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  1. Article ; Online: Predictors of All-Cause 30-Day Readmissions in Patients with Heart Failure at an Urban Safety Net Hospital

    Alexandra B. Steverson, MD, MPH / Paul J. Marano, MD / Caren Chen, MPH / Yifei Ma, MS / Rachel J. Stern, MD / Jean Feng, MS, PhD / Efstathios D. Gennatas, MBBS, PhD / James D. Marks, MD, PhD / Matthew S. Durstenfeld, MD, MAS / Jonathan D. Davis, MD, MPHS / Priscilla Y. Hsue, MD / Lucas S. Zier, MD, MS

    American Journal of Medicine Open, Vol 10, Iss , Pp 100060- (2023)

    The Importance of Social Determinants of Health and Mental Health

    2023  

    Abstract: Introduction: Heart failure (HF) is a frequent cause of readmissions. Despite caring for underresourced patients and dependence on government funding, safety net hospitals frequently incur penalties for failing to meet pay-for-performance readmission ... ...

    Abstract Introduction: Heart failure (HF) is a frequent cause of readmissions. Despite caring for underresourced patients and dependence on government funding, safety net hospitals frequently incur penalties for failing to meet pay-for-performance readmission metrics. Limited research exists on the causes of HF readmissions in safety net hospitals. Therefore, we sought to investigate predictors of 30-day all-cause readmission in HF patients in the safety net setting. Methods: We performed a retrospective chart review of patients admitted for HF from October 2018 to April 2019. We extracted data on demographics and medical comorbidities and performed patient-specific review of social determinants and mental health in 4 domains: race/ethnicity, housing status, substance use, and mental illness. Multivariable Poisson regression modeling was employed to evaluate associations with 30-day all-cause readmission. Results: The study population included 290 patients, among whom the mean age was 59 years and 71% (n = 207) were male; 42% (120) were Black/African American (AA), 22% (64) were Hispanic/Latino, and 96% (278) had public insurance; 28% (79) were not housed, 19% (56) had a diagnosis of mental illness, and active substance use was common. The 30-day readmission rate was 25.5% (n = 88). Factors that were associated with increased risk of readmission included self-identifying as Black/AA (relative risk 2.28, 95% confidence interval 1.00-5.20) or Hispanic/Latino (2.53, 1.07-6.00), experiencing homelessness (2.07, 1.21-3.56), living in a shelter (3.20, 1.27-8.02), or intravenous drug use (IVDU) (2.00, 1.08-3.70). Conclusion: Race/ethnicity, housing status, and substance use were associated with increased risk of 30-day all-cause readmission in HF patients in a safety net hospital. In contrast to prior studies, medical comorbidities were not associated with increased risk of readmission.
    Keywords Heart failure ; Readmission ; Safety net hospital ; Social determinants of health ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Autoantigen profiling reveals a shared post-COVID signature in fully recovered and long COVID patients

    Aaron Bodansky / Chung-Yu Wang / Aditi Saxena / Anthea Mitchell / Andrew F. Kung / Saki Takahashi / Khamal Anglin / Beatrice Huang / Rebecca Hoh / Scott Lu / Sarah A. Goldberg / Justin Romero / Brandon Tran / Raushun Kirtikar / Halle Grebe / Matthew So / Bryan Greenhouse / Matthew S. Durstenfeld / Priscilla Y. Hsue /
    Joanna Hellmuth / J. Daniel Kelly / Jeffrey N. Martin / Mark S. Anderson / Steven G. Deeks / Timothy J. Henrich / Joseph L. DeRisi / Michael J. Peluso

    JCI Insight, Vol 8, Iss

    2023  Volume 11

    Abstract: Some individuals do not return to baseline health following SARS-CoV-2 infection, leading to a condition known as long COVID. The underlying pathophysiology of long COVID remains unknown. Given that autoantibodies have been found to play a role in ... ...

    Abstract Some individuals do not return to baseline health following SARS-CoV-2 infection, leading to a condition known as long COVID. The underlying pathophysiology of long COVID remains unknown. Given that autoantibodies have been found to play a role in severity of SARS-CoV-2 infection and certain other post-COVID sequelae, their potential role in long COVID is important to investigate. Here, we apply a well-established, unbiased, proteome-wide autoantibody detection technology (T7 phage-display assay with immunoprecipitation and next-generation sequencing, PhIP-Seq) to a robustly phenotyped cohort of 121 individuals with long COVID, 64 individuals with prior COVID-19 who reported full recovery, and 57 pre-COVID controls. While a distinct autoreactive signature was detected that separated individuals with prior SARS-CoV-2 infection from those never exposed to SARS-CoV-2, we did not detect patterns of autoreactivity that separated individuals with long COVID from individuals fully recovered from COVID-19. These data suggest that there are robust alterations in autoreactive antibody profiles due to infection; however, no association of autoreactive antibodies and long COVID was apparent by this assay.
    Keywords COVID-19 ; Medicine ; R
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher American Society for Clinical investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Chronic viral coinfections differentially affect the likelihood of developing long COVID

