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  1. Article ; Online: ERAS pathway in colorectal surgery: structured implementation program and high adherence for improved outcomes.

    Catarci, Marco / Benedetti, Michele / Maurizi, Angela / Spinelli, Francesco / Bernacconi, Tonino / Guercioni, Gianluca / Campagnacci, Roberto

    Updates in surgery

    2020  Volume 73, Issue 1, Page(s) 123–137

    Abstract: Although there is clear evidence that an Enhanced Recovery After Surgery (ERAS) program in colorectal surgery leads to significantly reduced morbidity rates and length of hospital stay (LOS), it is still unclear what modalities and levels of ... ...

    Abstract Although there is clear evidence that an Enhanced Recovery After Surgery (ERAS) program in colorectal surgery leads to significantly reduced morbidity rates and length of hospital stay (LOS), it is still unclear what modalities and levels of implementation of the program are necessary to achieve these results. The purpose of this study is to analyze the methods and results of the first year of structured implementation of a colorectal ERAS program in two surgical units of the Azienda Sanitaria Unica Regionale (ASUR) Marche in Italy. A two-center observational study on a prospectively maintained database was performed on 196 consecutive colorectal resections (excluding emergencies and American Society of Anesthesiologists class > III cases) over a 1-year period. More than 50 variables including adherence to the individual items of the ERAS program were considered. Primary outcomes were overall morbidity, major morbidity, mortality and anastomotic leakage rates; secondary outcomes were LOS, re-admission and re-operation. The results were evaluated by univariate and multivariate analyses through logistic regression. After a median follow-up of 39.5 days, we recorded complications in 72 patients (overall morbidity 36.7%), major complications in 14 patients (major morbidity 7.1%), 6 deaths (mortality 3.1%), anastomotic dehiscence in 9 cases (4.9%), mean overall LOS of 6.6 days, 10 readmissions (5.1%) and 13 reoperations (6.7%). The mean adherence rate to the items of the ERAS program was 85.4%, showing a significant dose-effect curve for overall and major morbidity rates, anastomotic leakage rates and LOS. The implementation methods of a colorectal ERAS program in this study led to a high adherence (> 80%) to the program items. High adherence had significant effects also on major morbidity and anastomotic leakage rates.
    MeSH term(s) Aged ; Aged, 80 and over ; Anastomotic Leak/epidemiology ; Anastomotic Leak/etiology ; Anastomotic Leak/prevention & control ; Colon/surgery ; Colonic Diseases/surgery ; Colorectal Surgery/methods ; Critical Pathways ; Digestive System Surgical Procedures/adverse effects ; Digestive System Surgical Procedures/methods ; Enhanced Recovery After Surgery ; Female ; Follow-Up Studies ; Humans ; Length of Stay/statistics & numerical data ; Male ; Rectal Diseases/surgery ; Rectum/surgery ; Time Factors ; Treatment Outcome
    Keywords covid19
    Language English
    Publishing date 2020-10-22
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-020-00885-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Adipocytes properties and crosstalk with immune system in obesity-related inflammation.

    Maurizi, Giulia / Della Guardia, Lucio / Maurizi, Angela / Poloni, Antonella

    Journal of cellular physiology

    2018  Volume 233, Issue 1, Page(s) 88–97

    Abstract: Obesity is a condition likely associated with several dysmetabolic conditions or worsening of cardiovascular and other chronic disturbances. A key role in this mechanism seem to be played by the onset of low-grade systemic inflammation, highlighting the ... ...

