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  1. Article ; Online: Bisoprolol for treatment of symptomatic patients with obstructive hypertrophic cardiomyopathy. The BASIC (bisoprolol AS therapy in hypertrophic cardiomyopathy) study.

    Monda, Emanuele / Lioncino, Michele / Palmiero, Giuseppe / Franco, Francesco / Rubino, Marta / Cirillo, Annapaola / Verrillo, Federica / Fusco, Adelaide / Caiazza, Martina / Mazzella, Marialuisa / Moscarella, Elisabetta / Dongiglio, Francesca / Sepe, Joseph / Pacileo, Giuseppe / Calabrò, Paolo / Limongelli, Giuseppe

    International journal of cardiology

    2022  Volume 354, Page(s) 22–28

    Abstract: Aims: To evaluate the role of bisoprolol to control symptoms and left ventricular outflow tract obstruction (LVOTO) in a consecutive cohort of adults with hypertrophic cardiomyopathy (HCM).: Methods and results: In this retrospective study, patients ... ...

    Abstract Aims: To evaluate the role of bisoprolol to control symptoms and left ventricular outflow tract obstruction (LVOTO) in a consecutive cohort of adults with hypertrophic cardiomyopathy (HCM).
    Methods and results: In this retrospective study, patients with HCM with an LVOT gradient ≥50 mmHg after Valsalva manoeuvre and New York Heart Association (NYHA) class II-III symptoms were assigned to receive bisoprolol (starting at 1.25 mg daily). The initial dose was increased every two weeks to achieve the target in LVOT gradient <30 mmHg or the maximum tolerated dose. The primary endpoint was the achievement of a LVOT gradient <30 mmHg and ≥ 1 NYHA class improvement. The secondary endpoints were proportion of patients with LVOT gradient <30 mmHg or < 50 mmHg, proportion of patients with ≥1 NYHA class improvement, and change from baseline in LVOT gradient. Between December 2001 and December 2020, 92 patients were enrolled into the study. Sixteen (17%) patients on bisoprolol met the primary endpoint. Bisoprolol reduced the LVOT gradient to less than 30 mmHg in 33 (36%) patients, to less than 50 mmHg in 57 (62%), and improved NYHA class in 30 (33%). The mean reduction of LVOT gradient on bisoprolol was 28 (±14) mmHg and the percentage reduction was 42 (±21) %. In 35 (38%) patients, bisoprolol did not reduce the gradient to less than 50 mmHg requiring disopyramide and/or myectomy to achieve this goal.
    Conclusion: Treatment with bisoprolol was well-tolerated and effective in relieving obstruction and improving symptoms in a significant proportion of patients with symptomatic obstructive HCM.
    MeSH term(s) Adult ; Bisoprolol/therapeutic use ; Cardiomyopathy, Hypertrophic/diagnostic imaging ; Cardiomyopathy, Hypertrophic/drug therapy ; Disopyramide/therapeutic use ; Humans ; Retrospective Studies ; Ventricular Outflow Obstruction/diagnostic imaging ; Ventricular Outflow Obstruction/drug therapy
    Chemical Substances Disopyramide (GFO928U8MQ) ; Bisoprolol (Y41JS2NL6U)
    Language English
    Publishing date 2022-03-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2022.03.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1673: Show issues Location:
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  2. Article: Diagnosis and Management of Cardiovascular Involvement in Fabry Disease.

    Rubino, Marta / Monda, Emanuele / Lioncino, Michele / Caiazza, Martina / Palmiero, Giuseppe / Dongiglio, Francesca / Fusco, Adelaide / Cirillo, Annapaola / Cesaro, Arturo / Capodicasa, Laura / Mazzella, Marialuisa / Chiosi, Flavia / Orabona, Paolo / Bossone, Eduardo / Calabrò, Paolo / Pisani, Antonio / Germain, Dominique P / Biagini, Elena / Pieroni, Maurizio /
    Limongelli, Giuseppe

    Heart failure clinics

    2021  Volume 18, Issue 1, Page(s) 39–49

    Abstract: Fabry disease (FD, OMIM 301500) is an X-linked lysosomal storage disease caused by pathogenic variants in the GLA gene. Cardiac involvement is common in FD and is responsible for impaired quality of life and premature death. The classic cardiac ... ...

