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  1. Article ; Online: Molecular characterization of carbapenemases in Peru during 2019.

    Mayta-Barrios, Maritza Miriam / Ramirez-Illescas, Juan José / Pampa-Espinoza, Luis / Yagui-Moscoso, Martin Javier Alfredo

    Revista peruana de medicina experimental y salud publica

    2021  Volume 38, Issue 1, Page(s) 113–118

    Abstract: Resistance to carbapenems is a public health problem. This study presents the identification of carbapenemase enzymes in Enterobacteriaceae, Pseudomonas spp. and Acinetobacter spp. present in strains from 30 institutions that provide health services in ... ...

    Title translation Caracterización molecular de carbapenemasas en el Perú durante el 2019.
    Abstract Resistance to carbapenems is a public health problem. This study presents the identification of carbapenemase enzymes in Enterobacteriaceae, Pseudomonas spp. and Acinetobacter spp. present in strains from 30 institutions that provide health services in Peru as part of the quality control process in diagnoses. Phenotypic confirmation and enzymatic identification were performed using the Blue CARBA test and the synergy test with phenylboronic acid and ethylenediaminetetraacetic acid/sodium mercaptoacetic acid discs. 185 strains with carbapenemases were identified: 78 in Enterobacteriaceae, 61 in P. aeruginosa and 46 in Acinetobacter spp. The types of carbapenemases identified were: blaKPC, blaNDM, blaIMP, blaVIM, blaOXA-23, blaOXA-24, blaOXA-51 and the blaVIM/IMP co-production. It is important to strengthen the promotion of the rational use of antimicrobials and epidemiological surveillance in the country's hospitals.
    MeSH term(s) Anti-Bacterial Agents ; Bacterial Proteins/genetics ; Microbial Sensitivity Tests ; Peru ; beta-Lactamases/genetics
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; beta-Lactamases (EC 3.5.2.6) ; carbapenemase (EC 3.5.2.6)
    Language English
    Publishing date 2021-06-25
    Publishing country Peru
    Document type Journal Article
    ZDB-ID 2120092-0
    ISSN 1726-4642 ; 1726-4634
    ISSN (online) 1726-4642
    ISSN 1726-4634
    DOI 10.17843/rpmesp.2021.381.5882
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Resistencia antimicrobiana de Neisseria gonorrhoeae en Perú.

    Jorge-Berrocal, Ana / Mayta-Barrios, Maritza / Fiestas-Solórzano, Victor

    Revista peruana de medicina experimental y salud publica

    2018  Volume 35, Issue 1, Page(s) 155–156

    Title translation Antimicrobial resistance of Neisseria gonorrhoeae in Peru.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Drug Resistance, Bacterial ; Humans ; Neisseria gonorrhoeae/drug effects ; Peru
    Chemical Substances Anti-Bacterial Agents
    Language Spanish
    Publishing date 2018-10-04
    Publishing country Peru
    Document type Letter
    ZDB-ID 2120092-0
    ISSN 1726-4642 ; 1726-4634
    ISSN (online) 1726-4642
    ISSN 1726-4634
    DOI 10.17843/rpmesp.2018.351.3552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Primer reporte de carbapenemasa tipo KPC en Pseudomonas aeruginosa en un hospital del Perú.

    Salvador-Luján, Gina / Ramírez-Illescas, Juan / Delgado-Flores, Miluska / Núñez-Llanos, Alicia / Mayta-Barrios, Maritza

    Revista peruana de medicina experimental y salud publica

    2021  Volume 38, Issue 3, Page(s) 474–475

    Title translation First report of KPC-type carbapenemase in Pseudomonas aeruginosa at a peruvian hospital.
    MeSH term(s) Anti-Bacterial Agents ; Bacterial Proteins ; Hospitals ; Microbial Sensitivity Tests ; Peru ; Pseudomonas aeruginosa ; beta-Lactamases
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; beta-Lactamases (EC 3.5.2.6) ; carbapenemase (EC 3.5.2.6)
    Language Spanish
    Publishing date 2021-12-20
    Publishing country Peru
    Document type Letter
    ZDB-ID 2120092-0
    ISSN 1726-4642 ; 1726-4634
    ISSN (online) 1726-4642
    ISSN 1726-4634
    DOI 10.17843/rpmesp.2021.383.7044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Antimicrobial Susceptibility of Neisseria gonorrhoeae Isolates From Peru, 2018 and 2019.

    Jorge-Berrocal, Ana / Vargas-Herrera, Natalia / Benites, Carlos / Salazar-Quispe, Fabiola / Mayta-Barrios, Maritza / Barrios-Cárdenas, Yuli J / Melano, Roberto G / Yagui, Martin

    Sexually transmitted diseases

    2022  Volume 49, Issue 10, Page(s) 682–686

    Abstract: Background: Currently, in Latin America, including Peru, the treatment of gonorrhea is still empiric and information regarding antimicrobial resistance is scarce in some countries because of the limited resources, which can contribute to the rising ... ...

