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  1. AU="Mbanga, Luyanda"
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  1. Artikel ; Online: The spectrum, prevalence and in-hospital outcomes of cardiovascular diseases in a South African district hospital: a retrospective study.

    Mkoko, Philasande / Naidoo, Senlika / Niazi, Mak / Tahira, Atiqa / Godlwana, Xolile / Ndesi, Ntsikelelo / Majola, Thina / Pepino, Martha / Mbanga, Luyanda / Jama, Zimasa Vuyo / Alam, Nowshad / Mbhele, Brian / Maphalala, Lokuthula / Ntsekhe, Mpiko

    Cardiovascular journal of Africa

    2021  Band 32, Heft 5, Seite(n) 237–242

    Abstract: Introduction: The increasing prevalence of cardiovascular risk factors in South African rural communities is well reported. However, the prevalence of cardiovascular disease (CVD) leading to hospital admission and related in-hospital mortality in rural ... ...

    Abstract Introduction: The increasing prevalence of cardiovascular risk factors in South African rural communities is well reported. However, the prevalence of cardiovascular disease (CVD) leading to hospital admission and related in-hospital mortality in rural and semi-rural hospitals is unknown.
    Methods: We conducted a retrospective review of hospital records for patients admitted to the Department of Internal Medicine at Dora Nginza Hospital in Port Elisabeth, South Africa between 1 April and 31 October 2016. The study focused on patients who received a primary diagnosis of CVD.
    Results: During the seven-month study period, 4 884 patients were admitted to the unit, 1 325 of whom received a primary diagnosis of CVD, giving a prevalence of 27%. Patients with CVD had a mean (standard deviation) age of 60 (± 15) years, 32% of this patient population was younger than 55 years and 65% were female. Furthermore, 94% had a background medical history of systemic hypertension and 30% of diabetes mellitus. The three leading cardiovascular causes of hospital admission were stroke (38%), hypertensive heart disease plus heart failure (33%), and hypertensive emergency/urgency (18%). In-hospital outcome: 12.4% of patients admitted for CVD died during the index hospitalisation and strokes were responsible for 70% of the deaths.
    Conclusions: The prevalence of CVD in this cohort was high and accounted for significant morbidity and mortality. Systemic hypertension was a leading risk factor in our cohort and we need to intensify efforts to diagnose and treat systemic hypertension.
    Mesh-Begriff(e) Aged ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/therapy ; Female ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Hospital Mortality ; Hospitalization/statistics & numerical data ; Hospitals, District ; Humans ; Hypertension/diagnosis ; Hypertension/epidemiology ; Male ; Middle Aged ; Prevalence ; Retrospective Studies ; Risk Factors ; Socioeconomic Factors ; South Africa/epidemiology ; Stroke/complications ; Stroke/epidemiology
    Sprache Englisch
    Erscheinungsdatum 2021-06-10
    Erscheinungsland South Africa
    Dokumenttyp Journal Article
    ZDB-ID 2383233-2
    ISSN 1680-0745 ; 1996-3467 ; 1015-9657 ; 1995-1892
    ISSN (online) 1680-0745 ; 1996-3467
    ISSN 1015-9657 ; 1995-1892
    DOI 10.5830/CVJA-2021-016
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Risk factors for COVID-19 death in a population cohort study from the Western Cape Province, South Africa