    Michael J. Peluso / Tyler-Marie Deveau / Sadie E. Munter / Dylan Ryder / Amanda Buck / Gabriele Beck-Engeser / Fay Chan / Scott Lu / Sarah A. Goldberg / Rebecca Hoh / Viva Tai / Leonel Torres / Nikita S. Iyer / Monika Deswal / Lynn H. Ngo / Melissa Buitrago / Antonio Rodriguez / Jessica Y. Chen / Brandon C. Yee /
    Ahmed Chenna / John W. Winslow / Christos J. Petropoulos / Amelia N. Deitchman / Joanna Hellmuth / Matthew A. Spinelli / Matthew S. Durstenfeld / Priscilla Y. Hsue / J. Daniel Kelly / Jeffrey N. Martin / Steven G. Deeks / Peter W. Hunt / Timothy J. Henrich

    The Journal of Clinical Investigation, Vol 133, Iss

    2023  Volume 3

    Abstract: BACKGROUND The presence and reactivation of chronic viral infections, such as EBV, CMV, and HIV, have been proposed as potential contributors to long COVID (LC), but studies in well-characterized postacute cohorts of individuals with COVID-19 over a ... ...

    Abstract BACKGROUND The presence and reactivation of chronic viral infections, such as EBV, CMV, and HIV, have been proposed as potential contributors to long COVID (LC), but studies in well-characterized postacute cohorts of individuals with COVID-19 over a longer time course consistent with current case definitions of LC are limited.METHODS In a cohort of 280 adults with prior SARS-CoV-2 infection, we assessed the presence and types of LC symptoms and prior medical history (including COVID-19 history and HIV status) and performed serological testing for EBV and CMV using a commercial laboratory. We used covariate-adjusted binary logistic regression models to identify independent associations between variables and LC symptoms.RESULTS We observed that LC symptoms, such as fatigue and neurocognitive dysfunction, at a median of 4 months following initial diagnosis were independently associated with serological evidence suggesting recent EBV reactivation (early antigen–diffuse IgG positivity) or high nuclear antigen (EBNA) IgG levels but not with ongoing EBV viremia. Serological evidence suggesting recent EBV reactivation (early antigen–diffuse IgG positivity) was most strongly associated with fatigue (OR = 2.12). Underlying HIV infection was also independently associated with neurocognitive LC (OR = 2.5). Interestingly, participants who had serologic evidence of prior CMV infection were less likely to develop neurocognitive LC (OR = 0.52).CONCLUSION Overall, these findings suggest differential effects of chronic viral coinfections on the likelihood of developing LC and association with distinct syndromic patterns. Further assessment during the acute phase of COVID-19 is warranted.TRIAL REGISTRATION Long-term Impact of Infection with Novel Coronavirus; ClinicalTrials.gov NCT04362150.FUNDING This work was supported by NIH/National Institute of Allergy and Infectious Diseases grants (3R01AI141003-03S1, R01AI158013, and K24AI145806); the Zuckerberg San Francisco General Hospital Department of Medicine and Division of HIV, ...
    Keywords COVID-19 ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher American Society for Clinical Investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Researching COVID to Enhance Recovery (RECOVER) adult study protocol

