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  1. AU="Mauro Biffi"
  2. AU="Liening, Stefanie"
  3. AU="Melnyk, Andrew"
  4. AU="Brassart, Bertrand"
  5. AU="Paukshto, Michael"
  6. AU="Rosenberg, Amy S"
  7. AU=Kraus Courtney L
  8. AU="Herman, Andrew"
  9. AU="Xia, Y M"
  10. AU="Antonio, José"
  11. AU="Curci, C"
  12. AU="Baek, Seon-Hwa"
  13. AU="Wei, Xuecong"
  14. AU="Benarroch, Eduardo E."
  15. AU="Modesto Dutari-Valdés, José"
  16. AU="Bot, Merel"
  17. AU="Mackinnon, Alison C"
  18. AU="van Weeghel, Michel"
  19. AU="Halliday, Michael A. K"
  20. AU="Johnston, Carol S"
  21. AU="Bole-Feysot, Christine"
  22. AU="Beverly Rubik"
  23. AU="Nasiri, Asghar"
  24. AU=Han Huan
  25. AU="Pujades-Rodriguez, Mar"
  26. AU="Bertrand, P"
  27. AU="Hinzen, Wolfram"
  28. AU="Daniel Kupka"
  29. AU="Mayer, Tobias"

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  1. Artikel ; Online: A Historical Perspective of Cardiac Implantable Electronic Device Infection

    Giulia Massaro / Igor Diemberger / Matteo Ziacchi / Andrea Angeletti / Giovanni Statuto / Nazzareno Galiè / Mauro Biffi

    Hearts, Vol 2, Iss 16, Pp 202-

    How a Menace Can Drive Technological and Clinical Improvement

    2021  Band 212

    Abstract: In recent decades there has been a relevant increase in the implantation rate of cardiac implantable electronic devices (CIEDs), albeit with relevant geographical inhomogeneities. Despite the positive impact on clinical outcomes, the possibility of major ...

    Abstract In recent decades there has been a relevant increase in the implantation rate of cardiac implantable electronic devices (CIEDs), albeit with relevant geographical inhomogeneities. Despite the positive impact on clinical outcomes, the possibility of major complications is not negligible, particularly with respect to CIED infections. CIED infections significantly affect morbidity and mortality, especially in instances of delayed diagnosis and appropriate treatment. In the present review, we will start to depict the factors underlying the development of CIED infection as well as the difficulties related to its diagnosis and treatment. We will explain the reasons underlying the need to focus on prophylaxis rather than treatment, in view of the poor outcomes despite improvements in lead extraction procedures. This will lead to the consideration of management of this complication in a hub-spoke manner, and to our analysis of the several technological and procedural improvements developed to minimize this complication. These include prolongation of CIED longevity, the development of leadless devices, and integrated prophylactic approaches. We will conclude with a discussion regarding new devices and strategies under development. This complete excursus will provide the reader with a new perspective on how a major complication can drive technological improvements.
    Schlagwörter cardiac implantable electronic device infections ; management ; prevention ; clinical implications ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Correction

    Michele Bertelli / Sebastiano Toniolo / Matteo Ziacchi / Alessio Gasperetti / Marco Schiavone / Roberto Arosio / Claudio Capobianco / Gianfranco Mitacchione / Giovanni Statuto / Andrea Angeletti / Cristian Martignani / Igor Diemberger / Giovanni Battista Forleo / Mauro Biffi

    Journal of Clinical Medicine, Vol 12, Iss 2311, p

    Bertelli et al. Is Less Always More? A Prospective Two-Centre Study Addressing Clinical Outcomes in Leadless versus Transvenous Single-Chamber Pacemaker Recipients. J. Clin. Med. 2022, 11 , 6071

    2023  Band 2311

    Abstract: The authors wish to make the following corrections to this paper [.] ...

