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Article ; Online: Infertility in the Aging Male.

Mazur, Daniel J / Lipshultz, Larry I

2018 Volume 19, Issue 7, Page(s) 54

Abstract: Purpose of review: In many countries, the average age of paternity is rising. The negative effect of older age on fertility in women is well documented; however, less is known about the impact of paternal age on fecundity. In this review, we summarize ... ...

Abstract	Purpose of review: In many countries, the average age of paternity is rising. The negative effect of older age on fertility in women is well documented; however, less is known about the impact of paternal age on fecundity. In this review, we summarize the current knowledge of how paternal age affects semen parameters, reproductive success, and offspring health. Recent findings: Contemporary evidence confirms that aged men have worse semen parameters, including overall negative changes in sperm genetics. Reproductive outcomes with unassisted pregnancy tend to be worse with older fathers. While most current studies of assisted pregnancy do show a negative effect of paternal age, there are some conflicting results. Studies continue to show an overall increased risk of health problems, particularly neuropsychiatric conditions, in the offspring of older men. While men can often maintain fertility potential throughout a lifetime, increasing evidence indicates worsening of semen parameters, including sperm genetics, and potentially worse reproductive success. Older men should also be counseled on their offspring's possible increased risk of certain medical conditions.
MeSH term(s)	Age Factors ; Humans ; Infertility, Male/epidemiology ; Male ; Paternal Age ; Risk Factors ; Spermatozoa
Language	English
Publishing date	2018-05-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057354-6
ISSN	1534-6285 ; 1527-2737
ISSN (online)	1534-6285
ISSN	1527-2737
DOI	10.1007/s11934-018-0802-3
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Zs.A 5528: Show issues

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Article ; Online: Cannabis and Male Fertility: A Systematic Review.

Payne, Kelly S / Mazur, Daniel J / Hotaling, James M / Pastuszak, Alexander W

The Journal of urology

2019 Volume 202, Issue 4, Page(s) 674–681

Abstract: Purpose: With cannabis consumption on the rise and use prominent among males of reproductive age it is essential to understand the potential impact of cannabis on male fertility. We reviewed the literature regarding the effects of cannabis on male ... ...

Abstract	Purpose: With cannabis consumption on the rise and use prominent among males of reproductive age it is essential to understand the potential impact of cannabis on male fertility. We reviewed the literature regarding the effects of cannabis on male fertility. Materials and methods: We performed a literature search using PubMed®/MEDLINE® to identify relevant studies of the effects of cannabis on male fertility. Relevant studies were identified and reviewed. Results: The strongest evidence of cannabis induced alterations in male fertility is in the category of semen parameters. Research supports a role for cannabis in reducing sperm count and concentration, inducing abnormalities in sperm morphology, reducing sperm motility and viability, and inhibiting capacitation and fertilizing capacity. Animal models demonstrate a role for cannabis in testicular atrophy, and reduced libido and sexual function but to our knowledge these results have not yet been replicated in human studies. Studies of hormonal changes suggest inconclusive effects on testosterone levels, lowered luteinizing hormone levels and unchanged follicle-stimulating hormone levels. Conclusions: Current research suggests that cannabis may negatively impact male fertility. Further studies are needed to validate that robust findings in animal models will carry over into human experience. Clinicians should be aware of these potential effects when prescribing medical marijuana therapies to men of reproductive age, and they should consider the degree of cannabis use as a possible component of a complete male infertility workup.
MeSH term(s)	Animals ; Cell Survival/drug effects ; Disease Models, Animal ; Fertility/drug effects ; Humans ; Infertility, Male/chemically induced ; Infertility, Male/pathology ; Male ; Medical Marijuana/adverse effects ; Semen/drug effects ; Sperm Motility/drug effects ; Testis/drug effects ; Testis/pathology
Chemical Substances	Medical Marijuana
Language	English
Publishing date	2019-09-06
Publishing country	United States
Document type	Journal Article ; Systematic Review
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1097/JU.0000000000000248
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Article ; Online: Sperm retrieval and intracytoplasmic sperm injection outcomes in men with cystic fibrosis disease versus congenital bilateral absence of the vas deferens.

McBride, J Abram / Kohn, Taylor P / Mazur, Daniel J / Lipshultz, Larry I / Coward, R Matthew

Asian journal of andrology

2020 Volume 23, Issue 2, Page(s) 140–145

Abstract: Recent data suggest that cystic fibrosis transmembrane conductance regulator (CFTR) gene alterations negatively impact male fertility beyond obstruction. We sought to compare gene alterations, sperm retrieval rates, and intracytoplasmic sperm injection ( ... ...

