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Article ; Online: Cannabinoids as Potential Molecules for Addiction Disorders.

Martín Giménez, Virna Margarita / Mazzei, Luciana / Sanz, Raúl / Manucha, Walter

2022 Volume 23, Issue 3, Page(s) 152–157

Abstract: Background: Addictions are a group of chronic and recurrent diseases of the brain characterized by a pathological search for reward or relief through the use of a substance or other action. This situation implies an inability to control behavior, ... ...

Abstract	Background: Addictions are a group of chronic and recurrent diseases of the brain characterized by a pathological search for reward or relief through the use of a substance or other action. This situation implies an inability to control behavior, difficulty in permanent abstinence, a compelling desire to consume, decreased recognition of significant problems caused by behavior and interpersonal relationships, and a dysfunctional emotional response. The result is a decrease in the quality of life of the affected person, generating problems in their work, academic activities, social relationships, or family or partner relationships. Unfortunately, there are not enough pharmacotherapeutic solutions to treat addictions due to the complexity of their physiopathology and signaling pathways. Therefore, it is an imperative search for new pharmacological alternatives which may be used for this purpose. Purpose of review: This review summarizes the main recent findings of the potential therapeutic effects of different cannabinoids on treating several addictions, including alcohol, opioids, methamphetamine, cocaine, and nicotine use disorders. Highlights Standpoints: It has been demonstrated that many phyto, synthetic, and endogenous cannabinoids may act as therapeutic molecules in this psychiatric pathology through their action on multiple cannabinoid receptors. To highlight, cannabinoid receptors, types 1 and 2 (CB1 and CB2) have a crucial role in modulating the anti-addictive properties of these compounds.
MeSH term(s)	Cannabinoids/metabolism ; Cannabinoids/pharmacology ; Cannabinoids/therapeutic use ; Endocannabinoids/metabolism ; Humans ; Quality of Life ; Receptors, Cannabinoid/metabolism ; Signal Transduction
Chemical Substances	Cannabinoids ; Endocannabinoids ; Receptors, Cannabinoid
Language	English
Publishing date	2022-06-01
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	2045662-1
ISSN	1875-5550 ; 1389-2037
ISSN (online)	1875-5550
ISSN	1389-2037
DOI	10.2174/1389203723666220510121031
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Article ; Online: Metabolic Syndrome and Cardiac Remodeling Due to Mitochondrial Oxidative Stress Involving Gliflozins and Sirtuins.

Sanz, Raúl Lelio / Inserra, Felipe / García Menéndez, Sebastián / Mazzei, Luciana / Ferder, León / Manucha, Walter

Current hypertension reports

2023 Volume 25, Issue 6, Page(s) 91–106

Abstract: Purpose of review: To address the mechanistic pathways focusing on mitochondria dysfunction, oxidative stress, sirtuins imbalance, and other contributors in patient with metabolic syndrome and cardiovascular disease. Sodium glucose co-transporter type 2 ...

