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  1. Article: What you need to know about: acute liver failure.

    Matthewman, Madeline Coxwell / Warrillow, Stephen

    British journal of hospital medicine (London, England : 2005)

    2022  Volume 83, Issue 9, Page(s) 1–11

    Abstract: Acute liver failure is a rare but important clinical syndrome, with a high mortality rate. Prompt recognition, appropriate management and early referral to a liver transplant centre can lead to good outcomes in these critically unwell patients. This ... ...

    Abstract Acute liver failure is a rare but important clinical syndrome, with a high mortality rate. Prompt recognition, appropriate management and early referral to a liver transplant centre can lead to good outcomes in these critically unwell patients. This article gives an overview of the key clinical challenges and optimal management of patients with acute liver failure. Acute liver failure is defined and a comprehensive list of aetiologies and suggested investigations is provided. The clinical challenges of sepsis, renal impairment, coagulopathy, hypoglycaemia, haemodynamic instability and cerebral oedema are discussed. Quadruple H therapy, a combination of therapies aimed to reduce cerebral oedema in acute liver failure, is described. A systemic guide to managing patients with acute liver failure is provided, as are indications for referral to a liver transplant centre.
    MeSH term(s) Brain Edema/etiology ; Brain Edema/therapy ; Humans ; Hypoglycemia/complications ; Liver Failure, Acute/complications ; Liver Failure, Acute/diagnosis ; Liver Transplantation/adverse effects
    Language English
    Publishing date 2022-09-28
    Publishing country England
    Document type Journal Article
    ISSN 1750-8460
    ISSN 1750-8460
    DOI 10.12968/hmed.2022.0051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Mechanical ventilation for the non-anaesthetist 1: physiology and mechanics.

    Matthewman, Madeline Coxwell / Down, Jim

    British journal of hospital medicine (London, England : 2005)

    2019  Volume 79, Issue 12, Page(s) C188–C192

    MeSH term(s) Humans ; Respiration, Artificial/instrumentation ; Respiration, Artificial/methods
    Language English
    Publishing date 2019-01-23
    Publishing country England
    Document type Journal Article
    ISSN 1750-8460
    ISSN 1750-8460
    DOI 10.12968/hmed.2018.79.12.C188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Mechanical ventilation for the non-anaesthetist 2: practical tips.

    Matthewman, Madeline Coxwell / Down, Jim

    British journal of hospital medicine (London, England : 2005)

    2018  Volume 80, Issue 1, Page(s) C12–C16

    MeSH term(s) Airway Resistance ; Capillary Permeability ; Humans ; Hypoxia ; Lung Compliance ; Maximal Respiratory Pressures ; Pneumonia/therapy ; Pneumonia, Ventilator-Associated ; Positive-Pressure Respiration/methods ; Pressure ; Pulmonary Disease, Chronic Obstructive/therapy ; Respiration, Artificial/methods ; Respiratory Distress Syndrome, Adult/therapy ; Tidal Volume ; Ventilator-Induced Lung Injury/prevention & control
    Language English
    Publishing date 2018-12-28
    Publishing country England
    Document type Journal Article
    ISSN 1750-8460
    ISSN 1750-8460
    DOI 10.12968/hmed.2019.80.1.C12
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Dose equivalence for metaraminol and noradrenaline - A retrospective analysis.

    Costa-Pinto, Rahul / Neto, Ary Serpa / Matthewman, Madeline Coxwell / Osrin, Dean / Liskaser, Grace / Li, Jasun / Young, Marcus / Jones, Daryl / Udy, Andrew / Warrillow, Stephen / Bellomo, Rinaldo

    Journal of critical care

    2024  Volume 80, Page(s) 154430

    Abstract: Background: Noradrenaline and metaraminol are commonly used vasopressors in critically ill patients. However, little is known of their dose equivalence.: Methods: We conducted a single centre retrospective cohort study of all ICU patients who ... ...

    Abstract Background: Noradrenaline and metaraminol are commonly used vasopressors in critically ill patients. However, little is known of their dose equivalence.
    Methods: We conducted a single centre retrospective cohort study of all ICU patients who transitioned from metaraminol to noradrenaline infusions between August 26, 2016 and December 31, 2020. Patients receiving additional vasoactive drug infusion were excluded. Dose equivalence was calculated based on the last hour metaraminol dose (in μg/min) and the first hour noradrenaline dose (in μg/min) with the closest matched mean arterial pressure (MAP). Sensitivity analyses were performed on patients with acute kidney injury (AKI), sepsis and mechanical ventilation.
    Results: We studied 195 patients. The median conversion ratio of metaraminol to noradrenaline was 12.5:1 (IQR 7.5-20.0) for the overall cohort. However, the coefficient of variation was 77% and standard deviation was 11.8. Conversion ratios were unaffected by sepsis or mechanical ventilation but increased (14:1) with AKI. One in five patients had a MAP decrease of >10 mmHg during the transition period from metaraminol to noradrenaline. Post-transition noradrenaline dose (p < 0.001) and AKI (p = 0.045) were independently associated with metaraminol dose. The proportion of variation in noradrenaline dose predicted from metaraminol dose was low (R
    Conclusions: The median dose equivalence for metaraminol and noradrenaline in this study was 12.5:1. However, there was significant variance in dose equivalence, only half the proportion of variation in noradrenaline infusion dose was predicted by metaraminol dose, and conversion-associated hypotension was common.
    MeSH term(s) Humans ; Metaraminol ; Norepinephrine ; Retrospective Studies ; Sepsis/complications ; Acute Kidney Injury/complications
    Chemical Substances Metaraminol (818U2PZ2EH) ; Norepinephrine (X4W3ENH1CV)
    Language English
    Publishing date 2024-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2023.154430
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2152: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Pressure support ventilation in intensive care patients receiving prolonged invasive ventilation.

    Al-Bassam, Wisam / Parikh, Tapan / Neto, Ary Serpa / Idrees, Yamamah / Kubicki, Mark A / Hodgson, Carol L / Subramaniam, Ashwin / Reddy, Mallikarjuna Ponnapa / Gullapalli, Navya / Michel, Claire / Matthewman, Madeline Coxwell / Naughton, Jack / Pereira, Jason / Shehabi, Yahya / Bellomo, Rinaldo

    Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

    2023  Volume 23, Issue 4, Page(s) 394–402

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-10-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2401976-8
    ISSN 1441-2772
    ISSN 1441-2772
    DOI 10.51893/2021.4.OA4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6672: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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