    Abstract The authors wish to make the following corrections to this paper [.]
    Schlagwörter n/a ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Vascular Accesses in Cardiac Stimulation and Electrophysiology

    Matteo Ziacchi / Angelo Placci / Andrea Angeletti / Fabio Quartieri / Cristina Balla / Santo Virzi / Matteo Bertini / Roberto De Ponti / Mauro Biffi / Giuseppe Boriani / for AIAC Ricerca Investigators’ Network

    Biology, Vol 11, Iss 265, p

    An Italian Survey Promoted by AIAC (Italian Association of Arrhythmias and Cardiac Pacing)

    2022  Band 265

    Abstract: Cardiac implantable electronic device (CIED) implants and electrophysiological procedures share a common step: vascular access. On behalf of the AIAC Ricerca Investigators’ Network, we conducted a survey to outline Italian common practice regarding ... ...

    Abstract Cardiac implantable electronic device (CIED) implants and electrophysiological procedures share a common step: vascular access. On behalf of the AIAC Ricerca Investigators’ Network, we conducted a survey to outline Italian common practice regarding vascular access in EP-lab. All Italian physicians with experience in CIED implantation and electrophysiology were invited to answer an online questionnaire (from May 2020 to November 2020) featuring 20 questions. In total, 103 cardiologists (from 92 Italian hospitals) answered the survey. Vascular access during CIED implants was considered the most complex step following lead placement by 54 (52.4%) respondents and the most complex for 35 (33.9%). In total, 54 (52.4%) and 49 (47.6%) respondents considered the cephalic and subclavian vein the first option, respectively (intrathoracic and extrathoracic subclavian/axillary vein by 22 and 27, respectively). In total, 45 (43.7%) respondents performed close arterial femoral accesses manually; only 12 (11.7%) respondents made extensive use of vascular closure devices. A total of 46 out of 103 respondents had experience in ultrasound-guided vascular accesses, but only 10 (22%) used it for more than 50% of the accesses. In total, 81 (78.6%) respondents wanted to increase their ultrasound-guided vascular access skills. Reducing complications is a goal to reach in cardiac stimulation and electrophysiological procedures. Our survey shows the heterogeneity of the vascular approaches used in Italian centres. Some vascular accesses were proved to be superior to others in terms of complications, with ultrasound-guided puncture as an emerging technique. More effort to produce the standardization of vascular accesses could be made by scientific societies.
    Schlagwörter vascular access ; CIED ; electrophysiology ; survey ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 310
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Usefulness of the MAGGIC Score in Predicting the Competing Risk of Non-Sudden Death in Heart Failure Patients Receiving an Implantable Cardioverter-Defibrillator

    Marco Canepa / Pietro Palmisano / Gabriele Dell’Era / Matteo Ziacchi / Ernesto Ammendola / Michele Accogli / Eraldo Occhetta / Mauro Biffi / Gerardo Nigro / Pietro Ameri / Giulia Stronati / Italo Porto / Antonio Dello Russo / Federico Guerra

    Journal of Clinical Medicine, Vol 11, Iss 121, p

    A Sub-Analysis of the OBSERVO-ICD Registry

    2022  Band 121

    Abstract: The role of prognostic risk scores in predicting the competing risk of non-sudden death in heart failure patients with reduced ejection fraction (HFrEF) receiving an implantable cardioverter-defibrillator (ICD) is unclear. To this goal, we evaluated the ... ...

