LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 3 of total 3

Search options

  1. Article: GABA synthesizing lactic acid bacteria and genomic analysis of

    Matta, Tushar / Bhatia, Ruchika / Joshi, Santa Ram / Bishnoi, Mahendra / Chopra, Kanwaljit / Kondepudi, Kanthi Kiran

    3 Biotech

    2024  Volume 14, Issue 3, Page(s) 62

    Abstract: This study was conducted to investigate the γ-aminobutyric acid (GABA) production ability of 20 : Supplementary information: The online version contains supplementary material available at 10.1007/s13205-024-03918-7. ...

    Abstract This study was conducted to investigate the γ-aminobutyric acid (GABA) production ability of 20
    Supplementary information: The online version contains supplementary material available at 10.1007/s13205-024-03918-7.
    Language English
    Publishing date 2024-02-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2600522-0
    ISSN 2190-5738 ; 2190-572X
    ISSN (online) 2190-5738
    ISSN 2190-572X
    DOI 10.1007/s13205-024-03918-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Protective effect of olopatadine hydrochloride against LPS-induced acute lung injury: via targeting NF-κB signaling pathway.

    Kaur, Jaspreet / Rana, Priyanka / Matta, Tushar / Sodhi, Rupinder Kaur / Pathania, Khushboo / Pawar, Sandip V / Kuhad, Anurag / Kondepudi, Kanthi Kiran / Kaur, Tanzeer / Dhingra, Neelima / Sah, Sangeeta Pilkhwal

    Inflammopharmacology

    2023  Volume 32, Issue 1, Page(s) 603–627

    Abstract: Background: Morbidity and mortality rates associated with acute lung injury/acute respiratory distress syndrome (ALI/ARDS) are high (30-40%). Nuclear factor-kappa B (NF-κB) is a transcription factor, associated with transcription of numerous cytokines ... ...

    Abstract Background: Morbidity and mortality rates associated with acute lung injury/acute respiratory distress syndrome (ALI/ARDS) are high (30-40%). Nuclear factor-kappa B (NF-κB) is a transcription factor, associated with transcription of numerous cytokines leading to cytokine storm, and thereby, plays a major role in ALI/ARDS and in advanced COVID-19 syndrome.
    Methods: Considering the role of NF-κB in ALI, cost-effective in silico approaches were utilized in the study to identify potential NF-κB inhibitor based on the docking and pharmacokinetic results. The identified compound was then pharmacologically validated in lipopolysaccharide (LPS) rodent model of acute lung injury. LPS induces ALI by altering alveolar membrane permeability, recruiting activated neutrophils and macrophages to the lungs, and compromising the alveolar membrane integrity and ultimately impairs the gaseous exchange. Furthermore, LPS exposure is associated with exaggerated production of various proinflammatory cytokines in lungs.
    Results: Based on in silico studies Olopatadine Hydrochloride (Olo), an FDA-approved drug was found as a potential NF-κB inhibitor which has been reported for the first time, and considered further for the pharmacological validation. Intraperitoneal LPS administration resulted in ALI/ARDS by fulfilling 3 out of the 4 criteria described by ATS committee (2011) published workshop report. However, treatment with Olo attenuated LPS-induced elevation of proinflammatory markers (IL-6 and NF-κB), oxidative stress, neutrophil infiltration, edema, and damage in lungs. Histopathological studies also revealed that Olo treatment significantly ameliorated LPS-induced lung injury, thus conferring improvement in survival. Especially, the effects produced by Olo medium dose (1 mg/kg) were comparable to dexamethasone standard.
    Conclusion: In nutshell, inhibition of NF-κB pathway by Olo resulted in protection and reduced mortality in LPS- induced ALI and thus has potential to be used clinically to arrest disease progression in ALI/ARDS, since the drug is already in the market. However, the findings warrant further extensive studies, and also future studies can be planned to elucidate its role in COVID-19-associated ARDS or cytokine storm.
    MeSH term(s) Humans ; NF-kappa B ; Lipopolysaccharides/pharmacology ; Olopatadine Hydrochloride ; Cytokine Release Syndrome ; Signal Transduction ; Acute Lung Injury/chemically induced ; Acute Lung Injury/drug therapy ; I-kappa B Proteins ; Respiratory Distress Syndrome ; COVID-19 ; Cytokines
    Chemical Substances NF-kappa B ; Lipopolysaccharides ; Olopatadine Hydrochloride (2XG66W44KF) ; I-kappa B Proteins ; Cytokines
    Language English
    Publishing date 2023-10-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1080058-x
    ISSN 1568-5608 ; 0925-4692
    ISSN (online) 1568-5608
    ISSN 0925-4692
    DOI 10.1007/s10787-023-01353-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3274: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Glucogallin Attenuates the LPS-Induced Signaling in Macrophages and Protects Mice against Sepsis.

