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  1. Article ; Online: Human coronavirus OC43-elicited CD4

    Dos Santos Alves, Rúbens Prince / Timis, Julia / Miller, Robyn / Valentine, Kristen / Pinto, Paolla Beatriz Almeida / Gonzalez, Andrew / Regla-Nava, Jose Angel / Maule, Erin / Nguyen, Michael N / Shafee, Norazizah / Landeras-Bueno, Sara / Olmedillas, Eduardo / Laffey, Brett / Dobaczewska, Katarzyna / Mikulski, Zbigniew / McArdle, Sara / Leist, Sarah R / Kim, Kenneth / Baric, Ralph S /
    Ollmann Saphire, Erica / Elong Ngono, Annie / Shresta, Sujan

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 787

    Abstract: SARS-CoV-2-reactive T cells are detected in some healthy unexposed individuals. Human studies indicate these T cells could be elicited by the common cold coronavirus OC43. To directly test this assumption and define the role of OC43-elicited T cells that ...

    Abstract SARS-CoV-2-reactive T cells are detected in some healthy unexposed individuals. Human studies indicate these T cells could be elicited by the common cold coronavirus OC43. To directly test this assumption and define the role of OC43-elicited T cells that are cross-reactive with SARS-CoV-2, we develop a model of sequential infections with OC43 followed by SARS-CoV-2 in HLA-B*0702 and HLA-DRB1*0101 Ifnar1
    MeSH term(s) Humans ; Mice ; Animals ; SARS-CoV-2 ; COVID-19 ; Coronavirus OC43, Human ; Mice, Transgenic ; HLA-DRB1 Chains/genetics ; CD4-Positive T-Lymphocytes ; Spike Glycoprotein, Coronavirus
    Chemical Substances HLA-DRB1 Chains ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2024-01-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45043-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Potent Omicron-neutralizing antibodies isolated from a patient vaccinated 6 months before Omicron emergence.

    Hastie, Kathryn M / Yu, Xiaoying / Ana-Sosa-Batiz, Fernanda / Zyla, Dawid S / Harkins, Stephanie S / Hariharan, Chitra / Wasserman, Hal / Zandonatti, Michelle A / Miller, Robyn / Maule, Erin / Kim, Kenneth / Valentine, Kristen M / Shresta, Sujan / Saphire, Erica Ollmann

    Cell reports

    2023  Volume 42, Issue 5, Page(s) 112421

    Abstract: Therapeutic antibodies are an important tool in the arsenal against coronavirus infection. However, most antibodies developed early in the pandemic have lost most or all efficacy against newly emergent strains of severe acute respiratory syndrome ... ...

    Abstract Therapeutic antibodies are an important tool in the arsenal against coronavirus infection. However, most antibodies developed early in the pandemic have lost most or all efficacy against newly emergent strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), particularly those of the Omicron lineage. Here, we report the identification of a panel of vaccinee-derived antibodies that have broad-spectrum neutralization activity. Structural and biochemical characterization of the three broadest-spectrum antibodies reveal complementary footprints and differing requirements for avidity to overcome variant-associated mutations in their binding footprints. In the K18 mouse model of infection, these three antibodies exhibit protective efficacy against BA.1 and BA.2 infection. This study highlights the resilience and vulnerabilities of SARS-CoV-2 antibodies and provides road maps for further development of broad-spectrum therapeutics.
    MeSH term(s) Animals ; Mice ; Antibodies, Neutralizing ; COVID-19 ; SARS-CoV-2 ; Antibodies, Viral/therapeutic use ; Broadly Neutralizing Antibodies
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; Broadly Neutralizing Antibodies
    Language English
    Publishing date 2023-04-10
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112421
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: CD4

    Zhang, Gang / Campbell, Grant R / Zhang, Qiangzhe / Maule, Erin / Hanna, Jonathan / Gao, Weiwei / Zhang, Liangfang / Spector, Stephen A

    mBio

    2020  Volume 11, Issue 5

    Abstract: Therapeutic strategies that provide effective and broad-spectrum neutralization against HIV-1 infection are highly desirable. Here, we investigate the potential of nanoengineered ... ...

