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Article: Estimating number of European eel (

Halvorsen, Silje / Korslund, Lars / Mattingsdal, Morten / Slettan, Audun

2023 Volume 13, Issue 2, Page(s) e9785

Abstract: Knowledge about population genetic data is important for effective conservation management. Genetic research traditionally requires sampling directly from the organism, for example tissue, which can be challenging, time-consuming, and harmful to the ... ...

Abstract	Knowledge about population genetic data is important for effective conservation management. Genetic research traditionally requires sampling directly from the organism, for example tissue, which can be challenging, time-consuming, and harmful to the animal. Environmental DNA (eDNA) approaches offer a way to sample genetic material noninvasively. In attempts to estimate population size of aquatic species using eDNA, researchers have found positive correlations between biomass and eDNA concentrations, but the approach is debated because of variations in the production and degrading of DNA in water. Recently, a more accurate eDNA-approach has emerged, focusing on the genomic differences between individuals. In this study, we used eDNA from water samples to estimate the number of European eel (
Language	English
Publishing date	2023-02-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2635675-2
ISSN	2045-7758
ISSN	2045-7758
DOI	10.1002/ece3.9785
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Article: A Breast Cancer Polygenic Risk Score Is Feasible for Risk Stratification in the Norwegian Population.

Akdeniz, Bayram Cevdet / Mattingsdal, Morten / Dominguez-Valentin, Mev / Frei, Oleksandr / Shadrin, Alexey / Puustusmaa, Mikk / Saar, Regina / Sõber, Siim / Møller, Pål / Andreassen, Ole A / Padrik, Peeter / Hovig, Eivind

Cancers

2023 Volume 15, Issue 16

Abstract: Background: Statistical associations of numerous single nucleotide polymorphisms with breast cancer (BC) have been identified in genome-wide association studies (GWAS). Recent evidence suggests that a Polygenic Risk Score (PRS) can be a useful risk ... ...

Abstract	Background: Statistical associations of numerous single nucleotide polymorphisms with breast cancer (BC) have been identified in genome-wide association studies (GWAS). Recent evidence suggests that a Polygenic Risk Score (PRS) can be a useful risk stratification instrument for a BC screening strategy, and a PRS test has been developed for clinical use. The performance of the PRS is yet unknown in the Norwegian population. Aim: To evaluate the performance of PRS models for BC in a Norwegian dataset. Methods: We investigated a sample of 1053 BC cases and 7094 controls from different regions of Norway. PRS values were calculated using four PRS models, and their performance was evaluated by the area under the curve (AUC) and the odds ratio (OR). The effect of the PRS on the age of onset of BC was determined by a Cox regression model, and the lifetime absolute risk of developing BC was calculated using the iCare tool. Results: The best performing PRS model included 3820 SNPs, which yielded an AUC = 0.625 and an OR = 1.567 per one standard deviation increase. The PRS values of the samples correlate with an increased risk of BC, with a hazard ratio of 1.494 per one standard deviation increase (95% confidence interval of 1.406-1.588). The individuals in the highest decile of the PRS have at least twice the risk of developing BC compared to the individuals with a median PRS. The results in this study with Norwegian samples are coherent with the findings in the study conducted using Estonian and UK Biobank samples. Conclusion: The previously validated PRS models have a similar observed accuracy in the Norwegian data as in the UK and Estonian populations. A PRS provides a meaningful association with the age of onset of BC and lifetime risk. Therefore, as suggested in Estonia, a PRS may also be integrated into the screening strategy for BC in Norway.
Language	English
Publishing date	2023-08-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15164124
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Article: Combining population genomics with demographic analyses highlights habitat patchiness and larval dispersal as determinants of connectivity in coastal fish species

Knutsen, Halvor / Catarino, Diana / Rogers, Lauren / Sodeland, Marte / Mattingsdal, Morten / Jahnke, Marlene / Hutchings, Jeffrey A. / Mellerud, Ida / Espeland, Sigurd H. / Johanneson, Kerstin / Roth, Olivia / Hansen, Michael M. / Jentoft, Sissel / André, Carl / Jorde, Per Erik

Molecular ecology. 2022 May, v. 31, no. 9

2022

Abstract: Gene flow shapes spatial genetic structure and the potential for local adaptation. Among marine animals with nonmigratory adults, the presence or absence of a pelagic larval stage is thought to be a key determinant in shaping gene flow and the genetic ... ...