Abstract	Purpose of review: To address the mechanistic pathways focusing on mitochondria dysfunction, oxidative stress, sirtuins imbalance, and other contributors in patient with metabolic syndrome and cardiovascular disease. Sodium glucose co-transporter type 2 (SGLT-2) inhibitors deeply influence these mechanisms. Recent randomized clinical trials have shown impressive results in improving cardiac function and reducing cardiovascular and renal events. These unexpected results generate the need to deepen our understanding of the molecular mechanisms able to generate these effects to help explain such significant clinical outcomes. Recent findings: Cardiovascular disease is highly prevalent among individuals with metabolic syndrome and diabetes. Furthermore, mitochondrial dysfunction is a principal player in its development and persistence, including the consequent cardiac remodeling and events. Another central protagonist is the renin-angiotensin system; the high angiotensin II (Ang II) activity fuel oxidative stress and local inflammatory responses. Additionally, sirtuins decline plays a pivotal role in the process; they enhance oxidative stress by regulating adaptive responses to the cellular environment and interacting with Ang II in many circumstances, including cardiac and vascular remodeling, inflammation, and fibrosis. Fasting and lower mitochondrial energy generation are conditions that substantially reduce most of the mentioned cardiometabolic syndrome disarrangements. In addition, it increases sirtuins levels, and adenosine monophosphate-activated protein kinase (AMPK) signaling stimulates hypoxia-inducible factor-1β (HIF-1 beta) and favors ketosis. All these effects favor autophagy and mitophagy, clean the cardiac cells with damaged organelles, and reduce oxidative stress and inflammatory response, giving cardiac tissue protection. In this sense, SGLT-2 inhibitors enhance the level of at least four sirtuins, some located in the mitochondria. Moreover, late evidence shows that SLGT-2 inhibitors mimic this protective process, improving mitochondria function, oxidative stress, and inflammation. Considering the previously described protection at the cardiovascular level is necessary to go deeper in the knowledge of the effects of SGLT-2 inhibitors on the mitochondria function. Various of the protective effects these drugs clearly had shown in the trials, and we briefly describe it could depend on sirtuins enhance activity, oxidative stress reduction, inflammatory process attenuation, less interstitial fibrosis, and a consequent better cardiac function. This information could encourage investigating new therapeutic strategies for metabolic syndrome, diabetes, heart and renal failure, and other diseases.
MeSH term(s)	Humans ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Metabolic Syndrome/drug therapy ; Sirtuins/metabolism ; Sirtuins/pharmacology ; Cardiovascular Diseases/drug therapy ; Ventricular Remodeling ; Hypertension/drug therapy ; Diabetes Mellitus ; Oxidative Stress/physiology ; Angiotensin II/metabolism ; Fibrosis
Chemical Substances	Sodium-Glucose Transporter 2 Inhibitors ; Sirtuins (EC 3.5.1.-) ; Angiotensin II (11128-99-7)
Language	English
Publishing date	2023-04-13
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2057367-4
ISSN	1534-3111 ; 1522-6417
ISSN (online)	1534-3111
ISSN	1522-6417
DOI	10.1007/s11906-023-01240-w
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Article ; Online: Genomic or Non-Genomic? A Question about the Pleiotropic Roles of Vitamin D in Inflammatory-Based Diseases.

Holick, Michael F / Mazzei, Luciana / García Menéndez, Sebastián / Martín Giménez, Virna Margarita / Al Anouti, Fatme / Manucha, Walter

Nutrients

2023 Volume 15, Issue 3

Abstract: Vitamin D (vit D) is widely known for its role in calcium metabolism and its importance for the bone system. However, various studies have revealed a myriad of extra-skeletal functions, including cell differentiation and proliferation, antibacterial, ... ...

Abstract	Vitamin D (vit D) is widely known for its role in calcium metabolism and its importance for the bone system. However, various studies have revealed a myriad of extra-skeletal functions, including cell differentiation and proliferation, antibacterial, antioxidant, immunomodulatory, and anti-inflammatory properties in various cells and tissues. Vit D mediates its function via regulation of gene expression by binding to its receptor (VDR) which is expressed in almost all cells within the body. This review summarizes the pleiotropic effects of vit D, emphasizing its anti-inflammatory effect on different organ systems. It also provides a comprehensive overview of the genetic and epigenetic effects of vit D and VDR on the expression of genes pertaining to immunity and anti-inflammation. We speculate that in the context of inflammation, vit D and its receptor VDR might fulfill their roles as gene regulators through not only direct gene regulation but also through epigenetic mechanisms.
MeSH term(s)	Humans ; Vitamin D/pharmacology ; Receptors, Calcitriol/genetics ; Receptors, Calcitriol/metabolism ; Vitamins ; Anti-Inflammatory Agents/pharmacology ; Inflammation/genetics
Chemical Substances	Vitamin D (1406-16-2) ; Receptors, Calcitriol ; Vitamins ; Anti-Inflammatory Agents
Language	English
Publishing date	2023-02-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15030767
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Article ; Online: Growing evidence suggests WT1 effects in the kidney development are modulated by Hsp70/NO interaction.

Mazzei, Luciana / Manucha, Walter

Journal of nephrology

2017 Volume 30, Issue 1, Page(s) 11–18

Abstract: The study of kidney development at the cellular and molecular levels remains an active area of nephrology research. The functional integrity of the kidney depends on normal development as well as on physiological cell turnover. Apoptosis induction is ... ...

