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  1. Book: S3-Leitlinie Nicht erholsamer Schlaf, Schlafstörungen

    Mayer, Geert

    (Somnologie ; 13, Suppl. 1)

    2009  

    Author's details Steering-Komitee und Hrsg. G. Mayer
    Series title Somnologie ; 13, Suppl. 1
    Collection
    Language German
    Size 160 S.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT016141530
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: The need for new instruments to measure the manyfold aspects of excessive daytime sleepiness.

    Mayer, Geert

    Sleep

    2022  Volume 45, Issue 8

    MeSH term(s) Disorders of Excessive Somnolence/diagnosis ; Humans ; Narcolepsy
    Language English
    Publishing date 2022-06-17
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 424441-2
    ISSN 1550-9109 ; 0161-8105
    ISSN (online) 1550-9109
    ISSN 0161-8105
    DOI 10.1093/sleep/zsac144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Narkolepsie - Grundlagen und Diagnostik

    Mayer, Geert

    (Thieme-Refresher Neurologie ; 2006, März)

    2006  

    Author's details G. Mayer
    Series title Thieme-Refresher Neurologie ; 2006, März
    Collection
    Language German
    Size 15 S.
    Publisher Thieme
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    HBZ-ID HT014749318
    Database Catalogue ZB MED Medicine, Health

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  4. Book: Narkolepsie

    Mayer, Geert

    Taschenatlas spezial

    2006  

    Author's details Geert Mayer
    Keywords Narkolepsie
    Subject Hypnolepsie ; Narkoleptisches Syndrom ; Gélineau-Westphal Syndrom
    Language German
    Size VIII, 79 S. : Ill., graph. Darst., 19 cm
    Publisher Thieme
    Publishing place Stuttgart u.a.
    Publishing country Germany
    Document type Book
    Note Literaturverz. S. 69 - 74
    HBZ-ID HT014875947
    ISBN 978-3-13-134431-1 ; 3-13-134431-8
    Database Catalogue ZB MED Medicine, Health

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  5. Article ; Online: Idiopathic hypersomnia: the long journey from classification to an efficacious drug.

    Mayer, Geert / Rodenbeck, Andrea

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2023  Volume 19, Issue 10, Page(s) 1709–1710

    Language English
    Publishing date 2023-08-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.10776
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Grundlagen der Schlafmedizin. Bedeutung für die Pharmakologie / AMT Zertifizierte Fortbildung

    Mayer, Geert

    Arzneimitteltherapie

    2021  Volume 39, Issue 12, Page(s) 416/426

    Language German
    Document type Article
    ZDB-ID 380334-X
    ISSN 0723-6913
    Database Current Contents Medicine

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  7. Book: Narkolepsie

    Mayer, Geert

    Genetik, Immungenetik, motorische Störungen ; mit 40 Tabellen

    (Blackwell-Wissenschaft)

    2000  

    Author's details Geert Mayer
    Series title Blackwell-Wissenschaft
    Keywords Narkolepsie
    Subject Hypnolepsie ; Narkoleptisches Syndrom ; Gélineau-Westphal Syndrom
    Language German
    Size X, 187 S. : Ill., graph. Darst.
    Publisher Blackwell-Wiss.-Verl
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT012794150
    ISBN 3-89412-449-0 ; 978-3-89412-449-6
    Database Catalogue ZB MED Medicine, Health

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  8. Article ; Online: Frailty-Phänotyp und Risikofaktor gestörter Schlaf.

    Frohnhofen, Helmut / Stenmanns, Carla / Gronewold, Janine / Mayer, Geert

    Zeitschrift fur Gerontologie und Geriatrie

    2023  Volume 56, Issue 7, Page(s) 551–555

    Abstract: Regardless of the nature of its operationalization, frailty has significant negative consequences for the person concerned and the community. Even if a generally accepted definition of frailty is still missing, there is no doubt about the existence of ... ...

