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  1. Article: [Human bocavirus].

    Mazhul', L A / Isaeva, E I / Zlobin, V I / Viazov, S O

    Voprosy virusologii

    2009  Volume 54, Issue 3, Page(s) 4–7

    Abstract: Human bocavirus (HBoV) is a newly identified parvovirus associated with acute respiratory infections in young children in different parts of the world. It is not inconceivable that this virus is also capable of causing acute gastroenteritis and ... ...

    Abstract Human bocavirus (HBoV) is a newly identified parvovirus associated with acute respiratory infections in young children in different parts of the world. It is not inconceivable that this virus is also capable of causing acute gastroenteritis and asymptomatically persisting in infected children. HBoV is the third widespread human respiratory virus after respiratory syncytial virus and rhinovirus. Polymerase chain reaction remains the most reliable of HBoV detection in clinical samples. Phylogenetic analysis shows the presence of at least 2 circulating variants (genotypes) of HBoV.
    MeSH term(s) Acute Disease ; Adult ; Bocavirus/classification ; Bocavirus/genetics ; Bocavirus/physiology ; Child ; Child, Preschool ; Cytopathogenic Effect, Viral ; Gastroenteritis/diagnosis ; Gastroenteritis/epidemiology ; Gastroenteritis/virology ; Genome, Viral ; Global Health ; Humans ; Infant ; Infant, Newborn ; Parvoviridae Infections/diagnosis ; Parvoviridae Infections/epidemiology ; Parvoviridae Infections/virology ; Respiratory Tract Infections/virology
    Language Russian
    Publishing date 2009-05
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 201241-8
    ISSN 0507-4088
    ISSN 0507-4088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Human metapneumovirus as a common cause of respiratory tract disease].

    Mazhul', L A / Schildgen, O / Isaeva, E I / Viazov, S O

    Voprosy virusologii

    2007  Volume 52, Issue 3, Page(s) 4–8

    Abstract: Human metapneumovirus (HMPV), the newly identified paramyxovirus, causes respiratory infections in children, immunosuppressed patients, and the elderly in different countries of the world. The epidemiology and clinical manifestations of HMPV infection ... ...

    Abstract Human metapneumovirus (HMPV), the newly identified paramyxovirus, causes respiratory infections in children, immunosuppressed patients, and the elderly in different countries of the world. The epidemiology and clinical manifestations of HMPV infection are similar to those in human respiratory syncytial virus infection. The diagnosis of HMPV infection is based on the polymerase chain reaction detection of viral RNA or the recording of rising serum antibody titers. There are at least two genotypes and several subtypes of HMPV in the human population. The use of cell cultures and laboratory animals have provided new evidence for the pathogenesis of HMPV infection, the specific features of antiviral immunity and enabled recombinant HMPV vaccine candidates to be designed.
    MeSH term(s) Animals ; Antibodies, Viral/blood ; Genetic Variation ; Genome, Viral ; Global Health ; Humans ; Metapneumovirus/classification ; Metapneumovirus/genetics ; Metapneumovirus/immunology ; Metapneumovirus/isolation & purification ; Paramyxoviridae Infections/blood ; Paramyxoviridae Infections/diagnosis ; Paramyxoviridae Infections/epidemiology ; Polymerase Chain Reaction ; RNA, Viral/analysis ; Respiratory Tract Infections/blood ; Respiratory Tract Infections/diagnosis ; Respiratory Tract Infections/epidemiology ; Species Specificity ; Vaccines, Synthetic/immunology ; Viral Vaccines/immunology
    Chemical Substances Antibodies, Viral ; RNA, Viral ; Vaccines, Synthetic ; Viral Vaccines
    Language Russian
    Publishing date 2007-05
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 201241-8
    ISSN 0507-4088
    ISSN 0507-4088
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  3. Article: Izuchenie fermentativnoĭ aktivnosti neĭraminidazy razlichnykh shtammov virusa grippa A.

