LIVIVO - Search results -

Search results

Result 1 - 9 of total 9

Search options

Article ; Online: B cell somatic hypermutation following COVID-19 vaccination with Ad26.COV2.S.

Jacob-Dolan, Catherine / Lifton, Michelle / Powers, Olivia C / Miller, Jessica / Hachmann, Nicole P / Vu, Mya / Surve, Nehalee / Mazurek, Camille R / Fisher, Jana L / Rodrigues, Stefanie / Patio, Robert C / Anand, Trisha / Le Gars, Mathieu / Sadoff, Jerald / Schmidt, Aaron G / Barouch, Dan H

iScience

2024 Volume 27, Issue 5, Page(s) 109716

Abstract: The viral vector-based COVID-19 vaccine Ad26.COV2.S has been recommended by the WHO since 2021 and has been administered to over 200 million people. Prior studies have shown that Ad26.COV2.S induces durable neutralizing antibodies (NAbs) that increase in ...

Abstract	The viral vector-based COVID-19 vaccine Ad26.COV2.S has been recommended by the WHO since 2021 and has been administered to over 200 million people. Prior studies have shown that Ad26.COV2.S induces durable neutralizing antibodies (NAbs) that increase in coverage of variants over time, even in the absence of boosting or infection. Here, we studied humoral responses following Ad26.COV2.S vaccination in individuals enrolled in the initial Phase 1/2a trial of Ad26.COV2.S in 2020. Through 8 months post vaccination, serum NAb responses increased to variants, including B.1.351 (Beta) and B.1.617.2 (Delta), without additional boosting or infection. The level of somatic hypermutation, measured by nucleotide changes in the VDJ region of the heavy and light antibody chains, increased in Spike-specific B cells. Highly mutated mAbs from these sequences neutralized more SARS-CoV-2 variants than less mutated comparators. These findings suggest that the increase in NAb breadth over time following Ad26.COV2.S vaccination is mediated by affinity maturation.
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2024.109716
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Substantial Neutralization Escape by SARS-CoV-2 Omicron Variants BQ.1.1 and XBB.1.

Miller, Jessica / Hachmann, Nicole P / Collier, Ai-Ris Y / Lasrado, Ninaad / Mazurek, Camille R / Patio, Robert C / Powers, Olivia / Surve, Nehalee / Theiler, James / Korber, Bette / Barouch, Dan H

The New England journal of medicine

2023 Volume 388, Issue 7, Page(s) 662–664

MeSH term(s)	Humans ; Antibodies, Neutralizing/genetics ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/genetics ; Antibodies, Viral/immunology ; COVID-19/genetics ; COVID-19/immunology ; COVID-19/virology ; Immune Evasion/genetics ; Immune Evasion/immunology ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral
Language	English
Publishing date	2023-01-18
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2214314
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.34: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Waning immunity and IgG4 responses following bivalent mRNA boosting.

Science advances

2024 Volume 10, Issue 8, Page(s) eadj9945

Abstract: Messenger RNA (mRNA) vaccines were highly effective against the ancestral SARS-CoV-2 strain, but the efficacy of bivalent mRNA boosters against XBB variants was substantially lower. Here, we show limited durability of neutralizing antibody (NAb) ... ...

Abstract	Messenger RNA (mRNA) vaccines were highly effective against the ancestral SARS-CoV-2 strain, but the efficacy of bivalent mRNA boosters against XBB variants was substantially lower. Here, we show limited durability of neutralizing antibody (NAb) responses against XBB variants and isotype switching to immunoglobulin G4 (IgG4) responses following bivalent mRNA boosting. Bivalent mRNA boosting elicited modest XBB.1-, XBB.1.5-, and XBB.1.16-specific NAbs that waned rapidly within 3 months. In contrast, bivalent mRNA boosting induced more robust and sustained NAbs against the ancestral WA1/2020 strain, suggesting immune imprinting. Following bivalent mRNA boosting, serum antibody responses were primarily IgG2 and IgG4 responses with poor Fc functional activity. In contrast, a third monovalent mRNA immunization boosted all isotypes including IgG1 and IgG3 with robust Fc functional activity. These data show substantial immune imprinting for the ancestral spike and isotype switching to IgG4 responses following bivalent mRNA boosting, with important implications for future booster designs and boosting strategies.
MeSH term(s)	Antibody Formation ; Immunoglobulin G ; Antibodies, Neutralizing ; Immunization ; RNA, Messenger/genetics ; mRNA Vaccines
Chemical Substances	Immunoglobulin G ; Antibodies, Neutralizing ; RNA, Messenger ; mRNA Vaccines
Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adj9945
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Neutralization escape by SARS-CoV-2 Omicron subvariant BA.2.86.

