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  1. Article ; Online: Clinical benefits of symptom resolution after palliative surgery in advanced cancer: A single-center experience.

    Maddalon, Beatrice / Cenzi, Carola / Tonello, Marco / Pizzolato, Elisa / Barina, Andrea / De Simoni, Ottavia / Franzato, Boris / Gruppo, Mario / Mattara, Genny / Tolin, Francesca / Moretto, Valentina / Nardi, Mariateresa / Zagonel, Vittorina / Pilati, Pierluigi / Sommariva, Antonio

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

    2024  Volume 50, Issue 6, Page(s) 108368

    Abstract: Background: Palliative surgery (PS) is defined as any surgical procedure aimed at improving quality of life or relieving symptoms caused by an advanced or metastatic cancer. The involvement of patients, caregivers, and other professional figures is ... ...

    Abstract Background: Palliative surgery (PS) is defined as any surgical procedure aimed at improving quality of life or relieving symptoms caused by an advanced or metastatic cancer. The involvement of patients, caregivers, and other professional figures is crucial for obtaining optimal symptom relief and avoiding complications. This study aims to evaluate the short-term outcome and related factors in patients undergoing PS.
    Patients and methods: A retrospective analysis was performed in consecutive patients who underwent palliative gastrointestinal surgery at our surgical unit during the period June 2018 to May 2023. Demographic, clinical, pathological and follow-up data were collected from a prospectively maintained department database. The main outcomes were complications, symptoms palliation, symptoms recurrence and return to systemic chemotherapy. Standard statistical analysis was performed.
    Results: During the study period, 127 patients underwent palliative surgery. The Clavien-Dindo 3-5 complication rate and mortality rate were 19.7 % and 6 %, respectively. The resolution of symptoms was achieved in 109 patients (89 %). Successful symptom palliation was significantly related to the possibility of returning to systemic chemotherapy (SC) (OR 9.30 95 % CI 0.1.83-47.18, p 0.007). The only factor related to survival in multivariate analysis was the return to systemic chemotherapy (HR 0.25 95 % CI 0.15-0.42 0.001).
    Conclusion: PS in selected patients is effective for symptom resolution and improving overall survival, if the result is making anticancer therapy possible. Prospective data collection is in any case warranted in every institution performing PS for the purpose of monitoring appropriateness and quality of surgical care.
    Language English
    Publishing date 2024-04-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 632519-1
    ISSN 1532-2157 ; 0748-7983
    ISSN (online) 1532-2157
    ISSN 0748-7983
    DOI 10.1016/j.ejso.2024.108368
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1149: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 549: Show issues

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  2. Article ; Online: Multiple Artery Adventitial Cystic Disease: Which Theory?

    Bejko, Jonida / Sgorlon, Giada / Zanon, Chiara / Mattara, Genny / Grego, Franco / Zanon, Antonio

    Annals of vascular surgery

    2021  Volume 73, Page(s) e1–e2

    MeSH term(s) Adventitia/diagnostic imaging ; Adventitia/surgery ; Arteries ; Humans ; Treatment Outcome ; Vascular Diseases
    Language English
    Publishing date 2021-01-04
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1027366-9
    ISSN 1615-5947 ; 0890-5096
    ISSN (online) 1615-5947
    ISSN 0890-5096
    DOI 10.1016/j.avsg.2020.12.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2882: Show issues Location:
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  3. Article ; Online: Colic and rectal tumors with peritoneal metastases treated with cytoreductive surgery and HIPEC: One homogeneous condition or two different diseases? A systematic review and meta-analysis.

    Tonello, Marco / Sommariva, Antonio / Pirozzolo, Giovanni / Mattara, Genny / Pilati, Pierluigi

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

    2019  Volume 45, Issue 11, Page(s) 2003–2008

    Abstract: Colorectal cancer (CRC) peritoneal metastasis (PM) is one of the most important cause of cancer-related death in world. CRC PM is considered as a homogeneous disease without differentiating colonic or rectal origin. Aim of this study is to analyze ... ...

