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  1. Article: [No title information]

    Mayer, Beate

    Transfusionsmedizin

    2023  Volume 13, Issue 02, Page(s) 88–101

    Abstract: Die medikamentös induzierte Immunhämolyse stellt eine seltene, häufig fulminant und immer wieder letal verlaufende Sonderform der autoimmunhämolytischen Anämie dar. Sie ist wenig bekannt und ... ...

    Abstract Die medikamentös induzierte Immunhämolyse stellt eine seltene, häufig fulminant und immer wieder letal verlaufende Sonderform der autoimmunhämolytischen Anämie dar. Sie ist wenig bekannt und wird häufig übersehen. Dieser Beitrag stellt die Besonderheiten des Krankheitsbildes inkl. wesentlicher Aspekte zur Pathogenese, Klinik, Diagnostik und Therapie vor und zeigt, welche Medikamente häufig eine Immunhämolyse auslösen können.
    Keywords medikamentös induzierte Hämolysen ; medikamentenabhängige Antikörper ; intravasale Hämolyse ; erythrozytäre Autoantikörper ; drug-induced hemolysis ; drug-dependent antibodies ; intravascular hemolysis ; autoantibodies
    Language German
    Publishing date 2023-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2599278-8
    ISSN 2191-8813 ; 2191-8805
    ISSN (online) 2191-8813
    ISSN 2191-8805
    DOI 10.1055/a-1970-2938
    Database Thieme publisher's database

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  2. Book ; Online ; Thesis: Neue Aspekte zur Ätiologie und Diagnostik medikamentös induzierter Immunhämolysen

    Mayer, Beate [Verfasser]

    2022  

    Author's details Beate Mayer
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Medizinische Fakultät Charité - Universitätsmedizin Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
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  3. Article ; Online: Three different pathways of IgM-antibody-dependent hemolysis are mainly regulated by complement.

    Bartolmäs, Thilo / Pruß, Axel / Mayer, Beate

    Frontiers in immunology

    2023  Volume 14, Page(s) 1114509

    Abstract: Antibodies to red blood cells (RBCs) may hemolyze ... ...

    Abstract Antibodies to red blood cells (RBCs) may hemolyze erythrocytes
    MeSH term(s) Humans ; Hemolysis ; Immunoglobulin M ; Anemia, Hemolytic, Autoimmune ; Erythrocytes ; Complement System Proteins
    Chemical Substances Immunoglobulin M ; Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2023-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1114509
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  4. Article ; Online: Presence of anti-RBC antibodies correlates with parasitaemia and once-infected RBCs but not the extent of post-malaria haemolysis.

    Tober-Lau, Pinkus / Kneller, Anna Karolina / Lingscheid, Tilman / Mayer, Beate / Zoller, Thomas / Kurth, Florian

    Journal of travel medicine

    2024  

    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1212504-0
    ISSN 1708-8305 ; 1195-1982
    ISSN (online) 1708-8305
    ISSN 1195-1982
    DOI 10.1093/jtm/taae045
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  5. Book ; Thesis: Geschlechtsspezifische Unterschiede der Eckzahnbreite und ihrer Relation zur Interkuspidatdistanz

    Mayer, Beate

    1992  

    Author's details vorgelegt von Beate Mayer
    Size 1 Mikrofiche
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Münster (Westfalen), Univ., Diss., 1992
    Note Manuskript: 55, [12] Bl. : graph. Darst.
    HBZ-ID HT004502147
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1993 MB 519 order for loan Magazin

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  6. Book ; Thesis: Der Spontanverlauf isochroner und metachroner Lebermetastasen beim Coloncarcinom

    Mayer, Beate

    1989  

    Author's details vorgelegt von Beate Mayer
    Size 1 Mikrofiche : 24x
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Mainz, Univ., Diss., 1989
    Note Mikroreprod. e. Ms.: 91 Bl. : graph. Darst.
    HBZ-ID HT003684515
    Database Catalogue ZB MED Medicine, Health

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    1991 MB 703 order for loan Magazin

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  7. Article: Frühe und schwer verlaufende hämolytische Erkrankung des Fetus und Neugeborenen

    Mayer, Beate / Weichert, Alexander

    Transfusionsmedizin - Immunhämatologie · Hämotherapie · Transplantationsimmunologie · Zelltherapie

    2020  Volume 10, Issue 02, Page(s) 89–93

    Abstract: Eine schwere Alloimmunisierung der Schwangeren gegen erythrozytäre Blutgruppenmerkmale kann insbesondere bei Antikörpern der Spezifität Anti-K bereits vor der 20. Schwangerschaftswoche zu einer fetalen Anämie führen. Wir berichten über eine 37-jährige ... ...