Abstract	The study of kidney development at the cellular and molecular levels remains an active area of nephrology research. The functional integrity of the kidney depends on normal development as well as on physiological cell turnover. Apoptosis induction is essential for these mechanisms. A route to cell death revealed in the past decade shows that heat shock proteins (HSPs) and their cofactors are responsible for regulating the apoptotic pathway. Specifically, heat shock protein 70 (Hsp70), the most ubiquitous and highly conserved HSP, helps proteins adopt native conformation or regain function after misfolding. Hsp70 is an important cofactor for the function of Wilms' tumour 1 (WT1) and suggests a potential role for this chaperone during kidney differentiation. In addition, we have demonstrated that WT1 expression is modulated by nitric oxide (NO) availability and Hsp70 interaction after neonatal unilateral ureteral obstruction. NO has been identified as playing an important role in the developing kidney. These findings suggest that Hsp70 and NO may play a critical and fundamental role in the capacity to modulate both apoptotic pathway and oxidative stress during kidney development. Furthermore, the design of experimental protocols that assess renal epithelial functionality in this context, could contribute to the understanding of renal development and alterations.
MeSH term(s)	Adult ; Animals ; Apoptosis ; Epithelial-Mesenchymal Transition ; HSP70 Heat-Shock Proteins/physiology ; HSP72 Heat-Shock Proteins/physiology ; Humans ; Kidney/embryology ; Nitric Oxide/physiology ; Oxidative Stress ; WT1 Proteins/physiology
Chemical Substances	HSP70 Heat-Shock Proteins ; HSP72 Heat-Shock Proteins ; WT1 Proteins ; WT1 protein, human ; Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2017-02
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-016-0302-9
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Article ; Online: Alterations on a key nephrogenic/cardiogenic gene expression linked to hypertension development.

Mazzei, Luciana / Sanz, Raúl / Manucha, Walter

Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis

2019 Volume 32, Issue 2, Page(s) 70–78

Abstract: The elevation of blood pressure produces specific organic lesions, including kidney and cardiac damage. On the other hand, cardiovascular disease usually leads to the development of hypertension. Thus, hypertension could be both a cause and a consequence ...

Abstract	The elevation of blood pressure produces specific organic lesions, including kidney and cardiac damage. On the other hand, cardiovascular disease usually leads to the development of hypertension. Thus, hypertension could be both a cause and a consequence of cardiovascular disease. Previous studies linked the lack of nitric oxide to cardiovascular abnormalities, including hypertension, arteriosclerosis, myocardial infarction, cardiac hypertrophy, diastolic heart failure, and reduced endothelium-derived hyperpolarizing factor responses, with shorter survival. The lack of this gas also leads to renal/cardiac abnormalities. It is widely known that nephrogenic deficiency is a risk factor for kidney disease. Besides, recent evidence suggests that alterations in WT-1, a key nephrogenic factor, could contribute to the development of hypertension. Moreover, some genes involved in the development of hypertension depend on WT-1. This knowledge makes it essential to investigate and understand the mechanisms regulating the expression of these genes during renal/cardiac development, and hypertension. As a consequence, the most in-depth knowledge of the complex aetiopathogenic mechanism responsible for the hypertensive disease will allow us to propose novel therapeutic tools.
MeSH term(s)	Animals ; Blood Pressure/genetics ; Blood Pressure/physiology ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/genetics ; Gene Expression Regulation ; Humans ; Hypertension/complications ; Hypertension/etiology ; Hypertension/genetics ; Kidney Diseases/complications ; Kidney Diseases/etiology ; Kidney Diseases/genetics ; Nitric Oxide/metabolism ; Risk Factors ; WT1 Proteins/genetics
Chemical Substances	WT1 Proteins ; WT1 protein, human ; Nitric Oxide (31C4KY9ESH)
Language	Spanish
Publishing date	2019-08-28
Publishing country	Spain
Document type	Journal Article ; Review
ISSN	1578-1879
ISSN (online)	1578-1879
DOI	10.1016/j.arteri.2019.06.001
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Article ; Online: Vitamin D-mitochondria cross-talk could modulate the signaling pathway involved in hypertension development: a translational integrative overview.

Sanz, Raúl / Mazzei, Luciana / Santino, Nicolás / Ingrasia, Marco / Manucha, Walter

Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis

2020 Volume 32, Issue 4, Page(s) 144–155

Abstract: Vitamin D deficiency is a worldwide pandemic and results in osteoporosis, hypertension, and other cardiovascular diseases. At the cellular level, it produces significant oxidative stress, inflammatory markers, and mitochondrial damage. There is ... ...

