Article ; Online: The formation of complexes with albumin increases the stability of the protoporphyrin IX spectra.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
2023 Volume 74, Issue 4
Abstract: Photodynamic therapy is a high-target, low-invasive treatment utilized to manage a variety of malignant diseases and precancerous lesions. Protoporphyrin IX (PpIX) is one of the most important photosensitizers used in photodynamic therapy, carried to the ...
Abstract | Photodynamic therapy is a high-target, low-invasive treatment utilized to manage a variety of malignant diseases and precancerous lesions. Protoporphyrin IX (PpIX) is one of the most important photosensitizers used in photodynamic therapy, carried to the cancer tissue by serum albumin. Its delivery by transport protein is one of the major factors in determining the efficacy of photodynamic therapy. The distribution of the albumin-PpIX complexes to the target tissue enables the accomplishment of an optimal PDT effect. This study aimed to assess in vitro the stability of spectrofluorimetric spectra of albumin-PpIX complexes. The experiment used three chemicals: PpIX, human serum albumin (HSA), and bovine serum albumin (BSA). Spectral data was recorded using a Kontron SFM-25 Instrument AG, at two excitation wavelengths λ |
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MeSH term(s) | Humans ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/therapeutic use ; Serum Albumin/chemistry ; Protoporphyrins/chemistry ; Photochemotherapy/methods |
Chemical Substances | protoporphyrin IX (C2K325S808) ; Photosensitizing Agents ; Serum Albumin ; Protoporphyrins |
Language | English |
Publishing date | 2023-10-16 |
Publishing country | Poland |
Document type | Journal Article |
ZDB-ID | 1125221-2 |
ISSN | 1899-1505 ; 0867-5910 ; 0044-6033 |
ISSN (online) | 1899-1505 |
ISSN | 0867-5910 ; 0044-6033 |
DOI | 10.26402/jpp.2023.4.10 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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