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  1. Book: Surgical infections

    Mazuski, John E.

    (Surgical clinics of North America ; 89,2)

    2009  

    Author's details guest ed. John E. Mazuski
    Series title Surgical clinics of North America ; 89,2
    Collection
    Language English
    Size XIX S., S. 296 - 561 : graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT015921966
    ISBN 978-1-4377-0544-7 ; 1-4377-0544-8
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Perioperative Antibiotic Prophylaxis: Can We Do Better?

    Mazuski, John E

    Journal of the American College of Surgeons

    2020  Volume 231, Issue 6, Page(s) 768–769

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents ; Antibiotic Prophylaxis ; Humans ; Surgeons ; Surgical Wound Infection/prevention & control
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents
    Language English
    Publishing date 2020-10-06
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1181115-8
    ISSN 1879-1190 ; 1072-7515
    ISSN (online) 1879-1190
    ISSN 1072-7515
    DOI 10.1016/j.jamcollsurg.2020.09.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Review of the Tokyo Guidelines 2018: Antimicrobial Therapy for Acute Cholangitis and Cholecystitis.

    Buckman, Sara A / Mazuski, John E

    JAMA surgery

    2019  Volume 154, Issue 9, Page(s) 873–874

    MeSH term(s) Acute Disease ; Anti-Infective Agents/therapeutic use ; Cholangitis/diagnosis ; Cholangitis/drug therapy ; Cholecystitis/diagnosis ; Cholecystitis/drug therapy ; Evidence-Based Medicine ; Female ; Humans ; Male ; Practice Guidelines as Topic ; Risk Assessment ; Severity of Illness Index ; Tokyo ; Treatment Outcome
    Chemical Substances Anti-Infective Agents
    Language English
    Publishing date 2019-09-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2019.2169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Reduction of Surgical Site Infection After Trauma Laparotomy Through Use of a Specific Protocol for Antibiotic Prophylaxis.

    Mazuski, John E / Symons, William J / Jarman, Stephen / Sato, Bryan / Carroll, William / Bochicchio, Grant V / Kirby, John P / Schuerer, Douglas J

    Surgical infections

    2023  Volume 24, Issue 2, Page(s) 141–157

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Antibiotic Prophylaxis ; Surgical Wound Infection ; Ertapenem ; Laparotomy ; Abdominal Injuries
    Chemical Substances Ertapenem (G32F6EID2H)
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1440120-4
    ISSN 1557-8674 ; 1096-2964
    ISSN (online) 1557-8674
    ISSN 1096-2964
    DOI 10.1089/sur.2022.393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Empiric Antibiotics for Sepsis.

    Buckman, Sara A / Turnbull, Isaiah R / Mazuski, John E

    Surgical infections

    2018  Volume 19, Issue 2, Page(s) 147–154

    Abstract: Background: Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Early recognition and treatment are the cornerstones of management.: Methods: Review of the English-language literature.: Results: For ... ...

    Abstract Background: Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Early recognition and treatment are the cornerstones of management.
    Methods: Review of the English-language literature.
    Results: For both sepsis and septic shock "antimicrobials [should be] be initiated as soon as possible and within one hour" (Surviving Sepsis Campaign). The risk of progression from severe sepsis to septic shock increases 8% for each hour before antibiotics are started. Selection of antimicrobial agents is based on a combination of patient factors, predicted infecting organism(s), and local microbial resistance patterns. The initial drugs should have activity against typical gram-positive and gram-negative causative micro-organisms. Anaerobic coverage should be provided for intra-abdominal infections or others where anaerobes are significant pathogens. Empiric antifungal or antiviral therapy may be warranted. For patients with healthcare-associated infections, resistant micro-organisms will further complicate the choice of empiric antimicrobials. Recommendations are given for specific infections.
    Conclusion: Early administration of broad-spectrum antimicrobial drugs is one of the most important, if not the most important, treatment for patients with sepsis or septic shock. Drugs should be initiated as soon as possible, and the choice of should take into account patient factors, common local pathogens, hospital antibiograms and resistance patterns, and the suspected source of infection. Antimicrobial agent therapy should be de-escalated as soon as possible.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Antifungal Agents/therapeutic use ; Antiviral Agents/therapeutic use ; Cross Infection/drug therapy ; Drug Therapy/methods ; Humans ; Secondary Prevention ; Sepsis/drug therapy
    Chemical Substances Anti-Bacterial Agents ; Antifungal Agents ; Antiviral Agents
    Language English
    Publishing date 2018-01-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1440120-4
    ISSN 1557-8674 ; 1096-2964
    ISSN (online) 1557-8674
    ISSN 1096-2964
    DOI 10.1089/sur.2017.282
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The problem of infection has been inextricably linked with surgical therapy. Preface.

