Article ; Online: Gastrin: a new branch of the gastropancreatic axis that can explain the effect of sleeve gastrectomy on glucose metabolism.
2024 Volume 28, Issue 4, Page(s) 381–388
Abstract: Background: Among bariatric techniques, sleeve gastrectomy (SG) stands out owing to its efficiency. The role of the stomach as a secretory organ of many substances, such as gastrin, related to insulin secretion is well known. Gastrin induces insulin ... ...
| Abstract | Background: Among bariatric techniques, sleeve gastrectomy (SG) stands out owing to its efficiency. The role of the stomach as a secretory organ of many substances, such as gastrin, related to insulin secretion is well known. Gastrin induces insulin release in isolated pancreatic islets, limiting somatostatin-14 intraislet release, and has been associated with blood glucose level improvement in diabetic models after SG. SG involves gastric resection along the greater curvature. This study aimed to determine the role of gastrin in glucose metabolism improvement after SG with the aid of the gastrin antagonist netazepide. Methods: In 12 sham-operated, 12 SG-operated, and 12 SG-operated/netazepide-treated Wistar rats, we compared medium- and long-term plasma insulin, oral glucose tolerance test (OGTT) results, and plasma gastrin levels. In addition, gastrin expression was assessed in the gastric remnant, and the beta-cell mass was measured. Results: SG induced a medium-term elevation of the insulin response and plasma gastrin levels without modification of the OGTT results. However, long-term depletion of the insulin response with elevated OGTT areas under the curve and plasma gastrin levels appeared after SG. Netazepide prevented the SG effect on these parameters. Gastrin tissue expression was greater in SG animals than in SG/netazepide-treated or control animals. The beta-cell mass was lower in the SG group than in the control or SG/netazepide group. Conclusion: Gastrin plays a central role in glucose improvement after SG. It stimulates a medium-term strong insulin response but also causes long-term beta-cell mass depletion and a loss of insulin response. These effects are prevented by gastrin antagonists such as netazepide. |
|---|---|
| MeSH term(s) | Rats ; Animals ; Gastrins/metabolism ; Rats, Wistar ; Glucose/metabolism ; Insulin ; Gastrectomy/methods ; Blood Glucose/metabolism ; Diabetes Mellitus, Type 2/surgery ; Benzodiazepinones ; Phenylurea Compounds |
| Chemical Substances | YF 476 (HOU4I0G29C) ; Gastrins ; Glucose (IY9XDZ35W2) ; Insulin ; Blood Glucose ; Benzodiazepinones ; Phenylurea Compounds |
| Language | English |
| Publishing date | 2024-01-23 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ZDB-ID | 2012365-6 |
| ISSN | 1873-4626 ; 1934-3213 ; 1091-255X |
| ISSN (online) | 1873-4626 ; 1934-3213 |
| ISSN | 1091-255X |
| DOI | 10.1016/j.gassur.2024.02.015 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 5207: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
|||
| Zs.MO 354: Show issues |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.