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  1. Article ; Online: Is minimally invasive parathyroid surgery an option for patients with gestational primary hyperparathyroidism?

    Bendinelli, Cino / Nebauer, Shane / Quach, Tuan / Mcgrath, Shaun / Acharya, Shamasunder

    BMC pregnancy and childbirth

    2013  Volume 13, Page(s) 130

    Abstract: Background: Gestational primary hyperparathyroidism is associated with serious maternal and neonatal complications, which require prompt surgical treatment. Minimally invasive parathyroidectomy reduces pain, improves cosmesis and may achieve cure rates ... ...

    Abstract Background: Gestational primary hyperparathyroidism is associated with serious maternal and neonatal complications, which require prompt surgical treatment. Minimally invasive parathyroidectomy reduces pain, improves cosmesis and may achieve cure rates comparable to traditional open bilateral neck exploration. We report the clinical course of a woman with newly diagnosed gestational primary hyperparathyroidism and discuss the decision making behind the choice of video-assisted minimally invasive parathyroidectomy, amongst the other minimally invasive parathyroidectomy techniques available.
    Case presentation: A 38-years-old pregnant woman at 9 weeks of gestation, with severe hyperemesis and hypercalcaemia secondary to gestational primary hyperparathyroidism (ionised calcium 1.28 mmol/l) was referred for surgery. Ultrasound examination of her neck identified 2 suspicious parathyroid enlargements. In view of pregnancy, a radioisotope Sestamibi parathyroid scan was not performed. Bilateral four-gland exploration was therefore deemed necessary to guarantee cure. This was performed with video-assisted minimally invasive parathyroidectomy, which relies on a single 15 mm central incision with external retraction and endoscopic magnification, allowing bilateral neck exploration.
    Conclusion: Video-assisted minimally invasive parathyroidectomy allows bilateral four-gland exploration, and is an optimal technique to treat gestational primary hyperparathyroidism. This procedure removes the need for radiation exposure, reduces pain, improves cosmesis and may achieve cure rates comparable to traditional open bilateral neck exploration.
    MeSH term(s) Adenoma/complications ; Adenoma/surgery ; Adult ; Female ; Humans ; Hyperparathyroidism, Primary/etiology ; Hyperparathyroidism, Primary/surgery ; Minimally Invasive Surgical Procedures ; Parathyroid Neoplasms/complications ; Parathyroid Neoplasms/surgery ; Parathyroidectomy ; Pregnancy ; Pregnancy Complications, Neoplastic/surgery ; Pregnancy Trimester, Second ; Treatment Outcome ; Video-Assisted Surgery
    Language English
    Publishing date 2013-06-11
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1471-2393
    ISSN (online) 1471-2393
    DOI 10.1186/1471-2393-13-130
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  2. Article: Development and testing of novel chloroplast microsatellite markers for Lolium perenne and other grasses (Poaceae) from de novo sequencing and in silico sequences

    MCGRATH, S / HODKINSON, T.R / SALAMIN, N / BARTH, S

    Molecular ecology notes. 2006 June, v. 6, no. 2

    2006  

    Abstract: Twelve primers to amplify microsatellite markers from the chloroplast genome of Lolium perenne were designed and optimized using de novo sequencing and in silico sequences. With one exception, each locus was polymorphic with a range from two to nine ... ...

    Abstract Twelve primers to amplify microsatellite markers from the chloroplast genome of Lolium perenne were designed and optimized using de novo sequencing and in silico sequences. With one exception, each locus was polymorphic with a range from two to nine alleles in L. perenne. The newly developed primer pairs cross-amplified in different species of Lolium and in 50 other grass species representing nine grass subfamilies.
    Keywords Lolium perenne ; alleles ; chloroplast genome ; chloroplasts ; genetic markers ; grasses ; loci
    Language English
    Dates of publication 2006-06
    Size p. 449-452.
    Publisher Blackwell Publishing Ltd
    Publishing place Oxford, UK
    Document type Article
    ZDB-ID 2051527-3
    ISSN 1471-8278
    ISSN 1471-8278
    DOI 10.1111/j.1471-8286.2006.01267.x
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  3. Article: Morphological responses of wheat (Triticum aestivum L.) roots to phosphorus supply in two contrasting soils