    Boulle, Andrew / Davies, Mary-Ann / Hussey, Hannah / Ismail, Muzzammil / Morden, Erna / Vundle, Ziyanda / Zweigenthal, Virginia / Mahomed, Hassan / Paleker, Masudah / Pienaar, David / Tembo, Yamanya / Lawrence, Charlene / Isaacs, Washiefa / Mathema, Hlengani / Allen, Derick / Allie, Taryn / Bam, Jamy-Lee / Buddiga, Kasturi / Dane, Pierre /
    Heekes, Alexa / Matlapeng, Boitumelo / Mutemaringa, Themba / Muzarabani, Luckmore / Phelanyane, Florence / Pienaar, Rory / Rode, Catherine / Smith, Mariette / Tiffin, Nicki / Zinyakatira, Nesbert / Cragg, Carol / Marais, Frederick / Mudaly, Vanessa / Voget, Jacqueline / Davids, Jody / Roodt, Francois / van Zyl Smit, Nellis / Vermeulen, Alda / Adams, Kevin / Audley, Gordon / Bateman, Kathleen / Beckwith, Peter / Bernon, Marc / Blom, Dirk / Boloko, Linda / Botha, Jean / Boutall, Adam / Burmeister, Sean / Cairncross, Lydia / Calligaro, Gregory / Coccia, Cecilia / Corin, Chadwin / Daroowala, Remy / Dave, Joel A / De Bruyn, Elsa / De Villiers, Martin / Deetlefs, Mimi / Dlamini, Sipho / Du Toit, Thomas / Endres, Wilhelm / Europa, Tarin / Fieggan, Graham / Figaji, Anthony / Frankenfeld, Petro / Gatley, Elizabeth / Gina, Phindile / Govender, Evashan / Grobler, Rochelle / Gule, Manqoba Vusumuzi / Hanekom, Christoff / Held, Michael / Heynes, Alana / Hlatswayo, Sabelo / Hodkinson, Bridget / Holtzhausen, Jeanette / Hoosain, Shakeel / Jacobs, Ashely / Kahn, Miriam / Kahn, Thania / Khamajeet, Arvin / Khan, Joubin / Khan, Riaasat / Khwitshana, Alicia / Knight, Lauren / Kooverjee, Sharita / Krogscheepers, Rene / Jacque Kruger, Jean / Kuhn, Suzanne / Laubscher, Kim / Lazarus, John / Le Roux, Jacque / Lee Jones, Scott / Levin, Dion / Maartens, Gary / Majola, Thina / Manganyi, Rodgers / Marais, David / Marais, Suzaan / Maritz, Francois / Maughan, Deborah / Mazondwa, Simthandile / Mbanga, Luyanda / Mbatani, Nomonde / Mbena, Bulewa / Meintjes, Graeme / Mendelson, Marc / Möller, Ernst / Moore, Allison / Ndebele, Babalwa / Nortje, Marc / Ntusi, Ntobeko / Nyengane, Funeka / Ofoegbu, Chima / Papavarnavas, Nectarios / Peter, Jonny / Pickard, Henri / Pluke, Kent / Raubenheimer, Peter J / Robertson, Gordon / Rozmiarek, Julius / Sayed, A / Scriba, Matthias / Sekhukhune, Hennie / Singh, Prasun / Smith, Elsabe / Soldati, Vuyolwethu / Stek, Cari / van den berg, Robert / van der Merwe, Le Roux / Venter, Pieter / Vermooten, Barbra / Viljoen, Gerrit / Viranna, Santhuri / Vogel, Jonno / Vundla, Nokubonga / Wasserman, Sean / Zitha, Eddy / Lomas-Marais, Vanessa / Lombard, Annie / Stuve, Katrin / Viljoen, Werner / Basson, De Vries / Le Roux, Sue / Linden-Mars, Ethel / Victor, Lizanne / Wates, Mark / Zwanepoel, Elbe / Ebrahim, Nabilah / Lahri, Sa'ad / Mnguni, Ayanda / Crede, Thomas / de Man, Martin / Evans, Katya / Hendrikse, Clint / Naude, Jonathan / Parak, Moosa / Szymanski, Patrick / Van Koningsbruggen, Candice / Abrahams, Riezaah / Allwood, Brian / Botha, Christoffel / Henndrik Botha, Matthys / Broadhurst, Alistair / Claasen, Dirkie / Daniel, Che / Dawood, Riyaadh / du Preez, Marie / Du Toit, Nicolene / Erasmus, Kobie / Koegelenberg, Coenraad F N / Gabriel, Shiraaz / Hugo, Susan / Jardine, Thabiet / Johannes, Clint / Karamchand, Sumanth / Lalla, Usha / Langenegger, Eduard / Louw, Eize / Mashigo, Boitumelo / Mhlana, Nonte / Mnqwazi, Chizama / Moodley, Ashley / Moodley, Desiree / Moolla, Saadiq / Mowlana, Abdurasiet / Nortje, Andre / Olivier, Elzanne / Parker, Arifa / Paulsen, Chané / Prozesky, Hans / Rood, Jacques / Sabela, Tholakele / Schrueder, Neshaad / Sithole, Nokwanda / Sithole, Sthembiso / Taljaard, Jantjie J / Titus, Gideon / Van Der Merwe, Tian / van Schalkwyk, Marije / Vazi, Luthando / Viljoen, Abraham J / Yazied Chothia, Mogamat / Naidoo, Vanessa / Alan Wallis, Lee / Abbass, Mumtaz / Arendse, Juanita / Armien, Rizqa / Bailey, Rochelle / Bello, Muideen / Carelse, Rachel / Forgus, Sheron / Kalawe, Nosi / Kariem, Saadiq / Kotze, Mariska / Lucas, Jonathan / McClaughlin, Juanita / Murie, Kathleen / Najjaar, Leilah / Petersen, Liesel / Porter, James / Shaw, Melanie / Stapar, Dusica / Williams, Michelle / Aldum, Linda / Berkowitz, Natacha / Girran, Raakhee / Lee, Kevin / Naidoo, Lenny / Neumuller, Caroline / Anderson, Kim / Begg, Kerrin / Boerlage, Lisa / Cornell, Morna / de Waal, Renée / Dudley, Lilian / English, René / Euvrard, Jonathan / Groenewald, Pam / Jacob, Nisha / Jaspan, Heather / Kalk, Emma / Levitt, Naomi / Malaba, Thoko / Nyakato, Patience / Patten, Gabriela / Schneider, Helen / Shung King, Maylene / Tsondai, Priscilla / Van Duuren, James / van Schaik, Nienke / Blumberg, Lucille / Cohen, Cheryl / Govender, Nelesh / Jassat, Waasila / Kufa, Tendesayi / McCarthy, Kerrigan / Morris, Lynn / Hsiao, Nei-yuan / Marais, Ruan / Ambler, Jon / Ngwenya, Olina / Osei-Yeboah, Richard / Johnson, Leigh / Kassanjee, Reshma / Tamuhla, Tsaone

