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  1. Article ; Online: Reply to: "Letter regarding 'Survival benefit of adequate lymphadenectomy in patients undergoing liver resection for clinically node negative intrahepatic cholangiocarcinoma' ".

    Sposito, Carlo / Cucchetti, Alessandro / Mazzaferro, Vincenzo

    Journal of hepatology

    2023  Volume 78, Issue 5, Page(s) e170–e172

    MeSH term(s) Humans ; Cholangiocarcinoma/surgery ; Lymph Node Excision ; Hepatectomy ; Bile Ducts, Intrahepatic ; Bile Duct Neoplasms/surgery ; Retrospective Studies ; Survival Rate ; Prognosis
    Language English
    Publishing date 2023-02-01
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2023.01.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2027: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: ASO Author Reflections: A Green Eye on Lymphadenectomy for Gastric Cancer.

    Sposito, Carlo / Maspero, Marianna / Mazzaferro, Vincenzo

    Annals of surgical oncology

    2023  Volume 30, Issue 11, Page(s) 6812–6813

    MeSH term(s) Humans ; Stomach Neoplasms/surgery ; Lymph Node Excision
    Language English
    Publishing date 2023-07-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-13949-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: ASO Author Reflections: Amid Anatomic Restrictions, Three-Dimensional Surgical Planning Eases En Bloc Resection of the Retro-Hepatic Vena Cava and the Caudate Lobe of the Liver.

    Altomare, Michele / Mazzaferro, Vincenzo

    Annals of surgical oncology

    2021  Volume 28, Issue 11, Page(s) 6850–6851

    MeSH term(s) Hepatectomy ; Humans ; Liver/surgery
    Language English
    Publishing date 2021-01-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-020-09439-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Squaring the circle of selection and allocation in liver transplantation for HCC: An adaptive approach.

    Mazzaferro, Vincenzo

    Hepatology (Baltimore, Md.)

    2016  Volume 63, Issue 5, Page(s) 1707–1717

    MeSH term(s) Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/surgery ; Humans ; Liver Neoplasms/mortality ; Liver Neoplasms/pathology ; Liver Neoplasms/surgery ; Liver Transplantation ; Neoplasm Staging
    Language English
    Publishing date 2016-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.28420
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1660: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article: Newest Therapies for Cholangiocarcinoma: An Updated Overview of Approved Treatments with Transplant Oncology Vision.

    Zhang, Yuqi / Esmail, Abdullah / Mazzaferro, Vincenzo / Abdelrahim, Maen

    Cancers

    2022  Volume 14, Issue 20

    Abstract: A minority of cholangiocarcinoma (CCA) can be cured by surgical intervention (i.e., liver resection (LR) and liver transplantation (LT)). When modern criteria for LT are met, this intervention along with neoadjuvant treatments may achieve unprecedented ... ...

    Abstract A minority of cholangiocarcinoma (CCA) can be cured by surgical intervention (i.e., liver resection (LR) and liver transplantation (LT)). When modern criteria for LT are met, this intervention along with neoadjuvant treatments may achieve unprecedented survival in selected patients. Liver resection is associated with a median overall survival (OS) of 40 months, this number drastically decreases for unresectable advanced cholangiocarcinoma (CCA), which is treated with systemic therapy. The first-line chemotherapy regimen of gemcitabine and cisplatin is associated with a median overall survival of only 11.7 months. Since the Food and Drug Administration (FDA)'s approval of the isocitrate dehydrogenase (
    Language English
    Publishing date 2022-10-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14205074
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  6. Article ; Online: ASO Author Reflections: Less is more: Organ-Sparing Approach for the Surgical Treatment of Gastric Adenocarcinoma.

    Maspero, Marianna / Sposito, Carlo / Mazzaferro, Vincenzo

    Annals of surgical oncology

    2022  Volume 29, Issue 5, Page(s) 3109–3110

    MeSH term(s) Adenocarcinoma/surgery ; Humans ; Stomach Neoplasms/surgery
    Language English
    Publishing date 2022-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-11125-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Combined immunotherapy and VEGF-antagonist in hepatocellular carcinoma: a step forward.