    Abstract Eine schwere Alloimmunisierung der Schwangeren gegen erythrozytäre Blutgruppenmerkmale kann insbesondere bei Antikörpern der Spezifität Anti-K bereits vor der 20. Schwangerschaftswoche zu einer fetalen Anämie führen. Wir berichten über eine 37-jährige Schwangere (Gravida 6, Para 5) mit bekanntem Anti-K. In der Vorgeschichte kam es aufgrund einer K-Inkompatibilität in der 4. Schwangerschaft in der 34. Schwangerschaftswoche (SSW) zu einem Hydrops fetalis und in der 5. Schwangerschaft in der 22. SSW zu einem intrauterinen Fruchttod. Mittels eines nicht invasiven Pränataltests (NIPT) wurde in der aktuellen Schwangerschaft erneut ein K-positiver Fetus bestätigt. Aufgrund der Vorgeschichte erfolgte eine prophylaktische hochdosierte i. v. Immunglobulingabe (IVIG) (1 g/kgKG/Woche) ab der 14. SSW. In der 29 + 1 SSW war bei beginnender fetaler Anämie eine intrauterine Transfusion (IUT) erforderlich. Der weitere Schwangerschaftsverlauf gestaltete sich unter Fortführung der wöchentlichen IVIG-Therapie unauffällig. Das Kind kam in der 40 + 2 SSW durch Spontangeburt zur Welt. Bei positivem direktem Coombs-Test ließ sich im Eluat das mütterliche Anti-K nachweisen. Postpartal kam es bei dem Neugeborenen nur zu einem leichten Abfall der Hämoglobinkonzentration von 11,7 auf 9,5 g/dl. Eine Therapie war nicht erforderlich.
    Keywords hochdosierte intravenöse Immunglobulingabe ; therapeutische Plasmapherese ; erythrozytäre Alloimmunisierung in der Schwangerschaft ; intrauteriner Kindstod ; high-dose intravenous immunoglobulins ; therapeutic plasmapheresis ; RBC alloimmunization in pregnancy ; fetal loss
    Language German
    Publishing date 2020-05-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2599278-8
    ISSN 2191-8813 ; 2191-8805
    ISSN (online) 2191-8813
    ISSN 2191-8805
    DOI 10.1055/a-0972-6307
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  8. Article ; Online: A fluorometric erythrophagocytosis assay using differentiated monocytic THP-1 cells to assess the clinical significance of antibodies to red blood cells.

    Balola, Abdelwahab Hassan Ahmed / Mayer, Beate / Bartolmäs, Thilo / Salama, Abdulgabar

    Vox sanguinis

    2021  Volume 116, Issue 10, Page(s) 1106–1116

    Abstract: Background and objectives: The significance of antibodies to red blood cells (RBCs) is variable and cannot be predicted solely by serological testing. A flow cytometry-based erythrophagocytosis assay was established using phorbol 12-myristate 13-acetate ...

    Abstract Background and objectives: The significance of antibodies to red blood cells (RBCs) is variable and cannot be predicted solely by serological testing. A flow cytometry-based erythrophagocytosis assay was established using phorbol 12-myristate 13-acetate (PMA)-treated THP-1 cells and RBCs labelled with PKH26 to assess allo- and autoantibodies to RBCs.
    Materials and methods: THP-1 cells were differentiated into macrophage-like cells by treatment with PMA. RBC samples coated with alloantibodies or autoantibodies were obtained from 16 patients with autoimmune haemolytic anaemia of warm type (wAIHA) as well as from five pregnant women with warm autoantibodies. RBCs from healthy blood donors were used as controls. RBCs were labelled with the red lipophilic fluorescent dye PKH26 and incubated with PMA-treated THP-1 cells. After removal of nonadherent RBCs by washing and haemolysis of adherent RBCs, erythrophagocytosis was quantified by flow cytometry.
    Results: We observed significant phagocytosis of RBCs coated with clinically relevant alloantibodies (i.e. anti-D and anti-K) or autoantibodies from patients with active wAIHA, but not of those coated with alloantibodies (anti-Ch) or autoantibodies from patients and pregnant women without haemolysis.
    Conclusion: The flow cytometry-based erythrophagocytosis test described here is quantitative, highly reliable, and may be helpful for the assessment of the clinical significance of antibodies to RBCs.
    MeSH term(s) Anemia, Hemolytic, Autoimmune ; Autoantibodies ; Erythrocytes ; Female ; Humans ; Monocytes ; Phagocytosis ; Pregnancy ; THP-1 Cells
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2021-05-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 80313-3
    ISSN 1423-0410 ; 0042-9007
    ISSN (online) 1423-0410
    ISSN 0042-9007
    DOI 10.1111/vox.13105
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  9. Article ; Online: Silvernanoparticle-induced hemolysis confounded with direct antiglobulin test-negative autoimmune hemolytic anemias diagnosis.