Lasrado, Ninaad / Collier, Ai-Ris Y / Hachmann, Nicole P / Miller, Jessica / Rowe, Marjorie / Schonberg, Eleanor D / Rodrigues, Stefanie L / LaPiana, Austin / Patio, Robert C / Anand, Trisha / Fisher, Jana / Mazurek, Camille R / Guan, Ruoran / Wagh, Kshitij / Theiler, James / Korber, Bette T / Barouch, Dan H

Vaccine

2023 Volume 41, Issue 47, Page(s) 6904–6909

Abstract: The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variant BA.2.86 has over 30 mutations in spike compared with BA.2 and XBB.1.5, which raised the possibility that BA.2.86 might evade neutralizing antibodies (NAbs) induced by vaccination or ...

Abstract	The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variant BA.2.86 has over 30 mutations in spike compared with BA.2 and XBB.1.5, which raised the possibility that BA.2.86 might evade neutralizing antibodies (NAbs) induced by vaccination or infection. In this study, we show that NAb titers are substantially lower to BA.2.86 compared with BA.2 but are similar or slightly higher than to other current circulating variants, including XBB.1.5, EG.5.1, and FL.1.5.1. Moreover, NAb titers against all these variants were higher in vaccinated individuals with a history of XBB.1.5 infection compared with vaccinated individuals with no history of XBB.1.5 infection, suggesting the potential utility of the monovalent XBB.1.5 mRNA boosters.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2/genetics ; Antibodies, Neutralizing ; Immunization, Secondary ; Antibodies, Viral
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral
Language	English
Publishing date	2023-10-21
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2023.10.051
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 458: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Waning Immunity Against XBB.1.5 Following Bivalent mRNA Boosters.

Lasrado, Ninaad / Collier, Ai-Ris Y / Miller, Jessica / Hachmann, Nicole P / Liu, Jinyan / Sciacca, Michaela / Wu, Cindy / Anand, Trisha / Bondzie, Esther A / Fisher, Jana L / Mazurek, Camille R / Patio, Robert C / Powers, Olivia / Rodrigues, Stefanie L / Rowe, Marjorie / Surve, Nehalee / Ty, Darren M / Korber, Bette / Barouch, Dan H

bioRxiv : the preprint server for biology

2023

Abstract: The SARS-CoV-2 Omicron variant has continued to evolve. XBB is a recombinant between two BA.2 sublineages, XBB.1 includes the G252V mutation, and XBB.1.5 includes the G252V and F486P mutations. XBB.1.5 has rapidly increased in frequency and has become ... ...

Abstract	The SARS-CoV-2 Omicron variant has continued to evolve. XBB is a recombinant between two BA.2 sublineages, XBB.1 includes the G252V mutation, and XBB.1.5 includes the G252V and F486P mutations. XBB.1.5 has rapidly increased in frequency and has become the dominant virus in New England. The bivalent mRNA vaccine boosters have been shown to increase neutralizing antibody (NAb) titers to multiple variants, but the durability of these responses remains to be determined. We assessed humoral and cellular immune responses in 30 participants who received the bivalent mRNA boosters and performed assays at baseline prior to boosting, at week 3 after boosting, and at month 3 after boosting. Our data demonstrate that XBB.1.5 substantially escapes NAb responses but not T cell responses after bivalent mRNA boosting. NAb titers to XBB.1 and XBB.1.5 were similar, suggesting that the F486P mutation confers greater transmissibility but not increased immune escape. By month 3, NAb titers to XBB.1 and XBB.1.5 declined essentially to baseline levels prior to boosting, while NAb titers to other variants declined less strikingly.
Language	English
Publishing date	2023-01-23
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.01.22.525079
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Immunogenicity of BA.5 Bivalent mRNA Vaccine Boosters.

The New England journal of medicine

2023 Volume 388, Issue 6, Page(s) 565–567

MeSH term(s)	Humans ; Antibodies, Neutralizing ; Antibodies, Viral ; Vaccines, Combined/immunology ; Vaccines, Combined/therapeutic use ; Vaccines, Synthetic/immunology ; Vaccines, Synthetic/therapeutic use ; Immunogenicity, Vaccine/immunology ; COVID-19/genetics ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19/virology ; mRNA Vaccines
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Vaccines, Combined ; Vaccines, Synthetic
Language	English
Publishing date	2023-01-11
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2213948
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.34: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Immunogenicity of the BA.5 Bivalent mRNA Vaccine Boosters.

bioRxiv : the preprint server for biology

2022

Abstract: Waning immunity following mRNA vaccination and the emergence of SARS-CoV-2 variants has led to reduced mRNA vaccine efficacy against both symptomatic infection and severe disease. Bivalent mRNA boosters expressing the Omicron BA.5 and ancestral WA1/2020 ... ...

