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  1. Article ; Online: Feature Paper Special Issue for Editorial Board Members (EBMs) of Diseases

    Maurizio Battino

    Diseases, Vol 10, Iss 18, p

    2022  Volume 18

    Abstract: When you are part of a community, especially a scientific one, you are required to contribute significantly to its welfare, because the community as a whole represents each individual within it and, in turn, determines the wellbeing of the participants ... ...

    Abstract When you are part of a community, especially a scientific one, you are required to contribute significantly to its welfare, because the community as a whole represents each individual within it and, in turn, determines the wellbeing of the participants themselves [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Bioactive Phytochemicals and Functional Food Ingredients in Fruits and Vegetables

    Francesca Giampieri / Maurizio Battino

    International Journal of Molecular Sciences, Vol 21, Iss 3278, p

    2020  Volume 3278

    Abstract: Today, it is widely accepted that a plant-based diet produces wellbeing and prevents the onset of several human diseases [.] ...

    Abstract Today, it is widely accepted that a plant-based diet produces wellbeing and prevents the onset of several human diseases [.]
    Keywords n/a ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Diseases — the Reasons for a New Challenge in Open Access Medicine Research

    Maurizio Battino

    Diseases, Vol 2, Iss 1, Pp 1-

    2013  Volume 2

    Abstract: First, I would like to warmly welcome the readers, contributors, and editorial board members of Diseases journal as a new entrant to the international periodicals industry. [.] ...

    Abstract First, I would like to warmly welcome the readers, contributors, and editorial board members of Diseases journal as a new entrant to the international periodicals industry. [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2013-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Diabetes Mellitus and Periodontitis Share Intracellular Disorders as the Main Meeting Point

    Juliana Portes / Beatriz Bullón / José Luis Quiles / Maurizio Battino / Pedro Bullón

    Cells, Vol 10, Iss 2411, p

    2021  Volume 2411

    Abstract: Diabetes and periodontitis are two of the most prevalent diseases worldwide that negatively impact the quality of life of the individual suffering from them. They are part of the chronic inflammatory disease group or, as recently mentioned, non- ... ...

    Abstract Diabetes and periodontitis are two of the most prevalent diseases worldwide that negatively impact the quality of life of the individual suffering from them. They are part of the chronic inflammatory disease group or, as recently mentioned, non-communicable diseases, with inflammation being the meeting point among them. Inflammation hitherto includes vascular and tissue changes, but new technologies provide data at the intracellular level that could explain how the cells respond to the aggression more clearly. This review aims to emphasize the molecular pathophysiological mechanisms in patients with type 2 diabetes mellitus and periodontitis, which are marked by different impaired central regulators including mitochondrial dysfunction, impaired immune system and autophagy pathways, oxidative stress, and the crosstalk between adenosine monophosphate-activated protein kinase (AMPK) and the renin-angiotensin system (RAS). All of them are the shared background behind both diseases that could explain its relationship. These should be taken in consideration if we would like to improve the treatment outcomes. Currently, the main treatment strategies in diabetes try to reduce glycemia index as the most important aspect, and in periodontitis try to reduce the presence of oral bacteria. We propose to add to the therapeutic guidelines the handling of all the intracellular disorders to try to obtain better treatment success.
    Keywords periodontal disease ; diabetes ; mitochondrial dysfunction ; oxidative stress ; AMPK ; autophagy ; Biology (General) ; QH301-705.5
    Subject code 571
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: The Molecular Weaponry Produced by the Bacterium Hafnia alvei in Foods

    José Ramos-Vivas / Olga Tapia / María Elexpuru-Zabaleta / Kilian Tutusaus Pifarre / Yasmany Armas Diaz / Maurizio Battino / Francesca Giampieri

    Molecules, Vol 27, Iss 5585, p

    2022  Volume 5585

    Abstract: Hafnia alvei is receiving increasing attention from both a medical and veterinary point of view, but the diversity of molecules it produces has made the interest in this bacterium extend to the field of probiotics, the microbiota, and above all, to its ... ...