Title translation	La interacción vitamina D-mitocondria podría modular el camino de señalización involucrado en el desarrollo de la hipertensión: una visión integrativa translacional.
Abstract	Vitamin D deficiency is a worldwide pandemic and results in osteoporosis, hypertension, and other cardiovascular diseases. At the cellular level, it produces significant oxidative stress, inflammatory markers, and mitochondrial damage. There is increasing evidence about the role of vitamin D in the regulation of the renin-angiotensin-aldosterone system (RAAS). Moreover, there is evidence of involvement in cardiovascular complications, as well as in the immune system disorders. Vitamin D values below 25ng/mL are related to an increase in vascular tone mediated by smooth muscle contraction. Furthermore, it can produce direct effects on vascular smooth muscle cells, RAAS over-regulation, modulation of calcium metabolism, and secondary hyperparathyroidism. All this predisposes patients to develop hypertrophy of the left ventricle and vascular wall, causing hypertension. In this work, a review is presented of the main mechanisms involved in the development of hypertension due to vitamin D deficiency. Among them are the link established between the levels of extra-mitochondrial inorganic phosphate, its main regulatory hormones -such as vitamin D-, the cardiovascular system, reactive oxygen species, and mitochondrial metabolism. The role of the mitochondrial vitamin D receptor and the regulation of the respiratory chain could influence arterial remodelling since its activation would reduce oxidative damage and preserve cell life. However, there are aspects not yet understood about the intricate signalling network that appeared simple in experimental trials, but complex in clinical studies. In this way, the completion of new studies as VITAL, could clarify, and thus support or refute the possible benefits of vitamin D in hypertensive cardiovascular disease.
MeSH term(s)	Animals ; Humans ; Hypertension/etiology ; Hypertension/physiopathology ; Mitochondria/metabolism ; Oxidative Stress/physiology ; Receptors, Calcitriol/metabolism ; Renin-Angiotensin System/physiology ; Signal Transduction ; Vitamin D/metabolism ; Vitamin D Deficiency/complications
Chemical Substances	Receptors, Calcitriol ; Vitamin D (1406-16-2)
Language	Spanish
Publishing date	2020-05-23
Publishing country	Spain
Document type	Journal Article ; Review
ISSN	1578-1879
ISSN (online)	1578-1879
DOI	10.1016/j.arteri.2020.02.002
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Article ; Online: Implications of the transcription factor WT1 linked to the pathologic cardiac remodeling post-myocardial infarction.

Sanz, Raúl Lelio / Mazzei, Luciana / Manucha, Walter

Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis

2018 Volume 31, Issue 3, Page(s) 121–127

Abstract: New advances in the treatment of acute myocardial infarction involve novel signaling pathways and cellular progeny. In this sense, regeneration is a novel tool that would contribute to post-infarction physiological ventricular remodeling. More ... ...

Title translation	Implicaciones del factor de transcripción WT1 asociado al remodelado cardiaco patológico postinfarto miocárdico.
Abstract	New advances in the treatment of acute myocardial infarction involve novel signaling pathways and cellular progeny. In this sense, regeneration is a novel tool that would contribute to post-infarction physiological ventricular remodeling. More specifically, re-expression of the WT1 transcription factor in the myocardial wall by ischemia and infarction would be related to the invasion of cells with the capacity for regeneration. This mechanism seems not to be sufficient to restore muscle cells and lost vessels entirely. Of particular interest, the presence of the heat-shock response protein 70 (Hsp70) and its interaction with the vitamin D receptor would modulate the expression of WT1 positively. In this context, it is proposed that the activation of vitamin D receptors associated with Hsp70 could favor physiological cardiac remodeling and reduce the progression to heart failure.
MeSH term(s)	Disease Progression ; HSP70 Heat-Shock Proteins/metabolism ; Heart Failure/prevention & control ; Humans ; Myocardial Infarction/genetics ; Myocardial Infarction/therapy ; Receptors, Calcitriol/metabolism ; Ventricular Remodeling ; WT1 Proteins/genetics
Chemical Substances	HSP70 Heat-Shock Proteins ; Receptors, Calcitriol ; WT1 Proteins ; WT1 protein, human
Language	Spanish
Publishing date	2018-10-03
Publishing country	Spain
Document type	Journal Article ; Review
ISSN	1578-1879
ISSN (online)	1578-1879
DOI	10.1016/j.arteri.2018.08.003
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Article: Wt-1 Expression Linked to Nitric Oxide Availability during Neonatal Obstructive Nephropathy.