Abstract	Waning immunity following mRNA vaccination and the emergence of SARS-CoV-2 variants has led to reduced mRNA vaccine efficacy against both symptomatic infection and severe disease. Bivalent mRNA boosters expressing the Omicron BA.5 and ancestral WA1/2020 Spike proteins have been developed and approved, because BA.5 is currently the dominant SARS-CoV-2 variant and substantially evades neutralizing antibodies (NAbs). Our data show that BA.5 NAb titers were comparable following monovalent and bivalent mRNA boosters.
Language	English
Publishing date	2022-10-25
Publishing country	United States
Document type	Preprint
DOI	10.1101/2022.10.24.513619
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Mucosal boosting enhances vaccine protection against SARS-CoV-2 in macaques.

McMahan, Katherine / Wegmann, Frank / Aid, Malika / Sciacca, Michaela / Liu, Jinyan / Hachmann, Nicole P / Miller, Jessica / Jacob-Dolan, Catherine / Powers, Olivia / Hope, David / Wu, Cindy / Pereira, Juliana / Murdza, Tetyana / Mazurek, Camille R / Hoyt, Amelia / Boon, Adrianus C M / Davis-Gardner, Meredith / Suthar, Mehul S / Martinot, Amanda J /

Boursiquot, Mona / Cook, Anthony / Pessaint, Laurent / Lewis, Mark G / Andersen, Hanne / Tolboom, Jeroen / Serroyen, Jan / Solforosi, Laura / Costes, Lea M M / Zahn, Roland C / Barouch, Dan H

Nature

2023 Volume 626, Issue 7998, Page(s) 385–391

Abstract: A limitation of current SARS-CoV-2 vaccines is that they provide minimal protection against infection with current Omicron ... ...

Abstract	A limitation of current SARS-CoV-2 vaccines is that they provide minimal protection against infection with current Omicron subvariants
MeSH term(s)	Animals ; Humans ; Administration, Intranasal ; Antibodies, Neutralizing/biosynthesis ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/biosynthesis ; Antibodies, Viral/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19/virology ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/immunology ; Cytokines/immunology ; Immunity, Mucosal/immunology ; Immunization, Secondary/methods ; Immunoglobulin A/immunology ; Immunoglobulin G/immunology ; Injections, Intramuscular ; Killer Cells, Natural/immunology ; Lung/immunology ; Macaca mulatta/immunology ; Macaca mulatta/virology ; mRNA Vaccines/administration & dosage ; mRNA Vaccines/immunology ; SARS-CoV-2/classification ; SARS-CoV-2/immunology ; Trachea/immunology ; Trachea/virology
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; Cytokines ; Immunoglobulin A ; Immunoglobulin G ; mRNA Vaccines
Language	English
Publishing date	2023-12-14
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-023-06951-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 9: Show issues
Zs.MO 244: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Ad26.COV2.S and SARS-CoV-2 spike protein ferritin nanoparticle vaccine protect against SARS-CoV-2 Omicron BA.5 challenge in macaques.

Yu, Jingyou / Thomas, Paul V / Sciacca, Michaela / Wu, Cindy / Liu, Jinyan / He, Xuan / Miller, Jessica / Hachmann, Nicole P / Surve, Nehalee / McMahan, Katherine / Jacob-Dolan, Catherine / Powers, Olivia / Hall, Kevin / Barrett, Julia / Hope, David / Mazurek, Camille R / Murdza, Tetyana / Chang, William C / Golub, Emily /

Cell reports. Medicine

2023 Volume 4, Issue 4, Page(s) 101018

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines demonstrate reduced protection against acquisition of BA.5 subvariant but are still effective against severe disease. However, immune correlates of protection against BA.5 remain ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines demonstrate reduced protection against acquisition of BA.5 subvariant but are still effective against severe disease. However, immune correlates of protection against BA.5 remain unknown. We report the immunogenicity and protective efficacy of vaccine regimens consisting of the vector-based Ad26.COV2.S vaccine and the adjuvanted spike ferritin nanoparticle (SpFN) vaccine against a high-dose, mismatched Omicron BA.5 challenge in macaques. The SpFNx3 and Ad26 + SpFNx2 regimens elicit higher antibody responses than Ad26x3, whereas the Ad26 + SpFNx2 and Ad26x3 regimens induce higher CD8 T cell responses than SpFNx3. The Ad26 + SpFNx2 regimen elicits the highest CD4 T cell responses. All three regimens suppress peak and day 4 viral loads in the respiratory tract, which correlate with both humoral and cellular immune responses. This study demonstrates that both homologous and heterologous regimens involving Ad26.COV2.S and SpFN vaccines provide robust protection against a mismatched BA.5 challenge in macaques.
MeSH term(s)	Humans ; Animals ; Macaca ; Ad26COVS1 ; COVID-19/prevention & control ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Ferritins ; Nanoparticles ; Vaccines
Chemical Substances	spike protein, SARS-CoV-2 ; Ad26COVS1 (JT2NS6183B) ; Spike Glycoprotein, Coronavirus ; Ferritins (9007-73-2) ; Vaccines
Language	English
Publishing date	2023-03-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	2666-3791
ISSN (online)	2666-3791
DOI	10.1016/j.xcrm.2023.101018
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED