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  1. Book ; Thesis: Vergleich der Expression von ERCC1 und TS zwischen Adenokarzinom und Plattenepithelkarzinom im Primärtumor und der dazugehörigen Metastasen des Lungenkarzinoms

    Mayer, Christiane

    2018  

    Author's details vorgelegt von Christiane Mayer
    Language German
    Size X, 84 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Hannover
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Medizinische Hochschule Hannover, 2018
    HBZ-ID HT019891526
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2018 E 1459 order for loan Magazin

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  2. Book ; Online ; E-Book: Wie in der Psychotherapie Lösungen entstehen

    Mayer, Christian

    ein Prozessmodell mit Anregungen aus der Literatur- und Filmwissenschaft

    2017  

    Author's details von Christian Mayer
    Keywords Psychology ; Psychotherapy ; Counseling
    Subject code 616.8914
    Language German
    Size 1 Online-Ressource (VI, 200 Seiten), Illustrationen
    Publisher Springer Fachmedien Wiesbaden
    Publishing place Wiesbaden
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019441177
    ISBN 978-3-658-13865-3 ; 9783658138646 ; 3-658-13865-3 ; 3658138645
    DOI 10.1007/978-3-658-13865-3
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Putting Purpose Into Practice : The Economics of Mutuality

    Mayer, Colin / Roche, Bruno

    2021  

    Keywords Business ethics & social responsibility ; Business strategy ; Organizational theory & behaviour ; purpose, practice, mutuality, performance, ecosystems, partnerships, measurement
    Size 1 electronic resource (432 pages)
    Publisher Oxford University Press
    Publishing place Oxford
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021048768
    ISBN 9780198870708 ; 0198870701
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book ; Thesis: Neurodegeneration and subtype-specific susceptibilty of alpha retinal ganglion cells in autoimmune optic neuritis

    Mayer, Christina

    2021  

    Author's details vorgelegt von Christina Sabina Valeska Mayer
    Language English
    Size X, 130 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2021
    HBZ-ID HT021132482
    Database Catalogue ZB MED Medicine, Health

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    2021 E 1366 order for loan Magazin

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  5. Article: Genome-Wide Computational Analysis of Musa Microsatellites: Classification, Cross-Taxon Transferability, Functional Annotation, Association with Transposons & miRNAs, and Genetic Marker Potential

    Mayer, Christoph

    PLOS ONE, 10(6):e0131312

    2015  

    Abstract: The development of organized, informative, robust, user-friendly, and freely accessible molecular markers is imperative to the Musa marker assisted breeding program. Although several hundred SSR markers have already been developed, the number of ... ...

    Institution Zoologisches Forschungsmuseum Alexander Koenig
    Abstract The development of organized, informative, robust, user-friendly, and freely accessible molecular markers is imperative to the Musa marker assisted breeding program. Although several hundred SSR markers have already been developed, the number of informative, robust, and freely accessible Musa markers remains inadequate for some breeding applications. In view of this issue, we surveyed SSRs in four different data sets, developed large-scale non-redundant highly informative therapeutic SSR markers, and classified them according to their attributes, as well as analyzed their cross-taxon transferability and utility for the genetic study of Musa and its relatives. A high SSR frequency (177 per Mbp) was found in the Musa genome. AT-rich dinucleotide repeats are predominant, and trinucleotide repeats are the most abundant in transcribed regions. A significant number of Musa SSRs are associated with pre-miRNAs, and 83% of these SSRs are promising candidates for the development of therapeutic SSR markers. Overall, 74% of the SSR markers were polymorphic, and 94% were transferable to at least one Musa spp. Two hundred forty-three markers generated a total of 1047 alleles, with 2-8 alleles each and an average of 4.38 alleles per locus. The PIC values ranged from 0.31 to 0.89 and averaged 0.71. We report the largest set of non-redundant, polymorphic, new SSR markers to be developed in Musa. These additional markers could be a valuable resource for marker-assisted breeding, genetic diversity and genomic studies of Musa and related species.
    Keywords Animal genomics ; Bananas ; Genome analysis ; MicroRNAs ; Microsatellite loci ; Sequence motif analysis ; Polymerase chain reaction ; Plants
    Language English
    Document type Article
    Database Repository for Life Sciences

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  6. Article: Automatic selection of partitioning schemes for phylogenetic analyses using iterative k-means clustering of site rates

    Mayer, Christoph

    BMC evolutionary biology, 15:13

    2015  

    Abstract: BACKGROUND: Model selection is a vital part of most phylogenetic analyses, and accounting for the heterogeneity in evolutionary patterns across sites is particularly important. Mixture models and partitioning are commonly used to account for this ... ...

    Institution Zoologisches Forschungsmuseum Alexander Koenig
    Abstract BACKGROUND: Model selection is a vital part of most phylogenetic analyses, and accounting for the heterogeneity in evolutionary patterns across sites is particularly important. Mixture models and partitioning are commonly used to account for this variation, and partitioning is the most popular approach. Most current partitioning methods require some a priori partitioning scheme to be defined, typically guided by known structural features of the sequences, such as gene boundaries or codon positions. Recent evidence suggests that these a priori boundaries often fail to adequately account for variation in rates and patterns of evolution among sites. Furthermore, new phylogenomic datasets such as those assembled from ultra-conserved elements lack obvious structural features on which to define a priori partitioning schemes. The upshot is that, for many phylogenetic datasets, partitioned models of molecular evolution may be inadequate, thus limiting the accuracy of downstream phylogenetic analyses. RESULTS: We present a new algorithm that automatically selects a partitioning scheme via the iterative division of the alignment into subsets of similar sites based on their rates of evolution. We compare this method to existing approaches using a wide range of empirical datasets, and show that it consistently leads to large increases in the fit of partitioned models of molecular evolution when measured using AICc and BIC scores. In doing so, we demonstrate that some related approaches to solving this problem may have been associated with a small but important bias. CONCLUSIONS: Our method provides an alternative to traditional approaches to partitioning, such as dividing alignments by gene and codon position. Because our method is data-driven, it can be used to estimate partitioned models for all types of alignments, including those that are not amenable to traditional approaches to partitioning.
    Keywords Clustering ; K-means ; Model selection ; Partitionfinder ; Partitioning ; Phylogenetics ; Phylogenomics ; UCE’s ; Ultra-conserved elements
    Language English
    Document type Article
    Database Repository for Life Sciences

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  7. Article: Regional differentiation and extensive hybridization between mitochondrial clades of the Southern Ocean giant sea spider Colossendeis megalonyx

    Mayer, Christoph

    Royal Society Open Science, 2:140424

    2015  

    Abstract: Assessing the enormous diversity of Southern Ocean benthic species and their evolutionary histories is a central task in the era of global climate change. Based on mitochondrial markers, it was recently suggested that the circumpolar giant sea spider ... ...

    Institution Zoologisches Forschungsmuseum Alexander Koenig
    Abstract Assessing the enormous diversity of Southern Ocean benthic species and their evolutionary histories is a central task in the era of global climate change. Based on mitochondrial markers, it was recently suggested that the circumpolar giant sea spider Colossendeis megalonyx comprises a complex of at least six cryptic species with mostly small and non-overlapping distribution ranges. Here, we expand the sampling to include over 500 mitochondrial COI sequences of specimens from around the Antarctic. Using multiple species delimitation approaches, the number of distinct mitochondrial OTUs increased from six to 15–20 with our larger dataset. In contrast to earlier studies, many of these clades show almost circumpolar distributions. Additionally, analysis of the nuclear internal transcribed spacer region for a subset of these specimens showed incongruence between nuclear and mitochondrial results. These mito-nuclear discordances suggest that several of the divergent mitochondrial lineages can hybridize and should not be interpreted as cryptic species. Our results suggest survival of C. megalonyx during Pleistocene glaciations in multiple refugia, some of them probably located on the Antarctic shelf, and emphasize the importance of multi-gene datasets to detect the presence of cryptic species, rather than their inference based on mitochondrial data alone.
    Keywords Antarctic ; Pycnogonida ; benthos ; glacial refugia ; speciation ; phylogeography
    Language English
    Document type Article
    Database Repository for Life Sciences

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  8. Article: Order and Complexity in the RNA World.

