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  1. Book: Money and its use in medieval Europe

    Allen, Martin / Mayhew, Nicholas J / Spufford, Peter

    three decades on essays in honour of Professor Peter Spufford

    (Special publication / Royal Numismatic Society ; No. 52)

    2017  

    Author's details edited by Martin Allen and Nicholas Mayhew
    Series title Special publication / Royal Numismatic Society ; No. 52
    Language English
    Size xi, 179 Seiten, Illustrationen
    Document type Book
    ISBN 9780901405692 ; 0901405698
    Database ECONomics Information System

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  2. Book: Money, prices, and wages

    Allen, Martin / Mayhew, Nicholas J

    essays in honour of Professor Nicholas Mayhew

    (Palgrave studies in the history of finance)

    2015  

    Abstract: Professor Nicholas Mayhew is Professor of Numismatics and Monetary History at Oxford, a former Deputy Director of the Ashmolean Museum, Director of the Winton Institute for Monetary History and Fellow of St Cross College. Over the course of his forty- ... ...

    Author's details ed. by Martin Allen
    Series title Palgrave studies in the history of finance
    Abstract "Professor Nicholas Mayhew is Professor of Numismatics and Monetary History at Oxford, a former Deputy Director of the Ashmolean Museum, Director of the Winton Institute for Monetary History and Fellow of St Cross College. Over the course of his forty-year career, Mayhew has made key contributions to fields as diverse as medieval European monetary history, numismatics, financial history, price and wage history, and macroeconomic history. His recent analysis of the Price Revolution is the most influential account of one of the defining features of early modern English economic life. He has been instrumental in debunking notions of a pre-monetary, feudal past, and in the application of the Fisher Equation to historical data. Mayhew has inspired two generations of medieval historians and many colleagues in related disciplines. These essays, in his honour, demonstrate the analytical power and chronological reach of the novel interdisciplinary approach he has nurtured in himself and others"--
    Keywords Money/History ; Prices/History ; Wages/History ; Geldgeschichte ; Wirtschaftsgeschichte ; Fisher-Effekt ; Großbritannien
    Language English
    Size XIII, 284 S., Ill.
    Publisher Palgrave Macmillan
    Publishing place Basingstoke, Hampshire u.a.
    Document type Book
    Note Enth. 13 Beitr.
    ISBN 9781137394019 ; 1137394013
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  3. Book: Sterling

    Mayhew, Nicholas J

    the history of a currency

    2000  

    Author's details Nicholas Mayhew
    Keywords Pfund Sterling ; Geldgeschichte ; Großbritannien
    Language English
    Size XVI, 317 S, 20 cm
    Publisher Penguin Books
    Publishing place London u.a.
    Document type Book
    Note Originally published: London: Allen Lane, 1999
    ISBN 0140276327 ; 9780140276329
    Database Former special subject collection: coastal and deep sea fishing

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  4. Book: Sterling

    Mayhew, Nicholas J

    the history of a currency

    2000  

    Author's details Nicholas Mayhew
    Keywords Pfund Sterling ; Geldgeschichte ; Großbritannien
    Language English
    Size XVI, 317 S, 20 cm
    Document type Book
    Note Originally published: London: Allen Lane, 1999
    ISBN 0140276327 ; 9780140276329
    Database ECONomics Information System

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  5. Article ; Online: Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators.

    Rynearson, Kevin D / Buckle, Ronald N / Herr, R Jason / Mayhew, Nicholas J / Chen, Xinchao / Paquette, William D / Sakwa, Samuel A / Yang, Jinhai / Barnes, Keith D / Nguyen, Phuong / Mobley, William C / Johnson, Graham / Lin, Juinn H / Tanzi, Rudolph E / Wagner, Steven L

    Bioorganic & medicinal chemistry

    2020  Volume 28, Issue 22, Page(s) 115734

    Abstract: The evolution of gamma-secretase modulators (GSMs) through the introduction of novel heterocycles with the goal of aligning activity for reducing the levels of Aβ42 and properties consistent with a drug-like molecule are described. The insertion of a ... ...

    Abstract The evolution of gamma-secretase modulators (GSMs) through the introduction of novel heterocycles with the goal of aligning activity for reducing the levels of Aβ42 and properties consistent with a drug-like molecule are described. The insertion of a methoxypyridine motif within the tetracyclic scaffold provided compounds with improved activity for arresting Aβ42 production as well as improved properties, including solubility. In vivo pharmacokinetic analysis demonstrated that several compounds within the novel series were capable of crossing the BBB and accessing the therapeutic target. Treatment with methoxypyridine-derived compound 64 reduced Aβ42 levels in the plasma of J20 mice, in addition to reducing Aβ42 levels in the plasma and brain of Tg2576 mice.
    MeSH term(s) Amyloid Precursor Protein Secretases/antagonists & inhibitors ; Amyloid Precursor Protein Secretases/metabolism ; Amyloid beta-Peptides/analysis ; Amyloid beta-Peptides/antagonists & inhibitors ; Amyloid beta-Peptides/biosynthesis ; Animals ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Drug Design ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Female ; Humans ; Male ; Mice ; Mice, Transgenic ; Molecular Structure ; Pyridines/chemical synthesis ; Pyridines/chemistry ; Pyridines/pharmacology ; Structure-Activity Relationship
    Chemical Substances Amyloid beta-Peptides ; Enzyme Inhibitors ; Pyridines ; Amyloid Precursor Protein Secretases (EC 3.4.-)
    Language English
    Publishing date 2020-09-01
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/j.bmc.2020.115734
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3815: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Book: Sterling