    Abstract Colorectal cancer (CRC) peritoneal metastasis (PM) is one of the most important cause of cancer-related death in world. CRC PM is considered as a homogeneous disease without differentiating colonic or rectal origin. Aim of this study is to analyze survival of patients treated with cytoreductive surgery and HIPEC, according to the origin of PM. Literature search was performed to identify relevant articles. All meta-analysis were performed using mean difference and log of HR, when appropriate. The I
    MeSH term(s) Antineoplastic Agents/administration & dosage ; Carcinoma/secondary ; Carcinoma/therapy ; Colonic Neoplasms/pathology ; Colonic Neoplasms/therapy ; Combined Modality Therapy ; Cytoreduction Surgical Procedures/methods ; Disease-Free Survival ; Humans ; Hyperthermia, Induced/methods ; Infusions, Parenteral ; Peritoneal Neoplasms/secondary ; Peritoneal Neoplasms/therapy ; Prognosis ; Rectal Neoplasms/pathology ; Rectal Neoplasms/therapy ; Survival Rate ; Treatment Outcome
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2019-06-12
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 632519-1
    ISSN 1532-2157 ; 0748-7983
    ISSN (online) 1532-2157
    ISSN 0748-7983
    DOI 10.1016/j.ejso.2019.06.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1149: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 549: Show issues

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  4. Article: p53/

    Boldrin, Elisa / Piano, Maria Assunta / Bernaudo, Francesco / Alfieri, Rita / Biasin, Maria Raffaella / Montagner, Isabella Monia / Volpato, Alice / Mattara, Genny / Lamacchia, Francesco / Magni, Giovanna / Rosato, Antonio / Scapinello, Antonio / Pilati, Pierluigi / Curtarello, Matteo

    Cancers

    2023  Volume 15, Issue 10

    Abstract: Chromosomal instability (CIN) is very frequent in gastroesophageal adenocarcinoma (GEA) and it is characterized ... ...

    Abstract Chromosomal instability (CIN) is very frequent in gastroesophageal adenocarcinoma (GEA) and it is characterized by
    Language English
    Publishing date 2023-05-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15102783
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Managing the Consequences of Oncological Major Surgery: A Short- and Medium-Term Skills Assessment Proposal for Patient and Caregiver through M.A.D.I.T. Methodology.

    Turchi, Gian Piero / Fabbian, Alessandro / Alfieri, Rita / Da Roit, Anna / Marano, Salvatore / Mattara, Genny / Pilati, Pierluigi / Castoro, Carlo / Bassi, Davide / Dalla Riva, Marta Silvia / Orrù, Luisa / Pinto, Eleonora

    Behavioral sciences (Basel, Switzerland)

    2022  Volume 12, Issue 3

    Abstract: The effects of cancer surgery and treatment harm patients' life and working ability: major causes of this can be intensified by the postoperative symptoms. This study, the first part of the HEAGIS project (Health and Employment after Gastrointestinal ... ...

    Abstract The effects of cancer surgery and treatment harm patients' life and working ability: major causes of this can be intensified by the postoperative symptoms. This study, the first part of the HEAGIS project (Health and Employment after Gastrointestinal Surgery), proposes a method to assess patients and caregivers' competences in dealing with postoperative course and the related needs to improve the adequate competences. In this observational study, an ad hoc structured interview was conducted with 47 patients and 15 caregivers between the third and fifteenth postoperative day. Oesophageal (38%), esophagogastric junction (13%), gastric (30%), colon (8%) and rectum (11%) cancer patients were considered. Computerized textual data analysis methodology was used to identify levels of competences. Text analysis highlighted three different levels (low, medium and high) of four specific types of patients and caregivers' competences. In particular, the overall trend of the preview of future scenarios and use of resource competences was low. Less critical were situation evaluation and preview repercussion of own actions' competences. Caregivers' trends were similar. The Kruskal-Wallis test did not distinguish any differences in the level of competences related to the characteristics of the participants. Patients and caregivers are not accurate in planning the future after surgery, using personal beliefs rather than referring to physicians, and not recognizing adequate resources. The medium-low competences' trend leads to unexpected critical situations, and patients could not deal with them in a maximally effective way. Both patients and caregivers should be taken over by healthcare professionals to improve patients' competences and make the curative surgery effective in daily life.
    Language English
    Publishing date 2022-03-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651997-5
    ISSN 2076-328X
    ISSN 2076-328X
    DOI 10.3390/bs12030077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Critical Competences for the Management of Post-Operative Course in Patients with Digestive Tract Cancer: The Contribution of MADIT Methodology for a Nine-Month Longitudinal Study.