    Abstract Background: Currently, in Latin America, including Peru, the treatment of gonorrhea is still empiric and information regarding antimicrobial resistance is scarce in some countries because of the limited resources, which can contribute to the rising rates of reported multidrug-resistant gonococcal strains. In that context, it is mandatory to continuously monitor and report antimicrobial resistance in N. gonorrhoeae to update treatment recommendations.
    Methods: This descriptive study analyzed genital and anal samples from symptomatic patients who attended 15 sexually transmitted infections health facilities from 8 different regions in Peru during the years 2018 to 2019 within the framework of Sentinel Surveillance. After establishing the presumptive diagnosis, the isolates were sent to the Laboratory of Sexually Transmitted Bacteria of the National Institute of Health of Peru in Lima where the species were confirmed (N = 165) and susceptibility profiles were determined.
    Results: Among the 165 isolates, 95.2% corresponded to male patients, between 18 and 22 years of age (40.6%), half reported having a sexual partner and being heterosexual. Clinically, 89.7% manifested the presence of urethral exudate. Microbiology showed 95.2% of the isolates resistant to ciprofloxacin and 9.1% non-susceptible to azithromycin. Reduced susceptibility to ceftriaxone and cefixime was observed in 1.2% and 3.6% of the isolates respectively. All strains tested were susceptible to spectinomycin.
    Conclusions: This study demonstrated that in Peru, fluoroquinolones should not be recommended or used in N. gonorrhoeae infections due to the high percentage of resistant strains. In addition, nationwide access to gonococcal resistance testing, molecular diagnostics and antimicrobial stewardship should be implemented to control the spread of gonococcal antimicrobial resistance.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Azithromycin/pharmacology ; Azithromycin/therapeutic use ; Cefixime ; Ceftriaxone ; Ciprofloxacin ; Drug Resistance, Bacterial ; Fluoroquinolones ; Gonorrhea/drug therapy ; Gonorrhea/epidemiology ; Gonorrhea/microbiology ; Humans ; Male ; Microbial Sensitivity Tests ; Neisseria gonorrhoeae ; Peru/epidemiology ; Spectinomycin
    Chemical Substances Anti-Bacterial Agents ; Fluoroquinolones ; Ciprofloxacin (5E8K9I0O4U) ; Ceftriaxone (75J73V1629) ; Azithromycin (83905-01-5) ; Spectinomycin (93AKI1U6QF) ; Cefixime (97I1C92E55)
    Language English
    Publishing date 2022-07-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 435191-5
    ISSN 1537-4521 ; 0148-5717
    ISSN (online) 1537-4521
    ISSN 0148-5717
    DOI 10.1097/OLQ.0000000000001678
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Increased Detection of Carbapenemase-Producing Enterobacterales Bacteria in Latin America and the Caribbean during the COVID-19 Pandemic.

    Thomas, Genara Romero / Corso, Alejandra / Pasterán, Fernando / Shal, Justina / Sosa, Aldo / Pillonetto, Marcelo / de Souza Peral, Renata Tigulini / Hormazábal, Juan Carlos / Araya, Pamela / Saavedra, Sandra Yamile / Ovalle, Mariá Victoria / Jiménez Pearson, María Antonieta / Chacón, Grettel Chanto / Carbon, Eric / Mazariegos Herrera, Carmen Julia / Velásquez, Selene Del Carmen González / Satan-Salazar, Carolina / Villavicencio, Fernando / Touchet, Nancy Melgarejo /
    Busignani, Sofía / Mayta-Barrios, Maritza / Ramírez-Illescas, Juan / Vega, Mariana López / Mogdasy, Cristina / Rosas, Verónica / Salgado, Nuris / Quiroz, Rodolfo / El-Omeiri, Nathalie / Galas, Marcelo Fabián / Ramón-Pardo, Pilar / Melano, Roberto Gustavo

    Emerging infectious diseases

    2022  Volume 28, Issue 11, Page(s) 1–8

    Abstract: During 2020-2021, countries in Latin America and the Caribbean reported clinical emergence of carbapenemase-producing Enterobacterales that had not been previously characterized locally, increased prevalence of carbapenemases that had previously been ... ...

    Abstract During 2020-2021, countries in Latin America and the Caribbean reported clinical emergence of carbapenemase-producing Enterobacterales that had not been previously characterized locally, increased prevalence of carbapenemases that had previously been detected, and co-production of multiple carbapenemases in some isolates. These increases were likely fueled by changes related to the COVID-19 pandemic, including empirical antibiotic use for potential COVID-19-related bacterial infections and healthcare limitations resulting from the rapid rise in COVID-19 cases. Strengthening antimicrobial resistance surveillance, epidemiologic research, and infection prevention and control programs and antimicrobial stewardship in clinical settings can help prevent emergence and transmission of carbapenemase-producing Enterobacterales.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Pandemics ; Latin America/epidemiology ; beta-Lactamases/genetics ; Bacterial Proteins/genetics ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bacteria
    Chemical Substances carbapenemase (EC 3.5.2.6) ; beta-Lactamases (EC 3.5.2.6) ; Bacterial Proteins ; Anti-Bacterial Agents
    Language English
    Publishing date 2022-10-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2811.220415
    Database MEDical Literature Analysis and Retrieval System OnLINE

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