    Abstract The role of prognostic risk scores in predicting the competing risk of non-sudden death in heart failure patients with reduced ejection fraction (HFrEF) receiving an implantable cardioverter-defibrillator (ICD) is unclear. To this goal, we evaluated the accuracy and usefulness of the Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC) score. The present analysis included 1089 HFrEF ICD recipients enrolled in the OBSERVO-ICD registry (NCT02735811). During a median follow-up of 36 months (1st–3rd IQR 25–48 months), 193 patients (17.7%) experienced at least one appropriate ICD therapy, and 133 patients died (12.2%) without experiencing any ICD therapy. The frequency of patients receiving ICD therapies was stable around 17–19% across increasing tertiles of 3-year MAGGIC probability of death, whereas non-sudden mortality increased (6.4% to 9.8% to 20.8%, p < 0.0001). Accuracy of MAGGIC score was 0.60 (95% CI, 0.56–0.64) for the overall outcome, 0.53 (95% CI, 0.49–0.57) for ICD therapies and 0.65 (95% CI, 0.60–0.70) for non-sudden death. In patients with higher 3-year MAGGIC probability of death, the increase in the competing risk of non-sudden death during follow-up was greater than that of receiving an appropriate ICD therapy. Results were unaffected when analysis was limited to ICD shocks only. The MAGGIC risk score proved accurate and useful in predicting the competing risk of non-sudden death in HFrEF ICD recipients. Estimation of mortality risk should be taken into greater consideration at the time of ICD implantation.
    Schlagwörter competing risk ; ICD therapies ; implantable cardioverter-defibrillator ; sudden cardiac death ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2022-12-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Liver-directed lentiviral gene therapy corrects hemophilia A mice and achieves normal-range factor VIII activity in non-human primates

    Michela Milani / Cesare Canepari / Tongyao Liu / Mauro Biffi / Fabio Russo / Tiziana Plati / Rosalia Curto / Susannah Patarroyo-White / Douglas Drager / Ilaria Visigalli / Chiara Brombin / Paola Albertini / Antonia Follenzi / Eduard Ayuso / Christian Mueller / Andrea Annoni / Luigi Naldini / Alessio Cantore

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Band 14

    Abstract: Lentiviral gene therapy to the liver establishes stable long-term normal to supra-normal coagulation factor VIII activity in mouse models of hemophilia A and in non-human primates, representing a potential new treatment option for people with hemophilia ...

    Abstract “Lentiviral gene therapy to the liver establishes stable long-term normal to supra-normal coagulation factor VIII activity in mouse models of hemophilia A and in non-human primates, representing a potential new treatment option for people with hemophilia A.”.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2022-05-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Cardiac Contractility Modulation in Patients with Heart Failure with Reduced Left Ventricular Ejection Fraction

    Francesco Giallauria / Alessandro Parlato / Anna Di Lorenzo / Crescenzo Testa / Antonio D’Onofrio / Gianfranco Sinagra / Mauro Biffi / Carlo Vigorito / Andrew J. S. Coats

    Hearts, Vol 2, Iss 13, Pp 156-

    2021  Band 169

    Abstract: Cardiac contractility modulation is an innovative therapy conceived for the treatment of heart failure. It is a device-based therapy, employing multiple electrodes to deliver relatively high-voltage ( ~ 7.5 V) biphasic signals to the endocardium of the ... ...

    Abstract Cardiac contractility modulation is an innovative therapy conceived for the treatment of heart failure. It is a device-based therapy, employing multiple electrodes to deliver relatively high-voltage ( ~ 7.5 V) biphasic signals to the endocardium of the right ventricular septum, in order to improve heart failure symptoms, exercise capacity and quality of life. Multiple clinical and mechanistic studies have been conducted to investigate the potential usefulness of this technology and, as of now, they suggest that it could have a place in therapy and meet a relevant medical need for a specific sub-category of underserved heart failure patients with reduced left ventricular ejection fraction. More studies are needed to further investigate its effect on outcomes such as mortality and rate of hospitalizations.
    Schlagwörter cardiac contractility modulation ; heart failure ; HFrEF ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2021-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Cardiac Stimulation in the Third Millennium

    Mauro Biffi / Alberto Spadotto / Giuseppe Pio Piemontese / Sebastiano Toniolo / Lorenzo Bartoli / Sergio Sorrentino / Alessandro Minguzzi / Giulia Massaro / Claudio Capobianco / Giovanni Statuto

    Hearts, Vol 2, Iss 3, Pp 15-

    Where Do We Head from Here?

    2021  Band 35

    Abstract: Over the years, pacemakers have evolved from a life-saving tool to prevent asystole to a device to treat heart rhythm disorders and heart failure, aiming at improving both cardiac function and clinical outcomes. Cardiac stimulation nowadays aims to ... ...