    Abstract Fabry disease (FD, OMIM 301500) is an X-linked lysosomal storage disease caused by pathogenic variants in the GLA gene. Cardiac involvement is common in FD and is responsible for impaired quality of life and premature death. The classic cardiac involvement is a nonobstructive form of hypertrophic cardiomyopathy, usually manifesting as concentric left ventricular hypertrophy, with subsequent arrhythmogenic intramural fibrosis. Treatment of patients with FD should be directed to prevent the disease progression to irreversible organ damage and organ failure. The aim of this review is to describe the current state of knowledge regarding cardiovascular involvement in FD, focusing on clinical and instrumental features, cardiovascular management, and targeted therapy.
    MeSH term(s) Cardiomyopathy, Hypertrophic ; Enzyme Replacement Therapy ; Fabry Disease/complications ; Fabry Disease/diagnosis ; Fabry Disease/genetics ; Humans ; Hypertrophy, Left Ventricular ; Quality of Life
    Language English
    Publishing date 2021-10-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2212019-1
    ISSN 1551-7136
    ISSN 1551-7136
    DOI 10.1016/j.hfc.2021.07.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Diagnostic issues faced by a rare disease healthcare network during Covid-19 outbreak: data from the Campania Rare Disease Registry.

    Limongelli, Giuseppe / Iucolano, Stefano / Monda, Emanuele / Elefante, Pasquale / De Stasio, Chiara / Lubrano, Imma / Caiazza, Martina / Mazzella, Marialuisa / Fimiani, Fabio / Galdo, Maria / De Marchi, Giulia / Esposito, Martina / Rubino, Marta / Cirillo, Annapaola / Fusco, Adelaide / Esposito, Augusto / Trama, Ugo / Esposito, Salvatore / Scarano, Gioacchino /
    Sepe, Joseph / Andria, Generoso / Orlando, Valentina / Menditto, Enrica / Chiodini, Paolo

    Journal of public health (Oxford, England)

    2021  Volume 44, Issue 3, Page(s) 586–594

    Abstract: Background: The aims of this study were: to investigate the capacity of the rare disease healthcare network in Campania to diagnose patients with rare diseases during the outbreak of Covid-19; and to shed light on problematic diagnoses during this ... ...

    Abstract Background: The aims of this study were: to investigate the capacity of the rare disease healthcare network in Campania to diagnose patients with rare diseases during the outbreak of Covid-19; and to shed light on problematic diagnoses during this period.
    Methods: To describe the impact of the Covid-19 pandemic on the diagnosis of patients with rare diseases, a retrospective analysis of the Campania Region Rare Disease Registry was performed. A tailored questionnaire was sent to rare disease experts to investigate major issues during the emergency period.
    Results: Prevalence of new diagnoses of rare disease in March and April 2020 was significantly lower than in 2019 (117 versus 317, P < 0.001 and 37 versus 349, P < 0.001, respectively) and 2018 (117 versus 389, P < 0.001 and 37 versus 282, P < 0.001, respectively). Eighty-two among 98 rare disease experts completed the questionnaire. Diagnostic success (95%), access to diagnosis (80%) and follow-up (72%), lack of Personal Protective Equipment (60%), lack of Covid-19 guidelines (50%) and the need for home therapy (78%) were the most important issues raised during Covid-19 outbreak.
    Conclusions: This study describes the effects of the Covid-19 outbreak on the diagnosis of rare disease in a single Italian region and investigates potential issues of diagnosis and management during this period.
    MeSH term(s) COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19 Testing ; Delivery of Health Care ; Disease Outbreaks ; Humans ; Pandemics ; Rare Diseases/diagnosis ; Rare Diseases/epidemiology ; Registries ; Retrospective Studies
    Language English
    Publishing date 2021-05-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2142082-8
    ISSN 1741-3850 ; 1741-3842
    ISSN (online) 1741-3850
    ISSN 1741-3842
    DOI 10.1093/pubmed/fdab137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2186: Show issues Location:
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  4. Article ; Online: Protective effect of dimethyl sulfoxide on acute myocardial infarction in rats.

    Parisi, Antonio / Alfieri, Alessio / Mazzella, Marialuisa / Mazzella, Antonio / Scognamiglio, Mattia / Scognamiglio, Gianluigi / Mascolo, Nicola / Cicala, Carla

    Journal of cardiovascular pharmacology

    2010  Volume 55, Issue 1, Page(s) 106–109

    Abstract: Dimethyl sulfoxide (DMSO) is an organic compound widely used as solvent in biological studies and as vehicle for drug administration. DMSO has been shown to possess several biological effects, including antioxidant, anti-inflammatory, antinociceptive ... ...

