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  1. Article ; Online: Maternal iron supplementation in pregnancy and asthma in the offspring: follow-up of a randomised trial in Finland.

    Shaheen, Seif O / Gissler, Mika / Devereux, Graham / Erkkola, Maijaliisa / Kinnunen, Tarja I / Mcardle, Harry / Sheikh, Aziz / Hemminki, Elina / Nwaru, Bright I

    The European respiratory journal

    2020  Volume 55, Issue 6

    MeSH term(s) Asthma/drug therapy ; Asthma/epidemiology ; Dietary Supplements ; Female ; Finland/epidemiology ; Follow-Up Studies ; Humans ; Iron ; Pregnancy
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2020-06-04
    Publishing country England
    Document type Letter ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02335-2019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2322: Show issues Location:
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  2. Article ; Online: Is infant arterial stiffness associated with maternal blood pressure in pregnancy? Findings from a UK birth cohort (Baby VIP study).

    Ng, Ka Ying Bonnie / Simpson, Nigel A B / Cade, Janet E / Greenwood, Darren C / Mcardle, Harry J / Ciantar, Etienne / Alwan, Nisreen A

    PloS one

    2018  Volume 13, Issue 7, Page(s) e0200159

    Abstract: Background: In adults, arterial stiffness measured by pulse wave velocity (PWV) is regarded as a predictor of cardiovascular disease. Infant vascular development depends on factors related to pregnancy, including maternal blood pressure (BP). This study ...

    Abstract Background: In adults, arterial stiffness measured by pulse wave velocity (PWV) is regarded as a predictor of cardiovascular disease. Infant vascular development depends on factors related to pregnancy, including maternal blood pressure (BP). This study assessed the association between maternal BP in pregnancy and infant brachio-femoral PWV at age 2-6 weeks.
    Methods: The Baby Vascular health and Iron in Pregnancy (Baby VIP) study is a birth cohort which measured PWV and heart rate (HR) in 284 babies in Leeds, UK, at 2-6 weeks after birth. Maternal BP measurements at 12 and 36 weeks gestation was collected from antenatal clinical records. Multivariable linear regression models assessed associations between maternal systolic and diastolic BPs, and BP change from booking to 36 weeks, with infant PWV adjusting for covariables at both mother and baby level.
    Results: There was no evidence of an association between infant PWV and maternal systolic BP at booking (adjusted regression coefficient -0.01 m/s per 10mmHg, 95% CI -0.11, 0.14, p = 0.84) or at 36 weeks (adjusted regression coefficient 0.00 m/s per 10mmHg, 95% CI -0.12, 0.11, p = 0.95). Change between 12 and 36 weeks gestation of more than 30 mmHg in systolic BP or 15 mmHg in diastolic BP was also not associated with infant PWV. There was an inverse relationship between infant HR and infant PWV (regression coefficient -0.14 m/s per 10 bpm, 95% CI -0.22, -0.05, p<0.01).
    Conclusions: This study has shown no evidence of association between infant PWV at 2-6 weeks of age and maternal BP in early or late pregnancy. Infant HR was inversely associated with infant PWV. Further studies are required to determine the predictors of infant PWV as well as the importance and long term implications of PWV measurements in infants.
    MeSH term(s) Adult ; Blood Pressure/physiology ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/physiopathology ; Cohort Studies ; Female ; Gestational Age ; Heart Rate/physiology ; Humans ; Infant ; Infant, Newborn/physiology ; Linear Models ; Male ; Maternal-Fetal Exchange/physiology ; Predictive Value of Tests ; Pregnancy/physiology ; Prenatal Exposure Delayed Effects/etiology ; Prenatal Exposure Delayed Effects/physiopathology ; Pulse Wave Analysis ; Risk Factors ; United Kingdom ; Vascular Stiffness/physiology
    Language English
    Publishing date 2018-07-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0200159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Scientific opinion on the evaluation of authorised ferric sodium EDTA as an ingredient in the context of Regulation (EC) 258/97 on novel foods and Regulation (EU) 609/2013 on food intended for infants and young children, food for special medical purposes and total diet replacement for weight control.

    Younes, Maged / Aggett, Peter / Aguilar, Fernando / Crebelli, Riccardo / Dusemund, Birgit / Filipič, Metka / Frutos, Maria Jose / Galtier, Pierre / Gundert-Remy, Ursula / Kuhnle, Gunter Georg / Lambré, Claude / Leblanc, Jean-Charles / Lillegaard, Inger Therese / Moldeus, Peter / Mortensen, Alicja / Oskarsson, Agneta / Stankovic, Ivan / Waalkens-Berendsen, Ine / Woutersen, Rudolf Antonius /
    Wright, Matthew / Tobback, Paul / Mcardle, Harry / Germini, Andrea / Gott, David

    EFSA journal. European Food Safety Authority

    2018  Volume 16, Issue 8, Page(s) e05369

    Abstract: The present opinion deals with the evaluation of the proposed increase of the currently authorised maximum amounts of ferric sodium ethylenediaminetetraacetic acid (EDTA) as a novel food ingredient used as a source of iron, and its extension of use in ... ...

