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Article ; Online: Divided media-based simulations of tissue morphogenesis.

Chélin, Y / Averseng, J / Cañadas, P / Maurin, B

Computer methods in biomechanics and biomedical engineering

2013 Volume 16 Suppl 1, Page(s) 2–3

MeSH term(s)	Animals ; Apoptosis/physiology ; Biomechanical Phenomena ; Cell Proliferation ; Computer Simulation ; Epithelial Cells/cytology ; Epithelium/growth & development ; Humans ; Models, Biological ; Morphogenesis ; Plant Development/physiology
Language	English
Publishing date	2013
Publishing country	England
Document type	Journal Article
ZDB-ID	2071764-7
ISSN	1476-8259 ; 1025-5842
ISSN (online)	1476-8259
ISSN	1025-5842
DOI	10.1080/10255842.2013.815848
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Article ; Online: A new versatile MR-guided high-intensity focused ultrasound (HIFU) device for the treatment of musculoskeletal tumors.

Cabras, Paolo / Auloge, Pierre / Bing, Fabrice / Rao, Pramod Prabhakar / Hoarau, Stéphanie / Dumont, Erik / Durand, Alexandre / Maurin, Benjamin / Wach, Benoit / Cuvillon, Loïc / Breton, Elodie / Gangi, Afshin / Vappou, Jonathan

Scientific reports

2022 Volume 12, Issue 1, Page(s) 9095

Abstract: Magnetic Resonance (MR) Imaging-guided High Intensity focused Ultrasound (MRgHIFU) is a non-invasive, non-ionizing thermal ablation therapy that is particularly interesting for the palliative or curative treatment of musculoskeletal tumors. We introduce ... ...

Abstract	Magnetic Resonance (MR) Imaging-guided High Intensity focused Ultrasound (MRgHIFU) is a non-invasive, non-ionizing thermal ablation therapy that is particularly interesting for the palliative or curative treatment of musculoskeletal tumors. We introduce a new modular MRgHIFU device that allows the ultrasound transducer to be positioned precisely and interactively over the body part to be treated. A flexible, MR-compatible supporting structure allows free positioning of the transducer under MRI/optical fusion imaging guidance. The same structure can be rigidified using pneumatic depression, holding the transducer rigidly in place. Targeting accuracy was first evaluated in vitro. The average targeting error of the complete process was found to be equal to 5.4 ± 2.2 mm in terms of focus position, and 4.7° ± 2° in terms of transducer orientation. First-in-man feasibility is demonstrated on a patient suffering from important, uncontrolled pain from a bone metastasis located in the forearm. The 81 × 47 × 34 mm
MeSH term(s)	High-Intensity Focused Ultrasound Ablation/methods ; Humans ; Magnetic Resonance Imaging/methods ; Neoplasms, Connective and Soft Tissue ; Pain ; Thermometry
Language	English
Publishing date	2022-05-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-13213-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Simulation of cellular packing in non-proliferative epithelia.

Chélin, Y / Azzag, K / Cañadas, P / Averseng, J / Baghdiguian, S / Maurin, B

Journal of biomechanics

2013 Volume 46, Issue 6, Page(s) 1075–1080

Abstract: The physical laws governing the morphogenesis of biological tissues remain largely misunderstood. In particular, the role of the mechanical interactions occurring in this process needs to be better understood and studied. Inner follicular cells ... ...

Abstract	The physical laws governing the morphogenesis of biological tissues remain largely misunderstood. In particular, the role of the mechanical interactions occurring in this process needs to be better understood and studied. Inner follicular cells surrounding the oocytes of Ciona intestinalis form an epithelial monolayer resulting from an accretion process (without mitosis or apoptosis). This epithelium is elementary and useful for morphogenesis studies: the cells exhibit polygon packing with a specific but non-systematically repeatable topology (i.e. the distribution of pentagons, hexagons and heptagons changes). To understand the role of mechanical forces in tissue formation, we propose an innovative "2D spherical" model based on the physics of divided media. This approach simulates the cellular mechanical behavior and epithelium structuration by allowing cells to adopt a large variety of shapes and to self-organize in response to mechanical interactions. The numerical parameters considered in the model are derived from experimental data in order to perform pertinent and realistic simulations. The results obtained are compared to biological observations using the same counting method to characterize epithelium topology. Numerical and experimental data appear close enough to validate the model. It is then used for exploratory studies dealing with "Tissue Development Speed" variation, which is not easily attainable by experimentation. We show that the formation speed of the tissue influences its topology and hence its packing organization.
MeSH term(s)	Animals ; Ciona intestinalis ; Epithelial Cells/cytology ; Epithelium/growth & development ; Models, Biological ; Morphogenesis ; Oocytes/cytology
Language	English
Publishing date	2013-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	218076-5
ISSN	1873-2380 ; 0021-9290
ISSN (online)	1873-2380
ISSN	0021-9290
DOI	10.1016/j.jbiomech.2013.01.015
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Article ; Online: Key steps from the “RNA World” to the “DNA World”

Renard B.-L. / Maurin B. / Chambert S. / Décout J.-L.