    Ringel, Frauke / Kiesewetter, Holger / Mayer, Beate / Bartolmäs, Thilo / Sehouli, Jalid / Salama, Abdulgabar

    Transfusion

    2022  Volume 62, Issue 12, Page(s) 2648–2652

    Abstract: Background: We describe here the first patient with recurrent hemolysis related to disinfectant containing silver nanoparticles (AgNps).: Methods: A 58-year-old chemist repeatedly experienced DAT-negative (Coombs-negative) hemolysis during the last 5  ...

    Abstract Background: We describe here the first patient with recurrent hemolysis related to disinfectant containing silver nanoparticles (AgNps).
    Methods: A 58-year-old chemist repeatedly experienced DAT-negative (Coombs-negative) hemolysis during the last 5 years. He was treated with a number of immunosuppressive drugs including 18 times rituximab. The attempt to treat him with cyclosporine A served only to increase the rate of hemolysis. Only by chance, we revealed that the patient regularly used a hand disinfectant containing AgNps. Serological testing was performed using standard techniques. Eryptosis was measured by binding annexin to exposed phosphatidylserine (PS) of the circulating red blood cells (RBCs).
    Results: Antiglobulin tests remained negative, and PS exposing RBCs were detected two times during the last hemolytic episodes. Hemolysis completely disappeared following discontinuation of AgNp containing products.
    Conclusion: AgNps are increasingly being used in a large variety of products. Recently, it was reported that they induce in vitro prohemolytic and procoagulant effects via oxidative stress and eryptosis. The clinical findings imply the hemolysis was provoked by the patient's regular use of cleansing products containing AgNps. Our finding might help to explain the etiology of hemolytical disorders that may remain obscure in many cases.
    MeSH term(s) Humans ; Middle Aged ; Anemia, Hemolytic, Autoimmune/chemically induced ; Anemia, Hemolytic, Autoimmune/diagnosis ; Coombs Test ; Metal Nanoparticles/adverse effects ; Silver/adverse effects
    Chemical Substances Silver (3M4G523W1G)
    Language English
    Publishing date 2022-11-03
    Publishing country United States
    Document type Case Reports
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.17172
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  10. Article ; Online: Successful treatment of bleeding with tranexamic acid in a series of 12 patients with immune thrombocytopenia.

    Mayer, Beate / Salama, Abdulgabar

    Vox sanguinis

    2017  Volume 112, Issue 8, Page(s) 767–772

    Abstract: Background and objectives: The clinical significance of immune thrombocytopenia (ITP) is mainly reflected by bleeding and/or bleeding risks, which, in some cases, cannot be adequately controlled by standard therapy. Tranexamic acid (TA) is increasingly ... ...

    Abstract Background and objectives: The clinical significance of immune thrombocytopenia (ITP) is mainly reflected by bleeding and/or bleeding risks, which, in some cases, cannot be adequately controlled by standard therapy. Tranexamic acid (TA) is increasingly used in preventing and reducing bleeding in several medical settings. There is little information on whether TA may also be useful in the management of ITP.
    Materials and methods: Twelve patients with ITP were treated with TA (0·5-3 g/day) due to recognizable bleeding. Ten of the 12 patients were under regular treatment for ITP. The remaining two patients did not require additional therapy.
    Results: Cessation or, at least, significant improvement of bleeding was achieved shortly after the initiation of TA in all cases. TA was well tolerated and discontinued after cessation of bleeding.
    Conclusions: We recommend the use of TA in ITP patients with bleeding and/or an increased bleeding risk. Ultimately, cessation of bleeding plays a key role in the management of such affected patients. However, future studies are required to optimize dose and administration routes (intravenous or oral).
    Language English
    Publishing date 2017-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 80313-3
    ISSN 1423-0410 ; 0042-9007
    ISSN (online) 1423-0410
    ISSN 0042-9007
    DOI 10.1111/vox.12549
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