Article ; Online: Acute Blood Levels of Neurofilament Light Indicate One-Year White Matter Pathology and Functional Impairment in Repetitive Mild Traumatic Brain Injured Mice.
2023 Volume 40, Issue 11-12, Page(s) 1144–1163
Abstract: Mild traumatic brain injury (mTBI) mostly causes transient symptoms, but repeated (r)mTBI can lead to neurodegenerative processes. Diagnostic tools to evaluate the presence of ongoing occult neuropathology are lacking. In a mouse model of rmTBI, we ... ...
| Abstract | Mild traumatic brain injury (mTBI) mostly causes transient symptoms, but repeated (r)mTBI can lead to neurodegenerative processes. Diagnostic tools to evaluate the presence of ongoing occult neuropathology are lacking. In a mouse model of rmTBI, we investigated MRI and plasma biomarkers of brain damage before chronic functional impairment arose. Anesthetized adult male and female C57BL/6J mice were subjected to rmTBI or a sham procedure. Sensorimotor deficits were evaluated up to 12 months post-injury in SNAP and Neuroscore tests. Cognitive function was assessed in the novel object recognition test at six and 12 months. Diffusion tensor imaging (DTI) and structural magnetic resonance imaging (MRI) were performed at six and 12 months to examine white matter and structural damage. Plasma levels of neurofilament light (NfL) were assessed longitudinally up to 12 months. Brain histopathology was performed at 12 months. Independent groups of mice were used to examine the effects of 2-, 7- and 14-days inter-injury intervals on acute plasma NfL levels and on hyperactivity. Twelve months after an acute transient impairment, sensorimotor functions declined again in rmTBI mice ( |
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| MeSH term(s) | Rats ; Mice ; Animals ; Male ; Female ; White Matter/pathology ; Diffusion Tensor Imaging ; Intermediate Filaments ; Rats, Sprague-Dawley ; Mice, Inbred C57BL ; Brain/pathology ; Brain Concussion/complications ; Brain Concussion/diagnostic imaging ; Brain Concussion/pathology ; Brain Injuries, Traumatic/complications | |||||
| Language | English | |||||
| Publishing date | 2023-03-13 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 645092-1 | |||||
| ISSN | 1557-9042 ; 0897-7151 | |||||
| ISSN (online) | 1557-9042 | |||||
| ISSN | 0897-7151 | |||||
| DOI | 10.1089/neu.2022.0252 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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