Abstract	Gene flow shapes spatial genetic structure and the potential for local adaptation. Among marine animals with nonmigratory adults, the presence or absence of a pelagic larval stage is thought to be a key determinant in shaping gene flow and the genetic structure of populations. In addition, the spatial distribution of suitable habitats is expected to influence the distribution of biological populations and their connectivity patterns. We used whole genome sequencing to study demographic history and reduced representation (double‐digest restriction associated DNA) sequencing data to analyse spatial genetic structure in broadnosed pipefish (Syngnathus typhle). Its main habitat is eelgrass beds, which are patchily distributed along the study area in southern Norway. Demographic connectivity among populations was inferred from long‐term (~30‐year) population counts that uncovered a rapid decline in spatial correlations in abundance with distance as short as ~2 km. These findings were contrasted with data for two other fish species that have a pelagic larval stage (corkwing wrasse, Symphodus melops; black goby, Gobius niger). For these latter species, we found wider spatial scales of connectivity and weaker genetic isolation‐by‐distance patterns, except where both species experienced a strong barrier to gene flow, seemingly due to lack of suitable habitat. Our findings verify expectations that a fragmented habitat and absence of a pelagic larval stage promote genetic structure, while presence of a pelagic larvae stage increases demographic connectivity and gene flow, except perhaps over extensive habitat gaps.
Keywords	DNA ; Symphodus melops ; Syngnathus typhle ; Zostera marina ; fish ; gene flow ; genome ; habitat fragmentation ; habitats ; larvae ; metagenomics ; Norway
Language	English
Dates of publication	2022-05
Size	p. 2562-2577.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	1126687-9
ISSN	1365-294X ; 0962-1083
ISSN (online)	1365-294X
ISSN	0962-1083
DOI	10.1111/mec.16415
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Article ; Online: Stabilizing selection on Atlantic cod supergenes through a millennium of extensive exploitation.

Sodeland, Marte / Jentoft, Sissel / Jorde, Per Erik / Mattingsdal, Morten / Albretsen, Jon / Kleiven, Alf Ring / Synnes, Ann-Elin Wårøy / Espeland, Sigurd Heiberg / Olsen, Esben Moland / Andrè, Carl / Stenseth, Nils Chr / Knutsen, Halvor

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 8

Abstract: Life on Earth has been characterized by recurring cycles of ecological stasis and disruption, relating biological eras to geological and climatic transitions through the history of our planet. Due to the increasing degree of ecological abruption caused ... ...

Abstract	Life on Earth has been characterized by recurring cycles of ecological stasis and disruption, relating biological eras to geological and climatic transitions through the history of our planet. Due to the increasing degree of ecological abruption caused by human influences many advocate that we now have entered the geological era of the Anthropocene, or "the age of man." Considering the ongoing mass extinction and ecosystem reshuffling observed worldwide, a better understanding of the drivers of ecological stasis will be a requisite for identifying routes of intervention and mitigation. Ecosystem stability may rely on one or a few keystone species, and the loss of such species could potentially have detrimental effects. The Atlantic cod (
MeSH term(s)	Animals ; Aquaculture/methods ; Atlantic Ocean ; Conservation of Natural Resources/methods ; Ecosystem ; Fisheries ; Gadus morhua/genetics ; Gadus morhua/growth & development ; Genome ; Genomics ; Humans ; North Sea ; Population Dynamics
Language	English
Publishing date	2022-02-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2114904119
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Article ; Online: Combining population genomics with demographic analyses highlights habitat patchiness and larval dispersal as determinants of connectivity in coastal fish species.

Knutsen, Halvor / Catarino, Diana / Rogers, Lauren / Sodeland, Marte / Mattingsdal, Morten / Jahnke, Marlene / Hutchings, Jeffrey A / Mellerud, Ida / Espeland, Sigurd H / Johanneson, Kerstin / Roth, Olivia / Hansen, Michael M / Jentoft, Sissel / André, Carl / Jorde, Per Erik