    Abstract Over the years, pacemakers have evolved from a life-saving tool to prevent asystole to a device to treat heart rhythm disorders and heart failure, aiming at improving both cardiac function and clinical outcomes. Cardiac stimulation nowadays aims to correct the electrophysiologic roots of mechanical inefficiency in different structural heart diseases. This has led to awareness of the concealed risks of customary cardiac pacing that can inadvertently cause atrioventricular and inter-/intra-ventricular dyssynchrony, and has promoted the development of new pacing modalities and the use of stimulation sites different from the right atrial appendage and the right ventricular apex. The perspective of truly physiologic pacing is the leading concept of the continued research in the past 30 years, which has made cardiac stimulation procedure more sophisticated and challenging. In this article, we analyze the emerging evidence in favor of the available strategies to achieve an individualized physiologic setting in bradycardia pacing.
    Schlagwörter cardiac stimulation ; atrioventricular coupling ; physiologic pacing ; clinical outcome ; individualized therapy ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Preliminary Experience With Low Molecular Weight Heparin Strategy in COVID-19 Patients

    Pasquale Paolisso / Luca Bergamaschi / Emanuela Concetta D’Angelo / Francesco Donati / Maddalena Giannella / Sara Tedeschi / Renato Pascale / Michele Bartoletti / Giulia Tesini / Mauro Biffi / Benilde Cosmi / Carmine Pizzi / Pierluigi Viale / Nazzareno Galié

    Frontiers in Pharmacology, Vol

    2020  Band 11

    Abstract: BackgroundHeparin administration in COVID-19 patients is recommended by expert consensus, although evidence about dosage, duration and efficacy are limited. We aim to investigate the association between different dosages of low molecular weight heparin ( ... ...

    Abstract BackgroundHeparin administration in COVID-19 patients is recommended by expert consensus, although evidence about dosage, duration and efficacy are limited. We aim to investigate the association between different dosages of low molecular weight heparin (LMWH) and mortality among COVID-19 hospitalized patients.Methods and ResultsRetrospective study of 450 laboratory-confirmed COVID-19 patients admitted to Sant’Orsola Bologna Hospital from March 01 to April 10, 2020. Clinical, laboratory and treatment data were collected and analyzed. The in-hospital mortality between COVID-19 patients treated with standard prophylactic LMWH dosage vs. intermediate LMWH dosage was compared. Out of 450 patients, 361 received standard deep vein thrombosis (DVT) prophylaxis enoxaparin treatment (40-60mg daily) and 89 patients received intermediate enoxaparin dosage (40–60 mg twice daily) for 7 days. No significant differences in the main demographic characteristics and laboratory testings at admission were observed in the two heparin regimen subgroups, except for older age and prevalence of hypertension in the group treated with “standard” prophylaxis LMWH dosage. The intermediate LMWH administration was associated with a lower in-hospital all-cause mortality compared to the “standard” prophylactic LMWH dosage (18.8% vs. 5.8%, p = 0.02). This difference remained significant after adjustment with the propensity score for variables that differed significantly between the dosage groups (OR= 0.260, 95% CI 0.089–0.758, p=0.014).ConclusionsIntermediate LMWH dosage seems to be associated with lower incidence of mortality compared to standard DVT prophylaxys in hospitalized COVID-19 patients. Our study paves the way to further pathophysiological investigations and controlled studies of anticoagulation therapy in Covid-19 disease.
    Schlagwörter COVID- 19 ; heparin ; LMWH (low molecular weight heparin) ; in-hospital mortality ; DVT prophylaxis ; Therapeutics. Pharmacology ; RM1-950 ; covid19
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2020-08-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: The Impact of COVID-19 Pandemic and Lockdown Restrictions on Cardiac Implantable Device Recipients with Remote Monitoring

    Igor Diemberger / Alessandro Vicentini / Giuseppe Cattafi / Matteo Ziacchi / Saverio Iacopino / Giovanni Morani / Ennio Pisanò / Giulio Molon / Tiziana Giovannini / Antonio Dello Russo / Giuseppe Boriani / Emanuele Bertaglia / Mauro Biffi / Maria Grazia Bongiorni / Roberto Rordorf / Giulio Zucchelli

    Journal of Clinical Medicine, Vol 10, Iss 5626, p

    2021  Band 5626

    Abstract: From 2020, many countries have adopted several restrictions to limit the COVID-19 pandemic. The forced containment impacted on healthcare organizations and the everyday life of patients with heart disease. We prospectively analyzed data recorded from ... ...

