Article ; Online: Performance of the Fecal Immunochemical Test in Patients With a Family History of Colorectal Cancer.
Journal of the Canadian Association of Gastroenterology
2019 Volume 3, Issue 6, Page(s) 288–292
Abstract: Objective: To assess the performance of a fecal immunochemical test (FIT) among participants of a population-based colorectal cancer (CRC) screening program with one or more first-degree relatives (FDR) with CRC.: Methods: Asymptomatic 50 to 74 years ...
| Abstract | Objective: To assess the performance of a fecal immunochemical test (FIT) among participants of a population-based colorectal cancer (CRC) screening program with one or more first-degree relatives (FDR) with CRC. Methods: Asymptomatic 50 to 74 years olds with a FDR diagnosed with CRC, enrolled in a colon screening program completed FIT (two samples, cut-off 20 µg Hemoglobin/gram feces) and underwent colonoscopy. FIT-interval CRCs were identified from the British Columbia cancer registry. Logistic regression analysis was used to identify variables associated with the detection of CRC and high-risk polyps (nonmalignant findings that required a 3-year surveillance colonoscopy) in those patients undergoing FIT and colonoscopy. Results: Of the 1387 participants with a FDR with CRC, 1244 completed FIT with a positivity rate of 10.8%, 52 declined FIT but underwent colonoscopy and 90 declined screening. Seven CRCs were identified: six in patients with a positive FIT, one in a patient who only had colonoscopy. No CRCs were found in patients with a negative FIT. The positive and negative predictive values of FIT in the detection of CRC were 4.8% and 100%, respectively. On multivariate logistic regression, positive FIT, and not type of family history, was the only variable associated with detection of CRC or high-risk polyps. At 2-year follow-up, there was no FIT interval cancer detected in the study cohort. Conclusion: FIT is more strongly associated with high-risk findings on colonoscopy than type of family history. FIT may be an alternative screening strategy to colonoscopy in individuals with a single FDR with CRC. |
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| Language | English |
| Publishing date | 2019-10-04 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2940642-0 |
| ISSN | 2515-2092 ; 2515-2084 |
| ISSN (online) | 2515-2092 |
| ISSN | 2515-2084 |
| DOI | 10.1093/jcag/gwz027 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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