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Article ; Online: Measurement-Based Care for Depression in Youth: Practical Considerations for Selecting Measures to Assess Depression, Associated Features and Functioning.

Garza, Cynthia / Chapa, Diana / Hernandez, Catherine / Aramburu, Hayley / Mayes, Taryn L / Emslie, Graham J

2024

Abstract: Identification and management of major depressive disorder (MDD) in children and adolescents remains a significant area of public health need. The process for identifying depression (e.g. screening) and management (e.g. measurement based care [MBC]) is ... ...

Abstract	Identification and management of major depressive disorder (MDD) in children and adolescents remains a significant area of public health need. The process for identifying depression (e.g. screening) and management (e.g. measurement based care [MBC]) is substantially enhanced by utilization of clinical measures and rating scales. Measures can be self- or caregiver reported or clinician rated. They can aid recognition of at-risk individuals for future assessment and assist in clinical diagnosis and management of depression. In addition to assessing symptoms of depression, rating scales can be used to assess important associated features (e.g. anxiety, trauma) and functional outcomes (e.g. quality of life, performance/productivity). In this manuscript, we discuss practical considerations for clinicians and researchers when selecting rating instruments for assessing depression, associated factors, functioning, and treatment outcomes (i.e. adherence and side effects) as part of MBC in youth and provide a summary of rating scales commonly used in research and clinical settings.
Language	English
Publishing date	2024-01-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	223895-0
ISSN	1573-3327 ; 0009-398X
ISSN (online)	1573-3327
ISSN	0009-398X
DOI	10.1007/s10578-023-01652-4
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Article ; Online: Immune Dysregulation in Treatment-Resistant Depression: Precision Approaches to Treatment Selection and Development of Novel Treatments.

Chin Fatt, Cherise R / Mayes, Taryn L / Trivedi, Madhukar H

The Psychiatric clinics of North America

2023 Volume 46, Issue 2, Page(s) 403–413

Abstract: Owing to the link between immune dysfunction and treatment-resistant depression (TRD) and the overwhelming evidence that the immune dysregulation and major depressive disorder (MDD) are associated with each other, using immune profiles to identify the ... ...

Abstract	Owing to the link between immune dysfunction and treatment-resistant depression (TRD) and the overwhelming evidence that the immune dysregulation and major depressive disorder (MDD) are associated with each other, using immune profiles to identify the biological distinct subgroup may be the step forward to understanding MDD and TRD. This report aims to briefly review the role of inflammation in the pathophysiology of depression (and TRD in particular), the role of immune dysfunction to guide precision medicine, tools used to understand immune function, and novel statistical techniques.
MeSH term(s)	Humans ; Depressive Disorder, Major/drug therapy ; Depression ; Depressive Disorder, Treatment-Resistant/drug therapy ; Precision Medicine
Language	English
Publishing date	2023-05-20
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	431518-2
ISSN	1558-3147 ; 0193-953X
ISSN (online)	1558-3147
ISSN	0193-953X
DOI	10.1016/j.psc.2023.02.010
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Article ; Online: Addressing adherence to antidepressant treatment for depression.

Mayes, Taryn L / Trivedi, Madhukar H

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

2020 Volume 43, Issue 2, Page(s) 125–126

MeSH term(s)	Antidepressive Agents/therapeutic use ; Depression/drug therapy ; Humans ; Medication Adherence
Chemical Substances	Antidepressive Agents
Language	English
Publishing date	2020-11-13
Publishing country	Brazil
Document type	Editorial
ISSN	1809-452X
ISSN (online)	1809-452X
DOI	10.1590/1516-4446-2020-0022
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Article ; Online: Integration of Measurement-Based Care for Youth Depression and Suicidality Using VitalSign

Mitchell, Tarrah B / Wakefield, Sarah M / Rezaeizadeh, Afsaneh / Minhajuddin, Abu / Pipes, Ronny / Mayes, Taryn L / Elmore, Joshua S / Trivedi, Madhukar H

Child psychiatry and human development

2024

Abstract: Depression and suicidality are prevalent in youth and are associated with a range of negative outcomes. The current study aimed to evaluate a measurement-based care (MBC) software ( ... ...

