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  1. Article ; Online: Pathology in Practice.

    Conrado, Francisco O / Sharkey, Leslie C / Cudney, Sarah E / Paul, April L / Matthews, Morgan H / Robinson, Nicholas A

    Journal of the American Veterinary Medical Association

    2021  Volume 259, Issue 3, Page(s) 261–264

    MeSH term(s) Animal Diseases/diagnosis ; Animals
    Language English
    Publishing date 2021-07-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390811-2
    ISSN 1943-569X ; 0003-1488
    ISSN (online) 1943-569X
    ISSN 0003-1488
    DOI 10.2460/javma.259.3.261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Circulating melanin-containing cells and neutrophils with phagocytized melanin granules in a horse with disseminated melanoma.

    Conrado, Francisco O / Iapoce, Nicholas / Batista-Linhares, Mainity / Lopez, Sharleen / Matthews, Morgan H / McKinney, Caroline A / Rothacker, Caitlin

    Veterinary clinical pathology

    2020  Volume 49, Issue 4, Page(s) 624–631

    Abstract: An 18-year-old, grey, Thoroughbred Cross gelding was referred to the Cummings School of Veterinary Medicine at Tufts University following a 3-week history of low-grade fever of unknown origin, distal limb swelling, and weight loss. Clinical examination ... ...

    Abstract An 18-year-old, grey, Thoroughbred Cross gelding was referred to the Cummings School of Veterinary Medicine at Tufts University following a 3-week history of low-grade fever of unknown origin, distal limb swelling, and weight loss. Clinical examination identified a few black, round, smooth nodules along the ventral aspect of the proximal tail. Transabdominal ultrasound showed a markedly enlarged heterogenous spleen, hyperechoic liver nodules, and evidence of peritonitis with fibrin deposition. A mature neutrophilia was noted on complete blood count with variable numbers of phagocytized granules within neutrophils. The granules did not stain with Perl's Prussian blue, and were intensely positive when stained with Fontana-Mason, consistent with melanin. On necropsy, the spleen occupied approximately one-third of the abdominal cavity and was diffusely firm with abundant black pigment on cut section. The medullary space of the 18th thoracic vertebra was also diffusely blackened. The splenic, mediastinal, and tracheobronchial lymph nodes were five times the normal size and diffusely pigmented. The final anatomic diagnosis was disseminated malignant melanoma with extensive splenic involvement and hemolymphatic and vascular neoplastic dissemination. To the authors' knowledge, this is the first full report to identify circulating neutrophils containing phagocytized melanin granules, which confirmed an antemortem diagnosis of disseminated melanoma.
    MeSH term(s) Animals ; Horse Diseases ; Horses ; Lymph Nodes ; Male ; Melanins ; Melanoma/veterinary ; Neutrophils ; Skin Neoplasms/veterinary
    Chemical Substances Melanins
    Language English
    Publishing date 2020-11-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2114702-4
    ISSN 1939-165X ; 0275-6382
    ISSN (online) 1939-165X
    ISSN 0275-6382
    DOI 10.1111/vcp.12914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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