    Mazhul', L A / Ageeva, O N

    Voprosy virusologii

    1983  Volume 28, Issue 1, Page(s) 43–46

    Abstract: Some chemical properties of neuraminidase of the mouse-pathogenic strain A/PR/8/34 (H0N1) and the mouse-apathogenic strain A/Krasnodar/101/59 (H2N2) were studied. Neuraminidase of the pathogenic strain was shown to have a lower specific activity, lower ... ...

    Title translation Enzyme activity of the neuraminidase from various strains of the influenza A virus.
    Abstract Some chemical properties of neuraminidase of the mouse-pathogenic strain A/PR/8/34 (H0N1) and the mouse-apathogenic strain A/Krasnodar/101/59 (H2N2) were studied. Neuraminidase of the pathogenic strain was shown to have a lower specific activity, lower resistance and lower sensitivity to the inhibiting effect of CI ions than neuraminidase of the nonpathogenic strain.
    MeSH term(s) Animals ; Chemical Phenomena ; Chemistry ; Drug Stability ; Hot Temperature ; Hydrogen-Ion Concentration ; Influenza A virus/enzymology ; Influenza A virus/pathogenicity ; Kinetics ; Mice ; Neuraminidase/analysis ; Neuraminidase/metabolism ; Virulence
    Chemical Substances Neuraminidase (EC 3.2.1.18)
    Language Russian
    Publishing date 1983-01
    Publishing country Russia (Federation)
    Document type Comparative Study ; English Abstract ; Journal Article
    ZDB-ID 201241-8
    ISSN 0507-4088
    ISSN 0507-4088
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  4. Article ; Online: Contributi scientifici in memoria di Antonio Fusco.

    Betta, G / Cipolli, C / Carcione, F / Franco, S / Bonaiuto, P / Ciarnella, M / Petrilli, S / De Marco, G / Tuozzi, G / Gioia, E / Zagarella, F / Treglia, E / Cristini, C / Cesa-Bianchini, G / Cristini, L / Belova, S / Ushakov, D / Mazhul, L A / Knyazev, V N /
    De Caroli, M E / Licciardello, O / Falanga, R / Sagone, E / Tomassoni, R / Dorfman, L / D'Angiò, A / Trezza, T / Lungu, M A / Di Nuovo, S / Biasi, V / Montemurro, M / Salvatore, S / Mastandrea, S / Gorrese, A / Starnino, B / Bonaviri, G / Cogliani, M / Di Nenna, M / Dei, P / Petrov, V M / Carcione, M / Rigas, A V / Kalamakis, D / De Vito, Là / Madonna, F / Pulli, G / Åkerström, U / Tiozzo, E / Stamatina Panagiotakopoulou, I / Diamanti, L / Parsi, M R / Spinosa, G / Tudorel, O / Vintilă, M / Cosmin, G / D'Angiò, G / Viceconte, L / Goian, C / Baldassare, I / Ferdinandi, L / Greco, C / Matarazzo, O / Pallikaris, I / Zanon, A / Panaccione, D / Gargano, M / Broccoli, A / Santangelo, N / Mele, L M / Blezza, F / Paone, F / Brandolini, R / Petrini, M / Amodio, S / Barattucci, M

    La Clinica terapeutica

    2020  Volume 171, Issue 3 Supple 1, Page(s) 8–271

    Abstract: Come si leggerà nell'Introduzione della sezione propriamente scientifica del Volume, il presente testo nasce dalla volontà e, soprattutto, dall'esigenza culturale di omaggiare il fu Prof. Antonio Fusco. Un debito scientifico ed umano che trova il suo ... ...