Abstract	Depression and suicidality are prevalent in youth and are associated with a range of negative outcomes. The current study aimed to evaluate a measurement-based care (MBC) software (VitalSign
Language	English
Publishing date	2024-02-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	223895-0
ISSN	1573-3327 ; 0009-398X
ISSN (online)	1573-3327
ISSN	0009-398X
DOI	10.1007/s10578-024-01680-8
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Article ; Online: Treatment of Adolescent Depression: Comparison of Psychiatric and Pediatric Settings at an Academic Medical Center Using the VitalSign

Ayvaci, Emine Rabia / Minhajuddin, Abu / Elmore, Joshua S / Yagnik, Kush / Jha, Manish K / Emslie, Graham J / Mayes, Taryn L / Trivedi, Madhukar H

Journal of child and adolescent psychopharmacology

2024 Volume 34, Issue 2, Page(s) 80–88

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Adult ; Humans ; Adolescent ; Child ; Depressive Disorder, Major/diagnosis ; Depressive Disorder, Major/drug therapy ; Depression/diagnosis ; Depression/drug therapy ; Psychotherapy ; Ambulatory Care ; Academic Medical Centers
Language	English
Publishing date	2024-01-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1055410-5
ISSN	1557-8992 ; 1044-5463
ISSN (online)	1557-8992
ISSN	1044-5463
DOI	10.1089/cap.2023.0041
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Article: The 9-item Concise Health Risk Tracking - Self-Report (CHRT-SR

Nandy, Karabi / Rush, A John / Carmody, Thomas J / Mayes, Taryn L / Trivedi, Madhukar H

Frontiers in psychiatry

2023 Volume 14, Page(s) 1014766

Abstract: Purpose: To evaluate the psychometric properties of a 9-item Concise Health Risk Tracking Self-Report (or CHRT-SR: Methods: Overall, 369 adults completed the original 14-item version of CHRT-SR at baseline and within 4 months thereafter, from which ... ...

Abstract	Purpose: To evaluate the psychometric properties of a 9-item Concise Health Risk Tracking Self-Report (or CHRT-SR Methods: Overall, 369 adults completed the original 14-item version of CHRT-SR at baseline and within 4 months thereafter, from which the CHRT-SR Results: Confirmatory factor analysis identified the CHRT-SR Conclusion: The CHRT-SR
Language	English
Publishing date	2023-02-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2023.1014766
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Article ; Online: Improving Identification and Treatment Outcomes of Treatment-Resistant Depression Through Measurement-Based Care.

Mayes, Taryn L / Deane, Amber E / Aramburu, Hayley / Yagnik, Kush / Trivedi, Madhukar H

The Psychiatric clinics of North America

2023 Volume 46, Issue 2, Page(s) 227–245

Abstract: Measurement-based care (MBC) is the systematic screening and ongoing assessment of symptoms, side effects, and adherence to adjust treatments as needed based on these factors. Studies show MBC leads to improved outcomes for depression and treatment- ... ...

Abstract	Measurement-based care (MBC) is the systematic screening and ongoing assessment of symptoms, side effects, and adherence to adjust treatments as needed based on these factors. Studies show MBC leads to improved outcomes for depression and treatment-resistant depression (TRD). In fact, MBC may reduce the chances of developing TRD, as it leads to optimized treatment strategies based on symptom changes and compliance. There are many rating scales available for monitoring depressive symptoms, side effects, and adherence. These rating scales can be used in a variety of clinical settings to help guide treatment decisions, including depression treatment decisions.
MeSH term(s)	Humans ; Depression/therapy ; Antidepressive Agents/adverse effects ; Treatment Outcome ; Depressive Disorder, Treatment-Resistant/diagnosis ; Depressive Disorder, Treatment-Resistant/therapy ; Psychiatric Status Rating Scales
Chemical Substances	Antidepressive Agents
Language	English
Publishing date	2023-03-25
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	431518-2
ISSN	1558-3147 ; 0193-953X
ISSN (online)	1558-3147
ISSN	0193-953X
DOI	10.1016/j.psc.2023.02.002
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Article ; Online: Accelerated Brain Aging in Adults With Major Depressive Disorder Predicts Poorer Outcome With Sertraline: Findings From the EMBARC Study.