    YUAN, H. M / BLACKWELL, M / MCGRATH, S / GEORGE, T. S / GRANGER, S. H / HAWKINS, J. M. B / DUNHAM, S / SHEN, J. B

    Journal of agricultural science. 2016 Jan., v. 154, no. 1

    2016  

    Abstract: To cope with phosphorus (P) deficiency, plants adapt root morphology to enhance inorganic P (Pi) acquisition from soil by allocating more biomass to roots, but whether the responses can be modified across gradients of P supply is not fully understood. ... ...

    Abstract To cope with phosphorus (P) deficiency, plants adapt root morphology to enhance inorganic P (Pi) acquisition from soil by allocating more biomass to roots, but whether the responses can be modified across gradients of P supply is not fully understood. The present study examined changes in root-length density (RLD), root-hair density (RHD) and root-hair length (RHL) of wheat (Triticum aestivum L.) in two contrasting soils, the Rough and Barnfield soils. Wheat plants were grown for 3 weeks in thin-plate rhizotrons in two soils with additions of 0, 10, 25, 50, 100 and 200 mg P/kg soil. Contrary to published literature, as P additions increased it was observed that a concomitant increase in RHL (250 to 1054 μm in the Rough soil and 303–1075 μm in the Barnfield soil) and RHD (57 to 122/mm in the Rough soil and 56–120/mm in the Barnfield soil), while RLD generally decreased (2480–1130 cm/cm3 in the Rough soil and 1716–865 cm/cm3 in the Barnfield soil). The levels of added P that resulted in critical P concentrations in the soils enabling maximum shoot biomass production were 50 mg/kg P in the Rough soil and 100 mg/kg P in the Barnfield soil, and these additions influenced root morphological changes. Under severe P deficiency, P supply increased RHL and RHD, but RLD was decreased. Improvement in lateral root and root-hair responses in wheat at extreme P deficiency may be a worthy target for breeding more sustainable genotypes for future agroecosystems.
    Keywords Triticum aestivum ; agroecosystems ; biomass production ; breeding ; genotype ; inorganic phosphorus ; phosphorus ; root hairs ; soil ; wheat
    Language English
    Dates of publication 2016-01
    Size p. 98-108.
    Publishing place Cambridge University Press
    Document type Article
    ZDB-ID 1498349-7
    ISSN 1469-5146 ; 0021-8596
    ISSN (online) 1469-5146
    ISSN 0021-8596
    DOI 10.1017/S0021859615000702
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  4. Article: Phytoextraction of cadmium and zinc by Salix from soil historically amended with sewage sludge

    Maxted, A. P / Black, C. R / West, H. M / Crout, N. M. J / Mcgrath, S. P / Young, S. D

    Plant and soil. 2007 Jan., v. 290, no. 1-2

    2007  

    Abstract: Short rotation coppice (SRC) such as Salix spp. can be grown as an energy crop and offers some potential for economic and practical phytoextraction of marginally contaminated arable soil. This study tested various soil amendments intended to increase ... ...