    Bhoori, Sherrie / Mazzaferro, Vincenzo

    The Lancet. Oncology

    2020  Volume 21, Issue 6, Page(s) 740–741

    MeSH term(s) Antibodies, Monoclonal, Humanized ; Bevacizumab ; Carcinoma, Hepatocellular ; Humans ; Immunotherapy ; Liver Neoplasms ; Vascular Endothelial Growth Factor A
    Chemical Substances Antibodies, Monoclonal, Humanized ; Vascular Endothelial Growth Factor A ; Bevacizumab (2S9ZZM9Q9V) ; atezolizumab (52CMI0WC3Y)
    Language English
    Publishing date 2020-06-04
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(20)30211-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5696: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 460: Show issues

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  8. Article: The SIRveNIB and SARAH trials, radioembolization

    Sposito, Carlo / Mazzaferro, Vincenzo

    Hepatobiliary surgery and nutrition

    2019  Volume 7, Issue 6, Page(s) 487–489

    Language English
    Publishing date 2019-01-15
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn.2018.10.06
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The role of ischaemia-reperfusion injury and liver regeneration in hepatic tumour recurrence.

    Maspero, Marianna / Yilmaz, Sumeyye / Cazzaniga, Beatrice / Raj, Roma / Ali, Khaled / Mazzaferro, Vincenzo / Schlegel, Andrea

    JHEP reports : innovation in hepatology

    2023  Volume 5, Issue 11, Page(s) 100846

    Abstract: The risk of cancer recurrence after liver surgery mainly depends on tumour biology, but preclinical and clinical evidence suggests that the degree of perioperative liver injury plays a role in creating a favourable microenvironment for tumour cell ... ...

    Abstract The risk of cancer recurrence after liver surgery mainly depends on tumour biology, but preclinical and clinical evidence suggests that the degree of perioperative liver injury plays a role in creating a favourable microenvironment for tumour cell engraftment or proliferation of dormant micro-metastases. Understanding the contribution of perioperative liver injury to tumour recurrence is imperative, as these pathways are potentially actionable. In this review, we examine the key mechanisms of perioperative liver injury, which comprise mechanical handling and surgical stress, ischaemia-reperfusion injury, and parenchymal loss leading to liver regeneration. We explore how these processes can trigger downstream cascades leading to the activation of the immune system and the pro-inflammatory response, cellular proliferation, angiogenesis, anti-apoptotic signals, and release of circulating tumour cells. Finally, we discuss the novel therapies under investigation to decrease ischaemia-reperfusion injury and increase regeneration after liver surgery, including pharmaceutical agents, inflow modulation, and machine perfusion.
    Language English
    Publishing date 2023-07-11
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2589-5559
    ISSN (online) 2589-5559
    DOI 10.1016/j.jhepr.2023.100846
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Indocyanine Green Fluorescence-Guided Surgery for Gastrointestinal Tumors: A Systematic Review.

    Sposito, Carlo / Maspero, Marianna / Belotti, Paolo / Simonotti, Nicolò / Altomare, Michele / Ciana, Paolo / Mazzaferro, Vincenzo

    Annals of surgery open : perspectives of surgical history, education, and clinical approaches

    2022  Volume 3, Issue 3, Page(s) e190

    Abstract: Objective: To conduct a systematic review of the currently available literature on the use of ICG to guide surgical dissection in gastrointestinal (GI) cancer surgery.: Background: Real-time indocyanine green (ICG) fluorescence-guided surgery has the ...

    Abstract Objective: To conduct a systematic review of the currently available literature on the use of ICG to guide surgical dissection in gastrointestinal (GI) cancer surgery.
    Background: Real-time indocyanine green (ICG) fluorescence-guided surgery has the potential to enhance surgical outcomes by increasing patient-tailored oncological precision.
    Methods: MEDLINE, PubMed, EMBASE, and Google Scholar were searched for publications on the use of ICG as a contrast agent in GI cancer surgery until December 2020. Perfusion studies were excluded. Quality of the studies was assessed with the Methodological Index for nonrandomized Studies or Jadad scale for randomized controlled trials. A narrative synthesis of the results was provided, with descriptive statistics when appropriate.
    Results: Seventy-eight studies were included. ICG was used for primary tumor and metastases localization, for sentinel lymph node detection, and for lymph flow mapping. The detection rate for primary colorectal and gastric tumors was 100% after preoperative ICG endoscopic injection. For liver lesions, the detection rate after intravenous ICG infusion was 80% and up to 100% for lesions less than 8 mm from the liver surface. The detection rate for sentinel lymph nodes was 89.8% for esophageal, 98.6% for gastric, 87.4% for colorectal, and 83.3% for anal tumors, respectively. In comparative studies, ICG significantly increases the quality of D2 lymphadenectomy in oncological gastrectomy.
    Conclusion: The use of ICG as a guiding tool for dissection in GI surgery is promising. Further evidence from high-quality studies on larger sample sizes is needed to assess whether ICG-guided surgery may become standard of care.
    Language English
    Publishing date 2022-09-02
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2691-3593
    ISSN (online) 2691-3593
    DOI 10.1097/AS9.0000000000000190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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