Abstract	Recent data suggest that cystic fibrosis transmembrane conductance regulator (CFTR) gene alterations negatively impact male fertility beyond obstruction. We sought to compare gene alterations, sperm retrieval rates, and intracytoplasmic sperm injection (ICSI) outcomes among men with cystic fibrosis (CF) disease and congenital bilateral absence of the vas deferens (CBAVD) only. We retrospectively evaluated all men who underwent surgical sperm retrieval at two academic, high-volume andrology centers from 2010 to 2018. Only men with documented CFTR alterations and obstructive azoospermia from either CBAVD or CF were included. Differences between groups for CFTR abnormality, sperm retrieval, and ICSI outcomes were statistically analyzed. Overall, 39 patients were included with 10 in the CF and 29 in the CBAVD groups. Surgical sperm retrieval rates were significantly lower in the CF group for sperm concentration (14.8 × 10
MeSH term(s)	Adult ; Azoospermia/etiology ; Azoospermia/therapy ; Cystic Fibrosis/complications ; Cystic Fibrosis/physiopathology ; Humans ; Male ; Male Urogenital Diseases/complications ; Male Urogenital Diseases/physiopathology ; Sperm Injections, Intracytoplasmic ; Sperm Retrieval ; Treatment Outcome ; Vas Deferens/abnormalities ; Vas Deferens/physiopathology
Language	English
Publishing date	2020-11-22
Publishing country	China
Document type	Comparative Study ; Journal Article
ZDB-ID	2075824-8
ISSN	1745-7262 ; 1008-682X
ISSN (online)	1745-7262
ISSN	1008-682X
DOI	10.4103/aja.aja_48_20
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Zs.A 5739: Show issues

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Article ; Online: Mast cell function in prostate inflammation, fibrosis, and smooth muscle cell dysfunction.

Pattabiraman, Goutham / Bell-Cohn, Ashlee J / Murphy, Stephen F / Mazur, Daniel J / Schaeffer, Anthony J / Thumbikat, Praveen

American journal of physiology. Renal physiology

2021 Volume 321, Issue 4, Page(s) F466–F479

Abstract: Intraurethral inoculation of mice with ... ...

Abstract	Intraurethral inoculation of mice with uropathogenic
MeSH term(s)	Animals ; Anti-Allergic Agents/therapeutic use ; Cetirizine/therapeutic use ; Cromolyn Sodium/therapeutic use ; Escherichia coli ; Escherichia coli Infections/drug therapy ; Escherichia coli Infections/metabolism ; Escherichia coli Infections/pathology ; Fibrosis/metabolism ; Fibrosis/pathology ; Humans ; Male ; Mast Cells/physiology ; Mice ; Mice, Inbred C57BL ; Myocytes, Smooth Muscle/metabolism ; Myocytes, Smooth Muscle/pathology ; Prostate/metabolism ; Prostate/pathology ; Prostatic Diseases/metabolism ; Prostatic Diseases/pathology ; Urination
Chemical Substances	Anti-Allergic Agents ; Cromolyn Sodium (Q2WXR1I0PK) ; Cetirizine (YO7261ME24)
Language	English
Publishing date	2021-08-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	603837-2
ISSN	1522-1466 ; 0363-6127
ISSN (online)	1522-1466
ISSN	0363-6127
DOI	10.1152/ajprenal.00116.2021
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Article ; Online: Uropathogenic Escherichia coli-induced fibrosis, leading to lower urinary tract symptoms, is associated with type 2 cytokine signaling.

Bell-Cohn, Ashlee / Mazur, Daniel J / Hall, Christel / Schaeffer, Anthony J / Thumbikat, Praveen

American journal of physiology. Renal physiology

2019 Volume 316, Issue 4, Page(s) F682–F692

Abstract: Chronic inflammation and prostate fibrosis have been identified as contributors to lower urinary tract symptoms (LUTS) pathophysiology in humans. It has been shown that transurethral infection of an Escherichia coli strain named CP1, which was isolated ... ...