    Leora I Horwitz / Tanayott Thaweethai / Shari B Brosnahan / Mine S Cicek / Megan L Fitzgerald / Jason D Goldman / Rachel Hess / S L Hodder / Vanessa L Jacoby / Michael R Jordan / Jerry A Krishnan / Adeyinka O Laiyemo / Torri D Metz / Lauren Nichols / Rachel E Patzer / Anisha Sekar / Nora G Singer / Lauren E Stiles / Barbara S Taylor /
    Shifa Ahmed / Heather A Algren / Khamal Anglin / Lisa Aponte-Soto / Hassan Ashktorab / Ingrid V Bassett / Brahmchetna Bedi / Nahid Bhadelia / Christian Bime / Marie-Abele C Bind / Lora J Black / Andra L Blomkalns / Hassan Brim / Mario Castro / James Chan / Alexander W Charney / Benjamin K Chen / Li Qing Chen / Peter Chen / David Chestek / Lori B Chibnik / Dominic C Chow / Helen Y Chu / Rebecca G Clifton / Shelby Collins / Maged M Costantine / Sushma K Cribbs / Steven G Deeks / John D Dickinson / Sarah E Donohue / Matthew S Durstenfeld / Ivette F Emery / Kristine M Erlandson / Julio C Facelli / Rachael Farah-Abraham / Aloke V Finn / Melinda S Fischer / Valerie J Flaherman / Judes Fleurimont / Vivian Fonseca / Emily J Gallagher / Jennifer C Gander / Maria Laura Gennaro / Kelly S Gibson / Minjoung Go / Steven N Goodman / Joey P Granger / Frank L Greenway / John W Hafner / Jenny E Han / Michelle S Harkins / Kristine S P Hauser / James R Heath / Carla R Hernandez / On Ho / Matthew K Hoffman / Susan E Hoover / Carol R Horowitz / Harvey Hsu / Priscilla Y Hsue / Brenna L Hughes / Prasanna Jagannathan / Judith A James / Janice John / Sarah Jolley / S E Judd / Joy J Juskowich / Diane G Kanjilal / Elizabeth W Karlson / Stuart D Katz / J Daniel Kelly / Sara W Kelly / Arthur Y Kim / John P Kirwan / Kenneth S Knox / Andre Kumar / Michelle F Lamendola-Essel / Margaret Lanca / Joyce K Lee-Lannotti / R Craig Lefebvre / Bruce D Levy / Janet Y Lin / Brian P Logarbo / Jennifer K Logue / Michele T Longo / Carlos A Luciano / Karen Lutrick / Shahdi K Malakooti / Gail Mallett / Gabrielle Maranga / Jai G Marathe / Vincent C Marconi / Gailen D Marshall / Christopher F Martin / Jeffrey N Martin / Heidi T May / Grace A McComsey / Dylan McDonald / Hector Mendez-Figueroa / Lucio Miele / Murray A Mittleman / Sindhu Mohandas / Christian Mouchati / Janet M Mullington / Girish N Nadkarni / Erica R Nahin / Robert B Neuman / Lisa T Newman / Amber Nguyen / Janko Z Nikolich / Igho Ofotokun / Princess U Ogbogu / Anna Palatnik / Kristy T S Palomares / Tanyalak Parimon / Samuel Parry / Sairam Parthasarathy / Thomas F Patterson / Ann Pearman / Michael J Peluso / Priscilla Pemu / Christian M Pettker / Beth A Plunkett / Kristen Pogreba-Brown / Athena Poppas / J Zachary Porterfield / John G Quigley / Davin K Quinn / Hengameh Raissy / Candida J Rebello / Uma M Reddy / Rebecca Reece / Harrison T Reeder / Franz P Rischard / Johana M Rosas / Clifford J Rosen / Nadine G Rouphael / Dwight J Rouse / Adam M Ruff / Christina Saint Jean / Grecio J Sandoval / Jorge L Santana / Shannon M Schlater / Frank C Sciurba / Caitlin Selvaggi / Sudha Seshadri / Howard D Sesso / Dimpy P Shah / Eyal Shemesh / Zaki A Sherif / Daniel J Shinnick / Hyagriv N Simhan / Upinder Singh / Amber Sowles / Vignesh Subbian / Jun Sun / Mehul S Suthar / Larissa J Teunis / John M Thorp / Amberly Ticotsky / Alan T N Tita / Robin Tragus / Katherine R Tuttle / Alfredo E Urdaneta / P J Utz / Timothy M VanWagoner / Andrew Vasey / Suzanne D Vernon / Crystal Vidal / Tiffany Walker / Honorine D Ward / David E Warren / Ryan M Weeks / Steven J Weiner / Jordan C Weyer / Jennifer L Wheeler / Sidney W Whiteheart / Zanthia Wiley / Natasha J Williams / Juan P Wisnivesky / John C Wood / Lynn M Yee / Natalie M Young / Sokratis N Zisis / Andrea S Foulkes

    PLoS ONE, Vol 18, Iss 6, p e

    Rationale, objectives, and design.

    2023  Volume 0286297

    Abstract: Importance SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or other health effects after the acute phase of infection; termed post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID. The characteristics, prevalence, ... ...

    Abstract Importance SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or other health effects after the acute phase of infection; termed post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID. The characteristics, prevalence, trajectory and mechanisms of PASC are ill-defined. The objectives of the Researching COVID to Enhance Recovery (RECOVER) Multi-site Observational Study of PASC in Adults (RECOVER-Adult) are to: (1) characterize PASC prevalence; (2) characterize the symptoms, organ dysfunction, natural history, and distinct phenotypes of PASC; (3) identify demographic, social and clinical risk factors for PASC onset and recovery; and (4) define the biological mechanisms underlying PASC pathogenesis. Methods RECOVER-Adult is a combined prospective/retrospective cohort currently planned to enroll 14,880 adults aged ≥18 years. Eligible participants either must meet WHO criteria for suspected, probable, or confirmed infection; or must have evidence of no prior infection. Recruitment occurs at 86 sites in 33 U.S. states, Washington, DC and Puerto Rico, via facility- and community-based outreach. Participants complete quarterly questionnaires about symptoms, social determinants, vaccination status, and interim SARS-CoV-2 infections. In addition, participants contribute biospecimens and undergo physical and laboratory examinations at approximately 0, 90 and 180 days from infection or negative test date, and yearly thereafter. Some participants undergo additional testing based on specific criteria or random sampling. Patient representatives provide input on all study processes. The primary study outcome is onset of PASC, measured by signs and symptoms. A paradigm for identifying PASC cases will be defined and updated using supervised and unsupervised learning approaches with cross-validation. Logistic regression and proportional hazards regression will be conducted to investigate associations between risk factors, onset, and resolution of PASC symptoms. Discussion RECOVER-Adult is the first ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 150
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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