using [ Results: [ Conclusions: The TGs were undetectable on [
Language	English
Publishing date	2021-03-31
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2619892-7
ISSN	2191-219X
ISSN	2191-219X
DOI	10.1186/s13550-021-00779-6
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Article ; Online: Satisfied quantitative value can be acquired by short-time bone SPECT/CT using a whole-body cadmium-zinc-telluride gamma camera.

Yamane, Tomohiko / Takahashi, Masafumi / Matsusaka, Yohji / Fukushima, Kenji / Seto, Akira / Kuji, Ichiei / Matsunari, Ichiro

Scientific reports

2021 Volume 11, Issue 1, Page(s) 24320

Abstract: The aim of this study was to evaluate the quantitative values of short-time scan (STS) of metastatic lesions compared with a standard scan (SS) when acquired by whole-body bone SPECT/CT with cadmium-zinc-telluride (CZT) detectors. We retrospectively ... ...

Abstract	The aim of this study was to evaluate the quantitative values of short-time scan (STS) of metastatic lesions compared with a standard scan (SS) when acquired by whole-body bone SPECT/CT with cadmium-zinc-telluride (CZT) detectors. We retrospectively reviewed 13 patients with bone metastases from prostate cancer, who underwent SPECT/CT performed on whole-body CZT gamma cameras. STSs were obtained using 75, 50, 25, 10, and 5% of the list-mode data for SS, respectively. Regions of interest (ROIs) were set on the increased uptake areas diagnosed as metastases. Intraclass correlation coefficients (ICCs) of standardized uptake values (SUVs) for the ROIs were calculated between the SS and each STS, and ICC ≥ 0.8 was set as a perfect correlation. Moreover, the repeatability coefficient (RC) was calculated, and RC ≤ 20% was defined as acceptable. A total of 152 metastatic lesions were included in the analysis. The ICCs between the SS vs. 75%-STS, 50%-STS, 25%-STS, 10%-STS, and 5%-STS were 0.999, 0.997, 0.994, 0.983, and 0.955, respectively. The RCs of the SS vs. 75%-STS, 50%-STS, 25%-STS, 10%-STS, and 5%-STS were 7.9, 12.4, 19.8, 30.8, and 41.3%, respectively. When evaluating the quality of CZT bone SPECT/CT acquired by a standard protocol, 25%-STS may provide adequate quantitative values.
Language	English
Publishing date	2021-12-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-03853-0
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Article ; Online: Generative adversarial network-created brain SPECTs of cerebral ischemia are indistinguishable to scans from real patients.

Werner, Rudolf A / Higuchi, Takahiro / Nose, Naoko / Toriumi, Fujio / Matsusaka, Yohji / Kuji, Ichiei / Kazuhiro, Koshino

Scientific reports

2022 Volume 12, Issue 1, Page(s) 18787

Abstract: Deep convolutional generative adversarial networks (GAN) allow for creating images from existing databases. We applied a modified light-weight GAN (FastGAN) algorithm to cerebral blood flow SPECTs and aimed to evaluate whether this technology can ... ...

Abstract	Deep convolutional generative adversarial networks (GAN) allow for creating images from existing databases. We applied a modified light-weight GAN (FastGAN) algorithm to cerebral blood flow SPECTs and aimed to evaluate whether this technology can generate created images close to real patients. Investigating three anatomical levels (cerebellum, CER; basal ganglia, BG; cortex, COR), 551 normal (248 CER, 174 BG, 129 COR) and 387 pathological brain SPECTs using N-isopropyl p-I-123-iodoamphetamine (
MeSH term(s)	Humans ; Tomography, Emission-Computed, Single-Photon ; Brain/diagnostic imaging ; Brain Ischemia/diagnostic imaging ; Iofetamine ; Cerebrovascular Circulation ; Cerebral Infarction ; Image Processing, Computer-Assisted/methods
Chemical Substances	Iofetamine (C2A5X08042) ; Iodine-123 (8YWR746RPQ)
Language	English
Publishing date	2022-11-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-23325-3
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Article: [Imaging diagnosis of biliary tract cancer on PET].

Matsusaka, Yohji / Murakami, Koji

Nihon rinsho. Japanese journal of clinical medicine

2015 Volume 73 Suppl 3, Page(s) 515–519

MeSH term(s)	Biliary Tract Neoplasms/diagnostic imaging ; Biliary Tract Neoplasms/pathology ; Fluorodeoxyglucose F18 ; Humans ; Neoplasm Metastasis ; Positron-Emission Tomography ; Recurrence
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	Japanese
Publishing date	2015-03
Publishing country	Japan
Document type	Journal Article
ZDB-ID	390903-7
ISSN	0047-1852
ISSN	0047-1852
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Zs.A 429: Show issues

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Article ; Online: Performance Evaluation of a Preclinical SPECT Scanner with a Collimator Designed for Medium-Sized Animals.

Matsusaka, Yohji / Werner, Rudolf A / Arias-Loza, Paula / Nose, Naoko / Sasaki, Takanori / Chen, Xinyu / Lapa, Constantin / Higuchi, Takahiro

Molecular imaging

2022 Volume 2022, Page(s) 9810097

Abstract: Background: Equipped with two stationary detectors, a large bore collimator for medium-sized animals has been recently introduced for dedicated preclinical single-photon emission computed tomography (SPECT) imaging. We aimed to evaluate the basic ... ...

Abstract	Background: Equipped with two stationary detectors, a large bore collimator for medium-sized animals has been recently introduced for dedicated preclinical single-photon emission computed tomography (SPECT) imaging. We aimed to evaluate the basic performance of the system using phantoms and healthy rabbits. Methods: A general-purpose medium-sized animal (GP-MSA) collimator with 135 mm bore diameter and thirty-three holes of 2.5 mm diameter was installed on an ultrahigh-resolution scanner equipped with two large stationary detectors (U-SPECT5-E/CT). The sensitivity and uniformity were investigated using a point source and a cylinder phantom containing Results: In the performance evaluation, a sensitivity of 790 cps/MBq, a spatial resolution with the hot-rod phantom of 2.5 mm, and a uniformity of 39.2% were achieved. The CNRs of the rod size 2.5 mm were 1.37, 1.24, 1.20, and 0.85 for activity concentration of 29.2, 1.0, 0.5, and 0.1 MBq/mL, respectively. Dynamic SPECT imaging in rabbits allowed to visualize most of the thorax and to generate time-activity curves of the left myocardial wall and ventricular cavity. Conclusion: Preclinical U-SPECT5-E/CT equipped with a large bore collimator demonstrated adequate sensitivity and resolution for
MeSH term(s)	Animals ; Phantoms, Imaging ; Rabbits ; Radioisotopes ; Radiopharmaceuticals ; Technetium ; Tomography, Emission-Computed, Single-Photon/methods
Chemical Substances	Radioisotopes ; Radiopharmaceuticals ; Technetium (7440-26-8)
Language	English
Publishing date	2022-07-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2137435-1
ISSN	1536-0121 ; 1535-3508
ISSN (online)	1536-0121
ISSN	1535-3508
DOI	10.1155/2022/9810097
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