Abstract	Chronic inflammation and prostate fibrosis have been identified as contributors to lower urinary tract symptoms (LUTS) pathophysiology in humans. It has been shown that transurethral infection of an Escherichia coli strain named CP1, which was isolated from a patient with chronic prostatitis, can lead to the develop of differential chronic inflammation and pain in certain mouse strains. Therefore, we hypothesized that differential inflammation would influence fibrotic response in the prostate. This study showed that while prostatic infection by CP1 causes the development of chronic tactile allodynia in NOD/ShiltJ (NOD) but not C57BL/6 (B6) mice, both mice developed evidence of prostate inflammation, prostate fibrosis, and urinary dysfunction. Fibrosis was confirmed by the upregulation of fibrosis-associated messenger RNAs (mRNAs), α-smooth muscle actin immunohistochemistry, and collagen staining with picrosirius red. These findings were mainly focused on the dorsolateral lobes of the prostate. Both mouse strains also developed smaller, more frequent voiding patterns postinfection, examined via cystometry. B6 mice responded to CP1 infection with type 2 cytokines (IL-4 and IL-13), while NOD mice did not, which may explain the differing tactile allodynia responses and level of collagen deposition. When mice lacking signal transducer and activator of transcription 6 (STAT6), a transcription factor known to be important for the production and signaling of IL-4 and IL-13, were infected with CP1, fibrosis was attenuated. This study provides a potential model for studying the development of infection-induced prostatic fibrosis and LUTS. This study also demonstrates that CP1-induced prostate fibrosis has a STAT6-dependent mechanism in B6 mice.
MeSH term(s)	Animals ; Cytokines ; Escherichia coli Infections/pathology ; Escherichia coli Infections/physiopathology ; Fibrosis ; Hyperalgesia/etiology ; Interleukin-13/biosynthesis ; Interleukin-4/biosynthesis ; Lower Urinary Tract Symptoms/pathology ; Lower Urinary Tract Symptoms/physiopathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Mice, Knockout ; Pain Measurement ; Prostate/pathology ; STAT6 Transcription Factor/metabolism ; Signal Transduction ; Uropathogenic Escherichia coli
Chemical Substances	Cytokines ; Il4 protein, mouse ; Interleukin-13 ; STAT6 Transcription Factor ; Stat6 protein, mouse ; Interleukin-4 (207137-56-2)
Language	English
Publishing date	2019-01-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	603837-2
ISSN	1522-1466 ; 0363-6127
ISSN (online)	1522-1466
ISSN	0363-6127
DOI	10.1152/ajprenal.00222.2018
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Article ; Online: Role of gram-positive bacteria in chronic pelvic pain syndrome (CPPS).

Murphy, Stephen F / Anker, Jonathan F / Mazur, Daniel J / Hall, Christel / Schaeffer, Anthony J / Thumbikat, Praveen

The Prostate

2018 Volume 79, Issue 2, Page(s) 160–167

Abstract: Introduction: Chronic pelvic pain syndrome (CPPS) is a complex disorder that affects a large proportion of all men. A limited understanding of its etiology and pathogenesis is reflected by the absence of effective therapies. Although CPPS is deemed ... ...

