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Book ; Online ; E-Book: Role of Oxidative Stress in Pathophysiology of Diseases

Maurya, Pawan K. / Dua, Kamal

2020

Abstract: This book illustrates the importance and significance of oxidative stress in the pathophysiology of various human diseases. The book initially introduces the phenomenon of oxidative stress, basic chemical characteristics of the species involved and ... ...

Author's details	edited by Pawan K. Maurya, Kamal Dua
Abstract	This book illustrates the importance and significance of oxidative stress in the pathophysiology of various human diseases. The book initially introduces the phenomenon of oxidative stress, basic chemical characteristics of the species involved and summarizes the cellular oxidant and anti-oxidant system and the cellular effects and metabolism of the oxidative stress. In addition, it reviews the current understanding of the potential impact of oxidative stress on telomere shortening, aging, and age-related diseases. It also examines the role of oxidative stress in chronic diseases, including cancer, diabetes, cardiovascular diseases, and neurodegenerative disorders. Further, the book presents novel technologies for the detection of oxidative stress biomarkers using nanostructure biosensors, as well as in vitro and in vivo models to monitor oxidative stress. Lastly, the book addresses the drug delivery carriers that can help in combating oxidative stress.
Keywords	Oxidative stress ; Human physiology ; Cancer research ; Diabetes ; Neurosciences ; Nanotechnology ; Oxidative Stress ; Human Physiology ; Cancer Research ; Fisiologia patològica ; Estrès oxidatiu
Subject code	616.39
Language	English
Size	1 online resource (303 pages)
Edition	1st ed. 2020.
Publisher	Springer Singapore ; Imprint: Springer
Publishing place	Singapore
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	981-15-1568-9 ; 981-15-1567-0 ; 978-981-15-1568-2 ; 978-981-15-1567-5
DOI	10.1007/978-981-15-1568-2
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Asphyxiophilic death due to masochistic behaviour in a video game addict teen: A case report and reviews.

Singh, Bajrang K / Maurya, Pawan K / Baveja, Vishal S / Tomar, Jitendra S / Chauhan, Mohit

The Medico-legal journal

2023 , Page(s) 258172221141250

Abstract: The disorder of internet gaming is increasingly being blamed on major psychological problems affecting youth. Action video games are enjoyable for masochists. Video game chores that practise bondage and other acts that cause pain and anoxia may be ... ...

Abstract	The disorder of internet gaming is increasingly being blamed on major psychological problems affecting youth. Action video games are enjoyable for masochists. Video game chores that practise bondage and other acts that cause pain and anoxia may be masochistic in nature in order to promote player satisfaction. Asphyxia will result in pleasure in asphyxiophilia, a dangerous and occasionally lethal form of sexual masochism. Constriction of the neck with ligature materials is a frequent method of causing hypoxia. The subject of this case study was a compulsive player of online video games. During the masochistic act, along with a recording of it, he unintentionally died. Given that he was naked, had a ligature around his neck, had his wrists and legs bound, and had two fabric-holding clamps on his scrotum, asphyxiophilia was determined to be the cause of his death. At the scene of death, neither pornographic materials nor proof of frequent use of this kind of behaviour were discovered. Along with recording, the subject's cell phone's flash was on to help with the dim lighting and he may have been videotaping these masochistic acts as part of a videogame task. The results of the autopsy, circumstantial evidence, police inquiry and witness accounts all support accidental death.
Language	English
Publishing date	2023-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	390918-9
ISSN	2042-1834 ; 0025-8172
ISSN (online)	2042-1834
ISSN	0025-8172
DOI	10.1177/00258172221141250
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Article ; Online: Oxidative Stress and Accelerated Aging in Neurodegenerative and Neuropsychiatric Disorder.

Wadhwa, Ridhima / Gupta, Riya / Maurya, Pawan K

Current pharmaceutical design

2019 Volume 24, Issue 40, Page(s) 4711–4725

Abstract: Background: Neurodegenerative diseases are becoming more and more common in today's world. As people are continuously being exposed to exogenous factors like UV radiations, gamma rays, X-Rays, environmental pollutants and heavy metals, the cases of ... ...