    Abstract Obesity is a condition likely associated with several dysmetabolic conditions or worsening of cardiovascular and other chronic disturbances. A key role in this mechanism seem to be played by the onset of low-grade systemic inflammation, highlighting the importance of the interplay between adipocytes and immune system cells. Adipocytes express a complex and highly adaptive biological profile being capable to selectively activate different metabolic pathways in order to respond to environmental stimuli. It has been demonstrated how adipocytes, under appropriate stimulation, can easily differentiate and de-differentiate thereby converting themselves into different phenotypes according to metabolic necessities. Although underlying mechanisms are not fully understood, growing in adipocyte size and the inability of storing triglycerides under overfeeding conditions seem to be crucial for the switching to a dysfunctional metabolic profile, which is characterized by inflammatory and apoptotic pathways activation, and by the shifting to pro-inflammatory adipokines secretion. In obesity, changes in adipokines secretion along with adipocyte deregulation and fatty acids release into circulation contribute to maintain immune cells activation as well as their infiltration into regulatory organs. Over the well-established role of macrophages, recent findings suggest the involvement of new classes of immune cells such as T regulatory lymphocytes and neutrophils in the development inflammation and multi systemic worsening. Deeply understanding the pathways of adipocyte regulation and the de-differentiation process could be extremely useful for developing novel strategies aimed at curbing obesity-related inflammation and related metabolic disorders.
    MeSH term(s) Adipocytes/immunology ; Adipocytes/metabolism ; Adipocytes/pathology ; Adipogenesis ; Adipokines/metabolism ; Animals ; Apoptosis ; Cell Communication ; Cytokines/metabolism ; Humans ; Immune System/immunology ; Immune System/metabolism ; Immune System/pathology ; Inflammation/etiology ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation/pathology ; Inflammation Mediators/metabolism ; Lipid Metabolism ; Obesity/complications ; Obesity/immunology ; Obesity/metabolism ; Obesity/pathology ; Phenotype ; Signal Transduction
    Chemical Substances Adipokines ; Cytokines ; Inflammation Mediators
    Language English
    Publishing date 2018-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3116-1
    ISSN 1097-4652 ; 0021-9541
    ISSN (online) 1097-4652
    ISSN 0021-9541
    DOI 10.1002/jcp.25855
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Key-genes regulating the liposecretion process of mature adipocytes.

    Maurizi, Giulia / Petäistö, Tiina / Maurizi, Angela / Della Guardia, Lucio

    Journal of cellular physiology

    2017  Volume 233, Issue 5, Page(s) 3784–3793

    Abstract: White mature adipocytes (MAs) are plastic cells able to reversibly transdifferentiate toward fibroblast-like cells maintaining stem cell gene signatures. The main morphologic aspect of this transdifferentiation process, called liposecretion, is the ... ...

    Abstract White mature adipocytes (MAs) are plastic cells able to reversibly transdifferentiate toward fibroblast-like cells maintaining stem cell gene signatures. The main morphologic aspect of this transdifferentiation process, called liposecretion, is the secretion of large lipid droplets and the development of organelles necessary for exocrine secretion. There is a considerable interest in the adipocyte plastic properties involving liposecretion process, but the molecular details are incompletely explored. This review analyzes the gene expression of MAs isolated from human subcutaneous fat tissue with respect to bone marrow (BM)-derived mesenchymal stem cells (MSC) focusing on gene regulatory pathways involved into cellular morphology changes, cellular proliferation and transports of molecules through the membrane, suggesting potential ways to guide liposecretion. In particular, Wnt, MAPK/ERK, and AKT pathways were accurately described, studying up- and down-stream molecules involved. Moreover, adipogenic extra- and intra-cellular interactions were analyzed studying the role of CDH2, CDH11, ITGA5, E-Syt1, PAI-1, IGF1, and INHBB genes. Additionally, PLIN1 and PLIN2 could be key-genes of liposecretion process regulating molecules transport through the membrane. All together data demonstrated that liposecretion is regulated through a complex molecular networks that are able to respond to microenvironment signals, cytokines, and growth factors. Autocrine as well as external signaling molecules might activate liposecretion affecting adipocytes physiology.
    MeSH term(s) Adipocytes/cytology ; Adipogenesis/genetics ; Animals ; Bone Marrow Cells/cytology ; Cell Differentiation/genetics ; Cell Proliferation/genetics ; Humans ; Mesenchymal Stem Cells/cytology
    Language English
    Publishing date 2017-11-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3116-1
    ISSN 1097-4652 ; 0021-9541
    ISSN (online) 1097-4652
    ISSN 0021-9541
    DOI 10.1002/jcp.26188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Towards a National Food Sovereignty Plan: Application of a new Decision Support System for food planning and governance

    Stella, Giordano / Coli, Roberto / Maurizi, Angela / Famiani, Franco / Castellini, Cesare / Pauselli, Mariano / Tosti, Giacomo / Menconi, MariaElena

    Land use policy. 2019 Dec., v. 89

    2019  

    Abstract: This paper develops a Decision Support System (DSS), for achieving Food Sovereignty Plans at different territorial levels. The DSS calculates the land requirement for producing the food needs of a local community, the land suitability for the involved ... ...