    Abstract Short rotation coppice (SRC) such as Salix spp. can be grown as an energy crop and offers some potential for economic and practical phytoextraction of marginally contaminated arable soil. This study tested various soil amendments intended to increase soil metal availability to Salix, investigated the distribution of metal between different tree fractions and assessed the viability of phytoextraction using SRC on arable soils. Several Salix genotypes were grown in field trials over 4 years. Cd and Zn concentrations were generally ranked in the order leaves > bark > wood. Metal concentrations in wood increased towards the top of the willow stems, whereas concentrations in leaves showed the opposite trend. None of the amendments significantly increased uptake of Zn by willow. However, in response to a range of soil HCl treatments, mean Cd concentrations in stems and leaves were 112% and 130% of control values. Data from the current experiment, and previous studies, were combined to develop a predictive model of Cd and Zn stem uptake by Salix. The minimum biological concentration factor (BCF) required to achieve a prescribed soil metal target was also calculated based on typical proportions of bioavailable Cd in sludge-amended soils for a 25-year Salix rotation. The best Salix genotypes investigated achieved less than 20% of the uptake rate required to remove one third of the soil Cd content (equivalent to the average isotopically exchangeable Cd fraction in soils at the study site).
    Keywords bioenergy ; cadmium ; Salix ; sewage sludge ; zinc
    Language English
    Dates of publication 2007-01
    Size p. 157-172.
    Publisher Kluwer Academic Publishers
    Publishing place Dordrecht
    Document type Article
    ZDB-ID 208908-7
    ISSN 1573-5036 ; 0032-079X
    ISSN (online) 1573-5036
    ISSN 0032-079X
    DOI 10.1007/s11104-006-9149-5
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    Z 970: Show issues
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  5. Article: Synthesis of low molecular weight thiols in response to Cd exposure in Thlaspi caerulescens.

    Hernández-Allica, J / Garbisu, C / Becerril, J M / Barrutia, O / García-Plazaola, J I / Zhao, F J / Mcgrath, S P

    Plant, cell & environment

    2006  Volume 29, Issue 7, Page(s) 1422–1429

    Abstract: In this study, we investigated the accumulation of phytochelatins (PCs) and other low molecular weight (LMW) thiols in response to Cd exposure in two contrasting ecotypes differing in Cd accumulation. Using a root elongation test, we found that the ... ...

    Abstract In this study, we investigated the accumulation of phytochelatins (PCs) and other low molecular weight (LMW) thiols in response to Cd exposure in two contrasting ecotypes differing in Cd accumulation. Using a root elongation test, we found that the highly accumulating ecotype Ganges was more tolerant to Cd than the low Cd-accumulation ecotype Prayon. L-buthionine-(S,R)-sulphoximine (BSO), a potent inhibitor of the gamma-glutamylcysteine synthetase gamma-ECS) (an enzyme involved in the PC biosynthetic pathway), increased the Cd sensitivity of Prayon, but had no effect on Ganges. Although PC accumulation increased in response to Cd exposure, no significant differences were observed between the two ecotypes. Cd exposure induced a dose-dependent accumulation of both Cys and a still unidentified LMW thiol in roots of both ecotypes. Root accumulation of Cys and this thiol was higher in Ganges than in Prayon; the ecotypic differences were more pronounced when the plants were treated with BSO. These findings suggest that PCs do not contribute to the Cd hypertolerance displayed by the Ganges ecotype of Thlaspi caerulescens, whereas Cys and other LMW thiols might be involved.
    MeSH term(s) Cadmium/pharmacology ; Chromatography, High Pressure Liquid ; Glutathione/analysis ; Glutathione/biosynthesis ; Molecular Weight ; Phytochelatins ; Plant Roots/drug effects ; Plant Shoots/drug effects ; Sulfhydryl Compounds/metabolism ; Thlaspi/drug effects
    Chemical Substances Sulfhydryl Compounds ; Cadmium (00BH33GNGH) ; Phytochelatins (98726-08-0) ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2006-10-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 391893-2
    ISSN 1365-3040 ; 0140-7791
    ISSN (online) 1365-3040
    ISSN 0140-7791
    DOI 10.1111/j.1365-3040.2006.01525.x
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  6. Article: Synthesis of low molecular weight thiols in response to Cd exposure in Thlaspi caerulescens

    HERNÁNDEZ-ALLICA, J / GARBISU, C / BECERRIL, J.M / BARRUTIA, O / GARCÍA-PLAZAOLA, J.I / ZHAO, F.J / MCGRATH, S.P

    Plant, cell and environment. 2006 July, v. 29, no. 7

    2006  

    Abstract: In this study, we investigated the accumulation of phytochelatins (PCs) and other low molecular weight (LMW) thiols in response to Cd exposure in two contrasting ecotypes differing in Cd accumulation. Using a root elongation test, we found that the ... ...