    Abstract Hafnia alvei is receiving increasing attention from both a medical and veterinary point of view, but the diversity of molecules it produces has made the interest in this bacterium extend to the field of probiotics, the microbiota, and above all, to its presence and action on consumer foods. The production of Acyl Homoserine Lactones (AHLs), a type of quorum-sensing (QS) signaling molecule, is the most often-studied chemical signaling molecule in Gram-negative bacteria. H. alvei can use this communication mechanism to promote the expression of certain enzymatic activities in fermented foods, where this bacterium is frequently present. H. alvei also produces a series of molecules involved in the modification of the organoleptic properties of different products, especially cheeses, where it shares space with other microorganisms. Although some strains of this species are implicated in infections in humans, many produce antibacterial compounds, such as bacteriocins, that inhibit the growth of true pathogens, so the characterization of these molecules could be very interesting from the point of view of clinical medicine and the food industry. Lastly, in some cases, H. alvei is responsible for the production of biogenic amines or other compounds of special interest in food health. In this article, we will review the most interesting molecules that produce the H. alvei strains and will discuss some of their properties, both from the point of view of their biological activity on other microorganisms and the properties of different food matrices in which this bacterium usually thrives.
    Keywords Hafnia alvei ; quorum-sensing ; probiotics ; biopreservation ; foodborne pathogens ; Organic chemistry ; QD241-441
    Subject code 540
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Molecular Mechanisms of the Protective Effects of Olive Leaf Polyphenols against Alzheimer’s Disease

    Jose M. Romero-Márquez / Tamara Y. Forbes-Hernández / María D. Navarro-Hortal / Rosa Quirantes-Piné / Giuseppe Grosso / Francesca Giampieri / Vivian Lipari / Cristina Sánchez-González / Maurizio Battino / José L. Quiles

    International Journal of Molecular Sciences, Vol 24, Iss 4353, p

    2023  Volume 4353

    Abstract: Alzheimer’s Disease (AD) is the cause of around 60–70% of global cases of dementia and approximately 50 million people have been reported to suffer this disease worldwide. The leaves of olive trees ( Olea europaea ) are the most abundant by-products of ... ...

    Abstract Alzheimer’s Disease (AD) is the cause of around 60–70% of global cases of dementia and approximately 50 million people have been reported to suffer this disease worldwide. The leaves of olive trees ( Olea europaea ) are the most abundant by-products of the olive grove industry. These by-products have been highlighted due to the wide variety of bioactive compounds such as oleuropein (OLE) and hydroxytyrosol (HT) with demonstrated medicinal properties to fight AD. In particular, the olive leaf (OL), OLE, and HT reduced not only amyloid-β formation but also neurofibrillary tangles formation through amyloid protein precursor processing modulation. Although the isolated olive phytochemicals exerted lower cholinesterase inhibitory activity, OL demonstrated high inhibitory activity in the cholinergic tests evaluated. The mechanisms underlying these protective effects may be associated with decreased neuroinflammation and oxidative stress via NF-κB and Nrf2 modulation, respectively. Despite the limited research, evidence indicates that OL consumption promotes autophagy and restores loss of proteostasis, which was reflected in lower toxic protein aggregation in AD models. Therefore, olive phytochemicals may be a promising tool as an adjuvant in the treatment of AD.
    Keywords olive leaves ; bioactive compounds ; Alzheimer’s Disease ; oleuropein ; hydroxytyrosol ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Dietary antioxidants and lifespan

    Alfonso Varela-López / José M. Romero-Márquez / María D. Navarro-Hortal / César L. Ramirez-Tortosa / Maurizio Battino / Tamara Y. Forbes-Hernández / José L. Quiles

    Experimental Gerontology, Vol 178, Iss , Pp 112221- (2023)

    Relevance of environmental conditions, diet, and genotype of experimental models

    2023  

    Abstract: The rise of life expectancy in current societies is not accompanied, to date, by a similar increase in healthspan, which represents a great socio-economic problem. It has been suggested that aging can be manipulated and then, the onset of all age- ... ...