    Abstract Come si leggerà nell'Introduzione della sezione propriamente scientifica del Volume, il presente testo nasce dalla volontà e, soprattutto, dall'esigenza culturale di omaggiare il fu Prof. Antonio Fusco. Un debito scientifico ed umano che trova il suo locus naturale in questa prima parte del testo stesso, cui farà poi seguito la parte propriamente scientifica. In siffatta parentesi dovuta per le ragioni appena menzionate, il lettore, l'amico o l'allievo dell'opera del Prof. Fusco potranno trovare un suo sintetico Curriculum Vitae, correlato da una specifica ed accurata prosa, svolta dal già Magnifico Rettore Carlo Cipolli; il quale, oltre che evidenziare, ricordando, i meriti del collega oramai scomparso, aggiunge alsuo scritto un elemento che sarebbe imprescindibile a non trasformare lo stesso in una mera sequenza di parole: l'amicizia e l'affetto per un amico che, oramai, non c'è più. A fine lettura, evidente risuonerà il fatto che la vita di ognuno, se mossa dalla passione per ciò per cui si è predisposti cognitivamente e psicologicamente, può essere ricca di riconoscimenti, riconoscenze e soddisfazioni che, lungi dal divenire un cuscino di allori su cui adagiarsi, per una mente creativa come quella del Prof. Fusco hanno funto solo da motivazioni ad agire instancabilmente guardando sempre al futuro. Il lavoro di una vita che, materialmente, è sancito da un supporto poco più di cm 25x15: una targa. Una materialità evidente che, con grande commozione e riconoscenza, è stata affissa il 25 ottobre 2019 sull'aula fronte l'Aula Magna del Campus "La Folcara", a testimonianza che quello spirito creativo in continua evoluzione non si ferma; non si arresta neppure con la fine biologica di chi lo ha "posseduto". Rimangono le opere ed il pensiero del Prof. Fusco e restano gli affetti. A tal proposito, il lettore troverà una breve e sentita sezione su Testimonianze; coloro i quali hanno avuto modo, nell'arco della vita accademica ed umana, personale, di Fusco di conoscerlo. Ecco, allora, che i ricordi saranno i veri protagonisti di questa parentesi. Dopo di ciò, prima dei contributi prettamente scientifici dei lavori, tenutisi in occasione del Convegno Internazionale Psicologia, Arte, Letteratura. Antiche e Nuove Tendenze, seguiranno i saluti delle autorità che in quei due giorni si sono succedute a rappresentare non solo l'istituzione affiliata, ma anche la relazione di stima e di affetto che le legava al compianto Professore. Si passerà, infine, al volume tradizionalmente inteso.
    MeSH term(s) History, 21st Century ; Humans ; Italy ; Psychology/history
    Language English
    Publishing date 2020-11-02
    Publishing country Italy
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 123320-8
    ISSN 1972-6007 ; 0009-9074
    ISSN (online) 1972-6007
    ISSN 0009-9074
    DOI 10.7417/CT.2020.2227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Ugnetenie respiratornymi virusami (gripp, adenovirus) immunogo otveta u mysheĭ.

    Sidorova, E V / Agadzhanian, M G / Mazhul', L A / Biladi, I / Bakai, M / Berenchi, K

    Biulleten' eksperimental'noi biologii i meditsiny

    1991  Volume 111, Issue 5, Page(s) 510–512

    Abstract: The influence of respiratory viruses (adenovirus, influenza virus) on humoral immune response to heterologous T-dependent and T-independent antigens was studied. It was shown that inoculation of mice by the influenza virus (A/PR8/34-A/PR/8) 3 days before ...

