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Article ; Online: A Case of 17α-hydroxylase/17,20-lyase Deficiency Diagnosed at 45 Years of Age with Hyperaldosteronism.

Ikeya, Akira / Yamashita, Miho / Kakizawa, Keisuke / Kawauchi, Yuto / Matsushita, Akio / Fujisawa, Yasuko / Ogata, Tsutomu / Sasaki, Shigekazu

Internal medicine (Tokyo, Japan)

2024

Abstract: 17α-hydroxylase deficiency is a type of congenital adrenocortical hyperplasia that is typically diagnosed in childhood or adolescence. It manifests as hypertension with gonadal dysfunction as the primary symptom. We herein report 17α-hydroxylase/17,20- ... ...

Abstract	17α-hydroxylase deficiency is a type of congenital adrenocortical hyperplasia that is typically diagnosed in childhood or adolescence. It manifests as hypertension with gonadal dysfunction as the primary symptom. We herein report 17α-hydroxylase/17,20-lyase deficiency (17OHD) diagnosed at the age of 45 years. The patient presented with hypertension, irregular menstruation, and hyperaldosteronism. The clinical manifestations of 17OHD vary based on the specific variant pattern of CYP17A1. In this case, the variant was c.157_159 TCC del p. Phe53del, which has been frequently reported in Japan. The enzymatic deficiency due to this variant is partial, leading to a delay in making a correct diagnosis.
Language	English
Publishing date	2024-04-09
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.3084-23
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Article ; Online: Falsely elevated thyroid hormone levels associated with fibrin interference in patients receiving oral anticoagulant therapy.

Tokumaru, Mitsuaki / Ohba, Kenji / Kashiwabara, Yumiko / Takase, Hiroyuki / Hayashi, Chiga / Iwaki, Takayuki / Suzuki, Yasuhide / Matsushita, Akio / Sasaki, Shigekazu / Suda, Takafumi / Maekawa, Masato

Annals of clinical biochemistry

2023 Volume 60, Issue 4, Page(s) 249–258

Abstract: Objective: Unique clinical courses were observed in two asymptomatic patients receiving warfarin who referred to our hospital because of suspected central hyperthyroidism. We eventually diagnosed these patients with falsely elevated thyroid hormone ... ...

Abstract	Objective: Unique clinical courses were observed in two asymptomatic patients receiving warfarin who referred to our hospital because of suspected central hyperthyroidism. We eventually diagnosed these patients with falsely elevated thyroid hormone levels caused by macroscopically invisible fibrin. Although false results caused by fibrin interference in vitro have been identified in various immunoassays, especially in blood samples from patients receiving anticoagulant therapy, no studies on thyroid function testing have been reported. The experience in evaluating these cases prompted us to investigate the independent influence of oral anticoagulants via putative fibrin interference on thyroid function testing. Methods: We retrospectively reviewed known contributing factors that affect thyroid function testing including age, gender, medication history, body mass index, estimated glomerular filtration rate, smoking status, alcohol consumption, and the seasons of hospital visits from participants who presented the Department of Health Checkup between April 2010 and December 2020. Results: A propensity-matched analysis revealed that the median serum free thyroxine levels under oral anticoagulant were significantly higher (17.9 pmol/L, n = 60) than those without anticoagulants (16.0 pmol/L, n = 60; Conclusions: We report two patients receiving warfarin with falsely elevated thyroid hormone levels caused by fibrin interference resembling central hyperthyroidism for the first time. Our retrospective study suggests that the medication status of oral anticoagulants should be considered when evaluating thyroid function tests.
MeSH term(s)	Humans ; Retrospective Studies ; Thyroxine ; Warfarin/therapeutic use ; Thyrotropin ; Thyroid Hormones ; Hyperthyroidism/diagnosis ; Hyperthyroidism/drug therapy ; Thyroid Function Tests ; Anticoagulants/therapeutic use
Chemical Substances	Thyroxine (Q51BO43MG4) ; Warfarin (5Q7ZVV76EI) ; Thyrotropin (9002-71-5) ; Thyroid Hormones ; Anticoagulants
Language	English
Publishing date	2023-03-08
Publishing country	England
Document type	Journal Article
ZDB-ID	390309-6
ISSN	1758-1001 ; 0004-5632
ISSN (online)	1758-1001
ISSN	0004-5632
DOI	10.1177/00045632231159280
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Article ; Online: Retroperitoneal Paraganglioma With Asymptomatic Follicular Lymphoma: A Case Report.