    Clinical Infectious Diseases ; ISSN 1058-4838 1537-6591

    2020  

    Abstract: Abstract Background Risk factors for COVID-19 death in sub-Saharan Africa and the effects of HIV and tuberculosis on COVID-19 outcomes are unknown. Methods We conducted a population cohort study using linked data from adults attending public sector ... ...

    Abstract Abstract Background Risk factors for COVID-19 death in sub-Saharan Africa and the effects of HIV and tuberculosis on COVID-19 outcomes are unknown. Methods We conducted a population cohort study using linked data from adults attending public sector health facilities in the Western Cape, South Africa. We used Cox-proportional hazards models adjusted for age, sex, location and comorbidities to examine the association between HIV, tuberculosis and COVID-19 death from 1 March-9 June 2020 among (i) public sector “active patients” (≥1 visit in the 3 years before March 2020), (ii) laboratory-diagnosed COVID-19 cases and (iii) hospitalized COVID-19 cases. We calculated the standardized mortality ratio (SMR) for COVID-19 comparing HIV positive vs. negative adults using modelled population estimates. Results Among 3,460,932 patients (16% HIV positive), 22,308 were diagnosed with COVID-19, of whom 625 died. COVID-19 death was associated with male sex, increasing age, diabetes, hypertension and chronic kidney disease. HIV was associated with COVID-19 mortality (adjusted hazard ratio [aHR] 2.14; 95% confidence interval [CI] 1.70-2.70), with similar risks across strata of viral load and immunosuppression. Current and previous tuberculosis were associated with COVID-19 death (aHR [95%CI] 2.70 [1.81-4.04] and 1.51 [1.18-1.93] respectively). The SMR for COVID-19 death associated with HIV was 2.39 (95%CI 1.96-2.86); population attributable fraction 8.5% (95%CI 6.1-11.1). Conclusion While our findings may over-estimate HIV- and tuberculosis-associated COVID-19 mortality risks due to residual confounding, both HIV and current tuberculosis were independently associated with increased COVID-19 mortality. The associations between age, sex and other comorbidities and COVID-19 mortality were similar to other settings.
    Schlagwörter Microbiology (medical) ; Infectious Diseases ; covid19
    Sprache Englisch
    Verlag Oxford University Press (OUP)
    Erscheinungsland uk
    Dokumenttyp Artikel ; Online
    DOI 10.1093/cid/ciaa1198
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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