BIO Web of Conferences, Vol 2, p

2014 Volume 05002

Abstract: In the « RNA World » hypothesis of the origin of life, RNAs are assumed to be the central macromolecules able to self-replicate, conserve information and catalyze the reactions necessary for a primitive metabolism and many enzymatic cofactors may be ... ...

Abstract	In the « RNA World » hypothesis of the origin of life, RNAs are assumed to be the central macromolecules able to self-replicate, conserve information and catalyze the reactions necessary for a primitive metabolism and many enzymatic cofactors may be regarded as molecular fossils of the “RNA World”. In the key steps involved in the transition from the RNA World to the DNA World, two main steps can be distinguished: (i) the synthesis of 2’-deoxyribonucleotides from ribonucleotides catalyzed nowadays by the enzyme ribonucleotide reductase and (ii) the synthesis of thymine, a base specific for DNA, from uracil which is a base specific for RNA, catalyzed today by the enzyme thymidylate synthase. In regard to the chemistry of sulfur used by both enzymes for achieving their respective catalysis, we were interested in the search for simple sulfur reactions able to catalyze such transformations and report here on first results in an approach from thionucleosides to the catalysis involved in the conversion of uracil to thymine. In the RNA World, the recruitment of cofactors was crucial to expand the catalytic repertoire of RNA and we also describe interesting preliminary results obtained in the prebiotic synthesis of pyridoxal (vitamin B6) that is the precursor of the key coenzyme pyridoxal phosphate (PLP) able to catalyze nowadays seven different enzymatic reactions.
Keywords	Microbiology ; QR1-502 ; Physiology ; QP1-981 ; Zoology ; QL1-991
Subject code	540
Language	English
Publishing date	2014-02-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Mechanical model of cytoskeleton structuration during cell adhesion and spreading.

Maurin, B / Cañadas, P / Baudriller, H / Montcourrier, P / Bettache, N

Journal of biomechanics

2008 Volume 41, Issue 9, Page(s) 2036–2041

Abstract: The biomechanical behavior of an adherent cell is intimately dependent on its cytoskeleton structure. Several models have been proposed to study this structure taking into account its existing internal forces. However, the structural and geometrical ... ...

Abstract	The biomechanical behavior of an adherent cell is intimately dependent on its cytoskeleton structure. Several models have been proposed to study this structure taking into account its existing internal forces. However, the structural and geometrical complexities of the cytoskeleton's filamentous networks lead to difficulties for determining a biologically realistic architecture. The objective of this paper is to present a mechanical model, combined with a numerical method, devoted to the form-finding of the cytoskeleton structure (shape and internal forces) when a cell adheres on a substrate. The cell is modeled as a granular medium, using rigid spheres (grains) corresponding to intracellular cross-linking proteins and distant mechanical interactions to reproduce the cytoskeleton filament internal forces. At the initial state (i.e., before adhesion), these interactions are tacit. The adhesion phenomenon is then simulated by considering microtubules growing from the centrosome towards transmembrane integrin-like receptors. The simulated cell shape changes in this process and results in a mechanically equilibrated structure with traction and compression forces, in interaction with the substrate reactions. This leads to a compressive microtubule network and a corresponding tensile actin-filament network. The results provide coherent shape and forces information for developing a mechanical model of the cytoskeleton structure, which can be exploitable in future biomechanical studies of adherent cells.
MeSH term(s)	Animals ; Biomechanical Phenomena ; Cell Adhesion ; Cell Shape/physiology ; Computer Simulation ; Cytoskeleton/metabolism ; Models, Biological
Language	English
Publishing date	2008
Publishing country	United States
Document type	Journal Article
ZDB-ID	218076-5
ISSN	1873-2380 ; 0021-9290
ISSN (online)	1873-2380
ISSN	0021-9290
DOI	10.1016/j.jbiomech.2008.03.011
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Article: L'autolégitimation de la science économique par le biais de la physique

Maurin, Bernard

Sciences de la societé : revue scientifique internationale , No. 55 , p. 41-52

la question de la croyance en la science

2002 , Issue 55, Page(s) 41–52

Author's details	Bernard Maurin
Keywords	Wirtschaftswissenschaft ; Physik ; Wissenschaftliche Methode ; Dogmengeschichte
Language	French
Publisher	Presses Universitaires du Mirail
Publishing place	Toulouse
Document type	Article
Note	Zsfassung in engl. u. span. Sprache. - Zsfassung in engl. Sprache u.d.T.: The self-legitimization of economics by means of physic
ZDB-ID	1223957-4
Database	ECONomics Information System

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Article: Key steps from the “RNA World” to the “DNA World”

Renard B.-L. / Maurin B. / Chambert S. / Décout J.-L.