Kakizawa, Keisuke / Yamashita, Miho / Nakashima, Mitsuko / Kawauchi, Yuto / Ikeya, Akira / Matsushita, Akio / Sasaki, Shigekazu / Oki, Yutaka

Journal of the Endocrine Society

2021 Volume 5, Issue 12, Page(s) bvab171

Abstract: Paraganglioma (PGL) is a rare tumor originating from extra-adrenal paraganglionic chromaffin tissues, and most sympathetic PGLs have excessive catecholamine secretion. However, nonfunctional PGLs are sometimes found. Although malignant PGL is defined by ... ...

Abstract	Paraganglioma (PGL) is a rare tumor originating from extra-adrenal paraganglionic chromaffin tissues, and most sympathetic PGLs have excessive catecholamine secretion. However, nonfunctional PGLs are sometimes found. Although malignant PGL is defined by metastasis to nonchromaffin tissues, it is difficult to predict malignancies due to the lack of reliable markers of potential malignancies. We report the case of a 69-year-old Japanese woman with an incidental retroperitoneal tumor and multiple enlarged mesenteric lymph nodes simultaneously. The patient had no subjective symptoms and there were no laboratory findings suggesting catecholamine hypersecretion. Both the retroperitoneal tumor and the enlarged mesenteric lymph nodes showed high accumulation of fluorodeoxyglucose (FDG), whereas metaiodobenzylguanidine (MIBG) was accumulated only at the retroperitoneal tumor. Although a retroperitoneal tumor was diagnosed as nonfunctional PGL by examination including MIBG scintigraphy, the cause of enlarged mesenteric lymph nodes could not be diagnosed by imaging and biochemical tests. As a result of retroperitoneal tumor resection and mesenteric lymph nodes sampling, histopathological examination revealed that a retroperitoneal tumor was PGL and enlarged mesenteric lymph nodes were follicular lymphoma. To reveal an underlying genetic factor, we performed whole exome sequencing of genomic DNA, and we identified 2 possible candidate variants in
Language	English
Publishing date	2021-11-14
Publishing country	United States
Document type	Case Reports
ISSN	2472-1972
ISSN (online)	2472-1972
DOI	10.1210/jendso/bvab171
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Article ; Online: Impairment of the Hypothalamus-Pituitary-Thyroid Axis Caused by Naturally Occurring

Sakai, Yuki / Ohba, Kenji / Sasaki, Shigekazu / Matsushita, Akio / Nakamura, Hiroko Misawa / Kuroda, Go / Tsuriya, Daisuke / Yamashita, Miho / Suda, Takafumi

International journal of molecular sciences

2021 Volume 22, Issue 18

Abstract: The transcription factor GATA2 regulates gene expression in several cells and tissues, including hematopoietic tissues and the central nervous system. Recent studies revealed that loss-of-function mutations ... ...

Abstract	The transcription factor GATA2 regulates gene expression in several cells and tissues, including hematopoietic tissues and the central nervous system. Recent studies revealed that loss-of-function mutations in
MeSH term(s)	Blotting, Western ; GATA2 Transcription Factor/genetics ; Haploinsufficiency/genetics ; Haploinsufficiency/physiology ; Humans ; Hypothalamus/metabolism ; Hypothyroidism/genetics ; Mutation/genetics ; Pituitary Gland/metabolism ; Promoter Regions, Genetic/genetics ; Thyroid Gland/metabolism ; Thyrotropin, beta Subunit/genetics ; Thyrotropin, beta Subunit/metabolism ; Transcriptional Activation/genetics ; Transcriptional Activation/physiology
Chemical Substances	GATA2 Transcription Factor ; GATA2 protein, human ; Thyrotropin, beta Subunit
Language	English
Publishing date	2021-09-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms221810015
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Article ; Online: Clinical outcomes of 34 patients with resistance to thyroid hormone beta: a twenty-year experience in Japan.