    Mayer, Christian

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 3

    Abstract: The basic idea of the RNA world as an early step towards life relies on a molecular evolution process based on self-replicating RNA strands. It is probably the oldest and most convincing model for efficient prebiotic evolution. Obviously, the ... ...

    Abstract The basic idea of the RNA world as an early step towards life relies on a molecular evolution process based on self-replicating RNA strands. It is probably the oldest and most convincing model for efficient prebiotic evolution. Obviously, the functionality of RNA sequences depends on order (i.e., the definition of their sequence) as well as on complexity (i.e., the length of their sequence). Order and complexity seem to be crucial parameters in the course of RNA evolution. In the following, an attempt is made to define these parameters and to identify characteristic mechanisms of their development. Using a general RNA world scenario including the free monomer units, the sequential order is defined based on statistical thermodynamics. The complexity, on the other hand, is determined by the size of a minimal algorithm fully describing the system. Under these conditions, a diagonal line in an order/complexity-diagram represents the progress of molecular evolution. Elementary steps such as repeated random polymerization and selection follow characteristic pathways and finally add up to a state of high system functionality. Furthermore, the model yields a thermodynamic perspective on molecular evolution, as the development of a defined polymer sequence has a distinct influence on the entropy of the overall system.
    Language English
    Publishing date 2023-02-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13030603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Thesis: Evaluation einer Topogramm basierten automatischen Röhrenspannungsselektion für die thorakale und abdominelle Computertomographie hinsichtlich einer erweiterten Strahlendosisreduktion

    Mayer, Caroline

    2014  

    Author's details vorgelegt von Caroline Mayer
    Language German
    Size 49, [8] Bl., Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2015
    Note Enth. Sonderabdr.
    HBZ-ID HT018786346
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 E 1800 order for loan Magazin

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  10. Article: Selecting optimal partitioning schemes for phylogenomic datasets

    Mayer, Christoph

    BMC evolutionary biology, 14:82

    2014  

    Abstract: BACKGROUND: Partitioning involves estimating independent models of molecular evolution for different subsets of sites in a sequence alignment, and has been shown to improve phylogenetic inference. Current methods for estimating best-fit partitioning ... ...

    Institution Zoologisches Forschungsmuseum Alexander Koenig
    Abstract BACKGROUND: Partitioning involves estimating independent models of molecular evolution for different subsets of sites in a sequence alignment, and has been shown to improve phylogenetic inference. Current methods for estimating best-fit partitioning schemes, however, are only computationally feasible with datasets of fewer than 100 loci. This is a problem because datasets with thousands of loci are increasingly common in phylogenetics. METHODS: We develop two novel methods for estimating best-fit partitioning schemes on large phylogenomic datasets: strict and relaxed hierarchical clustering. These methods use information from the underlying data to cluster together similar subsets of sites in an alignment, and build on clustering approaches that have been proposed elsewhere. RESULTS: We compare the performance of our methods to each other, and to existing methods for selecting partitioning schemes. We demonstrate that while strict hierarchical clustering has the best computational efficiency on very large datasets, relaxed hierarchical clustering provides scalable efficiency and returns dramatically better partitioning schemes as assessed by common criteria such as AICc and BIC scores. CONCLUSIONS: These two methods provide the best current approaches to inferring partitioning schemes for very large datasets. We provide free open-source implementations of the methods in the PartitionFinder software. We hope that the use of these methods will help to improve the inferences made from large phylogenomic datasets.
    Keywords Clustering ; AIC ; AICc ; BIC ; Hierarchical clustering ; Model selection ; Partitionfinder ; Partitioning ; Phylogenetics ; Phylogenomics
    Language English
    Document type Article
    Database Repository for Life Sciences

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