Molecular ecology

2022 Volume 31, Issue 9, Page(s) 2562–2577

Abstract	Gene flow shapes spatial genetic structure and the potential for local adaptation. Among marine animals with nonmigratory adults, the presence or absence of a pelagic larval stage is thought to be a key determinant in shaping gene flow and the genetic structure of populations. In addition, the spatial distribution of suitable habitats is expected to influence the distribution of biological populations and their connectivity patterns. We used whole genome sequencing to study demographic history and reduced representation (double-digest restriction associated DNA) sequencing data to analyse spatial genetic structure in broadnosed pipefish (Syngnathus typhle). Its main habitat is eelgrass beds, which are patchily distributed along the study area in southern Norway. Demographic connectivity among populations was inferred from long-term (~30-year) population counts that uncovered a rapid decline in spatial correlations in abundance with distance as short as ~2 km. These findings were contrasted with data for two other fish species that have a pelagic larval stage (corkwing wrasse, Symphodus melops; black goby, Gobius niger). For these latter species, we found wider spatial scales of connectivity and weaker genetic isolation-by-distance patterns, except where both species experienced a strong barrier to gene flow, seemingly due to lack of suitable habitat. Our findings verify expectations that a fragmented habitat and absence of a pelagic larval stage promote genetic structure, while presence of a pelagic larvae stage increases demographic connectivity and gene flow, except perhaps over extensive habitat gaps.
MeSH term(s)	Animals ; Demography ; Ecosystem ; Fishes/genetics ; Larva/genetics ; Metagenomics ; Perciformes/genetics
Language	English
Publishing date	2022-03-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1126687-9
ISSN	1365-294X ; 0962-1083
ISSN (online)	1365-294X
ISSN	0962-1083
DOI	10.1111/mec.16415
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Article ; Online: The genetic structure of Norway.

Mattingsdal, Morten / Ebenesersdóttir, S Sunna / Moore, Kristjan H S / Andreassen, Ole A / Hansen, Thomas F / Werge, Thomas / Kockum, Ingrid / Olsson, Tomas / Alfredsson, Lars / Helgason, Agnar / Stefánsson, Kári / Hovig, Eivind

European journal of human genetics : EJHG

2021 Volume 29, Issue 11, Page(s) 1710–1718

Abstract: The aim of the present study was to describe the genetic structure of the Norwegian population using genotypes from 6369 unrelated individuals with detailed information about places of residence. Using standard single marker- and haplotype-based ... ...

Abstract	The aim of the present study was to describe the genetic structure of the Norwegian population using genotypes from 6369 unrelated individuals with detailed information about places of residence. Using standard single marker- and haplotype-based approaches, we report evidence of two regions with distinctive patterns of genetic variation, one in the far northeast, and another in the south of Norway, as indicated by fixation indices, haplotype sharing, homozygosity, and effective population size. We detect and quantify a component of Uralic Sami ancestry that is enriched in the North. On a finer scale, we find that rates of migration have been affected by topography like mountain ridges. In the broader Scandinavian context, we detect elevated relatedness between the mid- and northern border areas towards Sweden. The main finding of this study is that despite Norway's long maritime history and as a former Danish territory, the region closest to mainland Europe in the south appears to have been an isolated region in Norway, highlighting the open sea as a barrier to gene flow into Norway.
MeSH term(s)	Haplotypes ; Humans ; Norway ; Pedigree ; Polymorphism, Genetic ; Population/genetics
Language	English
Publishing date	2021-05-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1141470-4
ISSN	1476-5438 ; 1018-4813
ISSN (online)	1476-5438
ISSN	1018-4813
DOI	10.1038/s41431-021-00899-6
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Article ; Online: A continuous genome assembly of the corkwing wrasse (Symphodus melops).

Mattingsdal, Morten / Jentoft, Sissel / Tørresen, Ole K / Knutsen, Halvor / Hansen, Michael M / Robalo, Joana I / Zagrodzka, Zuzanna / André, Carl / Gonzalez, Enrique Blanco

Genomics

2018 Volume 110, Issue 6, Page(s) 399–403

Abstract: The wrasses (Labridae) are one of the most successful and species-rich families of the Perciformes order of teleost fish. Its members display great morphological diversity, and occupy distinct trophic levels in coastal waters and coral reefs. The ... ...