Ohba, Kenji / Sasaki, Shigekazu / Misawa Nakamura, Hiroko / Matsushita, Akio / Kuroda, Go / Sakai, Yuki / Nakamura, Hirotoshi

Endocrine journal

2021 Volume 69, Issue 2, Page(s) 179–188

Abstract: Resistance to thyroid hormone beta (RTHβ) caused by germline mutations in genes encoding thyroid hormone receptor beta (TRβ) is a rare disorder. Little information is available regarding the clinical experience of this syndrome in Japan. We ... ...

Abstract	Resistance to thyroid hormone beta (RTHβ) caused by germline mutations in genes encoding thyroid hormone receptor beta (TRβ) is a rare disorder. Little information is available regarding the clinical experience of this syndrome in Japan. We retrospectively reviewed the records of 34 patients with RTHβ (21 adult females and 13 adult males) with positive TRβ mutations identified at our division between 2000 and 2020. Of the 24 patients with available clinical history, 10 (41.7%) received inappropriate treatments such as antithyroid drugs, thyroidectomy, or radioactive iodine. Diagnostic delay and inappropriate management of RTHβ are still present in Japan. Every patient except one demonstrated thyroid hormone profiles indicative of syndrome of inappropriate secretion of thyrotropin (SITSH), characterized by a hormonal profile of hyperthyroxinemia with a non-suppressed TSH concentration. Since the most common forms of hyperthyroidism including Graves' disease feature elevated thyroid hormone levels with suppressed TSH concentrations, early diagnosis of SITSH is critical for preventing inappropriate management. One patient positive for anti-thyroglobulin antibody (Tg-Ab) and anti-thyroperoxidase antibody (TPO-Ab) showed remarkably elevated TSH (>200 μIU/mL) despite thyroid hormone concentrations within the reference ranges. At least one thyroid autoantibody (Tg-Ab, TPO-Ab, or thyrotropin receptor antibodies) was identified in 37.9% (11/29) of the patients tested. One patient developed overt Graves' disease nine years after RTHβ diagnosis. These findings suggest that RTHβ is frequently comorbid with additional autoimmune thyroid disorders. Further research is required to identify the most appropriate treatments for RTHβ patients who develop a second thyroid disorder.
MeSH term(s)	Adult ; Delayed Diagnosis ; Female ; Humans ; Iodine Radioisotopes ; Japan/epidemiology ; Male ; Retrospective Studies ; Thyroid Hormones ; Thyroid Neoplasms ; Thyrotropin
Chemical Substances	Iodine Radioisotopes ; Thyroid Hormones ; Thyrotropin (9002-71-5)
Language	English
Publishing date	2021-09-22
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1151918-6
ISSN	1348-4540 ; 0918-8959
ISSN (online)	1348-4540
ISSN	0918-8959
DOI	10.1507/endocrj.EJ21-0390
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Article ; Online: Abnormal thyroid hormone response to TRH in a case of macro-TSH and the cut-off value for screening cases of inappropriate TSH elevation.

Ohba, Kenji / Maekawa, Masato / Iwahara, Kunihiro / Suzuki, Yasuhide / Matsushita, Akio / Sasaki, Shigekazu / Oki, Yutaka / Nakamura, Hirotoshi

Endocrine journal

2019 Volume 67, Issue 2, Page(s) 125–130

Abstract: A 74-year-old asymptomatic Japanese man with suspected thyroid dysfunction was referred to our hospital. He had an elevated TSH (53.8 mIU/L; reference interval: 0.5-5.0) despite a free T4 (FT4) level (1.4 ng/dL; reference interval: 0.9-1.6). Further ... ...