    Title translation Frailty phenotype and risk factor for disturbed sleep.
    Abstract Regardless of the nature of its operationalization, frailty has significant negative consequences for the person concerned and the community. Even if a generally accepted definition of frailty is still missing, there is no doubt about the existence of this phenomenon. Pathophysiologically, a dysfunctional interaction between multiple complex systems is discussed. Therapeutic interventions show that frailty is a dynamic state that can be improved. The pathophysiological characteristics of frailty and sleep disturbances show numerous similarities. In addition, the risk of frailty is increased in individuals with sleep disturbances. As the majority of sleep disorders can usually be well treated, screening for sleep disorders should be integrated into a comprehensive concept of management of frailty.
    Language German
    Publishing date 2023-07-12
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 1227032-5
    ISSN 1435-1269 ; 0044-281X ; 0948-6704
    ISSN (online) 1435-1269
    ISSN 0044-281X ; 0948-6704
    DOI 10.1007/s00391-023-02219-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Efficacy of sodium oxybate on REM sleep behavior disorder in a patient with narcolepsy type 1.

    Mayer, Geert

    Neurology

    2016  Volume 87, Issue 24, Page(s) 2594–2595

    MeSH term(s) Humans ; Hypnotics and Sedatives/therapeutic use ; Male ; Middle Aged ; Narcolepsy/complications ; Narcolepsy/drug therapy ; Narcolepsy/physiopathology ; REM Sleep Behavior Disorder/complications ; REM Sleep Behavior Disorder/drug therapy ; REM Sleep Behavior Disorder/physiopathology ; Sodium Oxybate/therapeutic use
    Chemical Substances Hypnotics and Sedatives ; Sodium Oxybate (7G33012534)
    Language English
    Publishing date 2016-11-02
    Publishing country United States
    Document type Case Reports ; Journal Article ; Observational Study
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000003389
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Associations of sleep disorders with all-cause MCI/dementia and different types of dementia - clinical evidence, potential pathomechanisms and treatment options: A narrative review.

    Mayer, Geert / Frohnhofen, Helmut / Jokisch, Martha / Hermann, Dirk M / Gronewold, Janine

    Frontiers in neuroscience

    2024  Volume 18, Page(s) 1372326

    Abstract: Due to worldwide demographic change, the number of older persons in the population is increasing. Aging is accompanied by changes of sleep structure, deposition of beta-amyloid (Aß) and tau proteins and vascular changes and can turn into mild cognitive ... ...

    Abstract Due to worldwide demographic change, the number of older persons in the population is increasing. Aging is accompanied by changes of sleep structure, deposition of beta-amyloid (Aß) and tau proteins and vascular changes and can turn into mild cognitive impairment (MCI) as well as dementia. Sleep disorders are discussed both as a risk factor for and as a consequence of MCI/dementia. Cross-sectional and longitudinal population-based as well as case-control studies revealed sleep disorders, especially sleep-disorderded breathing (SDB) and excessive or insufficient sleep durations, as risk factors for all-cause MCI/dementia. Regarding different dementia types, SDB was especially associated with vascular dementia while insomnia/insufficient sleep was related to an increased risk of Alzheimer's disease (AD). Scarce and still inconsistent evidence suggests that therapy of sleep disorders, especially continuous positive airway pressure (CPAP) in SDB, can improve cognition in patients with sleep disorders with and without comorbid dementia and delay onset of MCI/dementia in patients with sleep disorders without previous cognitive impairment. Regarding potential pathomechanisms via which sleep disorders lead to MCI/dementia, disturbed sleep, chronic sleep deficit and SDB can impair glymphatic clearance of beta-amyloid (Aß) and tau which lead to amyloid deposition and tau aggregation resulting in changes of brain structures responsible for cognition. Orexins are discussed to modulate sleep and Aß pathology. Their diurnal fluctuation is suppressed by sleep fragmentation and the expression suppressed at the point of hippocampal atrophy, contributing to the progression of dementia. Additionally, sleep disorders can lead to an increased vascular risk profile and vascular changes such as inflammation, endothelial dysfunction and atherosclerosis which can foster neurodegenerative pathology. There is ample evidence indicating that changes of sleep structure in aging persons can lead to dementia and also evidence that therapy of sleep disorder can improve cognition. Therefore, sleep disorders should be identified and treated early.
    Language English
    Publishing date 2024-03-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2024.1372326
    Database MEDical Literature Analysis and Retrieval System OnLINE

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