BIO web of conferences. 2014 Feb., v. 2

2014

Abstract	In the « RNA World » hypothesis of the origin of life, RNAs are assumed to be the central macromolecules able to self-replicate, conserve information and catalyze the reactions necessary for a primitive metabolism and many enzymatic cofactors may be regarded as molecular fossils of the “RNA World”. In the key steps involved in the transition from the RNA World to the DNA World, two main steps can be distinguished: (i) the synthesis of 2’-deoxyribonucleotides from ribonucleotides catalyzed nowadays by the enzyme ribonucleotide reductase and (ii) the synthesis of thymine, a base specific for DNA, from uracil which is a base specific for RNA, catalyzed today by the enzyme thymidylate synthase. In regard to the chemistry of sulfur used by both enzymes for achieving their respective catalysis, we were interested in the search for simple sulfur reactions able to catalyze such transformations and report here on first results in an approach from thionucleosides to the catalysis involved in the conversion of uracil to thymine. In the RNA World, the recruitment of cofactors was crucial to expand the catalytic repertoire of RNA and we also describe interesting preliminary results obtained in the prebiotic synthesis of pyridoxal (vitamin B6) that is the precursor of the key coenzyme pyridoxal phosphate (PLP) able to catalyze nowadays seven different enzymatic reactions.
Keywords	DNA ; RNA ; catalytic activity ; metabolism ; prebiotics ; pyridoxal ; pyridoxal phosphate ; pyridoxine ; ribonucleotide reductase ; ribonucleotides ; sulfur ; thymidylate synthase ; thymine ; uracil
Language	English
Dates of publication	2014-02
Publishing place	EDP Sciences
Document type	Article
ZDB-ID	2673408-4
ISSN	2117-4458
ISSN	2117-4458
DOI	10.1051/bioconf/20140205002
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A new 9-alkyladenine-cyclic methylglyoxal diadduct activates wt- and F508del-cystic fibrosis transmembrane conductance regulator (CFTR) in vitro and in vivo.

Boucherle, Benjamin / Bertrand, Johanna / Maurin, Bruno / Renard, Brice-Loïc / Fortuné, Antoine / Tremblier, Brice / Becq, Frédéric / Norez, Caroline / Décout, Jean-Luc

European journal of medicinal chemistry

2014 Volume 83, Page(s) 455–465

Abstract: Cystic fibrosis transmembrane conductance regulator (CFTR) is the main chloride channel present in the apical membrane of epithelial cells and the F508 deletion (F508del-CFTR) in the CF gene is the most common cystic fibrosis-causing mutation. In the ... ...

Abstract	Cystic fibrosis transmembrane conductance regulator (CFTR) is the main chloride channel present in the apical membrane of epithelial cells and the F508 deletion (F508del-CFTR) in the CF gene is the most common cystic fibrosis-causing mutation. In the search for a pharmacotherapy of cystic fibrosis caused by the F508del-CFTR, a bi-therapy could be developed associating a corrector of F508del-CFTR trafficking and an activator of the channel activity of CFTR. Here, we report on the synthesis of 9-alkyladenine derivatives analogues of our previously discovered activator of wt-CFTR and F508del-CFTR, GPact-11a, and the identification of a new activator of these channels, GPact-26a, through various flux assays on human airway epithelial CF and non-CF cell lines and in vivo measurement of rat salivary secretion. This study reveals that the possible modifications of the side chain introduced at the N9 position of the main pharmacophore are highly limited since only an allyl group can replace the propyl side chain present in GPact-11a to lead to a strong activation of wt-CFTR in CHO cells. Docking simulations of the synthesised compounds and of four described modulators performed using a 3D model of the wt-type CFTR protein suggest five possible binding sites located at the interface of the nucleotide binding domains NBD1/NBD2. However, the docking study did not allow the differentiation between active and non-active compounds.
MeSH term(s)	Adenine/chemistry ; Adenine/pharmacology ; Animals ; CHO Cells ; Cricetinae ; Cricetulus ; Cystic Fibrosis Transmembrane Conductance Regulator/chemistry ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism ; Drug Design ; Humans ; Male ; Models, Molecular ; Protein Conformation ; Rats ; Sequence Deletion
Chemical Substances	Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6) ; Adenine (JAC85A2161)
Language	English
Publishing date	2014-08-18
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2014.06.028
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Article ; Online: The non-proliferative nature of ascidian folliculogenesis as a model of highly ordered cellular topology distinct from proliferative epithelia.