Mazzei, Luciana / Manucha, Walter

Advances in urology

2013 Volume 2013, Page(s) 401750

Abstract: The wt-1 gene encodes a zinc finger DNA-binding protein that acts as a transcriptional activator or repressor depending on the cellular or chromosomal context. The wt-1 regulates the expression of a large number of genes that have a critical role in ... ...

Abstract	The wt-1 gene encodes a zinc finger DNA-binding protein that acts as a transcriptional activator or repressor depending on the cellular or chromosomal context. The wt-1 regulates the expression of a large number of genes that have a critical role in kidney development. Congenital obstructive nephropathy disrupts normal renal development and causes chronic progressive interstitial fibrosis, which contributes to renal growth arrest, ultimately leading to chronic renal failure. Wt-1 is downregulated during congenital obstructive nephropathy, leading to apoptosis. Of great interest, nitric oxide bioavailability associated with heat shock protein 70 (Hsp70) interaction may modulate wt-1 mRNA expression, preventing obstruction-induced cell death during neonatal unilateral ureteral obstruction. Moreover, recent genetic researches have allowed characterization of many of the complex interactions among the individual components cited, but the realization of new biochemical, molecular, and functional experiments as proposed in our and other research labs allows us to establish a deeper level of commitment among proteins involved and the potential pathogenic consequences of their imbalance.
Language	English
Publishing date	2013-10-31
Publishing country	Egypt
Document type	Journal Article ; Review
ZDB-ID	2397564-7
ISSN	1687-6377 ; 1687-6369
ISSN (online)	1687-6377
ISSN	1687-6369
DOI	10.1155/2013/401750
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Article ; Online: Anti-inflammatory, antioxidant, antihypertensive, and antiarrhythmic effect of indole-3-carbinol, a phytochemical derived from cruciferous vegetables

Prado, Natalia Jorgelina / Ramírez, Daniela / Mazzei, Luciana / Parra, Micaela / Casarotto, Mariana / Calvo, Juan Pablo / Cuello carrión, Darío / Ponce Zumino, Amira Zulma / Diez, Emiliano Raúl / Camargo, Alejandra / Manucha, Walter

Heliyon. 2022 Feb., v. 8, no. 2 p.e08989-

2022

Abstract: Cardiovascular inflammation and oxidative stress are determining factors in high blood pressure and arrhythmias. Indole-3-carbinol is a cruciferous-derived phytochemical with potential anti-inflammatory and antioxidant effects. However, its implications ... ...

Abstract	Cardiovascular inflammation and oxidative stress are determining factors in high blood pressure and arrhythmias. Indole-3-carbinol is a cruciferous-derived phytochemical with potential anti-inflammatory and antioxidant effects. However, its implications on the modulation of cardiovascular inflammatory-oxidative markers are unknown. To establish the effects of indole-3-carbinol on the oxidative-inflammatory-proarrhythmic conditions associated with hypertension. Histological, biochemical, molecular, and functional aspects were evaluated in 1) Culture of mouse BV-2 glial cells subjected to oxidative-inflammatory damage by lipopolysaccharides (100 ng/mL) in the presence or absence of 40 μM indole-3-carbinol (n = 5); 2) Male spontaneously hypertensive rats (SHR) and Wistar Kyoto rats receiving indole-3-carbinol (2000 ppm/day, orally) during the first 8 weeks of life (n = 15); 3) Isolated rat hearts were submitted to 10 min regional ischemia and 10 min reperfusion. 1) lipopolysaccharides induced oxidative stress and increased inflammatory markers; indole-3-carbinol reversed both conditions (interleukin 6, tumor necrosis factor α, the activity of nicotinamide adenine dinucleotide phosphate oxidase, nitric oxide, inducible nitric oxide synthase, heat shock protein 70, all p < 0.01 vs lipopolysaccharides). 2) SHR rats showed histological, structural, and functional changes with increasing systolic blood pressure (154 ± 8 mmHg vs. 122 ± 7 mmHg in Wistar Kyoto rats, p < 0.01); Inflammatory-oxidative markers also increased, and nitric oxide and heat shock protein 70 decreased. Conversely, indole-3-carbinol reduced oxidative-inflammatory markers and systolic blood pressure (133 ± 8 mmHg, p < 0.01 vs. SHR). 3) indole-3-carbinol reduced reperfusion arrhythmias from 8/10 in SHR to 0/10 (p = 0.0007 by Fisher's exact test). Indole-3-carbinol reduces the inflammatory-oxidative-proarrhythmic process of hypertension. The nitric oxide and heat shock protein 70 are relevant mechanisms of indole-3-carbinol protective actions. Further studies with this pleiotropic phytochemical as a promising cardioprotective are guaranteed.
Keywords	Brassicaceae ; NADP (coenzyme) ; antioxidants ; heat-shock protein 70 ; histology ; hypertension ; inducible nitric oxide synthase ; inflammation ; interleukin-6 ; ischemia ; lipopolysaccharides ; males ; mice ; nitric oxide ; oxidative stress ; phytochemicals ; rats ; systolic blood pressure ; tumor necrosis factors ; Indole-3-carbinol ; Arrhythmias ; Hsp70
Language	English
Dates of publication	2022-02
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e08989
Database	NAL-Catalogue (AGRICOLA)