Abstract	Background: Neurodegenerative diseases are becoming more and more common in today's world. As people are continuously being exposed to exogenous factors like UV radiations, gamma rays, X-Rays, environmental pollutants and heavy metals, the cases of increased oxidative damage are increasing. Even though some amount of oxidative damage occurs in all metabolic reactions but their increase from the normal level in organisms causes neurodegenerative diseases. These neurodegenerative disorders like Alzeimers, Parkinsons disease and neuropsychiatric disorders such as schizophrenia, bipolar, depression are caused due to the decline in physiological and psychological functions caused by ROS and RNS. These ROS and RNS are formed as the result of excess oxidative damage in the system. Methods: The following article goes into detail explaining all the effects caused by excess oxidative damage like ROS/RNS formation and telomere shortening. Further, it explains the pathways of neurodegenerative diseases and neuropsychiatric diseases. This article also sheds light on the effective treatments of such disorders by changing lifestyle and activating antioxidant pathways. Conclusion: It is clear that neurodegenerative diseases are caused due to excess oxidative stress and alter the functioning of the central nervous system. The central nervous system undergoes neurodegenerative or neuropsychiatric changes.
MeSH term(s)	Aging/metabolism ; Animals ; Humans ; Neurodegenerative Diseases/metabolism ; Oxidative Stress ; Psychotic Disorders/metabolism
Language	English
Publishing date	2019-01-14
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1381612825666190115121018
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Article: Sukshmjeevanu in Vedas: The Forgotten Past of Microbiology in Indian Vedic Knowledge.

Kuhad, Urvashi / Goel, Gunjan / Maurya, Pawan K / Kuhad, Ramesh C

Indian journal of microbiology

2020 Volume 61, Issue 1, Page(s) 108–110

Abstract: No one questions the existence of presumptive knowledge of invisible organisms causing disease, decay and destruction mentioned before the discovery of the microbial world by Antonie Van Leeuwenhoek, who was the first to describe the invisible world as ... ...

Abstract	No one questions the existence of presumptive knowledge of invisible organisms causing disease, decay and destruction mentioned before the discovery of the microbial world by Antonie Van Leeuwenhoek, who was the first to describe the invisible world as per literature available today. However, the knowledge about microbial world by Indian Rishis presented in Sanskrit shlokas or suktas of our traditional manuscripts such as Vedas remained unseen, where the Rishis had predicted the role of microorganisms known as Krimi or Jeevanu years before Leeuwenhoek. This note is an attempt to bring an emphasis to revisit our traditional Vedic knowledge and establish them through research based facts for wider acceptance globally.
Language	English
Publishing date	2020-10-19
Publishing country	India
Document type	Journal Article
ZDB-ID	413422-9
ISSN	0973-7715 ; 0046-8991
ISSN (online)	0973-7715
ISSN	0046-8991
DOI	10.1007/s12088-020-00911-5
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Article ; Online: Peroxisomes: role in cellular ageing and age related disorders.

Deori, Nayan M / Kale, Avinash / Maurya, Pawan K / Nagotu, Shirisha

Biogerontology

2018 Volume 19, Issue 5, Page(s) 303–324

Abstract: Peroxisomes are dynamic organelles essential for optimum functioning of a eukaryotic cell. Biogenesis of these organelles and the diverse functions performed by them have been extensively studied in the past decade. Their ability to perform functions ... ...

Abstract	Peroxisomes are dynamic organelles essential for optimum functioning of a eukaryotic cell. Biogenesis of these organelles and the diverse functions performed by them have been extensively studied in the past decade. Their ability to perform functions depending on the cell type and growth conditions is unique and remarkable. Oxidation of fatty acids and reactive oxygen species metabolism are the two most important functions of these ubiquitous organelles. They are often referred to as both source and sink of reactive oxygen species in a cell. Recent research connects peroxisome dysfunction to fatal oxidative damage associated with ageing-related diseases/disorders. It is now widely accepted that mitochondria and peroxisomes are required to maintain oxidative balance in a cell. However, our understanding on the inter-dependence of these organelles to maintain cellular homeostasis of reactive oxygen species is still in its infancy. Herein, we summarize findings that highlight the role of peroxisomes in cellular reactive oxygen species metabolism, ageing and age-related disorders.
MeSH term(s)	Aging/metabolism ; Cellular Senescence/physiology ; Humans ; Oxidative Stress/physiology ; Peroxisomes/metabolism
Language	English
Publishing date	2018-07-02
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2047160-9
ISSN	1573-6768 ; 1389-5729
ISSN (online)	1573-6768
ISSN	1389-5729
DOI	10.1007/s10522-018-9761-9
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Article: Prospects of Nanostructure Materials and Their Composites as Antimicrobial Agents.

Baranwal, Anupriya / Srivastava, Ananya / Kumar, Pradeep / Bajpai, Vivek K / Maurya, Pawan K / Chandra, Pranjal

Frontiers in microbiology

2018 Volume 9, Page(s) 422

Abstract: Nanostructured materials (NSMs) have increasingly been used as a substitute for antibiotics and additives in various products to impart microbicidal effect. In particular, use of silver nanoparticles (AgNPs) has garnered huge researchers' attention as ... ...

Abstract	Nanostructured materials (NSMs) have increasingly been used as a substitute for antibiotics and additives in various products to impart microbicidal effect. In particular, use of silver nanoparticles (AgNPs) has garnered huge researchers' attention as potent bactericidal agent due to the inherent antimicrobial property of the silver metal. Moreover, other nanomaterials (carbon nanotubes, fullerenes, graphene, chitosan, etc.) have also been studied for their antimicrobial effects in order ensure their application in widespread domains. The present review exclusively emphasizes on materials that possess antimicrobial activity in nanoscale range and describes their various modes of antimicrobial action. It also entails broad classification of NSMs along with their application in various fields. For instance, use of AgNPs in consumer products, gold nanoparticles (AuNPs) in drug delivery. Likewise, use of zinc oxide nanoparticles (ZnO-NPs) and titanium dioxide nanoparticles (TiO
Language	English
Publishing date	2018-03-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2018.00422
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Article ; Online: Oxidative, inflammatory, genetic, and epigenetic biomarkers associated with chronic obstructive pulmonary disorder.

Aggarwal, Taru / Wadhwa, Ridhima / Thapliyal, Noopur / Sharma, Kanishka / Rani, Varsha / Maurya, Pawan K

Journal of cellular physiology

2018 Volume 234, Issue 3, Page(s) 2067–2082

Abstract: A large body of evidence indicates that chronic obstructive pulmonary disorder (COPD) is accompanied by oxidative stress and inflammatory and genetic pathways. Epidemiological studies indicate that COPD is a major cause of mortality and morbidity in the ... ...

Abstract	A large body of evidence indicates that chronic obstructive pulmonary disorder (COPD) is accompanied by oxidative stress and inflammatory and genetic pathways. Epidemiological studies indicate that COPD is a major cause of mortality and morbidity in the world. Recent research development in COPD focuses on accelerated aging and various oxidative stress biomarkers. It involves the clinical manifestation of the disease process and may also contain biochemical, immunological, physiological, morphological, and genetic aspects that add to the progressiveness of the disease. Herein, we summarize findings that highlight the role of dimensions of COPD in the investigation of oxidative stress, inflammatory responses, genetic and epigenetic studies, and pharmacological and dietary antioxidant intervention.
MeSH term(s)	Antioxidants/metabolism ; Biomarkers/metabolism ; Epigenesis, Genetic ; Humans ; Oxidative Stress/genetics ; Pulmonary Disease, Chronic Obstructive/genetics ; Pulmonary Disease, Chronic Obstructive/metabolism ; Pulmonary Disease, Chronic Obstructive/pathology
Chemical Substances	Antioxidants ; Biomarkers
Language	English
Publishing date	2018-09-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	3116-1
ISSN	1097-4652 ; 0021-9541
ISSN (online)	1097-4652
ISSN	0021-9541
DOI	10.1002/jcp.27181
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Article ; Online: Evaluation of polysaccharide-based chiral stationary phases in quality control of (S)-mirtazapine.

Rao, R Nageswara / Maurya, Pawan K / Guruprasad, K

Biomedical chromatography : BMC

2012 Volume 26, Issue 2, Page(s) 142–146

Abstract: High-performance liquid chromatographic methods were developed for separation of the enantiomers of mirtazapine and its four process-related substances. The direct separations were achieved on chiral stationary phases containing amylose tris(3,5- ... ...

Abstract	High-performance liquid chromatographic methods were developed for separation of the enantiomers of mirtazapine and its four process-related substances. The direct separations were achieved on chiral stationary phases containing amylose tris(3,5-dimethylphenylcarbamate) (Chiralpak AD-H), cellulose tris(3,5-dimethylphenylcarbamate) (Chiralcel OD-H) and cellulose tris(4-methylbenzoate) (Chiralcel OJ-H ). The experimental data were utilized to discuss the effects of the mobile phase composition, the nature of the alcoholic modifier and the specific structural features of the analytes on retention and separation. The elution sequence was determined under the optimized separation conditions.
MeSH term(s)	Amylose/analogs & derivatives ; Amylose/chemistry ; Cellulose/analogs & derivatives ; Cellulose/chemistry ; Chromatography, High Pressure Liquid/instrumentation ; Chromatography, High Pressure Liquid/methods ; Mianserin/analogs & derivatives ; Mianserin/chemistry ; Mianserin/standards ; Phenylcarbamates/chemistry ; Stereoisomerism
Chemical Substances	Phenylcarbamates ; Chiracel OJ (108173-48-4) ; cellulose tris-3,5-dimethylphenyl-carbamate (110735-13-2) ; Chiralpak AD (138361-09-8) ; Mianserin (250PJI13LM) ; Cellulose (9004-34-6) ; Amylose (9005-82-7) ; mirtazapine (A051Q2099Q)
Language	English
Publishing date	2012-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632848-9
ISSN	1099-0801 ; 0269-3879
ISSN (online)	1099-0801
ISSN	0269-3879
DOI	10.1002/bmc.1638
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Article ; Online: Gonadotropin-releasing hormone agonist induces downregulation of tensin 1 in women with endometriosis.