    Abstract This paper develops a Decision Support System (DSS), for achieving Food Sovereignty Plans at different territorial levels. The DSS calculates the land requirement for producing the food needs of a local community, the land suitability for the involved crops, and the percentage of the food self-sufficiency achievable. The paper reports two case studies at different scales (Italy and Umbria region) for highlighting the strengths and the weaknesses of the DSS. Finally, the paper outlines the use of the developed DSS for enhancing participatory processes to achieve a National Food Sovereignty Plan.
    Keywords case studies ; crops ; decision support systems ; food sovereignty ; governance ; land suitability ; planning ; Italy
    Language English
    Dates of publication 2019-12
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 852476-2
    ISSN 0264-8377
    ISSN 0264-8377
    DOI 10.1016/j.landusepol.2019.104216
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Pancreatic Surgery.

    Maurizi, Angela / Partelli, Stefano / Falconi, Massimo

    Frontiers of hormone research

    2015  Volume 44, Page(s) 139–148

    Abstract: Pancreatic neuroendocrine tumors (pNETs) are rare and clinically demanding diseases. They are clinically defined as functioning or nonfunctioning depending on the presence of a syndrome related to inappropriate hormone secretion. Functioning pNETs are ... ...

    Abstract Pancreatic neuroendocrine tumors (pNETs) are rare and clinically demanding diseases. They are clinically defined as functioning or nonfunctioning depending on the presence of a syndrome related to inappropriate hormone secretion. Functioning pNETs are often small in size and localization may be difficult also due to their possible extraduodenal-pancreatic origin in the jejunum, stomach, mesentery, spleen and ovaries. The improvement and the widespread use of cross-sectional imaging techniques has significantly increased the detection of small, nonfunctioning pNETs. The European Neuroendocrine Tumor Society (ENETS) guidelines now suggest a 'wait and see' policy for these small, incidentally discovered tumors, which are smaller than 2 cm. On the other hand, surgery still always represents the treatment of choice for pNETs >2 cm and/or for symptoms. A large proportion of patients with pNETs have locally advanced disease at diagnosis. Radical surgery of pNETs includes both typical and atypical pancreatic resections. At diagnosis, between 25 and 93% of patients with pNETs have synchronous neuroendocrine tumor liver metastases. Radical resection of the primary tumor, associated with complete, eventually multistep, resection of the liver metastases, can be considered in selected cases. In recent years minimally invasive approaches, either laparoscopic or robotic, have played an increasing role in the treatment of pNETs.
    MeSH term(s) Digestive System Surgical Procedures/methods ; Digestive System Surgical Procedures/standards ; Humans ; Neuroendocrine Tumors/surgery ; Pancreatic Neoplasms/surgery
    Language English
    Publishing date 2015
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 1662-3762 ; 0301-3073
    ISSN (online) 1662-3762
    ISSN 0301-3073
    DOI 10.1159/000382143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The importance of traditional uses and nutraceutical aspects of some edible wild plants in human nutrition: the case of Umbria (central Italy)

    Ranfa, Aldo / Maurizi, Angela / Romano, Bruno / Bodesmo, Mara

    Plant biosystems. 2014 Mar. 4, v. 148, no. 2

    2014  

    Abstract: This study aimed to show how the importance of edible wild plants regards not only a question of uses linked to folk traditions but also their value in human nutrition. Data on the use of 50 species were collected through informed consent semi-structured ...

    Abstract This study aimed to show how the importance of edible wild plants regards not only a question of uses linked to folk traditions but also their value in human nutrition. Data on the use of 50 species were collected through informed consent semi-structured interviews with local informants. They were eaten raw in salads (43%), boiled (35%), as ravioli filling (10%), fried without or with eggs (8%) and in vegetable soup (4%). Furthermore, the nutraceutical analysis centred on four of the commonly used wild edible plants demonstrates how these species contain many of the so-called minor nutrients, such as antioxidising vitamins and polyphenols, which were highest in Sanguisorba minor L.
    Keywords Sanguisorba minor ; eggs ; functional foods ; human nutrition ; interviews ; nutrients ; pasta ; polyphenols ; salads ; soups ; traditions ; vegetables ; vitamins ; wild plants ; Italy
    Language English
    Dates of publication 2014-0304
    Size p. 297-306.
    Publishing place Taylor & Francis
    Document type Article
    ISSN 1724-5575
    DOI 10.1080/11263504.2013.770805
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Total phallic reconstruction after penile amputation for donkey bite: Case report and review of the literature.

