Article ; Online: Response of vulval lichen sclerosus and squamous hyperplasia to photodynamic treatment using sustained topical delivery of aminolevulinic acid from a novel bioadhesive patch system.
Photodermatology, photoimmunology & photomedicine
2009 Volume 25, Issue 2, Page(s) 111–113
Abstract: This study evaluated the clinical and histopathological responses of vulval lichen sclerosus (LS) and squamous hyperplasia (SH) to photodynamic therapy (PDT). A novel bioadhesive patch containing aminolevulinic acid (ALA) at a dose of (38 mg/cm(2)) was ... ...
| Abstract | This study evaluated the clinical and histopathological responses of vulval lichen sclerosus (LS) and squamous hyperplasia (SH) to photodynamic therapy (PDT). A novel bioadhesive patch containing aminolevulinic acid (ALA) at a dose of (38 mg/cm(2)) was used to treat 10 patients before irradiation with light of 630 nm. Clinical, histopathological and pathological responses to treatment were assessed at 6 weeks post-treatment. After 17 cycles of PDT, six patients reported significant symptomatic relief and no cutaneous photosensitivity. Histopathological differences were not demonstrated, but statistically significant induction of apoptosis was seen. It can be concluded that ALA-PDT patch-based formulation is pragmatic and primarily offers symptomatic management of vulval LS and SH. |
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| MeSH term(s) | Adhesiveness ; Administration, Cutaneous ; Aminolevulinic Acid/administration & dosage ; Aminolevulinic Acid/pharmacology ; Aminolevulinic Acid/therapeutic use ; Female ; Humans ; Hyperplasia/pathology ; Hyperplasia/therapy ; Photochemotherapy ; Photosensitizing Agents/administration & dosage ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/therapeutic use ; Vulvar Lichen Sclerosus/pathology ; Vulvar Lichen Sclerosus/therapy | |||||
| Chemical Substances | Photosensitizing Agents ; Aminolevulinic Acid (88755TAZ87) | |||||
| Language | English | |||||
| Publishing date | 2009-04 | |||||
| Publishing country | England | |||||
| Document type | Clinical Trial ; Journal Article | |||||
| ZDB-ID | 1028855-7 | |||||
| ISSN | 1600-0781 ; 0108-9684 ; 0905-4383 | |||||
| ISSN (online) | 1600-0781 | |||||
| ISSN | 0108-9684 ; 0905-4383 | |||||
| DOI | 10.1111/j.1600-0781.2009.00410.x | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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