    Abstract Therapeutic strategies that provide effective and broad-spectrum neutralization against HIV-1 infection are highly desirable. Here, we investigate the potential of nanoengineered CD4
    Keywords covid19
    Language English
    Publishing date 2020-09-15
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.00903-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: SARS-CoV-2 Omicron (B.1.1.529) shows minimal neurotropism in a double-humanized mouse model.

    Alves, Rubens Prince Dos Santos / Wang, Ying-Ting / Mikulski, Zbigniew / McArdle, Sara / Shafee, Norazizah / Valentine, Kristen M / Miller, Robyn / Verma, Shailendra Kumar / Batiz, Fernanda Ana Sosa / Maule, Erin / Nguyen, Michael N / Timis, Julia / Mann, Colin / Zandonatti, Michelle / Alarcon, Suzie / Rowe, Jenny / Kronenberg, Mitchell / Weiskopf, Daniela / Sette, Alessandro /
    Hastie, Kathryn / Saphire, Erica Ollmann / Festin, Stephen / Kim, Kenneth / Shresta, Sujan

    Antiviral research

    2023  Volume 212, Page(s) 105580

    Abstract: Although severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) initially infects the respiratory tract, it also directly or indirectly affects other organs, including the brain. However, little is known about the relative neurotropism of SARS-CoV- ... ...

    Abstract Although severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) initially infects the respiratory tract, it also directly or indirectly affects other organs, including the brain. However, little is known about the relative neurotropism of SARS-CoV-2 variants of concern (VOCs), including Omicron (B.1.1.529), which emerged in November 2021 and has remained the dominant pathogenic lineage since then. To address this gap, we examined the relative ability of Omicron, Beta (B.1.351), and Delta (B.1.617.2) to infect the brain in the context of a functional human immune system by using human angiotensin-converting enzyme 2 (hACE2) knock-in triple-immunodeficient NGC mice with or without reconstitution with human CD34
    MeSH term(s) Animals ; Humans ; Mice ; SARS-CoV-2 ; COVID-19 ; Brain ; Antiviral Agents ; Disease Models, Animal
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2023-03-20
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 306628-9
    ISSN 1872-9096 ; 0166-3542
    ISSN (online) 1872-9096
    ISSN 0166-3542
    DOI 10.1016/j.antiviral.2023.105580
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Mucosal Adenoviral-vectored Vaccine Boosting Durably Prevents XBB.1.16 Infection in Nonhuman Primates.

    Gagne, Matthew / Flynn, Barbara J / Andrew, Shayne F / Flebbe, Dillon R / Mychalowych, Anna / Lamb, Evan / Davis-Gardner, Meredith E / Burnett, Matthew R / Serebryannyy, Leonid A / Lin, Bob C / Pessaint, Laurent / Todd, John-Paul M / Ziff, Zohar E / Maule, Erin / Carroll, Robin / Naisan, Mursal / Jethmalani, Yogita / Case, James Brett / Dmitriev, Igor P /
    Kashentseva, Elena A / Ying, Baoling / Dodson, Alan / Kouneski, Katelyn / Doria-Rose, Nicole A / O'Dell, Sijy / Godbole, Sucheta / Laboune, Farida / Henry, Amy R / Marquez, Josue / Teng, I-Ting / Wang, Lingshu / Zhou, Qiong / Wali, Bushra / Ellis, Madison / Zouantchangadou, Serge / Ry, Alex Van / Lewis, Mark G / Andersen, Hanne / Kwong, Peter D / Curiel, David T / Foulds, Kathryn E / Nason, Martha C / Suthar, Mehul S / Roederer, Mario / Diamond, Michael S / Douek, Daniel C / Seder, Robert A

    bioRxiv : the preprint server for biology

    2023  

    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.11.06.565765
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Mucosal Adenoviral-vectored Vaccine Boosting Durably Prevents XBB.1.16 Infection in Nonhuman Primates

