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  1. AU="Maxime Mermod"
  2. AU="Asrani, R K"
  3. AU=Cook Daniel C
  4. AU=Clark T G
  5. AU="Batina, Nikola"
  6. AU="Busche, Jacob A"
  7. AU="Quaresima, Luigi"
  8. AU="Arnaud Gautier"
  9. AU="Leary Peter"
  10. AU="Currò, Mariaconcetta"
  11. AU=Schulte Ryan T
  12. AU=Wichmann D
  13. AU="Arora, Prateek"
  14. AU="Junqueira, Helena Couto"
  15. AU="Kataria, Saurabh"
  16. AU=Wang Xia AU=Wang Xia
  17. AU="Tonnesen, Morten"
  18. AU="Ebrahimi-Fakhari, Darius"
  19. AU="Kalinich, Chaney C"
  20. AU="O'Neal, David N"
  21. AU="Bennett, Matthew R"
  22. AU="Chagas, Mariana W"

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  1. Artikel ; Online: Rosai-Dorfman disease presenting as stridor and hoarseness in a young female patient

    Vivianne Kokje, MD, PhD / Claudio De Vito, MD, PhD / Flavia Costa Varela, MD / Yan Monnier, MD, PhD / Nicolas Dulguerov, MD / Minerva Becker, MD / Maxime Mermod, MD, PhD

    Radiology Case Reports, Vol 18, Iss 2, Pp 591-

    2023  Band 595

    Abstract: Rosai-Dorfman disease is a non-Langherans cell histiocytosis typically revealed by lymphadenopathy. Extranodal involvement occurs in 43% and most commonly involves the head and neck, skin, and bones. Few reports have described laryngeal lesions. We ... ...

    Abstract Rosai-Dorfman disease is a non-Langherans cell histiocytosis typically revealed by lymphadenopathy. Extranodal involvement occurs in 43% and most commonly involves the head and neck, skin, and bones. Few reports have described laryngeal lesions. We report the case of a Rosai-Dorfman disease in a 27-year-old female, presenting as an obstructing transglottic mass. We provide the results of the MRI and PET-scanner examination. As the treatment relies on surgical excision and the diagnosis depends on pathological examination, we also detail the analysis results that followed the surgical resection. This report highlights the necessity to consider Rosai-Dorfman disease as a potential diagnosis in case of a laryngeal submucosal mass.
    Schlagwörter Rosai-Dorfman disease ; Larynx ; Head and neck ; Magnetic resonance imaging ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Sprache Englisch
    Erscheinungsdatum 2023-02-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Cellular Barcoding Identifies Clonal Substitution as a Hallmark of Local Recurrence in a Surgical Model of Head and Neck Squamous Cell Carcinoma

    Vincent Roh / Pierre Abramowski / Agnès Hiou-Feige / Kerstin Cornils / Jean-Paul Rivals / Alexandre Zougman / Tim Aranyossy / Lars Thielecke / Zinnia Truan / Maxime Mermod / Yan Monnier / Vladimir Prassolov / Ingmar Glauche / Ali Nowrouzi / Amir Abdollahi / Boris Fehse / Christian Simon / Genrich V. Tolstonog

    Cell Reports, Vol 25, Iss 8, Pp 2208-2222.e

    2018  Band 7

    Abstract: Summary: Local recurrence after surgery for head and neck squamous cell carcinoma (HNSCC) remains a common event associated with a dismal prognosis. Improving this outcome requires a better understanding of cancer cell populations that expand from ... ...

    Abstract Summary: Local recurrence after surgery for head and neck squamous cell carcinoma (HNSCC) remains a common event associated with a dismal prognosis. Improving this outcome requires a better understanding of cancer cell populations that expand from postsurgical minimal residual disease (MRD). Therefore, we assessed clonal dynamics in a surgical model of barcoded HNSCC growing in the submental region of immunodeficient mice. Clonal substitution and massive reduction of clonal heterogeneity emerged as hallmarks of local recurrence, as the clones dominating in less heterogeneous recurrences were scarce in their matched primary tumors. These lineages were selected by their ability to persist after surgery and competitively expand from MRD. Clones enriched in recurrences exhibited both private and shared genetic features and likely originated from ancestors shared with clones dominating in primary tumors. They demonstrated high invasiveness and epithelial-to-mesenchymal transition, eventually providing an attractive target for obtaining better local control for these tumors. : Roh et al. combine fluorescent protein marking and cellular barcoding to investigate the clonal composition of matched primary and recurrent tumors in a surgical model of HNSCC. They demonstrate that clones present in primary tumors are substituted by other initially rare clones expanding after resection. Keywords: head and neck squamous cell carcinoma, clonal heterogeneity, clonal substitution, recurrent tumor-initiating clones, epithelial-mesenchymal transition, invasion, RGB marking, DNA barcoding, LeGO vectors
    Schlagwörter Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2018-11-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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