    Abstract From 2020, many countries have adopted several restrictions to limit the COVID-19 pandemic. The forced containment impacted on healthcare organizations and the everyday life of patients with heart disease. We prospectively analyzed data recorded from implantable defibrillators and/or cardiac resynchronization devices of Italian patients during the lockdown (LDP), post-lockdown period (PLDP) and a control period (CP) of the previous year. We analyzed device data of the period 9 March 2019–31 May 2020 of remotely monitored patients from 34 Italian centers. Patients were also categorized according to areas with high/low infection prevalence. Among 696 patients, we observed a significant drop in median activity in LDP as compared to CP that significantly increased in the PLDP, but well below CP (all p < 0.0001). The median day heart rate and heart rate variability showed a similar trend. This behavior was associated during LDP with a significant increase in the burden of atrial arrhythmias ( p = 0.0150 versus CP) and of ventricular arrhythmias [6.6 vs. 1.5 per 100 patient-weeks in CP; p = 0.0026]; the latter decreased in PLDP [0.3 per 100 patient-weeks; p = 0.0035 vs. LDP]. No modifications were recorded in thoracic fluid levels. The high/low prevalence of COVID-19 infection had no significant impact. We found an increase in the arrhythmic burden in LDP coupled with a decrease in physical activity and heart rate variability, without significant modifications of transthoracic impedance, independent from COVID-19 infection prevalence. These findings suggest a negative impact of the COVID-19 pandemic, probably related to lockdown restrictions.
    Schlagwörter COVID-19 ; pandemia ; physical activity ; arrhythmias ; heart failure ; telemonitoring ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-11-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel: Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing

    Amabile, Angelo / Alessandro Migliara / Paola Capasso / Mauro Biffi / Davide Cittaro / Luigi Naldini / Angelo Lombardo

    Cell. 2016 Sept. 22, v. 167

    2016  

    Abstract: Gene silencing is instrumental to interrogate gene function and holds promise for therapeutic applications. Here, we repurpose the endogenous retroviruses’ silencing machinery of embryonic stem cells to stably silence three highly expressed genes in ... ...

    Abstract Gene silencing is instrumental to interrogate gene function and holds promise for therapeutic applications. Here, we repurpose the endogenous retroviruses’ silencing machinery of embryonic stem cells to stably silence three highly expressed genes in somatic cells by epigenetics. This was achieved by transiently expressing combinations of engineered transcriptional repressors that bind to and synergize at the target locus to instruct repressive histone marks and de novo DNA methylation, thus ensuring long-term memory of the repressive epigenetic state. Silencing was highly specific, as shown by genome-wide analyses, sharply confined to the targeted locus without spreading to nearby genes, resistant to activation induced by cytokine stimulation, and relieved only by targeted DNA demethylation. We demonstrate the portability of this technology by multiplex gene silencing, adopting different DNA binding platforms and interrogating thousands of genomic loci in different cell types, including primary T lymphocytes. Targeted epigenome editing might have broad application in research and medicine.
    Schlagwörter DNA ; DNA methylation ; Retroviridae ; T-lymphocytes ; cytokines ; embryonic stem cells ; epigenetics ; gene expression ; gene silencing ; genes ; histones ; loci ; medicine ; repressor proteins ; somatic cells
    Sprache Englisch
    Erscheinungsverlauf 2016-0922
    Umfang p. 219-232.e14.
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2016.09.006
    Datenquelle NAL Katalog (AGRICOLA)

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