    Mazuski, John E

    The Surgical clinics of North America

    2009  Volume 89, Issue 2, Page(s) xvii–xix

    MeSH term(s) Humans ; Quality Assurance, Health Care ; Surgical Wound Infection/etiology ; Surgical Wound Infection/prevention & control
    Language English
    Publishing date 2009-04
    Publishing country United States
    Document type Introductory Journal Article
    ZDB-ID 215713-5
    ISSN 1558-3171 ; 0039-6109
    ISSN (online) 1558-3171
    ISSN 0039-6109
    DOI 10.1016/j.suc.2009.02.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Feeding the injured intestine: enteral nutrition in the critically ill patient.

    Mazuski, John E

    Current opinion in critical care

    2008  Volume 14, Issue 4, Page(s) 432–437

    Abstract: Purpose of review: The utilization of enteral nutrition in critically ill patients is frequently suboptimal. This may be due, in part, to ongoing controversies regarding appropriate use of enteral support, but there are also perceived barriers to its ... ...

    Abstract Purpose of review: The utilization of enteral nutrition in critically ill patients is frequently suboptimal. This may be due, in part, to ongoing controversies regarding appropriate use of enteral support, but there are also perceived barriers to its use even when there is good evidence that it can be given. This review was undertaken to outline some of these controversies and barriers to use of enteral nutrition in the ICU.
    Recent findings: Although the advantages of enteral nutrition may have been overstated, it remains preferable to parenteral nutrition for support of critically ill patients. Early initiation of enteral support is a reasonable approach. Many patients with perceived contraindications to enteral therapy are actually good candidates for its use. Frequent interruptions in enteral nutrition lead to suboptimal nutrient delivery, but might be overcome by use of specific protocols emphasizing safe and effective utilization of enteral support.
    Summary: Use of enteral nutritional support is recommended for critically ill patients requiring specialized nutritional support. Barriers to its use could be overcome by better educating providers about indications for use and by developing methods to avoid undue interruption of therapy.
    MeSH term(s) Contraindications ; Critical Illness ; Enteral Nutrition ; Humans ; Intestines/injuries
    Language English
    Publishing date 2008-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0b013e328307390b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Vancomycin-resistant enterococcus: risk factors, surveillance, infections, and treatment.

    Mazuski, John E

    Surgical infections

    2008  Volume 9, Issue 6, Page(s) 567–571

    Abstract: Background: The use of vancomycin has continued to expand because of the increasing number of patients infected or colonized with methicillin-resistant Staphylococcus aureus, causing an increase in the prevalence of vancomycin-resistant Enterococcus ( ... ...

    Abstract Background: The use of vancomycin has continued to expand because of the increasing number of patients infected or colonized with methicillin-resistant Staphylococcus aureus, causing an increase in the prevalence of vancomycin-resistant Enterococcus (VRE).
    Methods: Review of the pertinent English language literature.
    Results: Vancomycin-resistant Enterococcus spp. are being identified more often in nosocomial infections of surgical patients. The biology of resistance, modes of transmission, patient risk factors, and current treatment strategies are discussed.
    Conclusions: The reservoir of resistance in enterococci looms as a major threat for genetic transfer and the emergence of increasing numbers of vancomycin-resistant S. aureus.
    MeSH term(s) Carrier State/drug therapy ; Cross Infection/drug therapy ; Cross Infection/epidemiology ; Cross Infection/prevention & control ; Enterococcus/drug effects ; Gram-Positive Bacterial Infections/drug therapy ; Gram-Positive Bacterial Infections/epidemiology ; Gram-Positive Bacterial Infections/prevention & control ; Humans ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Prevalence ; Sentinel Surveillance ; Vancomycin Resistance
    Keywords covid19
    Language English
    Publishing date 2008-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1440120-4
    ISSN 1557-8674 ; 1096-2964
    ISSN (online) 1557-8674
    ISSN 1096-2964
    DOI 10.1089/sur.2008.9955
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Antimicrobial treatment for intra-abdominal infections.