Abstract	The wrasses (Labridae) are one of the most successful and species-rich families of the Perciformes order of teleost fish. Its members display great morphological diversity, and occupy distinct trophic levels in coastal waters and coral reefs. The cleaning behaviour displayed by some wrasses, such as corkwing wrasse (Symphodus melops), is of particular interest for the salmon aquaculture industry to combat and control sea lice infestation as an alternative to chemicals and pharmaceuticals. There are still few genome assemblies available within this fish family for comparative and functional studies, despite the rapid increase in genome resources generated during the past years. Here, we present a highly continuous genome assembly of the corkwing wrasse using PacBio SMRT sequencing (x28.8) followed by error correction with paired-end Illumina data (x132.9). The present genome assembly consists of 5040 contigs (N50 = 461,652 bp) and a total size of 614 Mbp, of which 8.5% of the genome sequence encode known repeated elements. The genome assembly covers 94.21% of highly conserved genes across ray-finned fish species. We find evidence for increased copy numbers specific for corkwing wrasse possibly highlighting diversification and adaptive processes in gene families including N-linked glycosylation (ST8SIA6) and stress response kinases (HIPK1). By comparative analyses, we discover that de novo repeats, often not properly investigated during genome annotation, encode hundreds of immune-related genes. This new genomic resource, together with the ballan wrasse (Labrus bergylta), will allow for in-depth comparative genomics as well as population genetic analyses for the understudied wrasses.
MeSH term(s)	Animals ; Genetics, Population ; Genome ; Male ; Perciformes/genetics ; Sequence Analysis, DNA
Language	English
Publishing date	2018-04-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	356334-0
ISSN	1089-8646 ; 0888-7543
ISSN (online)	1089-8646
ISSN	0888-7543
DOI	10.1016/j.ygeno.2018.04.009
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Article ; Online: Demographic history has shaped the strongly differentiated corkwing wrasse populations in Northern Europe.

Mattingsdal, Morten / Jorde, Per Erik / Knutsen, Halvor / Jentoft, Sissel / Stenseth, Nils Christian / Sodeland, Marte / Robalo, Joana I / Hansen, Michael M / André, Carl / Blanco Gonzalez, Enrique

Molecular ecology

2019 Volume 29, Issue 1, Page(s) 160–171

Abstract: Understanding the biological processes involved in genetic differentiation and divergence between populations within species is a pivotal aim in evolutionary biology. One particular phenomenon that requires clarification is the maintenance of genetic ... ...

Abstract	Understanding the biological processes involved in genetic differentiation and divergence between populations within species is a pivotal aim in evolutionary biology. One particular phenomenon that requires clarification is the maintenance of genetic barriers despite the high potential for gene flow in the marine environment. Such patterns have been attributed to limited dispersal or local adaptation, and to a lesser extent to the demographic history of the species. The corkwing wrasse (Symphodus melops) is an example of a marine fish species where regions of particular strong divergence are observed. One such genetic break occurred at a surprisingly small spatial scale (F
MeSH term(s)	Animals ; Demography ; Ecology ; Europe ; Female ; Fishes/genetics ; Fishes/physiology ; Gene Flow ; Genetic Drift ; Genome/genetics ; Male ; Reproductive Isolation
Language	English
Publishing date	2019-12-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1126687-9
ISSN	1365-294X ; 0962-1083
ISSN (online)	1365-294X
ISSN	0962-1083
DOI	10.1111/mec.15310
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Article: Genome-wide association study identifies genetic loci associated with body mass index and high density lipoprotein-cholesterol levels during psychopharmacological treatment - a cross-sectional naturalistic study.

Athanasiu, Lavinia / Brown, Andrew A / Birkenaes, Astrid B / Mattingsdal, Morten / Agartz, Ingrid / Melle, Ingrid / Steen, Vidar M / Andreassen, Ole A / Djurovic, Srdjan

Psychiatry research

2012 Volume 197, Issue 3, Page(s) 327–336

Abstract: Metabolic and cardiovascular side effects are serious clinical problems related to psychopharmacological treatment, but the underlying mechanisms are mostly unknown. We performed a genome-wide association study of metabolic and cardiovascular risk ... ...