Azzag, Karim / Chelin, Yoann / Rousset, François / Le Goff, Emilie / Martinand-Mari, Camille / Martinez, Anne-Marie / Maurin, Bernard / Daujat-Chavanieu, Martine / Godefroy, Nelly / Averseng, Julien / Mangeat, Paul / Baghdiguian, Stephen

PloS one

2015 Volume 10, Issue 5, Page(s) e0126341

Abstract: Previous studies have addressed why and how mono-stratified epithelia adopt a polygonal topology. One major additional, and yet unanswered question is how the frequency of different cell shapes is achieved and whether the same distribution applies ... ...

Abstract	Previous studies have addressed why and how mono-stratified epithelia adopt a polygonal topology. One major additional, and yet unanswered question is how the frequency of different cell shapes is achieved and whether the same distribution applies between non-proliferative and proliferative epithelia. We compared different proliferative and non-proliferative epithelia from a range of organisms as well as Drosophila melanogaster mutants, deficient for apoptosis or hyperproliferative. We show that the distribution of cell shapes in non-proliferative epithelia (follicular cells of five species of tunicates) is distinctly, and more stringently organized than proliferative ones (cultured epithelial cells and Drosophila melanogaster imaginal discs). The discrepancy is not supported by geometrical constraints (spherical versus flat monolayers), number of cells, or apoptosis events. We have developed a theoretical model of epithelial morphogenesis, based on the physics of divided media, that takes into account biological parameters such as cell-cell contact adhesions and tensions, cell and tissue growth, and which reproduces the effects of proliferation by increasing the topological heterogeneity observed experimentally. We therefore present a model for the morphogenesis of epithelia where, in a proliferative context, an extended distribution of cell shapes (range of 4 to 10 neighbors per cell) contrasts with the narrower range of 5-7 neighbors per cell that characterizes non proliferative epithelia.
MeSH term(s)	Animals ; Apoptosis/physiology ; Cell Proliferation/physiology ; Cell Shape/physiology ; Drosophila melanogaster/cytology ; Epithelial Cells/cytology ; Epithelium/growth & development ; Morphogenesis/physiology ; Urochordata/cytology
Language	English
Publishing date	2015-05-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0126341
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Article ; Online: An expeditious access to 5-pyrimidinol derivatives from cyclic methylglyoxal diadducts, formation of argpyrimidines under physiological conditions and discovery of new CFTR inhibitors.

Renard, Brice-Loïc / Boucherle, Benjamin / Maurin, Bruno / Molina, Marie-Carmen / Norez, Caroline / Becq, Frédéric / Décout, Jean-Luc

European journal of medicinal chemistry

2011 Volume 46, Issue 5, Page(s) 1935–1941

Abstract: In the study of previously reported modulators of CFTR chloride channels that are cyclic methylglyoxal (MG) diadducts (CMGD) to aromatic α-aminoazaheterocycles, we optimized a new expeditious one pot route for preparing in water novel aromatic polycyclic ...

Abstract	In the study of previously reported modulators of CFTR chloride channels that are cyclic methylglyoxal (MG) diadducts (CMGD) to aromatic α-aminoazaheterocycles, we optimized a new expeditious one pot route for preparing in water novel aromatic polycyclic azaheterocycles and described 5-pyrimidinols antioxidants through the formation of 2-oxoaldehyde diadducts to aromatic α-aminoazaheterocycles, amidines, guanidines and thiourea. In regard to the importance as biomarkers of diabetic complications of the 5-pyrimidinols "argpyrimidines" formed in proteins from MG and arginine residues, we demonstrated that argpyrimidines are slowly formed under physiological conditions from CMGD to arginine derivatives according to the synthesis route described. Among the 5-pyrimidinol derivatives prepared, two polycyclic derivatives appeared to inhibit strongly the activity of CFTR channels in wt-CHO cells.
MeSH term(s)	Animals ; CHO Cells ; Chemistry, Physical ; Cricetinae ; Cricetulus ; Cystic Fibrosis Transmembrane Conductance Regulator/antagonists & inhibitors ; Drug Discovery ; Molecular Conformation ; Ornithine/analogs & derivatives ; Ornithine/chemistry ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Pyrimidines/pharmacology ; Pyruvaldehyde/analogs & derivatives ; Pyruvaldehyde/chemistry ; Stereoisomerism ; Structure-Activity Relationship
Chemical Substances	Pyrimidines ; argpyrimidine ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6) ; Pyruvaldehyde (722KLD7415) ; Ornithine (E524N2IXA3)
Language	English
Publishing date	2011-05
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2011.02.037
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