    Abstract The rise of life expectancy in current societies is not accompanied, to date, by a similar increase in healthspan, which represents a great socio-economic problem. It has been suggested that aging can be manipulated and then, the onset of all age-associated chronic disorders can be delayed because these pathologies share age as primary underlying risk factor. One of the most extended ideas is that aging is consequence of the accumulation of molecular damage. According to the oxidative damage theory, antioxidants should slow down aging, extending lifespan and healthspan. The present review analyzes studies evaluating the effect of dietary antioxidants on lifespan of different aging models and discusses the evidence on favor of their antioxidant activity as anti-aging mechanisms. Moreover, possible causes for differences between the reported results are evaluated.
    Keywords Aging ; Ageing ; Longevity ; Bioactive compounds ; Nutrient-sensing pathways ; Hormesis ; Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Phages and Enzybiotics in Food Biopreservation

    José Ramos-Vivas / María Elexpuru-Zabaleta / María Luisa Samano / Alina Pascual Barrera / Tamara Y. Forbes-Hernández / Francesca Giampieri / Maurizio Battino

    Molecules, Vol 26, Iss 5138, p

    2021  Volume 5138

    Abstract: Presently, biopreservation through protective bacterial cultures and their antimicrobial products or using antibacterial compounds derived from plants are proposed as feasible strategies to maintain the long shelf-life of products. Another emerging ... ...

    Abstract Presently, biopreservation through protective bacterial cultures and their antimicrobial products or using antibacterial compounds derived from plants are proposed as feasible strategies to maintain the long shelf-life of products. Another emerging category of food biopreservatives are bacteriophages or their antibacterial enzymes called “phage lysins” or “enzybiotics”, which can be used directly as antibacterial agents due to their ability to act on the membranes of bacteria and destroy them. Bacteriophages are an alternative to antimicrobials in the fight against bacteria, mainly because they have a practically unique host range that gives them great specificity. In addition to their potential ability to specifically control strains of pathogenic bacteria, their use does not generate a negative environmental impact as in the case of antibiotics. Both phages and their enzymes can favor a reduction in antibiotic use, which is desirable given the alarming increase in resistance to antibiotics used not only in human medicine but also in veterinary medicine, agriculture, and in general all processes of manufacturing, preservation, and distribution of food. We present here an overview of the scientific background of phages and enzybiotics in the food industry, as well as food applications of these biopreservatives.
    Keywords bacteriophage ; endolysin ; enzybiotics ; biopreservation ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Influence of Altitudes and Development Stages on the Chemical Composition, Antioxidant, and Antimicrobial Capacity of the Wild Andean Blueberry ( Vaccinium floribundum Kunth)

    Mabel Guevara-Terán / Katherine Padilla-Arias / Andrea Beltrán-Novoa / Ana M. González-Paramás / Francesca Giampieri / Maurizio Battino / Wilson Vásquez-Castillo / Paulina Fernandez-Soto / Eduardo Tejera / José M. Alvarez-Suarez

    Molecules, Vol 27, Iss 7525, p

    2022  Volume 7525

    Abstract: The chemical composition and biological capacities of berries depend on environmental parameters, maturity, and location. The Andean blueberry ( Vaccinium floribundum Kunth), also known as mortiño, presents a unique combination of several phytochemicals, ...

