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  1. Article: Resect a little, resect more, irradiate or ablate-what is the best approach?

    Maxwell, Conor M / Fernando, Hiran C

    Journal of thoracic disease

    2022  Volume 14, Issue 9, Page(s) 3108–3110

    Language English
    Publishing date 2022-08-19
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd-22-1099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Stereotactic Body Radiation Therapy Versus Ablation Versus Surgery for Early-Stage Lung Cancer in High-Risk Patients.

    Maxwell, Conor M / Ng, Calvin / Fernando, Hiran C

    Thoracic surgery clinics

    2023  Volume 33, Issue 2, Page(s) 179–187

    Abstract: Current treatment for early-stage lung cancer focuses on surgical intervention as the mainstay of treatment; however, this poses issues in patients that are high-risk or unable to tolerate any operation. In this case, sublobar resection or radiation ... ...

    Abstract Current treatment for early-stage lung cancer focuses on surgical intervention as the mainstay of treatment; however, this poses issues in patients that are high-risk or unable to tolerate any operation. In this case, sublobar resection or radiation therapy has been the primary treatment for these subsets of patients. Alternative approaches include stereotactic body radiation therapy (SBRT) and thermal ablation. In this article, we focus on treatment strategies using SBRT, thermal ablation, or surgery as it pertains to high-risk patients with early-stage lung cancer.
    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; Carcinoma, Non-Small-Cell Lung/surgery ; Carcinoma, Non-Small-Cell Lung/pathology ; Lung Neoplasms/radiotherapy ; Lung Neoplasms/surgery ; Lung Neoplasms/pathology ; Radiosurgery ; Pneumonectomy ; Neoplasm Staging
    Language English
    Publishing date 2023-02-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2149218-9
    ISSN 1558-5069 ; 1547-4127
    ISSN (online) 1558-5069
    ISSN 1547-4127
    DOI 10.1016/j.thorsurg.2023.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Intercostal Cryoablation During Video-Assisted Lung Resection Can Decrease Postoperative Opioid Use.

    Maxwell, Conor M / Weksler, Benny / Houda, Joseph / Fernando, Hiran C

    Innovations (Philadelphia, Pa.)

    2023  Volume 18, Issue 4, Page(s) 352–356

    Abstract: Objective: Pain requiring opioid use remains an issue even with minimally invasive thoracic surgery. The objective of this study was to investigate the effectiveness of intercostal nerve cryoablation (CRYO) for pain control in adult patients undergoing ... ...

    Abstract Objective: Pain requiring opioid use remains an issue even with minimally invasive thoracic surgery. The objective of this study was to investigate the effectiveness of intercostal nerve cryoablation (CRYO) for pain control in adult patients undergoing pulmonary resection.
    Methods: A retrospective analysis of patients undergoing pulmonary resection by uniportal video-assisted thoracic (uVATS) approach was undertaken. Patients treated with our usual pain regimen (STANDARD) were compared with those who additionally received CRYO. STANDARD includes intercostal bupivacaine, patient-controlled analgesia (24 h), ketorolac (48 to 72 h), and tramadol. Intraoperative CRYO was performed on 5 intercostal levels. The primary aim was to compare pain scores (range, 0 to 10) and morphine equivalent dosages (MED). Secondary outcomes included length of stay, chest tube duration, presence of an air leak, and adverse events. A
    Results: There were 49 patients (34 female, 15 male). The median age was 74 (37 to 90) years. Procedures included lobectomy (
    Conclusions: CRYO can be performed safely during pulmonary resection and can decrease in-hospital opioid use. The results from this retrospective study will need to be validated in future prospective studies.
    MeSH term(s) Adult ; Humans ; Male ; Female ; Aged ; Analgesics, Opioid/therapeutic use ; Pain, Postoperative/drug therapy ; Pain, Postoperative/prevention & control ; Retrospective Studies ; Cryosurgery/adverse effects ; Thoracic Surgery, Video-Assisted/adverse effects ; Thoracic Surgery, Video-Assisted/methods ; Lung
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2023-07-17
    Publishing country United States
    Document type Journal Article
    ISSN 1559-0879
    ISSN (online) 1559-0879
    DOI 10.1177/15569845231185583
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Minimally Invasive Hepatopancreatobiliary Surgery at a Large Regional Health System: Assessing the Safety of Program Expansion.

    Falls, Samantha J / Maxwell, Conor M / Kaye, Dylan J / Dighe, Shruti G / Schiffman, Suzanne C / Bartlett, David L / Wagner, Patrick L / Allen, Casey J

    The American surgeon

    2023  Volume 90, Issue 1, Page(s) 85–91

    Abstract: Background: Complex, minimally invasive hepatopancreatobiliary surgery (MIS HPB) is safe at high-volume centers, yet outcomes during early implementation are unknown. We describe our experience during period of rapid growth in an MIS HPB program at a ... ...