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Article: Consumption of oil macerated with garlic produces renovascular protective effects in adult apolipoprotein E-deficient mice

Torres Palazzolo, Carolina / Martín Giménez, Virna Margarita / Mazzei, Luciana / De Paola, Matilde / Quesada, Isabel / Cuello Carrión, Fernando Darío / Fornés, Miguel Walter / Camargo, Alejandra Beatríz / Castro, Claudia / Manucha, Walter

Food & function. 2022 Aug. 1, v. 13, no. 15

2022

Abstract: Oxidative stress and chronic inflammatory conditions contribute as key determinants in the development of vascular and renal diseases. Organosulfur compounds (OSCs) of oil macerated with garlic (OMG) are promising phytochemicals which could protect us ... ...

Abstract	Oxidative stress and chronic inflammatory conditions contribute as key determinants in the development of vascular and renal diseases. Organosulfur compounds (OSCs) of oil macerated with garlic (OMG) are promising phytochemicals which could protect us from hyper-inflammation and oxidative stress-induced organ damage. The present work evaluated the effect of OMG intake in apolipoprotein E-knockout (ApoE-KO) mice. Adult female ApoE-KO mice were randomly divided into three groups and fed with control chow, oil-supplemented diet and OMG-supplemented diet. After 8 weeks, the animals were euthanized and blood, aorta, kidneys, liver and abdominal adipose tissues were obtained for further analysis. Biochemical parameters were measured in plasma, lipid peroxidation as malondialdehyde (MDA) levels was determined in the adipose tissue, oil red O was used to stain atherosclerotic lesions, and histological and ultrastructural analyses of the kidneys were performed. Renal expression levels of Tumor Necrosis Factor α (TNF-α), Interleukin-6 (IL-6) and Wilms’ Tumor Protein (WT-1) were determined by western blotting and the co-immunoprecipitation assay (p53/WT-1). Also, transmission electron microscopy for studying the expression of mitofusin 2 (Mfn-2) was used to assess mitochondrial damage. The results showed that long-term moderate intake of OMG improved serum triglyceride levels, diminished the atheroma plaque area, and reduced lipid peroxidation. Furthermore, we found a decrease in oxidative and inflammatory markers, less apoptosis and reduced WT-1 expression in the kidneys. Also, OMG increased p53/WT-1 protein interactions and reduced mitochondrial damage. Our findings suggest that OMG intake would produce anti-atherosclerotic, antifibrotic, anti-inflammatory and antiapoptotic effects in adult ApoE-KO mice, conferring significant renovascular protective actions in a mechanism mediated, at least in part, by WT-1.
Keywords	adipose tissue ; adults ; aorta ; apoptosis ; blood serum ; diet ; females ; garlic ; histology ; interleukin-6 ; lipid peroxidation ; liver ; malondialdehyde ; mitochondria ; neoplasms ; oils ; oxidative stress ; phytochemicals ; precipitin tests ; transmission electron microscopy ; triacylglycerols
Language	English
Dates of publication	2022-0801
Size	p. 8131-8142.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d2fo01509a
Database	NAL-Catalogue (AGRICOLA)

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