    De Luca, Francesco / Garaffa, Giulio / Maurizi, Angela / Manzi, Emy / De Dominicis, Carlo / Ralph, David

    Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

    2017  Volume 89, Issue 2, Page(s) 166–168

    Abstract: There are very few reported cases of traumatic amputation of the male genitalia due to animal bite. The management involves thorough washout of the wounds, debridement, antibiotic prophylaxis, tetanus and rabies immunization followed by immediate ... ...

    Abstract There are very few reported cases of traumatic amputation of the male genitalia due to animal bite. The management involves thorough washout of the wounds, debridement, antibiotic prophylaxis, tetanus and rabies immunization followed by immediate reconstruction or primary wound closure with delayed reconstruction, when immediate reconstruction is not feasible. When immediate reconstruction is not feasible, long-term good functional and cosmetic results are still possible in the majority of cases by performing total phallic reconstruction. In particular, it is now possible to fashion a cosmetically acceptable sensate phallus with incorporated neourethra, to allow the patient to void while standing and to ejaculate, and with enough bulk to allow the insertion of a penile prosthesis to guarantee the rigidity necessary to engage in penetrative sexual intercourse.
    Language English
    Publishing date 2017-06-30
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1153526-x
    ISSN 2282-4197 ; 1124-3562 ; 1120-8538
    ISSN (online) 2282-4197
    ISSN 1124-3562 ; 1120-8538
    DOI 10.4081/aiua.2017.2.166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Advanced chondrosarcoma of the pelvis: A rare case of urinary obstruction.

    Olivieri, Valerio / Fortunati, Valentina / Annoscia, Scipio / Massarelli, Massimo / Bellei, Luca / Ollino, Massimo / Manzi, Emy / Maurizi, Angela / De Luca, Francesco

    Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

    2019  Volume 90, Issue 4, Page(s) 293–294

    Abstract: Chondrosarcoma is the second most common malignant tumor of the bone with an incidence of 1 in 200.000 per year. Axial skeleton is frequently involved showing poorer oncological outcomes than appendicular one: human pelvis is a site predilection. It is ... ...

    Abstract Chondrosarcoma is the second most common malignant tumor of the bone with an incidence of 1 in 200.000 per year. Axial skeleton is frequently involved showing poorer oncological outcomes than appendicular one: human pelvis is a site predilection. It is rarely associated to urinary obstruction but according to its localization, it can be frequently linked to compression of pelvic organs as bladder, prostate or bowel. We describe the case of a 52 years old caucasian male with history of advanced pelvic chondrosarcoma and severe hydronephrosis due to total bladder dislocation.
    MeSH term(s) Bone Neoplasms/diagnosis ; Bone Neoplasms/pathology ; Chondrosarcoma/diagnosis ; Chondrosarcoma/pathology ; Humans ; Hydronephrosis/etiology ; Male ; Middle Aged ; Pelvic Bones/pathology ; Urinary Bladder/pathology
    Language English
    Publishing date 2019-01-17
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 1153526-x
    ISSN 2282-4197 ; 1124-3562 ; 1120-8538
    ISSN (online) 2282-4197
    ISSN 1124-3562 ; 1120-8538
    DOI 10.4081/aiua.2018.4.293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Characterization of Volatile Fraction of Saffron from Central Italy (Cascia, Umbria)

    Urbani, Eleonora / Blasi, Francesca / Chiesi, Claudia / Maurizi, Angela / Cossignani, Lina

    International journal of food properties. 2015 Oct. 3, v. 18, no. 10

    2015  

    Abstract: Saffron, the world’s most expensive spice, is valuable for its color, taste, aroma, and properties, which are influenced by the postharvest treatments. In this research solid-phase micro-extraction coupled with gas chromatography-mass spectrometry was ... ...