    Pinto, Eleonora / Fabbian, Alessandro / Alfieri, Rita / Da Roit, Anna / Marano, Salvatore / Mattara, Genny / Pilati, Pierluigi / Castoro, Carlo / Cavarzan, Marco / Dalla Riva, Marta Silvia / Orrù, Luisa / Turchi, Gian Piero

    Behavioral sciences (Basel, Switzerland)

    2022  Volume 12, Issue 4

    Abstract: There is a high postoperative morbidity rate after cancer surgery, that impairs patients’ self-management, job condition and economic strength. This paper describes the results of a peculiar psychological intervention on patients undergoing surgery for ... ...

    Abstract There is a high postoperative morbidity rate after cancer surgery, that impairs patients’ self-management, job condition and economic strength. This paper describes the results of a peculiar psychological intervention on patients undergoing surgery for esophageal, gastric and colorectal cancer. The intervention aimed to enhance patients’ competences in the management of postoperative daily life. A narrative approach (M.A.D.I.T.—Methodology for the Analysis of Computerised Text Data) was used to create a questionnaire, Health and Employment after Gastro-Intestinal Surgery—Dialogical Questionnaire, HEAGIS-DQ, that assesses four competences. It was administered to 48 participants. Results were used as guidance for specific intervention, structured on patients’ competence profiles. The intervention lasted nine months after surgery and was structured in weekly to monthly therapeutic sessions. Quality of Life questionnaires were administered too. At the end of the intervention, 94% of patients maintained their job and only 10% of patients asked for financial support. The mean self-perception of health-related quality of life was 71.2. The distribution of three of four competences increased after nine months (p < 0.05). Despite economic difficulties due to lasting symptoms after surgery, and to the current pandemic scenario, a structured intervention with patients let them to resume their jobs and continue activities after surgery.
    Language English
    Publishing date 2022-04-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651997-5
    ISSN 2076-328X
    ISSN 2076-328X
    DOI 10.3390/bs12040101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Complete mesocolic excision versus conventional hemicolectomy in patients with right colon cancer: a systematic review and meta-analysis.

    De Simoni, Ottavia / Barina, Andrea / Sommariva, Antonio / Tonello, Marco / Gruppo, Mario / Mattara, Genny / Toniato, Antonio / Pilati, Pierluigi / Franzato, Boris

    International journal of colorectal disease

    2020  Volume 36, Issue 5, Page(s) 881–892

    Abstract: Purpose: Complete mesocolic excision (CME) has introduced a promising surgical approach for treatment of right colon cancer. However, benefits of CME are still a matter of debate. We conducted a systematic review and meta-analysis to assess safety and ... ...

    Abstract Purpose: Complete mesocolic excision (CME) has introduced a promising surgical approach for treatment of right colon cancer. However, benefits of CME are still a matter of debate. We conducted a systematic review and meta-analysis to assess safety and long-term outcomes of CME versus conventional right hemicolectomy (CRH).
    Methods: We systematically searched MEDLINE, the Cochrane Database of Systematic Reviews, Scopus, Web of Science, and Embase for retrieving studies comparing CME with CRH in right colon cancer. After data extraction from the included studies, meta-analysis was performed to compare postoperative complications, anastomotic leakage, 30-day mortality, number of lymph node yield, disease-free survival (DFS), and overall survival (OS).
    Results: Eight studies met the inclusion criteria with a total of 1871 patients enrolled. No difference was observed in postoperative complications (OR 1.13, 95% CI 0.88-1.47, p = 0.34). CME was associated with significantly higher number of lymph nodes retrieved (MD 9.17, CI 4.67-13.68, p < 0.001). CME also improved 3-year OS (OR 1.57, 95% CI 1.17-2.11, p = 0.003), 5-year OS (OR 1.41, 95% CI 1.06-1.89, p = 0.02), and 5-year DFS (OR 1.99, 95% CI 1.29-3.07, p = 0.002). A sub-group analysis for patients with stage III colon cancer showed no significant impact of CME on 3-year and 5-year OS (OR 2.47, 95% CI 0.86-7.06, p = 0.09; OR 1.23, 95% CI 0.78-1.94, p = 0.38).
    Conclusion: Although with limited evidence, CME shows similar postoperative complication rates and an improved survival outcome compared with CRH.
    MeSH term(s) Colectomy ; Colonic Neoplasms/surgery ; Humans ; Laparoscopy ; Lymph Node Excision ; Mesocolon/surgery ; Treatment Outcome
    Language English
    Publishing date 2020-11-10
    Publishing country Germany
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 84975-3
    ISSN 1432-1262 ; 0179-1958
    ISSN (online) 1432-1262
    ISSN 0179-1958
    DOI 10.1007/s00384-020-03797-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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