    Abstract The present opinion deals with the evaluation of the proposed increase of the currently authorised maximum amounts of ferric sodium ethylenediaminetetraacetic acid (EDTA) as a novel food ingredient used as a source of iron, and its extension of use in processed cereal-based foods and baby foods. The applicant also provided information on two forms of ferric sodium EDTA, one previously assessed by EFSA and a new one of finer consistency. To support the proposed changes to the uses of ferric sodium EDTA, the applicant proposed a revision of the current acceptable daily intake (ADI) for EDTA, derived from that set for the food additive calcium disodium EDTA (E 385). The Panel confirmed that ferric sodium EDTA is a source from which iron is bioavailable. In assessing the safety of the proposed revision to the existing specifications for the novel food ingredient ferric sodium EDTA, the Panel noted that this would not discriminate between the previously evaluated substance and the one of finer consistency. In particular, the Panel noted that particle size was not one of the proposed parameters for the revised specifications. The Panel noted that it was not possible to determine whether particles of ferric sodium EDTA in the nano range were present in the product with finer consistency in the solid form. The toxicological data submitted did not add any new relevant information to the database on which the current ADI for EDTA is based. Consequently, the Panel concluded that there was no sound scientific justification to increase the ADI for EDTA and hence increase the use levels of ferric sodium EDTA or introduce additional uses as proposed by the applicant. The Panel recommended that additional toxicological data should be provided to address the shortcomings in the available toxicity database prior to the re-evaluation of calcium disodium EDTA (E 385).
    Language English
    Publishing date 2018-08-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2540248-1
    ISSN 1831-4732 ; 1831-4732
    ISSN (online) 1831-4732
    ISSN 1831-4732
    DOI 10.2903/j.efsa.2018.5369
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Iron and copper interactions in development and the effect on pregnancy outcome.

    Gambling, Lorraine / Danzeisen, Ruth / Fosset, Cedric / Andersen, Henriette S / Dunford, Susan / Srai, S Kaila S / MCArdle, Harry J

    The Journal of nutrition

    2003  Volume 133, Issue 5 Suppl 1, Page(s) 1554S–6S

    Abstract: During pregnancy, nutrients are transferred from mother to fetus across the placenta. The mechanisms whereby this occurs, and the adaptations that occur in response to deficiency or overload of iron (Fe) and copper (Cu) are examined in this review. Fe ... ...

    Abstract During pregnancy, nutrients are transferred from mother to fetus across the placenta. The mechanisms whereby this occurs, and the adaptations that occur in response to deficiency or overload of iron (Fe) and copper (Cu) are examined in this review. Fe deficiency during pregnancy is common and has serious consequences both in the short and the long term such as fetal growth retardation and cardiovascular problems in the adult offspring. Similarly, Cu deficiency, although not so common, also has deleterious effects. The placenta minimizes the effect of the deficiency by up-regulating the proteins involved in Fe transfer. For example, transferrin receptor levels increase inversely to maternal Fe levels. Divalent metal transporter 1 (DMT1) mRNA in the iron-responsive element (IRE) regulated, but not the non-IRE regulated form is increased, as is the placenta Cu oxidase. Conversely, iron-regulated gene 1 (IREG1) expression is not affected. Fe deficiency increases Cu levels in maternal liver, serum and placenta, but has much less effect in the fetal serum and liver. Apart from maternal ceruloplasmin, mRNA levels of Cu-related proteins are not changed. The Cu oxidase, which we suggest fulfils the function of hephaestin in placenta, is regulated by Cu as well as by Fe. Fe deficiency also has marked effects on cytokine levels in the placenta. Tumor necrosis factor alpha (TNFalpha) and TNFalpha receptor 1 (TNFalphaR1) levels both increase. The data show that altering Fe status has a marked effect on metabolism of other metals and of other important mediators of cell function. This is particularly important during pregnancy, when the developing fetus is very vulnerable to inappropriate micronutrient status.
    MeSH term(s) Animals ; Copper/metabolism ; Embryonic and Fetal Development/physiology ; Female ; Humans ; Infant, Newborn ; Iron/metabolism ; Liver/metabolism ; Placenta/metabolism ; Pregnancy ; Pregnancy Outcome
    Chemical Substances Copper (789U1901C5) ; Iron (E1UOL152H7)
    Language English
    Publishing date 2003-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 218373-0
    ISSN 1541-6100 ; 0022-3166
    ISSN (online) 1541-6100
    ISSN 0022-3166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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