Abstract	Metabolic and cardiovascular side effects are serious clinical problems related to psychopharmacological treatment, but the underlying mechanisms are mostly unknown. We performed a genome-wide association study of metabolic and cardiovascular risk factors during pharmacological therapy. Twelve indicators of metabolic side effects as well as cardiovascular risk factors were analyzed in a naturalistic sample of 594 patients of Norwegian ancestry. We analyzed interactions between gene variants and three categories of psychopharmacological agents based on their reported potential for side effects. For body mass index (BMI), two significantly associated loci were identified on 8q21.3. There were seven markers in one 30-kb region, and the strongest signal was rs7838490. In another locus 140kb away, six markers were significant, and rs6989402 obtained the strongest signal. Both of these loci are located upstream of the gene matrix metalloproteinase 16 (MMP16). For high density lipoprotein cholesterol (HDL-C), marker rs11615274 on 12q21 was significant. The results highlight three genomic regions potentially harboring susceptibility genes for drug-induced metabolic side effects, identifying MMP16 as a candidate gene. This deserves to be replicated in additional populations to provide more evidence for molecular genetic mechanisms of side effects during psychopharmacological treatment.
MeSH term(s)	Adolescent ; Adult ; Aged ; Antidepressive Agents/adverse effects ; Antipsychotic Agents/adverse effects ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Blood Pressure/drug effects ; Blood Pressure/genetics ; Body Mass Index ; C-Reactive Protein/metabolism ; Cholesterol, HDL/blood ; Cross-Sectional Studies ; European Continental Ancestry Group/genetics ; European Continental Ancestry Group/psychology ; Female ; Genetic Loci/genetics ; Genome-Wide Association Study/methods ; Genome-Wide Association Study/statistics & numerical data ; Genotype ; Heart Rate/drug effects ; Heart Rate/genetics ; Humans ; Male ; Matrix Metalloproteinase 16/genetics ; Mental Disorders/blood ; Mental Disorders/drug therapy ; Mental Disorders/genetics ; Middle Aged ; Polymorphism, Single Nucleotide ; Risk Factors
Chemical Substances	Antidepressive Agents ; Antipsychotic Agents ; Blood Glucose ; Cholesterol, HDL ; MMP16 protein, human ; C-Reactive Protein (9007-41-4) ; Matrix Metalloproteinase 16 (EC 3.4.24.-)
Language	English
Publishing date	2012-05-30
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0165-1781 ; 0925-4927
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0165-1781 ; 0925-4927
DOI	10.1016/j.psychres.2011.12.036
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Article ; Online: Altered Brain Activation during Emotional Face Processing in Relation to Both Diagnosis and Polygenic Risk of Bipolar Disorder.

Tesli, Martin / Kauppi, Karolina / Bettella, Francesco / Brandt, Christine Lycke / Kaufmann, Tobias / Espeseth, Thomas / Mattingsdal, Morten / Agartz, Ingrid / Melle, Ingrid / Djurovic, Srdjan / Westlye, Lars T / Andreassen, Ole A

PloS one

2015 Volume 10, Issue 7, Page(s) e0134202

Abstract: Objectives: Bipolar disorder (BD) is a highly heritable disorder with polygenic inheritance. Among the most consistent findings from functional magnetic imaging (fMRI) studies are limbic hyperactivation and dorsal hypoactivation. However, the relation ... ...

Abstract	Objectives: Bipolar disorder (BD) is a highly heritable disorder with polygenic inheritance. Among the most consistent findings from functional magnetic imaging (fMRI) studies are limbic hyperactivation and dorsal hypoactivation. However, the relation between reported brain functional abnormalities and underlying genetic risk remains elusive. This is the first cross-sectional study applying a whole-brain explorative approach to investigate potential influence of BD case-control status and polygenic risk on brain activation. Methods: A BD polygenic risk score (PGRS) was estimated from the Psychiatric Genomics Consortium BD case-control study, and assigned to each individual in our independent sample (N=85 BD cases and 121 healthy controls (HC)), all of whom participated in an fMRI emotional faces matching paradigm. Potential differences in BOLD response across diagnostic groups were explored at whole-brain level in addition to amygdala as a region of interest. Putative effects of BD PGRS on brain activation were also investigated. Results: At whole-brain level, BD cases presented with significantly lower cuneus/precuneus activation than HC during negative face processing (Z-threshold=2.3 as cluster-level correction). The PGRS was associated positively with increased right inferior frontal gyrus (rIFG) activation during negative face processing. For amygdala activation, there were no correlations with diagnostic status or PGRS. Conclusions: These findings are in line with previous reports of reduced precuneus and altered rIFG activation in BD. While these results demonstrate the ability of PGRS to reveal underlying genetic risk of altered brain activation in BD, the lack of convergence of effects at diagnostic and PGRS level suggests that this relation is a complex one.
MeSH term(s)	Adult ; Bipolar Disorder/diagnosis ; Bipolar Disorder/genetics ; Bipolar Disorder/physiopathology ; Brain/pathology ; Brain/physiopathology ; Case-Control Studies ; Cross-Sectional Studies ; Emotions/physiology ; Facial Expression ; Facial Recognition/physiology ; Female ; Functional Neuroimaging ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Multifactorial Inheritance ; Polymorphism, Single Nucleotide ; Risk Factors ; Young Adult
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0134202
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