Jha, Manish K / Chin Fatt, Cherise / Minhajuddin, Abu / Mayes, Taryn L / Trivedi, Madhukar H

Biological psychiatry. Cognitive neuroscience and neuroimaging

2022 Volume 8, Issue 4, Page(s) 462–470

Abstract: Background: Major depressive disorder (MDD) may be associated with accelerated brain aging (higher brain age than chronological age). This report evaluated whether brain age is a clinically useful biomarker by checking its test-retest reliability using ... ...

Abstract	Background: Major depressive disorder (MDD) may be associated with accelerated brain aging (higher brain age than chronological age). This report evaluated whether brain age is a clinically useful biomarker by checking its test-retest reliability using magnetic resonance imaging scans acquired 1 week apart and by evaluating the association of accelerated brain aging with symptom severity and antidepressant treatment outcomes. Methods: Brain age was estimated in participants of the EMBARC (Establishing Moderators and Biosignatures of Antidepressant Response in Clinical Care) study using T1-weighted structural magnetic resonance imaging (MDD n = 290; female n = 192; healthy control participants n = 39; female n = 24). Intraclass correlation coefficient was used for baseline-to-week-1 test-retest reliability. Association of baseline Δ brain age (brain age minus chronological age) with Hamilton Depression Rating Scale-17 and Concise Health Risk Tracking Self-Report domains (impulsivity, suicide propensity [measures: pessimism, helplessness, perceived lack of social support, and despair], and suicidal thoughts) were assessed at baseline (linear regression) and during 8-week-long treatment with either sertraline or placebo (repeated-measures mixed models). Results: Mean ± SD baseline chronological age, brain age, and Δ brain age were 37.1 ± 13.3, 40.6 ± 13.1, and 3.1 ± 6.1 years in MDD and 37.1 ± 14.7, 38.4 ± 12.9, and 0.6 ± 5.5 years in healthy control groups, respectively. Test-retest reliability was high (intraclass correlation coefficient = 0.98-1.00). Higher baseline Δ brain age in the MDD group was associated with higher baseline impulsivity and suicide propensity and predicted smaller baseline-to-week-8 reductions in Hamilton Depression Rating Scale-17, impulsivity, and suicide propensity with sertraline but not with placebo. Conclusions: Brain age is a reliable and potentially clinically useful biomarker that can prognosticate antidepressant treatment outcomes.
MeSH term(s)	Adult ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Aging ; Antidepressive Agents/therapeutic use ; Biomarkers ; Brain/diagnostic imaging ; Depressive Disorder, Major/diagnosis ; Reproducibility of Results ; Sertraline/therapeutic use
Chemical Substances	Antidepressive Agents ; Biomarkers ; Embarc ; Sertraline (QUC7NX6WMB)
Language	English
Publishing date	2022-09-27
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2879089-3
ISSN	2451-9030 ; 2451-9022
ISSN (online)	2451-9030
ISSN	2451-9022
DOI	10.1016/j.bpsc.2022.09.006
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Article ; Online: Experiencing bullying's impact on adolescent depression and anxiety: Mediating role of adolescent resilience.

Anderson, Jacqueline R / Mayes, Taryn L / Fuller, Anne / Hughes, Jennifer L / Minhajuddin, Abu / Trivedi, Madhukar H

Journal of affective disorders

2022 Volume 310, Page(s) 477–483

Abstract: Youth who experience bullying are at risk for psychopathology, indicating the necessity of identifying factors that may protect against the deleterious effects of being bullied. The present study expands upon prior research by examining resilience as a ... ...

