Article ; Online: Germline STAT3 gain-of-function mutations in primary immunodeficiency
Biomedical Journal, Vol 44, Iss 4, Pp 412-
Impact on the cellular and clinical phenotype
2021 Volume 421
Abstract: Signal transducer and activator of transcription 3 (STAT3) is a key transcription factor involved in regulation of immune cell activation and differentiation. Recent discoveries highlight the role of germline activating STAT3 mutations in inborn errors ... ...
Abstract | Signal transducer and activator of transcription 3 (STAT3) is a key transcription factor involved in regulation of immune cell activation and differentiation. Recent discoveries highlight the role of germline activating STAT3 mutations in inborn errors of immunity characterized by early-onset multi-organ autoimmunity and lymphoproliferation. Much progress has been made in defining the clinical spectrum of STAT3 GOF disease and unraveling the molecular and cellular mechanisms underlying this disease. In this review, we summarize our current understanding of the disease and discuss the clinical phenotype, diagnostic approach, cellular and molecular effects of STAT3 GOF mutations and therapeutic concepts for these patients. |
---|---|
Keywords | STAT3 GOF ; Inborn errors of immunity ; Autoimmunity ; T cell ; Lymphoproliferation ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5 |
Language | English |
Publishing date | 2021-08-01T00:00:00Z |
Publisher | Elsevier |
Document type | Article ; Online |
Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
Full text online
More links
Kategorien
Inter-library loan at ZB MED
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.