    Abstract Dimethyl sulfoxide (DMSO) is an organic compound widely used as solvent in biological studies and as vehicle for drug administration. DMSO has been shown to possess several biological effects, including antioxidant, anti-inflammatory, antinociceptive effects, and it has been proposed to be therapeutic in several disorders, such as gastrointestinal diseases, rheumatologic diseases, and for the treatment of several manifestations of amyloidosis. To better define the biological profile of DMSO, we investigated its effect on an in vivo model of acute myocardial infarction in rats, caused by left anterior descending coronary artery ligation. Our results show that pretreatment of rats with intraperitoneal (ip) DMSO (500 microL/Kg) for 3 consecutive days before left anterior descending coronary artery ligation significantly (P < 0.05) reduced cardiac damage from 18.75 +/- 4.88% (n = 12) to 4.46 +/- 2.01% (n = 8); serum levels of troponin I from 29.35 +/- 12.32 ng/mL (n = 8) to 2.95 +/- 1.32 ng/mL (n = 4); and serum levels of myoglobin from 46.86 +/- 10.35 ng/mL (n = 7) to 13.75 +/- 0.85 ng/mL (n = 4). Our data demonstrate that DMSO has a protective effect in a model of acute myocardial infarction in rats.
    MeSH term(s) Animals ; Antioxidants/pharmacology ; Dimethyl Sulfoxide/pharmacology ; Disease Models, Animal ; Injections, Intraperitoneal ; Male ; Myocardial Infarction/drug therapy ; Myocardial Infarction/physiopathology ; Myoglobin/blood ; Myoglobin/drug effects ; Rats ; Rats, Wistar ; Troponin I/blood ; Troponin I/drug effects
    Chemical Substances Antioxidants ; Myoglobin ; Troponin I ; Dimethyl Sulfoxide (YOW8V9698H)
    Language English
    Publishing date 2010-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 391970-5
    ISSN 1533-4023 ; 0160-2446
    ISSN (online) 1533-4023
    ISSN 0160-2446
    DOI 10.1097/FJC.0b013e3181c87a65
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1471: Show issues Location:
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  5. Article ; Online: Resveratrol-containing gel for the treatment of acne vulgaris: a single-blind, vehicle-controlled, pilot study.

    Fabbrocini, Gabriella / Staibano, Stefania / De Rosa, Giuseppe / Battimiello, Valeria / Fardella, Nunzio / Ilardi, Gennaro / La Rotonda, Maria Immacolata / Longobardi, Amelia / Mazzella, Marialuisa / Siano, Maria / Pastore, Francesco / De Vita, Valerio / Vecchione, Maria Luisa / Ayala, Fabio

    American journal of clinical dermatology

    2011  Volume 12, Issue 2, Page(s) 133–141

    Abstract: Background: Acne vulgaris is a complex, chronic, and common skin disorder of pilosebaceous units. The major pathogenic factors involved are ductal hyperkeratinization, obstruction of sebaceous follicles resulting from abnormal keratinization of the ... ...