Abstract	Introduction: Chronic pelvic pain syndrome (CPPS) is a complex disorder that affects a large proportion of all men. A limited understanding of its etiology and pathogenesis is reflected by the absence of effective therapies. Although CPPS is deemed clinically non-infectious with no well-defined etiological role for microbes, bacteria is readily isolated from both healthy and patient prostate secretion and urine samples. Our laboratory has previously demonstrated that a specific gram-negative bacterial isolate can induce CPPS-like symptoms in mice. Here we aimed to expand on these findings examining the role of gram-positive patient-derived bacteria in CPPS. Methods: A retrospective analysis of bacterial cultures from CPPS patients from a single center was performed. Gram-positive bacteria were isolated from the expressed prostatic secretion (EPS) of three CPPS-patients (pain inducers, PI) and one from a healthy volunteer (non-pain inducer, NPI). These bacteria were inoculated intra-urethrally in two mouse backgrounds and analyzed for their ability to induce tactile allodynia, voiding dysfunction, and colonize the murine prostate. Host immune responses to bacterial instillation were analyzed by flow cytometry. Results: PI strains (Staphylococcus haemolyticus 2551, Enterococcus faecalis 427, and Staphylococcus epidermidis 7244) induced and maintained tactile allodynia responses (200% increase above baseline) for 28 days in NOD/ShiLtJ mice. Conversely the healthy subject derived strain (Staphylococcus epidermidis NPI) demonstrated no significant pelvic allodynia induction. Intra-urethral inoculation of the four bacterial strains into C57BL/6 mice did not induce significant increases in pain responses. Infected NOD/ShiLtJ displayed significant voiding dysfunction compared to their control counterparts. Colony counts of prostate tissues from both NOD/ShiLtJ and C57BL/6 mice at day 28 demonstrated that bacterial strains colonized equally well, including NPI. We also determined that mechanistically, the patient-isolates induced prostate inflammation specifically involving T-cells and monocytes. Conclusions: Gram-positive isolates from CPPS patients showed enhanced ability to induce tactile allodynia compared to a single taxonomically similar gram-positive strain isolated from a healthy control. Responses were shown to be dependent on host genetic background and not on colonization differences between strains.
MeSH term(s)	Animals ; Chronic Pain/immunology ; Chronic Pain/microbiology ; Gram-Positive Bacteria/isolation & purification ; Gram-Positive Bacterial Infections/immunology ; Gram-Positive Bacterial Infections/microbiology ; Humans ; Hyperalgesia/microbiology ; Lymph Nodes/immunology ; Lymph Nodes/microbiology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Pelvic Pain/immunology ; Pelvic Pain/microbiology ; Prostate/immunology ; Prostate/microbiology ; Prostatitis/microbiology ; Random Allocation ; Retrospective Studies ; T-Lymphocytes/immunology ; Urethral Diseases/immunology ; Urethral Diseases/microbiology
Language	English
Publishing date	2018-09-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	604707-5
ISSN	1097-0045 ; 0270-4137
ISSN (online)	1097-0045
ISSN	0270-4137
DOI	10.1002/pros.23721
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Article ; Online: Management of non-catheter-associated complicated urinary tract infection.

Dielubanza, Elodi J / Mazur, Daniel J / Schaeffer, Anthony J

Infectious disease clinics of North America

2014 Volume 28, Issue 1, Page(s) 121–134

Abstract: This article presents an overview of non-catheter-associated complicated urinary tract infection (UTI) from a urologic point of view. Discussion includes the evaluation and workup a complicated UTI through history, physical examination, laboratory ... ...

Abstract	This article presents an overview of non-catheter-associated complicated urinary tract infection (UTI) from a urologic point of view. Discussion includes the evaluation and workup a complicated UTI through history, physical examination, laboratory analysis, and radiographic studies. Specific types of complicated UTI, such as urinary obstruction and renal abscess, are reviewed.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Bacteriuria/diagnosis ; Bacteriuria/drug therapy ; Bacteriuria/etiology ; Female ; Humans ; Male ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; Urinary Tract Infections/complications ; Urinary Tract Infections/diagnosis ; Urinary Tract Infections/therapy
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2014-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1077676-x
ISSN	1557-9824 ; 0891-5520
ISSN (online)	1557-9824
ISSN	0891-5520
DOI	10.1016/j.idc.2013.10.005
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Article ; Online: Update on Antibiotic Prophylaxis for Genitourinary Procedures in Patients with Artificial Joint Replacement and Artificial Heart Valves.

Mazur, Daniel J / Fuchs, Daniel J / Abicht, Travis O / Peabody, Terrance D

The Urologic clinics of North America

2015 Volume 42, Issue 4, Page(s) 441–447

Abstract: Infection of artificial joint replacements and heart valves is an uncommon but serious complication encountered anytime after the implantation of these prostheses. It is known that bacteremia can lead to infection of a prosthetic device. However, there ... ...

Abstract	Infection of artificial joint replacements and heart valves is an uncommon but serious complication encountered anytime after the implantation of these prostheses. It is known that bacteremia can lead to infection of a prosthetic device. However, there is no strong evidence to correlate urologic procedures with the development of periprosthetic joint infection or prosthetic valve endocarditis. Therefore, antibiotic prophylaxis for the prevention of endocarditis is not recommended in patients undergoing urologic procedures. However, guidelines regarding prophylaxis to prevent infection of an artificial joint in the setting of a genitourinary procedure are more varied.
MeSH term(s)	Antibiotic Prophylaxis ; Bacteremia/prevention & control ; Endocarditis, Bacterial/prevention & control ; Heart Valve Prosthesis ; Humans ; Joint Prosthesis ; Practice Guidelines as Topic ; Prosthesis-Related Infections/prevention & control ; Urogenital Surgical Procedures/adverse effects
Language	English
Publishing date	2015-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	192293-2
ISSN	1558-318X ; 0094-0143
ISSN (online)	1558-318X
ISSN	0094-0143
DOI	10.1016/j.ucl.2015.06.003
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Article ; Online: Simultaneous urethrocutaneous and urethrocavernous fistula after proximal corporospongiosal shunt for priapism.