    Abstract Saffron, the world’s most expensive spice, is valuable for its color, taste, aroma, and properties, which are influenced by the postharvest treatments. In this research solid-phase micro-extraction coupled with gas chromatography-mass spectrometry was performed to analyze saffron produced in the area of Cascia, central Italy. The samples were dried under different conditions as a function of time and temperature. The main volatiles in addition to safranal were isophorone, 4-ketoisophorone, and 2,2,6-trimethyl-1,4-cyclohexanedione. In some samples, two new compounds (2,4,4-trimethyl-1-pentene and 1,3,3-trimethyl-7-oxabicyclo[4.1.0]heptane-2,5-dione) were identified. Their content increased with drying temperature and time and they could be characteristic of saffron produced in the selected geographical area. Moreover the results confirmed that the drying conditions strongly influenced saffron volatile profile.
    Keywords color ; drying ; drying temperature ; gas chromatography-mass spectrometry ; microextraction ; odors ; postharvest treatment ; saffron ; taste ; volatile compounds ; Italy
    Language English
    Dates of publication 2015-1003
    Size p. 2223-2230.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 1402715-x
    ISSN 1532-2386 ; 1094-2912
    ISSN (online) 1532-2386
    ISSN 1094-2912
    DOI 10.1080/10942912.2014.968787
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Implementazione strutturata ed elevata aderenza al programma ERAS in chirurgia colorettale in due unità operative dell’ASUR Marche.

    Catarci, Marco / Maurizi, Angela / Benedetti, Michele / Giachetta, Antonella / Ciotti, Simona / Spinelli, Francesco / Bernacconi, Tonino / Gionni, Barbara / Astolfi, Luca / Paoletti, Claudia / Forlini, Giorgio / Marzocchini, Silvia / Casuale, Giovanna / Valeri, Maria Valeria / Clementi, Nicoletta / Cicconi, Simone / Marziali, Irene / Guercioni, Gianluca / Campagnacci, Roberto

    Recenti progressi in medicina

    2021  Volume 112, Issue 1, Page(s) 30–44

    Abstract: Background: An Enhanced Recovery After Surgery (ERAS) program in colorectal surgery is able to significantly reduce the morbidity rates and postoperative hospital stay (LOS) related to the intervention. However, it is not clear what modalities and ... ...

    Title translation Structured implementation and high adherence to the ERAS program in colorectal surgery in two operating units of the ASUR Marche.
    Abstract Background: An Enhanced Recovery After Surgery (ERAS) program in colorectal surgery is able to significantly reduce the morbidity rates and postoperative hospital stay (LOS) related to the intervention. However, it is not clear what modalities and levels of implementation are necessary to achieve these results. The purpose of this work is to analyze the methods and results of the first year of implementation of the program in two centers of the Agenzia Sanitaria Unica Regionale (ASUR) Marche.
    Materials: After a structured implementation pathway, characterized by the creation of a core team, field training, internal courses and coaching, the details of 196 consecutive cases of patients submitted to colorectal resection over a one-year period in two surgical units of the ASUR Marche were prospectively loaded in a database, considering over 50 variables including adherence to the individual items of the ERAS program. The primary outcomes were: overall and major morbidity, mortality and anastomotic dehiscence rates; secondary outcomes were: LOS, re-admission and re-intervention rates. The results of primary endpoints were evaluated by univariable and multivariable analyses with logistic regression and, thereafter, according to ERAS item adherence rate.
    Results: After a median (interquartile range, IQR) follow-up of 40 (32-94) days, we recorded complications in 72 patients (overall morbidity 36.7%), major morbidity in 14 patients (7.1%), 6 deaths (mortality 3.1%), an anastomotic dehiscence in 9 cases (4.9%), median (IQR) overalll LOS 5 (3-7) days, 10 readmissions (5.1%) and 13 reoperations (6.7%). The mean adherence rate to the items of the ERAS program was 85.4%, showing a significant dose-effect curve for overall morbidity, major morbidity, anastomotic leakage and for overall LOS.
    Discussion: The ERAS implementation methods in this project led to a high adherence (>80%) to the program items. All the results showed a significant improvement compared to the previous pre-implementation period and according to the adherence to program items rate.
    MeSH term(s) Colorectal Surgery ; Enhanced Recovery After Surgery ; Humans ; Length of Stay ; Postoperative Complications/epidemiology ; Postoperative Complications/prevention & control
    Language Italian
    Publishing date 2021-01-29
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 138266-4
    ISSN 2038-1840 ; 0034-1193
    ISSN (online) 2038-1840
    ISSN 0034-1193
    DOI 10.1701/3525.35122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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