    Abstract Background: Acne vulgaris is a complex, chronic, and common skin disorder of pilosebaceous units. The major pathogenic factors involved are ductal hyperkeratinization, obstruction of sebaceous follicles resulting from abnormal keratinization of the infundibular epithelium, stimulation of sebaceous gland secretion by androgens, and microbial colonization of pilosebaceous units by Propionibacterium acnes, which promotes perifollicular inflammation.
    Aim: The aim of the study was to investigate the therapeutic effects of resveratrol, a natural phytoalexin produced by some spermatophytes, such as grapes and other plants, on acneic skin.
    Methods: Resveratrol was incorporated in a carboxymethylcellulose-based gel. The chemical stability of resveratrol after storage at 4°C for 30 days was investigated by high-performance liquid chromatography (HPLC). The resveratrol-containing hydrogel was administered to 20 patients affected by acne vulgaris enrolled in this single-blind study. The resveratrol-containing formulation was applied daily as a solo treatment on the right side of the face for 60 days, while the hydrogel vehicle was applied to the left side of the face as a control. To objectively evaluate the results, a digital photographic database was used to collect images. The number and type of lesions were recorded for each patient, to compare the Global Acne Grading System (GAGS) score before treatment with that obtained at the end of the study. Moreover, with the innovative technique of follicular biopsy, areas of acneic skin were prepared for histopathology. The average area occupied by microcomedones at baseline was compared with that at the end of treatment.
    Results: HPLC analysis demonstrated that resveratrol, upon incorporation into the gel, did not convert to its cis-isomer when stored at 4°C for 30 days. All patients were satisfied with the active treatment and none experienced adverse effects. Clinical evaluation showed a 53.75% mean reduction in the GAGS score on the resveratrol-treated sides of the face compared with 6.10% on the vehicle-treated sides of the face. These data were supported by histologic analysis, which showed a 66.7% mean reduction in the average area of microcomedones on the resveratrol-treated sides of the face. The comparison with the vehicle-treated side of the face (9.7% reduction) showed a clinically relevant and statistically significant decrease of lesions in areas treated with resveratrol-containing hydrogel.
    Conclusion: This pilot study showed positive results for resveratrol gel in acne, and should be considered a valid starting point for further testing of the effectiveness of this molecule in different concentrations and formulations and in a larger group of patients.
    MeSH term(s) Acne Vulgaris/drug therapy ; Acne Vulgaris/microbiology ; Acne Vulgaris/pathology ; Adolescent ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Biopsy ; Carboxymethylcellulose Sodium/chemistry ; Chromatography, High Pressure Liquid ; Drug Stability ; Drug Storage ; Female ; Humans ; Hydrogels ; Male ; Pharmaceutical Vehicles/chemistry ; Photography ; Pilot Projects ; Propionibacterium acnes/isolation & purification ; Single-Blind Method ; Stilbenes/administration & dosage ; Stilbenes/pharmacology ; Stilbenes/therapeutic use ; Treatment Outcome ; Young Adult
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Hydrogels ; Pharmaceutical Vehicles ; Stilbenes ; Carboxymethylcellulose Sodium (K679OBS311) ; resveratrol (Q369O8926L)
    Language English
    Publishing date 2011-04-01
    Publishing country New Zealand
    Document type Controlled Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1502476-3
    ISSN 1179-1888 ; 1175-0561
    ISSN (online) 1179-1888
    ISSN 1175-0561
    DOI 10.2165/11530630-000000000-00000
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5639: Show issues Location:
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  6. Article: Aldehyde-encapsulating liposomes impair marine grazer survivorship.

    Buttino, Isabella / De Rosa, Giuseppe / Carotenuto, Ylenia / Mazzella, Marialuisa / Ianora, Adrianna / Esposito, Francesco / Vitiello, Valentina / Quaglia, Fabiana / La Rotonda, Maria Immacolata / Miralto, Antonio

    The Journal of experimental biology

    2008  Volume 211, Issue Pt 9, Page(s) 1426–1433

    Abstract: In the last decade, there has been an increased awareness that secondary metabolites produced by marine diatoms negatively impact the reproductive success of their principal predators, the copepods. Several oxylipins, products of the enzymatic oxidation ... ...

    Abstract In the last decade, there has been an increased awareness that secondary metabolites produced by marine diatoms negatively impact the reproductive success of their principal predators, the copepods. Several oxylipins, products of the enzymatic oxidation of fatty acids, are produced when these unicellular algae are damaged, as occurs during grazing. In the past, the dinoflagellate Prorocentrum minimum, which does not produce the oxylipin 2-trans,4-trans-decadienal (DD), has been used as a live carrier to calculate daily ingestion rates of this molecule by copepod crustaceans. However, since the interaction between oxylipins and live carriers is unknown, the question as to how much and for how long ingestion of these molecules affects copepod reproduction remains a critical point to understanding the functional role of such compounds at sea. In the investigation presented here we used giant liposomes ( approximately 7 mum) as a delivery system for the oxylipin DD, prepared in the same size range as copepod food and containing known amounts of DD. The aim of this work was to relate the ingestion of DD to the reproductive failure of the copepods Temora stylifera and Calanus helgolandicus. Liposomes were very stable over time and after 10 days of feeding, liposomes encapsulating DD reduced egg hatching success and female survival with a concomitant appearance of apoptosis in both copepod embryos and female tissues. Concentrations of DD inducing blockage were one order of magnitude lower that those used in classical feeding experiments demonstrating that liposomes are a useful tool to quantitatively analyze the impact of toxins on copepods.
    MeSH term(s) Aldehydes/analysis ; Aldehydes/toxicity ; Animals ; Copepoda/drug effects ; Diatoms/chemistry ; Fluorescein-5-isothiocyanate ; Liposomes ; Particle Size ; Reproduction/drug effects ; Survival Analysis
    Chemical Substances Aldehydes ; Liposomes ; 2,4-decadienal (2363-88-4) ; Fluorescein-5-isothiocyanate (I223NX31W9)
    Language English
    Publishing date 2008-05
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218085-6
    ISSN 1477-9145 ; 0022-0949
    ISSN (online) 1477-9145
    ISSN 0022-0949
    DOI 10.1242/jeb.015859
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    Zs.A 2629: Show issues Location:
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