    Title translation Immunosuppression induced by respiratory viruses (influenza virus, adenovirus) in mice.
    Abstract The influence of respiratory viruses (adenovirus, influenza virus) on humoral immune response to heterologous T-dependent and T-independent antigens was studied. It was shown that inoculation of mice by the influenza virus (A/PR8/34-A/PR/8) 3 days before sheep red blood cells administration led to the inhibition of antibody forming cell (AFC) and immunoglobulin, forming cell (IFC) increase on 69% and 59% respectively. Adenovirus type 6 induced the similar suppression of AFC and IFC formation. Thus, viruses induced immuno-suppression, which was polyclonal. It was also shown that virus of one strain (type) could inhibit immune response to another strain (type) of virus. The immune response to T-independent antigen was not suppressed. The virus-induced immunosuppression was dependent on: 1) the infectivity of respiratory viruses, 2) the route of virus and heterologous antigen injection, and 3) the interval between the viruses and antigen inoculation.
    MeSH term(s) Adenoviridae/immunology ; Animals ; Antibodies, Viral/analysis ; Antibody Formation ; Antigens, Viral/immunology ; Female ; Immunosuppression ; Influenza A virus/immunology ; Mice ; Mice, Inbred BALB C
    Chemical Substances Antibodies, Viral ; Antigens, Viral
    Language Russian
    Publishing date 1991-05
    Publishing country Russia (Federation)
    Document type Comparative Study ; English Abstract ; Journal Article
    ZDB-ID 127365-6
    ISSN 0365-9615 ; 0006-4041
    ISSN 0365-9615 ; 0006-4041
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  6. Article: Prochnoe sviazyvanie RNK s belkom v chastitsakh palochkovidnogo virusa pod deĭstviem formal'degida.

    Mazhul', L A / Dobrov, E N / Tikhonenko, T I

    Biokhimiia (Moscow, Russia)

    1978  Volume 43, Issue 1, Page(s) 138–145

    Abstract: The formaldehyde-induced formation of tightly bound RNA-protein complexes of rod-like plant viruses was studied. The preparations of tobacco mosaic virus and closely related cucumber virus 4 were incubated with 1.5% formaldehyde for 20-50 hrs at 50 ... ...

    Title translation Formaldehyde-induced tight binding of protein to RNA in particles of rod-like virus.
    Abstract The formaldehyde-induced formation of tightly bound RNA-protein complexes of rod-like plant viruses was studied. The preparations of tobacco mosaic virus and closely related cucumber virus 4 were incubated with 1.5% formaldehyde for 20-50 hrs at 50 degrees C. Then the viral particles were disrupted, free protein was removed and viral RNA was centrifuged in the linear gradient of Cs2SO4. The RNAs from the formaldehyde-untreated viruses and RNA from the formaldehyde-treated tobacco masaic virus had the density of 1.65-1.66 g/cm3, while RNA from the formaldehyde-treated cucumber virus had the density of 1.57-1.42 g/cm3, depending on the incubation time. This is indicative of the protein binding to RNA. Treatment of the cucumber virus complex with pronase resulted in a liberation of free RNA with the density of 1.66 g/cm3; incubation for 2 min at 100 degrees C in a dissociating mixture (2% sodium dodecyl sulfate + 0.2% mercaptoethanol) did not cause the dissociation of the complex. Polyacrylamide gel electrophoresis showed that the most part of the protein molecules are bound within the complex not by covalent protein-protein cross-links.
    MeSH term(s) Formaldehyde/pharmacology ; Mosaic Viruses/drug effects ; Mosaic Viruses/metabolism ; Plant Viruses/metabolism ; Pronase ; Protein Binding ; RNA, Viral/metabolism ; Species Specificity ; Tobacco Mosaic Virus/metabolism ; Viral Proteins/metabolism
    Chemical Substances RNA, Viral ; Viral Proteins ; Formaldehyde (1HG84L3525) ; Pronase (EC 3.4.24.-)
    Language Russian
    Publishing date 1978-01
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 1109-5
    ISSN 1608-3040 ; 0320-9725 ; 0006-2979 ; 0320-9717
    ISSN (online) 1608-3040
    ISSN 0320-9725 ; 0006-2979 ; 0320-9717
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Sravnitel'noe izuchenie biologicheskikh svoĭstv preparatov virusa grippa, ochishchennykh metodami tsentrifugirovaniia i khromatografii.