Manjunath, Adarsh S / Mazur, Daniel J / Han, Justin S / Gonzalez, Christopher M

Urology

2015 Volume 85, Issue 3, Page(s) e13–4

Abstract: Proximal corporospongiosal shunts are used for the most refractory cases of priapism. Here, we present the case of a 58-year-old man whose priapism was only partially responsive to phenylephrine injections and distal shunting. Proximal shunting was ... ...

Abstract	Proximal corporospongiosal shunts are used for the most refractory cases of priapism. Here, we present the case of a 58-year-old man whose priapism was only partially responsive to phenylephrine injections and distal shunting. Proximal shunting was required, and he subsequently developed fistulization of the proximal penile urethra into the skin and the corpora cavernosa. The formation of simultaneous urethrocutaneous and urethrocavernous fistulae is a rare complication of proximal corporospongiosal shunts that can be initially managed with urinary diversion with a suprapubic tube.
MeSH term(s)	Anastomosis, Surgical/adverse effects ; Cutaneous Fistula/etiology ; Fistula/etiology ; Humans ; Male ; Penile Diseases/etiology ; Penis/surgery ; Priapism/surgery ; Prostheses and Implants ; Urethral Diseases/etiology ; Urinary Fistula/etiology ; Urologic Surgical Procedures, Male/adverse effects ; Urologic Surgical Procedures, Male/methods
Language	English
Publishing date	2015-03
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2014.12.018
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Zs.A 1142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Selective Androgen Receptor Modulators: Current Knowledge and Clinical Applications.

Solomon, Zachary J / Mirabal, Jorge Rivera / Mazur, Daniel J / Kohn, Taylor P / Lipshultz, Larry I / Pastuszak, Alexander W

Sexual medicine reviews

2018 Volume 7, Issue 1, Page(s) 84–94

Abstract: Introduction: Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors depending on each SARM's chemical structure. As a result, SARMs result in anabolic cellular activity while avoiding many of the side effects of ... ...

Abstract	Introduction: Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors depending on each SARM's chemical structure. As a result, SARMs result in anabolic cellular activity while avoiding many of the side effects of currently available anabolic steroids. SARMs have been studied in the treatment of breast cancer and cachexia and have also been used as performance-enhancing agents. Here, we evaluate and summarize the current literature on SARMs. Aim: To present the background, mechanisms, current and potential clinical applications, as well as risks and benefits of SARMs. Methods: A literature review was performed in MEDLINE using the terms selective androgen receptor modulator, hypogonadism, cachexia, breast cancer, benign prostatic hyperplasia, libido, and lean muscle mass. Both basic research and clinical studies were included. Main outcome measure: To complete a review of peer-reviewed literature. Results: Although there are currently no U.S. Food and Drug Agency-approved indications for SARMs, investigators are exploring the potential uses for these compounds. Basic research has focused on the pharmacokinetics and pharmacodynamics of these agents, demonstrating good availability with a paucity of drug interactions. Early clinical studies have demonstrated potential uses for SARMs in the treatment of cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and breast cancer, with positive results. Conclusion: SARMs have numerous possible clinical applications, with promise for the safe use in the treatment of cachexia, BPH, hypogonadism, breast cancer, and prostate cancer. Solomon ZJ, Mirabal JR, Mazur DJ, et al. Selective Androgen Receptor Modulators: Current Knowledge and Clinical Applications. Sex Med Rev 2019;7:84-94.
MeSH term(s)	Androgen Receptor Antagonists/pharmacology ; Androgen Receptor Antagonists/therapeutic use ; Androgens/blood ; Breast Neoplasms/drug therapy ; Breast Neoplasms/prevention & control ; Cachexia/drug therapy ; Clinical Trials as Topic ; Female ; Humans ; Hypogonadism/drug therapy ; Male ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/prevention & control ; Receptors, Androgen/drug effects
Chemical Substances	Androgen Receptor Antagonists ; Androgens ; Receptors, Androgen
Language	English
Publishing date	2018-11-30
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2722257-3
ISSN	2050-0521 ; 2050-0513
ISSN (online)	2050-0521
ISSN	2050-0513
DOI	10.1016/j.sxmr.2018.09.006
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