Abstract	A 74-year-old asymptomatic Japanese man with suspected thyroid dysfunction was referred to our hospital. He had an elevated TSH (53.8 mIU/L; reference interval: 0.5-5.0) despite a free T4 (FT4) level (1.4 ng/dL; reference interval: 0.9-1.6). Further analysis revealed macro-TSH. A notable finding was that a 500-μg TRH stimulation test revealed a blunted free T3 (FT3) response despite a prolonged TSH response. Macro-TSH typically presents with inappropriately marked elevation of serum TSH levels compared with other thyroid hormones, as exhibited in our case. However, the level of TSH elevation that might differentiate macro-TSH from subclinical hypothyroidism is poorly known. We retrospectively analyzed 8,183 concurrent measurements of TSH and FT4 in individuals previously examined in our hospital to define the cut-off value for screening cases of inappropriate TSH elevation. FT4 values were rounded off to one decimal place, and the 97.5th percentile of TSH against each FT4 value was calculated. The data of our patient and that of 30 cases of macro-TSH extracted from the English literature were then assessed. When the approximate curve obtained from the 97.5th percentile of TSH values was defined as the cut-off value [Log
MeSH term(s)	Aged ; Antigen-Antibody Complex/blood ; Antigen-Antibody Complex/immunology ; Humans ; Male ; Pituitary Function Tests ; Reference Values ; Thyroid Function Tests ; Thyrotropin/blood ; Thyrotropin/immunology ; Thyrotropin-Releasing Hormone ; Thyroxine/blood ; Triiodothyronine/blood
Chemical Substances	Antigen-Antibody Complex ; Triiodothyronine (06LU7C9H1V) ; Thyrotropin-Releasing Hormone (5Y5F15120W) ; Thyrotropin (9002-71-5) ; Thyroxine (Q51BO43MG4)
Language	English
Publishing date	2019-10-24
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	1151918-6
ISSN	1348-4540 ; 0918-8959
ISSN (online)	1348-4540
ISSN	0918-8959
DOI	10.1507/endocrj.EJ19-0320
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Article: Hyperfunctioning Papillary Thyroid Carcinoma with a

Shinkai, Shinsuke / Ohba, Kenji / Kakudo, Kennichi / Iwaki, Takayuki / Mimura, Yoshihiro / Matsushita, Akio / Kuroda, Go / Sakai, Yuki / Nishino, Nobuhiko / Umemura, Kazuo / Suda, Takafumi / Sasaki, Shigekazu

European thyroid journal

2021 Volume 10, Issue 3, Page(s) 262–267

Abstract: Introduction: Hyperfunctioning papillary thyroid carcinoma (PTC) is rare and consequently, little information on its molecular etiology is available. Although : Case presentation: Ultrasonography detected a 26-mm nodule in the right lobe of the ... ...

Abstract	Introduction: Hyperfunctioning papillary thyroid carcinoma (PTC) is rare and consequently, little information on its molecular etiology is available. Although Case presentation: Ultrasonography detected a 26-mm nodule in the right lobe of the thyroid gland of a 48-year-old man. Thyroid function tests indicated that he was hyperthyroid with a TSH level of 0.01 mIU/L (reference range: 0.05-5.00) and a free thyroxine level of 23.2 pmol/L (reference range: 11.6-21.9). TSHR autoantibodies were <0.8 IU/L (reference value: <2.0 IU/L). The Discussion and conclusions: We report a case of hyperfunctioning PTC with a
Language	English
Publishing date	2021-03-05
Publishing country	England
Document type	Case Reports
ZDB-ID	2659767-6
ISSN	2235-0802 ; 2235-0640
ISSN (online)	2235-0802
ISSN	2235-0640
DOI	10.1159/000513552
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Article: The Mechanism of Negative Transcriptional Regulation by Thyroid Hormone: Lessons From the Thyrotropin β Subunit Gene.

Sasaki, Shigekazu / Matsushita, Akio / Kuroda, Go / Nakamura, Hiroko M / Oki, Yutaka / Suda, Takafumi

Vitamins and hormones

2017 Volume 106, Page(s) 97–127

Abstract: Thyroid hormone (T3) activates (positive regulation) or represses (negative regulation) target genes at the transcriptional level. The molecular mechanism of the former has been elucidated in detail; however, the mechanism for negative regulation has not ...