    Mayhew, Nicholas J

    the rise and fall of a currency

    1999  

    Author's details Nicholas Mayhew
    Keywords Pfund Sterling ; Geldgeschichte ; Welt ; Großbritannien
    Language English
    Size XIV, 305 p., [8] p. of plates, Ill, 24 cm.
    Document type Book
    ISBN 0713992581 ; 9780713992588
    Database ECONomics Information System

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  7. Book ; Conference proceedings: Credit and debt in medieval England, c.1180 - c.1350

    Mayhew, Nicholas J / Schofield, Phillipp R

    2002  

    Institution Conference Credit and Debt in Medieval and Early Modern England
    Event/congress Conference Credit and Debt in Medieval and Early Modern England (2000.09.14-15, Oxford)
    Author's details [Conference Credit and Debt in Medieval and Early Modern England, ... St Cross College, Oxford, 14 and 15 September 2000] . Ed. by P.R. Schofield and N. J. Mayhew
    Keywords Kreditmarkt ; Schulden ; Geschichte ; England
    Language English
    Size X, 164 S, graph. Darst
    Document type Book ; Conference proceedings
    Note Enth. 6 Beitr. ; Includes bibliographical references (S. [149] - 159) and index
    ISBN 1842170732 ; 9781842170731
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  8. Article ; Online: Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme.

    Rynearson, Kevin D / Buckle, Ronald N / Barnes, Keith D / Herr, R Jason / Mayhew, Nicholas J / Paquette, William D / Sakwa, Samuel A / Nguyen, Phuong D / Johnson, Graham / Tanzi, Rudolph E / Wagner, Steven L

    Bioorganic & medicinal chemistry letters

    2016  Volume 26, Issue 16, Page(s) 3928–3937

    Abstract: The design and construction of a series of novel aminothiazole-derived γ-secretase modulators is described. The incorporation of heterocyclic replacements of the terminal phenyl D-ring of lead compound 1 was conducted in order to align potency with ... ...

    Abstract The design and construction of a series of novel aminothiazole-derived γ-secretase modulators is described. The incorporation of heterocyclic replacements of the terminal phenyl D-ring of lead compound 1 was conducted in order to align potency with favorable drug-like properties. γ-Secretase modulator 28 displayed good activity for in vitro inhibition of Aβ42, as well as substantial improvement in ADME and physicochemical properties, including aqueous solubility. Pharmacokinetic evaluation of compound 28 in mice revealed good brain penetration, as well as good clearance, half-life, and volume of distribution which collectively support the continued development of this class of compounds.
    MeSH term(s) Amyloid Precursor Protein Secretases/chemistry ; Amyloid Precursor Protein Secretases/metabolism ; Amyloid beta-Peptides/antagonists & inhibitors ; Amyloid beta-Peptides/metabolism ; Animals ; Drug Design ; Half-Life ; Humans ; Kinetics ; Male ; Mice ; Microsomes, Liver/metabolism ; Peptide Fragments/antagonists & inhibitors ; Peptide Fragments/metabolism ; Rats ; Solubility ; Structure-Activity Relationship ; Thiazoles/chemical synthesis ; Thiazoles/chemistry ; Thiazoles/pharmacokinetics
    Chemical Substances Amyloid beta-Peptides ; Peptide Fragments ; Thiazoles ; amyloid beta-protein (1-42) ; Amyloid Precursor Protein Secretases (EC 3.4.-)
    Language English
    Publishing date 2016--15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2016.07.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3203: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Book ; Conference proceedings: Later medieval mints

    Mayhew, Nicholas J / Spufford, Peter

    organisation, administration and techniques

    (BAR international series ; 389)

    1988  

    Institution Oxford Symposium on Coinage and Monetary History
    Event/congress Oxford Symposium on Coinage and Monetary History (8th, AshmoleanMuseum)
    Author's details the eighth Oxford Symposium on Coinage and Monetary History
    Series title BAR international series ; 389
    Language English ; French ; German
    Size 242 S., Ill., 30 cm
    Publisher B.A.R
    Publishing place Oxford
    Document type Book ; Conference proceedings
    Note Includes bibliographical references and index ; Papers in English, French, and German ; This meeting took place ... under the auspices of the Heberden Coin Room of the Ashmolean Museum in September 1985"--P. 3
    ISBN 0860545032 ; 9780860545033
    Database Former special subject collection: coastal and deep sea fishing

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