    Singh, Rajveer / Chandel, Shivani / Ghosh, Arijit / Matta, Tushar / Gautam, Anupam / Bhattacharya, Arka / Babu, Srivalliputturu Sarath / Sukla, Soumi / Nag, Debasish / Ravichandiran, Velayutham / Roy, Syamal / Ghosh, Dipanjan

    International journal of molecular sciences

    2022  Volume 23, Issue 19

    Abstract: The anti-oxidant and anti-inflammatory effect of beta-glucogallin (BGG), a plant-derived natural product, was evaluated in both in vitro and in vivo studies. For the in vitro study, the ability of BGG pre-treatment to quench LPS-induced effects compared ... ...

    Abstract The anti-oxidant and anti-inflammatory effect of beta-glucogallin (BGG), a plant-derived natural product, was evaluated in both in vitro and in vivo studies. For the in vitro study, the ability of BGG pre-treatment to quench LPS-induced effects compared to LPS alone in macrophages was investigated. It was found that BGG pre-treatment showed a significant decrease in ROS, NO, superoxide, and pro-inflammatory cytokines (TNF-alpha, IL-4, IL-17, IL-1β, and IL-6) and increased reduced glutathione coupled with the restoration of mitochondrial membrane potential. Gene profiling and further validation by qPCR showed that BGG pre-treatment downregulated the LPS-induced expression of c-Fos, Fas, MMP-9, iNOS, COX-2, MyD88, TRIF, TRAF6, TRAM, c-JUN, and NF-κB. We observed that BGG pre-treatment reduced nuclear translocation of LPS-activated NF-κB and thus reduced the subsequent expressions of NLRP3 and IL-1β, indicating the ability of BGG to inhibit inflammasome formation. Molecular docking studies showed that BGG could bind at the active site of TLR4. Finally, in the LPS-driven sepsis mouse model, we showed that pre-treatment with BGG sustained toxic shock, as evident from their 100% survival. Our study clearly showed the therapeutic potential of BGG in toxic shock syndrome.
    MeSH term(s) Adaptor Proteins, Vesicular Transport/metabolism ; Animals ; Anti-Inflammatory Agents/adverse effects ; Antioxidants/pharmacology ; Biological Products/pharmacology ; Cyclooxygenase 2/metabolism ; Cytokines/metabolism ; Glutathione/metabolism ; Hydrolyzable Tannins ; Inflammasomes/metabolism ; Interleukin-17/metabolism ; Interleukin-4/metabolism ; Interleukin-6/metabolism ; Lipopolysaccharides/adverse effects ; Macrophages/metabolism ; Matrix Metalloproteinase 9/metabolism ; Mice ; Molecular Docking Simulation ; Myeloid Differentiation Factor 88/metabolism ; NF-kappa B/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Reactive Oxygen Species/metabolism ; Sepsis/metabolism ; Superoxides/metabolism ; TNF Receptor-Associated Factor 6/metabolism ; Toll-Like Receptor 4/metabolism ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Adaptor Proteins, Vesicular Transport ; Anti-Inflammatory Agents ; Antioxidants ; Biological Products ; Cytokines ; Hydrolyzable Tannins ; Inflammasomes ; Interleukin-17 ; Interleukin-6 ; Lipopolysaccharides ; Myeloid Differentiation Factor 88 ; NF-kappa B ; NLR Family, Pyrin Domain-Containing 3 Protein ; Reactive Oxygen Species ; TNF Receptor-Associated Factor 6 ; Toll-Like Receptor 4 ; Tumor Necrosis Factor-alpha ; Superoxides (11062-77-4) ; Interleukin-4 (207137-56-2) ; glucogallin (58511-73-2) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2022-09-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms231911254
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top