Abstract	Youth who experience bullying are at risk for psychopathology, indicating the necessity of identifying factors that may protect against the deleterious effects of being bullied. The present study expands upon prior research by examining resilience as a mediator of the effects of experiencing bullying on depression and anxiety within a sample of 2155 adolescents. Results indicated that youth who experienced bullying were more likely to have higher symptoms of depression and anxiety and lower resilience, while higher levels of resilience were associated with fewer symptoms of depression and anxiety. Resilience partially mediated the associations of experiencing bullying with depression and anxiety symptoms, suggesting that resilience may serve as a protective factor for adolescents who experience bullying. These findings have implications for programming that seeks to address bullying, peer victimization, and promotion of adolescent mental health.
MeSH term(s)	Adolescent ; Anxiety/epidemiology ; Anxiety/psychology ; Anxiety Disorders/epidemiology ; Bullying/psychology ; Crime Victims/psychology ; Depression/epidemiology ; Depression/psychology ; Humans
Language	English
Publishing date	2022-04-04
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2022.04.003
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Article ; Online: Considering depression as a secondary outcome in the optimization of physical activity interventions for breast cancer survivors in the PACES trial: a factorial randomized controlled trial.

Rethorst, Chad D / Carmody, Thomas J / Argenbright, Keith E / Mayes, Taryn L / Hamann, Heidi A / Trivedi, Madhukar H

The international journal of behavioral nutrition and physical activity

2023 Volume 20, Issue 1, Page(s) 47

Abstract: Background: Depressive symptoms result in considerable burden for breast cancer survivors. Increased physical activity may reduce these burdens but existing evidence from physical activity interventions in equivocal. Furthermore, physical activity ... ...

Abstract	Background: Depressive symptoms result in considerable burden for breast cancer survivors. Increased physical activity may reduce these burdens but existing evidence from physical activity interventions in equivocal. Furthermore, physical activity intervention strategies may differentially impact depressive symptoms, which should be considered in designing and optimizing behavioral interventions for breast cancer survivors. Methods: The Physical Activity for Cancer Survivors (PACES) trial enrolled 336 participants breast cancer survivors, who were 3 months to 10 years post-treatment, and insufficiently active (< 150 min of moderate-to-vigorous physical activity per week). Participants were randomly assigned to a combination of 4 intervention strategies in a full-factorial design: 1) supervised exercise sessions, 2) facility access, 3) Active Living Every Day, and 4) Fitbit self-monitoring. Depressive symptoms were assessed at baseline, mid-intervention (3 months), and post-intervention (6 months) using the Quick Inventory for Depressive Symptoms. Change in depressive symptoms were analyzed using a linear mixed-effects model. Results: Results from the linear mixed-effects model indicated that depressive symptoms decreased significantly across the entire study sample over the 6-month intervention (F = 4.09, p = 0.044). A significant ALED x time interaction indicated participants who received the ALED intervention experienced greater reductions in depressive symptoms (F = 5.29, p = 0.022). No other intervention strategy significantly impacted depressive symptoms. Conclusions: The ALED intervention consists of strategies (i.e., goal setting, social support) that may have a beneficial impact on depressive symptoms above and beyond the effect of increased physical activity. Our findings highlight the need to consider secondary outcomes when designing and optimizing physical activity interventions. Trial registration: ClinicalTrials.gov NCT03060941. Posted February 23, 2017.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/therapy ; Cancer Survivors ; Exercise ; Depression/therapy ; Survivors ; Quality of Life
Language	English
Publishing date	2023-04-20
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2134691-4
ISSN	1479-5868 ; 1479-5868
ISSN (online)	1479-5868
ISSN	1479-5868
DOI	10.1186/s12966-023-01437-x
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