    Iordan, A G / Mazhul', L A / Shcheglovitova, O N / Ageeva, O N

    Voprosy virusologii

    1983  , Issue 2, Page(s) 150–154

    Abstract: A comparative study of chromatography and centrifugation as applied to purification of 2 influenza virus strains with different antigenic structure (H0N1 and H2N2) and of some biological properties of the resulting preparations was carried out. Certain ... ...

    Title translation Comparative study of the biological properties of influenza virus preparations purified by centrifugation and chromatography.
    Abstract A comparative study of chromatography and centrifugation as applied to purification of 2 influenza virus strains with different antigenic structure (H0N1 and H2N2) and of some biological properties of the resulting preparations was carried out. Certain strain-specific differences manifested in their chromatographic behaviour and in the degree of purification of virions from the allantoic fluid proteins were found. Some quantitative differences observed in the capacity of the resulting virus preparations to infect chick embryos and primary and continuous cells are insignificant and cannot be used for judgement of advantages of one or the other of the methods used for influenza virus purification.
    MeSH term(s) Animals ; Centrifugation, Isopycnic/methods ; Chick Embryo ; Chromatography, DEAE-Cellulose/methods ; Chromatography, Gel ; Influenza A virus/isolation & purification ; Species Specificity ; Ultracentrifugation/methods
    Language Russian
    Publishing date 1983-03
    Publishing country Russia (Federation)
    Document type Comparative Study ; English Abstract ; Journal Article
    ZDB-ID 201241-8
    ISSN 0507-4088
    ISSN 0507-4088
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  8. Article: Genotipy virusa gepatita C u bol'nykh gemofilieĭ.

    Kuzin, S N / Mazhul', L A / Snegireva, I B / Pliushts, O P / Gorbarets, I P / Shakhgil'dian, I V / Viazov, S O

    Voprosy virusologii

    1996  Volume 41, Issue 2, Page(s) 63–65

    Abstract: Testing of blood sera of 63 hemophiliacs revealed markers of hepatitides B and C in 97 and 98% cases, respectively. Polymerase chain reaction confirmed the presence of hepatitis C virus (HCV) RNA in 31 (94%) out of 33 sera tested which contained ... ...

    Title translation Genotype of hepatitis C virus in hemophiliacs.
    Abstract Testing of blood sera of 63 hemophiliacs revealed markers of hepatitides B and C in 97 and 98% cases, respectively. Polymerase chain reaction confirmed the presence of hepatitis C virus (HCV) RNA in 31 (94%) out of 33 sera tested which contained antibodies to HCV. Gene typing of the isolated strains revealed the presence of three types of HCV: 1b (94%), 2a (3%), and 3a (3%). Similar distribution of HCV genotypes was revealed in the blood sera of 39 patients with chronic hepatitis C.
    MeSH term(s) Chronic Disease ; Genotype ; Hemophilia A/complications ; Hepacivirus/classification ; Hepacivirus/genetics ; Hepacivirus/isolation & purification ; Hepatitis C/complications ; Hepatitis C Antibodies/blood ; Humans ; Immunoenzyme Techniques ; Polymerase Chain Reaction ; RNA, Viral/blood
    Chemical Substances Hepatitis C Antibodies ; RNA, Viral
    Language Russian
    Publishing date 1996-03
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 201241-8
    ISSN 0507-4088
    ISSN 0507-4088
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  9. Article: Protektivnoe deĭstvie vkliuchennykh v liposomy poverkhnostnykh antigenov virusa grippa pri razlichnykh sposobakh immunizatsii.

    Burkhanov, S A / Mazhul', L A / Torchilin, V P / Ageeva, O N / Saatov, T S

    Voprosy virusologii

    1988  Volume 33, Issue 2, Page(s) 151–153

    Abstract: The influence of different routes of immunization on the protective effect of liposome-incorporated influenza A/PR/8/34 virus surface antigens was studied. Influenza virus surface antigens, neuraminidase and hemagglutinin, incorporated into liposomes, ... ...