    Mazuski, John E

    Expert opinion on pharmacotherapy

    2007  Volume 8, Issue 17, Page(s) 2933–2945

    Abstract: Treatment of patients with complicated intra-abdominal infections involves antimicrobial therapy, generally in conjunction with an interventional procedure to control the source of the infection. Antimicrobial regimens effective against common gram- ... ...

    Abstract Treatment of patients with complicated intra-abdominal infections involves antimicrobial therapy, generally in conjunction with an interventional procedure to control the source of the infection. Antimicrobial regimens effective against common gram-negative and anaerobic enteric pathogens are the mainstay of therapy. For patients with community-acquired intra-abdominal infections, efficacy is comparable among the various single-agent or combination regimens recommended for therapy. Narrower-spectrum antimicrobial agents with a low potential for iatrogenic complications are appropriate for these patients. Patients with nosocomially-acquired, intra-abdominal infections are more likely to harbor resistant pathogens. Inadequate empiric antimicrobial therapy is associated with treatment failure and death. Therefore, broader spectrum antimicrobial regimens are recommended for these patients. In addition to coverage of more resistant gram-negative bacilli and anaerobes, use of agents effective against enterococci, resistant staphylococci and Candida should be considered. De-escalation of an initially broad antimicrobial regimen should be undertaken once definitive culture results are available.
    MeSH term(s) Abdominal Abscess/drug therapy ; Abdominal Abscess/microbiology ; Abdominal Cavity/microbiology ; Anti-Infective Agents/administration & dosage ; Anti-Infective Agents/therapeutic use ; Bacterial Infections/drug therapy ; Bacterial Infections/microbiology ; Community-Acquired Infections/drug therapy ; Community-Acquired Infections/microbiology ; Drug Administration Schedule ; Drug Resistance, Bacterial ; Humans ; Peritonitis/drug therapy ; Peritonitis/microbiology ; Practice Guidelines as Topic ; Treatment Outcome
    Chemical Substances Anti-Infective Agents
    Language English
    Publishing date 2007-09-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1517/14656566.8.17.2933
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Overview of severe Clostridium difficile infection.

    Eaton, Stephen R / Mazuski, John E

    Critical care clinics

    2013  Volume 29, Issue 4, Page(s) 827–839

    Abstract: Clostridium difficile is an anaerobic, spore-forming, gram-positive bacillus that can produce severe colitis resulting in death. There has been an overall increase in the incidence of Clostridium difficile-associated disease and, particularly, an ... ...

    Abstract Clostridium difficile is an anaerobic, spore-forming, gram-positive bacillus that can produce severe colitis resulting in death. There has been an overall increase in the incidence of Clostridium difficile-associated disease and, particularly, an increase in the more virulent forms of the disease. Treatment of severe C difficile infection includes management of severe sepsis and shock, pathogen-directed antibiotic therapy, and, in selected cases, surgical intervention. Ultimately, prevention is the key to limiting the devastating effects of this microorganism.
    MeSH term(s) Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/adverse effects ; Clostridium difficile ; Cross Infection/prevention & control ; Enterocolitis, Pseudomembranous/diagnosis ; Enterocolitis, Pseudomembranous/epidemiology ; Enterocolitis, Pseudomembranous/therapy ; Humans ; Incidence ; Severity of Illness Index
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2013-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1006423-0
    ISSN 1557-8232 ; 0749-0704
    ISSN (online) 1557-8232
    ISSN 0749-0704
    DOI 10.1016/j.ccc.2013.06.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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