Rahmawati, Endah / Yang, Wei-Chung V / Lei, Yen-Ping / Maurya, Pawan K / Chen, Huei-Wen / Tzeng, Chii-Ruey

Acta obstetricia et gynecologica Scandinavica

2018 Volume 98, Issue 2, Page(s) 222–231

Abstract: Introduction: Many cell migration-related molecules are associated with endometriosis. Tensin 1 (TNS1), which has been implicated in cell migration, may play a role in endometriosis. The study goal was to evaluate the TNS1 expression in endometrial ... ...

Abstract	Introduction: Many cell migration-related molecules are associated with endometriosis. Tensin 1 (TNS1), which has been implicated in cell migration, may play a role in endometriosis. The study goal was to evaluate the TNS1 expression in endometrial tissue and serum from women with endometriosis treated with gonadotropin-releasing hormone agonist (GnRHa). Material and methods: Tissue and serum samples were collected from women with endometriosis who were treated (n = 29) with GnRHa or untreated (n = 30). TNS1 mRNA was examined using quantitative PCR. TNS1 protein levels in tissue and serum samples were investigated using Western blot, immunohistochemistry and ELISA. Eleven women with endometriosis participated in a follow-up investigation of serum TNS1 before and after GnRHa treatment. Results: TNS1 mRNA (P = 0.006) and protein (P = 0.001) were significantly downregulated in endometriotic tissue from women with endometriosis who received GnRHa. Immunolocalization of TNS1 showed strong expression in the epithelial and stromal cells of endometriotic tissue from women untreated with GnRHa, whereas endometriotic tissue from GnRHa-treated women showed low TNS1 expression. Follow-up monitoring of serum TNS1 concentration in 11 women showed an average decrease in concentration of 53%, from 294.9 ± 66.69 to 140.3 ± 55.21 pg/mL, following GnRHa treatment (P = 0.003). Conclusions: GnRHa induces downregulation of TNS1 in tissue and serum in women with endometriosis. These results emphasize the importance TNS1 as a potential therapeutic molecular target for the treatment of endometriosis with GnRHa.
MeSH term(s)	Adult ; Down-Regulation ; Endometriosis/drug therapy ; Endometriosis/metabolism ; Endometriosis/pathology ; Endometrium/metabolism ; Endometrium/pathology ; Female ; Gonadotropin-Releasing Hormone/agonists ; Humans ; Immunohistochemistry ; RNA, Messenger/analysis ; Signal Transduction ; Taiwan ; Tensins/blood ; Tensins/metabolism
Chemical Substances	RNA, Messenger ; TNS1 protein, human ; Tensins ; Gonadotropin-Releasing Hormone (33515-09-2)
Language	English
Publishing date	2018-11-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80019-3
ISSN	1600-0412 ; 0001-6349
ISSN (online)	1600-0412
ISSN	0001-6349
DOI	10.1111/aogs.13481
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Article: Development of a molecularly imprinted polymer for selective extraction followed by liquid chromatographic determination of sitagliptin in rat plasma and urine

Rao, R. Nageswara / Maurya, Pawan K / Khalid, Sara

Talanta. 2011 Aug. 15, v. 85, no. 2

2011

Abstract: A novel water-compatible molecularly imprinted solid-phase extraction (MISPE) combined with zwitterionic hydrophilic interaction liquid chromatography (ZIC-HILIC) method for selective extraction and determination of sitagliptin in rat serum and urine was ...

Abstract	A novel water-compatible molecularly imprinted solid-phase extraction (MISPE) combined with zwitterionic hydrophilic interaction liquid chromatography (ZIC-HILIC) method for selective extraction and determination of sitagliptin in rat serum and urine was developed and validated. The effects of progenic solvents, pH, cross linker and amount of monomer were studied to optimize the efficiency and selectivity. The adsorption kinetics and isotherms were measured. The molecularly imprinted polymer (MIP) showed good specific adsorption capacity with an optimum of 180mg/g at pH 7.5 and selective extraction of sitagliptin from rat plasma and urine. The recovery of sitagliptin from rat urine and plasma was >98%. The limits of detection (LOD) and quantification (LOQ) were 0.03 and 0.10μg/L respectively. The proposed method overcomes the matrix effects of phospholipids generally encountered while preparation of plasma samples by precipitation of proteins.
Keywords	adsorption ; blood serum ; detection limit ; hydrophilic interaction chromatography ; molecular imprinting ; pH ; phospholipids ; polymers ; proteins ; rats ; solid phase extraction ; solvents ; urine ; zwitterions
Language	English
Dates of publication	2011-0815
Size	p. 950-957.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2011.05.002
Database	NAL-Catalogue (AGRICOLA)

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