    Abstract In this study, we investigated the accumulation of phytochelatins (PCs) and other low molecular weight (LMW) thiols in response to Cd exposure in two contrasting ecotypes differing in Cd accumulation. Using a root elongation test, we found that the highly accumulating ecotype Ganges was more tolerant to Cd than the low Cd-accumulation ecotype Prayon. [smallcapital l]-buthionine-(S,R)-sulphoximine (BSO), a potent inhibitor of the γ-glutamylcysteine synthetase (γ-ECS) (an enzyme involved in the PC biosynthetic pathway), increased the Cd sensitivity of Prayon, but had no effect on Ganges. Although PC accumulation increased in response to Cd exposure, no significant differences were observed between the two ecotypes. Cd exposure induced a dose-dependent accumulation of both Cys and a still unidentified LMW thiol in roots of both ecotypes. Root accumulation of Cys and this thiol was higher in Ganges than in Prayon; the ecotypic differences were more pronounced when the plants were treated with BSO. These findings suggest that PCs do not contribute to the Cd hypertolerance displayed by the Ganges ecotype of Thlaspi caerulescens, whereas Cys and other LMW thiols might be involved.
    Keywords Thlaspi caerulescens ; ecotypes ; molecular weight ; root growth ; roots ; thiols
    Language English
    Dates of publication 2006-07
    Size p. 1422-1429.
    Publisher Blackwell Publishing Ltd
    Publishing place Oxford, UK
    Document type Article
    ZDB-ID 391893-2
    ISSN 1365-3040 ; 0140-7791
    ISSN (online) 1365-3040
    ISSN 0140-7791
    DOI 10.1111/j.1365-3040.2006.01525.x
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  7. Article: Studies of adrenocortical function in long-distance fliers.

    GOFTON, J P / MCGRATH, S D

    The Journal of aviation medicine

    1953  Volume 24, Issue 2, Page(s) 107–112

    MeSH term(s) Adrenal Cortex/physiology ; Aerospace Medicine ; Animals ; Aviation ; Humans ; Medicine ; Perciformes
    Language English
    Publishing date 1953-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410452-3
    ISSN 0095-991X
    ISSN 0095-991X
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 57: Show issues Location:
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    Zs.MA 15: Show issues

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  8. Article: The use of reserpine (serpasil) in psychiatry.

    MCGRATH, S D / RYAN, J P / FENNELLY, J J

    Journal of the Irish Medical Association

    1956  Volume 39, Issue 229, Page(s) 1–4

    MeSH term(s) Antihypertensive Agents ; Psychiatry ; Reserpine ; Schizophrenia/therapy ; Secologanin Tryptamine Alkaloids/therapeutic use
    Chemical Substances Antihypertensive Agents ; Secologanin Tryptamine Alkaloids ; Reserpine (8B1QWR724A)
    Language English
    Publishing date 1956-07
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 422683-5
    ISSN 0021-129X
    ISSN 0021-129X
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  9. Article: A study of the eosinophil response to exercise in man.

    WAKE, R F / GRAHAM, B F / MCGRATH, S D

    The Journal of aviation medicine

    1953  Volume 24, Issue 2, Page(s) 127–130

    MeSH term(s) Adrenal Cortex/physiology ; Aerospace Medicine ; Aviation ; Eosinophils ; Exercise ; Leukocyte Count
    Language English
    Publishing date 1953-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410452-3
    ISSN 0095-991X
    ISSN 0095-991X
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  10. Article: Evaluation of changes in eosinophil levels in studies of adrenocortical function and stress.

    GOFTON, J P / GRAHAM, B F / MCGRATH, S D / CLEGHORN, R A

    The Journal of aviation medicine

    1953  Volume 24, Issue 2, Page(s) 123–126

    MeSH term(s) Adrenal Cortex ; Adrenal Cortex Function Tests ; Aerospace Medicine ; Aviation ; Eosinophils ; Leukocyte Count ; Medicine ; Stress, Physiological/blood
    Language English
    Publishing date 1953-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410452-3
    ISSN 0095-991X
    ISSN 0095-991X
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