Abstract	Thyroid hormone (T3) activates (positive regulation) or represses (negative regulation) target genes at the transcriptional level. The molecular mechanism of the former has been elucidated in detail; however, the mechanism for negative regulation has not been established. The best example of the gene that is negatively regulated by T3 is the thyrotropin (thyroid-stimulating hormone) β subunit (TSHβ) gene. Analogous to the T3-responsive element (TRE) in positive regulation, a negative TRE (nTRE) has been postulated in the TSHβ gene. However, TSHβ promoter analysis, performed in the presence of transcription factors Pit1 and GATA2, which are determinants of thyrotroph differentiation in the pituitary, revealed that the nTRE is dispensable for inhibition by T3. We propose a tethering model in which the T3 receptor is tethered to GATA2 via protein-protein interaction and inhibits GATA2-dependent transactivation of the TSHβ gene in a T3-dependent manner.
MeSH term(s)	Animals ; Gene Expression Regulation/physiology ; Humans ; Thyroid Hormones/physiology ; Thyrotropin, beta Subunit/physiology
Chemical Substances	Thyroid Hormones ; Thyrotropin, beta Subunit
Language	English
Publishing date	2017-08-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	201161-x
ISSN	2162-2620 ; 0083-6729
ISSN (online)	2162-2620
ISSN	0083-6729
DOI	10.1016/bs.vh.2017.06.006
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Article: Dose-Dependent Influence of Antithyroid Drugs on the Difference in Free Thyroxine Levels between Mothers with Graves' Hyperthyroidism and Their Neonates.

Iwaki, Hiroyuki / Ohba, Kenji / Okada, Eisaku / Murakoshi, Takeshi / Kashiwabara, Yumiko / Hayashi, Chiga / Matsushita, Akio / Sasaki, Shigekazu / Suda, Takafumi / Oki, Yutaka / Gemma, Rieko

European thyroid journal

2020 Volume 10, Issue 5, Page(s) 372–381

Abstract: Background: Several guidelines have recommended that the use of the lowest effective dose of antithyroid drugs (ATDs) that maintains maternal serum free thyroxine (FT4) levels at or moderately above the upper limit of the reference range is appropriate ... ...

Abstract	Background: Several guidelines have recommended that the use of the lowest effective dose of antithyroid drugs (ATDs) that maintains maternal serum free thyroxine (FT4) levels at or moderately above the upper limit of the reference range is appropriate for fetal euthyroid status. However, little is known about whether ATD dosage affects the difference in serum FT4 levels between the mother and neonate. We conducted a retrospective study at a tertiary hospital in Japan to investigate the dose-dependent influence of ATDs on both maternal and fetal thyroid hormone status. Materials and methods: We retrospectively examined 62 pregnant women who delivered between 2007 and 2016 and were treated for Graves' hyperthyroidism with ATD at any stage during pregnancy. We selected individuals whose data on maternal FT4 level within 4 weeks of their deliveries and cord FT4 level of their infants at the time of delivery were available. Those with multiple pregnancies, iodine or glucocorticoid treatment, and fetal goiter detected by ultrasonography were excluded. Results: After the exclusion criteria were applied, we recruited 40 individuals. The cord FT4 levels were significantly lower than the maternal FT4 levels in patients treated with high-dosage ATDs (methimazole >5 mg daily or propylthiouracil >100 mg daily). However, there were no significant differences between maternal and cord FT4 levels in patients treated with low-dosage ATDs (methimazole ≤5 mg daily or propylthiouracil ≤100 mg daily). We selected 35 individuals whose data on maternal thyrotropin receptor-binding inhibitory immunoglobulin (TBII) level were available. Multiple linear regression analysis adjusted for ATD dosage, maternal TBII level, and gestational period found that ATD dosage was a significant predictor of the difference in serum FT4 levels between the mother and neonate. In terms of maternal complications, multiple logistic regression analysis identified maternal free triiodothyronine (FT3) level as a significant predictor of the incidence of preterm delivery. Conclusions: We found a dose-dependent influence of ATDs on the difference in serum FT4 levels between mothers with Graves' hyperthyroidism and their neonates. Further studies to evaluate the optimal target FT4 and FT3 levels for the mother and neonate during pregnancy may improve the outcome of pregnant women with Graves' hyperthyroidism.
Language	English
Publishing date	2020-08-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2659767-6
ISSN	2235-0802 ; 2235-0640
ISSN (online)	2235-0802
ISSN	2235-0640
DOI	10.1159/000509324
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Article ; Online: G ATA2 mediates the negative regulation of the prepro-thyrotropin-releasing hormone gene by liganded T3 receptor β2 in the rat hypothalamic paraventricular nucleus.

