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  1. Article ; Online: Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities

    Maxime Lecerf / Alexia Kanyavuz / Sofia Rossini / Jordan D. Dimitrov

    Communications Biology, Vol 4, Iss 1, Pp 1-

    2021  Volume 13

    Abstract: Lecerf et al. examine over 100 samples with variable region sequences matching clinical-stage immunoglobulin antibodies, to demonstrate that many interact with heme. They find that those that do interact with heme possess specific sequence traits that ... ...

    Abstract Lecerf et al. examine over 100 samples with variable region sequences matching clinical-stage immunoglobulin antibodies, to demonstrate that many interact with heme. They find that those that do interact with heme possess specific sequence traits that manifest qualities such as increased hydrophobicity, self-binding and intrinsic polyreactivity, thus suggesting that heme interaction is a predictor for therapeutically important qualities.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Oxidized hemoglobin triggers polyreactivity and autoreactivity of human IgG via transfer of heme

    Cyril Planchais / Remi Noe / Marie Gilbert / Maxime Lecerf / Srini V. Kaveri / Sébastien Lacroix-Desmazes / Lubka T. Roumenina / Jordan D. Dimitrov

    Communications Biology, Vol 6, Iss 1, Pp 1-

    2023  Volume 15

    Abstract: Oxidized hemoglobin induces polyreactivity and autoreactivity of human IgG through direct transfer and binding of heme to the variable region of IgG, which contributes to a better understanding of the physiopathology of hemolytic diseases. ...

    Abstract Oxidized hemoglobin induces polyreactivity and autoreactivity of human IgG through direct transfer and binding of heme to the variable region of IgG, which contributes to a better understanding of the physiopathology of hemolytic diseases.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  3. Article ; Online: Aromatic Guanylhydrazones for the Control of Heme-Induced Antibody Polyreactivity

    Nina Božinović / Vladimir Ajdačić / Jelena Lazic / Maxime Lecerf / Victoria Daventure / Jasmina Nikodinovic-Runic / Igor M. Opsenica / Jordan D. Dimitrov

    ACS Omega, Vol 4, Iss 24, Pp 20450-

    2019  Volume 20458

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2019-11-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Clinical and Autoimmune Profile of Scleroderma Patients from Western India

    Vandana Pradhan / Anjali Rajadhyaksha / Milind Nadkar / Pallavi Pandit / Prathamesh Surve / Maxime Lecerf / Jagadeesh Bayry / Srinivas Kaveri / Kanjaksha Ghosh

    International Journal of Rheumatology, Vol

    2014  Volume 2014

    Keywords Diseases of the musculoskeletal system ; RC925-935 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Cryptic polyreactivity of IgG expressed by splenic marginal zone B-cell lymphoma

    Mahendra, Ankit / Bagirath Gangadharan / Cyril Planchais / Frédéric Davi / Jordan D. Dimitrov / Maxime Lecerf / Myriam Boudjoghra / Sébastien André / Sébastien Lacroix-Desmazes / Srinivas V. Kaveri

    Molecular Immunology. 2014 July, v. 60

    2014  

    Abstract: Polyreactive antibodies represent a significant fraction of immune repertoires and play an important role in the immune defense and immune homeostasis. Polyreactive B-cell receptors (BCR), however, are frequently expressed by B-cell lymphomas. It was ... ...

    Abstract Polyreactive antibodies represent a significant fraction of immune repertoires and play an important role in the immune defense and immune homeostasis. Polyreactive B-cell receptors (BCR), however, are frequently expressed by B-cell lymphomas. It was suggested that polyreactive BCR on lymphoma cells might deliver stimulation signals by binding to various endogenous or exogenous antigens, thus promoting the survival of the malignant cells. In addition to natural polyreactive antibodies, immune repertoires contain antibodies that acquire polyreactivity after exposure to different redox-active substances such as reactive oxygen species, iron ions and heme. Here, we demonstrate that an antibody cloned from a patient's splenic marginal zone B-cell lymphoma acquires physiologically relevant binding affinity to various autoantigens following exposure to heme. We elucidated the mechanisms underlying polyreactive antigen binding. The results obtained in this study imply that antigen-binding receptors expressed on some malignant cells acquire polyreactivity after exposure to redox substances that are released at sites of inflammation or as a result of cellular damage. The acquisition of novel BCR specificities under hemolytic or inflammatory conditions may play an important role in the physiopathology of certain B-cell malignancies.
    Keywords antibodies ; autoantigens ; binding capacity ; B-lymphocytes ; heme ; homeostasis ; immune response ; immunoglobulin G ; inflammation ; ions ; lymphoma ; neoplasm cells ; pathophysiology ; patients ; reactive oxygen species ; receptors
    Language English
    Dates of publication 2014-07
    Size p. 54-61.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 424427-8
    ISSN 1872-9142 ; 0161-5890
    ISSN (online) 1872-9142
    ISSN 0161-5890
    DOI 10.1016/j.molimm.2014.03.009
    Database NAL-Catalogue (AGRICOLA)

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