    Gagne, Matthew / Flynn, Barbara J. / Andrew, Shayne F. / Flebbe, Dillon R. / Mychalowych, Anna / Lamb, Evan / Davis-Gardner, Meredith E. / Burnett, Matthew R. / Serebryannyy, Leonid A. / Lin, Bob C. / Pessaint, Laurent / Todd, John-Paul M. / Ziff, Zohar E. / Maule, Erin / Carroll, Robin / Naisan, Mursal / Jethmalani, Yogita / Case, James Brett / Dmitriev, Igor P. /
    Kashentseva, Elena A. / Ying, Baoling / Dodson, Alan / Kouneski, Katelyn / Doria-Rose, Nicole A. / O'Dell, Sijy / Godbole, Sucheta / Laboune, Farida / Henry, Amy R. / Marquez, Josue / Teng, I-Ting / Wang, Lingshu / Zhou, Qiong / Wali, Bushra / Ellis, Madison / Zouantchangadou, Serge / Van Ry, Alex / Lewis, Mark G. / Andersen, Hanne / Kwong, Peter D. / Curiel, David T. / Foulds, Kathryn E. / Nason, Martha C. / Suthar, Mehul S. / Roederer, Mario / Diamond, Michael S. / Douek, Daniel C. / Seder, Robert A.

    bioRxiv

    Abstract: Waning immunity and continued virus evolution have limited the durability of protection from symptomatic infection mediated by intramuscularly (IM)-delivered mRNA vaccines against COVID-19 although protection from severe disease remains high. Mucosal ... ...

    Abstract Waning immunity and continued virus evolution have limited the durability of protection from symptomatic infection mediated by intramuscularly (IM)-delivered mRNA vaccines against COVID-19 although protection from severe disease remains high. Mucosal vaccination has been proposed as a strategy to increase protection at the site of SARS-CoV-2 infection by enhancing airway immunity, potentially reducing rates of infection and transmission. Here, we compared protection against XBB.1.16 virus challenge 5 months following IM or mucosal boosting in non-human primates (NHP) that had previously received a two-dose mRNA-1273 primary vaccine regimen. The mucosal boost was composed of a bivalent chimpanzee adenoviral-vectored vaccine encoding for both SARS-CoV-2 WA1 and BA.5 spike proteins (ChAd-SARS-CoV-2-S) and delivered either by an intranasal mist or an inhaled aerosol. An additional group of animals was boosted by the IM route with bivalent WA1/BA.5 spike-matched mRNA (mRNA-1273.222) as a benchmark control. NHP were challenged in the upper and lower airways 18 weeks after boosting with XBB.1.16, a heterologous Omicron lineage strain. Cohorts boosted with ChAd-SARS-CoV-2-S by an aerosolized or intranasal route had low to undetectable virus replication as assessed by levels of subgenomic SARS-CoV-2 RNA in the lungs and nose, respectively. In contrast, animals that received the mRNA-1273.222 boost by the IM route showed minimal protection against virus replication in the upper airway but substantial reduction of virus RNA levels in the lower airway. Immune analysis showed that the mucosal vaccines elicited more durable antibody and T cell responses than the IM vaccine. Protection elicited by the aerosolized vaccine was associated with mucosal IgG and IgA responses, whereas protection elicited by intranasal delivery was mediated primarily by mucosal IgA. Thus, durable immunity and effective protection against a highly transmissible heterologous variant in both the upper and lower airways can be achieved by mucosal delivery of a virus-vectored vaccine. Our study provides a template for the development of mucosal vaccines that limit infection and transmission against respiratory pathogens.
    Keywords covid19
    Language English
    Publishing date 2023-11-08
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2023.11.06.565765
    Database COVID19

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