    Abstract The chemical composition and biological capacities of berries depend on environmental parameters, maturity, and location. The Andean blueberry ( Vaccinium floribundum Kunth), also known as mortiño, presents a unique combination of several phytochemicals, which play a synergistic role in its characterization as a functional food. We aimed to expose the possible variations that exist in the profile of the phenolic compounds as well as the antioxidant and antimicrobial capacity of the wild Andean blueberry with respect to three ripeness stages and two different altitudes. We found that polyphenols are the predominant compounds in the berry during the early ripeness stage and are the main bioactive compounds that give rise to the antioxidant capacity and inhibition effect on the growth of gram-positive and gram-negative bacteria. Moreover, the accumulation of ascorbic acid, free amino acids, and anthocyanins increases as the ripening process progresses, and they were the main bioactive compounds in the ripe berry. The latter compounds influence the production of the typical bluish or reddish coloration of ripe blueberries. In addition, it was determined that environmental conditions at high altitudes could have a positive influence in all cases. Overall, our data provide evidence regarding the high functional value of the wild Andean blueberry.
    Keywords Andean blueberry ; altitude ; ripeness ; chemical composition ; antioxidant capacity ; antimicrobial activity ; Organic chemistry ; QD241-441
    Subject code 540
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Alcohol Consumption, Bone Mineral Density, and Risk of Osteoporotic Fractures

    Justyna Godos / Francesca Giampieri / Emanuele Chisari / Agnieszka Micek / Nadia Paladino / Tamara Y. Forbes-Hernández / José L. Quiles / Maurizio Battino / Sandro La Vignera / Giuseppe Musumeci / Giuseppe Grosso

    International Journal of Environmental Research and Public Health, Vol 19, Iss 1515, p

    A Dose–Response Meta-Analysis

    2022  Volume 1515

    Abstract: Excess alcohol consumption is known to be detrimental to human health. However, the role of light-to-moderate alcohol intake is under investigation for potential certain health benefits—mostly related to the cardiovascular system. Nevertheless, there is ... ...

    Abstract Excess alcohol consumption is known to be detrimental to human health. However, the role of light-to-moderate alcohol intake is under investigation for potential certain health benefits—mostly related to the cardiovascular system. Nevertheless, there is no univocal agreement on this matter, and research is still ongoing to clarify whether there might be other potential outcomes affected by alcohol intake. In this regard, there is evidence that excess alcohol intake may negatively influence the risk of osteoporotic fractures. However, there is no comprehensive evidence of literature assessing the role of alcohol consumption in bone mineral density (BMD) and the risk of osteoporotic fractures. Thus, the aim of this study was to quantitatively assess the dose–response relationship between alcohol intake and BMD and risk of osteoporotic fractures. The Embase and MEDLINE electronic databases were searched from their inception to December 2021 for articles providing a quantifiable measurement of alcohol consumption for at least three categories and (1) a measurement of BMD (and dispersion as continuous variables) in some area of the body or (2) risk of osteoporotic fracture provided as relative risk (RR) or hazard ratio (HR), with a 95% confidence interval (CI) as the measure of the association of each category with alcohol intake. A total of 11 studies including 46,916 individuals with BMD assessment and 8 studies including 240,871 individuals with risk of fracture analysis were included. Compared to non-drinkers, consumption of up to two standard drinks of alcohol per day was correlated with higher lumbar and femur neck BMD values, while up to one standard drink of alcohol was correlated with higher hip BMD compared to no alcohol consumption. Higher risk of hip fractures was found starting from three standard drinks of alcohol per day (RR = 1.33, 95% CI: 1.04; 1.69 for three alcoholic drinks/d, and RR = 1.59, 95% CI: 1.23; 2.05 for four alcoholic drinks/d) compared to no alcohol consumption, with no evidence of heterogeneity. Concerning the risk of any osteoporotic fractures, the risk steadily increased with higher intake of alcohol, although never reaching statistical significance. In conclusion, there is consistent evidence that increased alcohol consumption is associated with higher risk of osteoporotic hip fracture; however, the role of alcohol at lower doses is uncertain, as BMD was even higher in light drinkers compared to abstainers.
    Keywords alcohol ; osteoporosis ; bone mineral density ; meta-analysis ; bone health ; fractures ; Medicine ; R
    Subject code 310
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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