Kuroda, Go / Sasaki, Shigekazu / Matsushita, Akio / Ohba, Kenji / Sakai, Yuki / Shinkai, Shinsuke / Nakamura, Hiroko Misawa / Yamagishi, Satoru / Sato, Kohji / Hirahara, Naoko / Oki, Yutaka / Ito, Masahiko / Suzuki, Tetsuro / Suda, Takafumi

PloS one

2020 Volume 15, Issue 11, Page(s) e0242380

Abstract: Thyroid hormone (T3) inhibits thyrotropin-releasing hormone (TRH) synthesis in the hypothalamic paraventricular nucleus (PVN). Although the T3 receptor (TR) β2 is known to mediate the negative regulation of the prepro-TRH gene, its molecular mechanism ... ...

Abstract	Thyroid hormone (T3) inhibits thyrotropin-releasing hormone (TRH) synthesis in the hypothalamic paraventricular nucleus (PVN). Although the T3 receptor (TR) β2 is known to mediate the negative regulation of the prepro-TRH gene, its molecular mechanism remains unknown. Our previous studies on the T3-dependent negative regulation of the thyrotropin β subunit (TSHβ) gene suggest that there is a tethering mechanism, whereby liganded TRβ2 interferes with the function of the transcription factor, GATA2, a critical activator of the TSHβ gene. Interestingly, the transcription factors Sim1 and Arnt2, the determinants of PVN differentiation in the hypothalamus, are reported to induce expression of TRβ2 and GATA2 in cultured neuronal cells. Here, we confirmed the expression of the GATA2 protein in the TRH neuron of the rat PVN using immunohistochemistry with an anti-GATA2 antibody. According to an experimental study from transgenic mice, a region of the rat prepro-TRH promoter from nt. -547 to nt. +84 was able to mediate its expression in the PVN. We constructed a chloramphenicol acetyltransferase (CAT) reporter gene containing this promoter sequence (rTRH(547)-CAT) and showed that GATA2 activated the promoter in monkey kidney-derived CV1 cells. Deletion and mutation analyses identified a functional GATA-responsive element (GATA-RE) between nt. -357 and nt. -352. When TRβ2 was co-expressed, T3 reduced GATA2-dependent promoter activity to approximately 30%. Unexpectedly, T3-dependent negative regulation was maintained after mutation of the reported negative T3-responsive element, site 4. T3 also inhibited the GATA2-dependent transcription enhanced by cAMP agonist, 8-bromo-cAMP. A rat thyroid medullary carcinoma cell line, CA77, is known to express the preproTRH mRNA. Using a chromatin immunoprecipitation assay with this cell line where GATA2 expression plasmid was transfected, we observed the recognition of the GATA-RE by GATA2. We also confirmed GATA2 binding using gel shift assay with the probe for the GATA-RE. In CA77 cells, the activity of rTRH(547)-CAT was potentiated by overexpression of GATA2, and it was inhibited in a T3-dependent manner. These results suggest that GATA2 transactivates the rat prepro-TRH gene and that liganded TRβ2 interferes with this activation via a tethering mechanism as in the case of the TSHβ gene.
MeSH term(s)	Animals ; Cell Line ; GATA2 Transcription Factor/metabolism ; GATA2 Transcription Factor/physiology ; Gene Expression Regulation/genetics ; Genes, Reporter/genetics ; Ligands ; Male ; Paraventricular Hypothalamic Nucleus/metabolism ; Paraventricular Hypothalamic Nucleus/pathology ; Promoter Regions, Genetic/genetics ; Protein Precursors ; Rats ; Rats, Wistar ; Receptors, Thyroid Hormone/metabolism ; Thyroid Hormone Receptors beta/genetics ; Thyroid Hormone Receptors beta/metabolism ; Thyroid Hormones ; Thyrotropin, beta Subunit/metabolism ; Thyrotropin-Releasing Hormone/genetics ; Thyrotropin-Releasing Hormone/metabolism ; Transcription Factors ; Transcriptional Activation ; Triiodothyronine/metabolism
Chemical Substances	GATA2 Transcription Factor ; Gata2 protein, rat ; Ligands ; Protein Precursors ; Receptors, Thyroid Hormone ; Thyroid Hormone Receptors beta ; Thyroid Hormones ; Thyrotropin, beta Subunit ; Transcription Factors ; Triiodothyronine (06LU7C9H1V) ; prepro-thyrotropin-releasing hormone (100469-84-9) ; Thyrotropin-Releasing Hormone (5Y5F15120W)
Language	English
Publishing date	2020-11-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0242380
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