    Abstract Background: Complex, minimally invasive hepatopancreatobiliary surgery (MIS HPB) is safe at high-volume centers, yet outcomes during early implementation are unknown. We describe our experience during period of rapid growth in an MIS HPB program at a large regional health system.
    Methods: During an increase in MIS HPB (60% greater from preceding year), hospital records of patients who underwent HPB surgery between 1/1/2019 and 12/31/2020 were reviewed. Operative time, estimated blood loss (EBL), conversion rates, length of stay (LOS), and perioperative outcomes were assessed.
    Results: 267 patients' cases were reviewed. The population was 62 ± 13 years, 50% female, 90% white. MIS was more frequently performed for hepatic than pancreatic resections (59% vs 21%,
    Discussion: During a surgical expansion phase within our regional health system, MIS HPB offered improved perioperative outcomes when compared to open surgery. These data support the safety of implementation even during intervals of rapid programmatic growth.
    MeSH term(s) Humans ; Female ; Male ; Liver/surgery ; Hepatectomy ; Pancreatectomy ; Length of Stay ; Pancreas/surgery ; Minimally Invasive Surgical Procedures ; Retrospective Studies
    Language English
    Publishing date 2023-08-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 202465-2
    ISSN 1555-9823 ; 0003-1348
    ISSN (online) 1555-9823
    ISSN 0003-1348
    DOI 10.1177/00031348231192073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Socioeconomic Factors Predict Long-Term Quality of Life of Cancer Survivors: An International Survey.

    Maxwell, Conor M / Bhat, Akash / Falls, Samantha J / Yin, Yue / Wagner, Patrick L / Bartlett, David L / Allen, Casey J

    The Journal of surgical research

    2023  Volume 293, Page(s) 389–395

    Abstract: Introduction: Despite advances in cancer treatment, the quality of life (QOL) of survivors varies significantly. We assessed the correlation between socioeconomic factors and long-term QOL in a global cohort of cancer survivors.: Materials and methods! ...

    Abstract Introduction: Despite advances in cancer treatment, the quality of life (QOL) of survivors varies significantly. We assessed the correlation between socioeconomic factors and long-term QOL in a global cohort of cancer survivors.
    Materials and methods: Patients were offered surveys via online support groups. Using the Short Form-12 validated questionnaire, physical QOL (PQOL) and mental QOL (MQOL) well-being were compared to the general population. Socioeconomic factors were assessed with regression analysis for impact on QOL.
    Results: Seven hundred eighty two survivors from six continents responded. They were 57 ± 13 y and 68% female, 90.8% White, with 43 distinct cancer diagnoses. All survivors had PQOL and MQOL scores lower than the general population. Lower education level, household income, and non-White race all correlated with reduced PQOL and/or MQOL. Age was negatively correlated with PQOL (r = -0.08, P = 0.03) and positively correlated with MQOL (r = 0.142, P < 0.001). Care at large regional/academic centers was associated with higher MQOL (42 ± 14 versus 38 ± 11, P = 0.005). Age (β = -0.1, P = 0.04), education (β = 1.1, P = 0.005), and income (β = 2.0, P < 0.001) were predictors of PQOL, while age (β = 0.2, P < 0.001), income (β = 1.7, P = 0.002), and community hospital care (β = -3.6, P = 0.013) were predictors of MQOL.
    Conclusions: In a large international survey of cancer survivors, we identified socioeconomic factors and their associations with QOL. Further work should be directed to provide durable support across all socioeconomic classes.
    MeSH term(s) Humans ; Female ; Male ; Quality of Life ; Cancer Survivors ; Socioeconomic Factors ; Surveys and Questionnaires ; Income ; Neoplasms/therapy
    Language English
    Publishing date 2023-10-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80170-7
    ISSN 1095-8673 ; 0022-4804
    ISSN (online) 1095-8673
    ISSN 0022-4804
    DOI 10.1016/j.jss.2023.09.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Comprehensive value implications of surgeon volume for lung cancer surgery: Use of an analytic framework within a regional health system.

    Maxwell, Conor M / Bhat, Akash M / Falls, Samantha J / Bigbee, Matthew / Yin, Yue / Chalikonda, Sricharan / Bartlett, David L / Fernando, Hiran C / Allen, Casey J

    JTCVS open

    2023  Volume 17, Page(s) 286–294

    Abstract: Objective: We used a framework to assess the value implications of thoracic surgeon operative volume within an 8-hospital health system.: Methods: Surgical cases for non-small cell lung cancer were assessed from March 2015 to March 2021. High-volume ( ...

    Abstract Objective: We used a framework to assess the value implications of thoracic surgeon operative volume within an 8-hospital health system.
    Methods: Surgical cases for non-small cell lung cancer were assessed from March 2015 to March 2021. High-volume (HV) surgeons performed >25 pulmonary resections annually. Metrics include length of stay, infection rates, 30-day readmission, in-hospital mortality, median 30-day charges and direct costs, and 3-year recurrence-free and overall survival. Multivariate regression-based propensity scores matched patients between groups. Metrics were graphed on radar charts to conceptualize total value.
    Results: All 638 lung resections were performed by 12 surgeons across 6 hospitals. Two HV surgeons performed 51% (n = 324) of operations, and 10 low-volume surgeons performed 49% (n = 314). Median follow-up was 28.8 months (14.0-42.3 months). Lobectomy was performed in 71% (n = 450) of cases. HV surgeons performed more segmentectomies (33% [n = 107] vs 3% [n = 8];
    Conclusions: HV surgeons provide comprehensive value across a health system. This multidomain framework can be used to help drive oncologic care decisions within a health system.
    Language English
    Publishing date 2023-11-24
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-2736
    ISSN (online) 2666-2736
    DOI 10.1016/j.xjon.2023.11.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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