    Title translation Protective action of liposome-incorporated surface antigens of the influenza virus by different methods of immunization.
    Abstract The influence of different routes of immunization on the protective effect of liposome-incorporated influenza A/PR/8/34 virus surface antigens was studied. Influenza virus surface antigens, neuraminidase and hemagglutinin, incorporated into liposomes, were shown to have a significant protective effect upon intraperitoneal and intranasal administration against a lethal dose of influenza virus as compared with immunization using a free antigen solution against the same infection. The protective effect is poor in intravenous immunization with influenza virus antigen-containing liposomes. It is concluded that combining of influenza virus antigens with liposomes may be used for preparation of new influenza vaccines.
    MeSH term(s) Animals ; Antigens, Surface/administration & dosage ; Antigens, Surface/immunology ; Antigens, Viral/administration & dosage ; Antigens, Viral/immunology ; Drug Evaluation, Preclinical ; Hemagglutinins, Viral/administration & dosage ; Hemagglutinins, Viral/immunology ; Immunization/methods ; Influenza A virus/immunology ; Liposomes/administration & dosage ; Mice ; Mice, Inbred BALB C ; Neuraminidase/administration & dosage ; Neuraminidase/immunology ; Orthomyxoviridae Infections/mortality ; Orthomyxoviridae Infections/prevention & control
    Chemical Substances Antigens, Surface ; Antigens, Viral ; Hemagglutinins, Viral ; Liposomes ; Neuraminidase (EC 3.2.1.18)
    Language Russian
    Publishing date 1988-03
    Publishing country Russia (Federation)
    Document type Comparative Study ; English Abstract ; Journal Article
    ZDB-ID 201241-8
    ISSN 0507-4088
    ISSN 0507-4088
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  10. Article: Ispol'zovanie tsvitterionnogo detergenta sul'fobetaina-12 dlia polucheniia virosom i izuchenie ikh immunogennykh i protektivnykh svoĭstv.

    Mazhul', L A / Smirnova, G V / Lotte, V D / Zhigis, L S / Reshetov, P D

    Molekuliarnaia genetika, mikrobiologiia i virusologiia

    1988  , Issue 12, Page(s) 42–47

    Abstract: Virosomes were prepared by using the zwitterion detergent sulfobetaine-12. The virosomes included the surface antigens and virus-specific lipids of influenza virus, strain A/PR/8/34. Immunogenic and protective properties of the surface antigens in the ... ...

    Title translation Use of the zwitterion detergent Sulfobetain-12 for preparation of virosomes and investigation of their immunogenic and protective properties.
    Abstract Virosomes were prepared by using the zwitterion detergent sulfobetaine-12. The virosomes included the surface antigens and virus-specific lipids of influenza virus, strain A/PR/8/34. Immunogenic and protective properties of the surface antigens in the micellar form and as a complex with the virosomes were studied. The surface antigens of this complex, like the intact virus, were found to possess the high immunogenic and protective activity in relation to the following infection with the homologous pathogenic virus.
    MeSH term(s) Animals ; Antibodies/analysis ; Detergents ; Influenza A virus/drug effects ; Influenza A virus/immunology ; Mice ; Orthomyxoviridae Infections/immunology ; Orthomyxoviridae Infections/prevention & control ; Quaternary Ammonium Compounds ; Solubility ; Surface-Active Agents
    Chemical Substances Antibodies ; Detergents ; Quaternary Ammonium Compounds ; Surface-Active Agents ; zwittergent 3-12 (14933-08-5)
    Language Russian
    Publishing date 1988-12
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 989858-x
    ISSN 0208-0613
    ISSN 0208-0613
    Database MEDical Literature Analysis and Retrieval System OnLINE

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