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  1. Article: ECOLOGICALLY VALID LONG-TERM MOOD MONITORING OF INDIVIDUALS WITH BIPOLAR DISORDER USING SPEECH.

    Karam, Zahi N / Provost, Emily Mower / Singh, Satinder / Montgomery, Jennifer / Archer, Christopher / Harrington, Gloria / Mcinnis, Melvin G

    Proceedings of the ... IEEE International Conference on Acoustics, Speech, and Signal Processing. ICASSP (Conference)

    2014  Volume 2014, Page(s) 4858–4862

    Abstract: Speech patterns are modulated by the emotional and neurophysiological state of the speaker. There exists a growing body of work that computationally examines this modulation in patients suffering from depression, autism, and post-traumatic stress ... ...

    Abstract Speech patterns are modulated by the emotional and neurophysiological state of the speaker. There exists a growing body of work that computationally examines this modulation in patients suffering from depression, autism, and post-traumatic stress disorder. However, the majority of the work in this area focuses on the analysis of structured speech collected in controlled environments. Here we expand on the existing literature by examining bipolar disorder (BP). BP is characterized by mood transitions, varying from a healthy euthymic state to states characterized by mania or depression. The speech patterns associated with these mood states provide a unique opportunity to study the modulations characteristic of mood variation. We describe methodology to collect unstructured speech continuously and unobtrusively via the recording of day-to-day cellular phone conversations. Our pilot investigation suggests that manic and depressive mood states can be recognized from this speech data, providing new insight into the feasibility of unobtrusive, unstructured, and continuous speech-based wellness monitoring for individuals with BP.
    Language English
    Publishing date 2014-07-14
    Publishing country United States
    Document type Journal Article
    ISSN 1520-6149
    ISSN 1520-6149
    DOI 10.1109/ICASSP.2014.6854525
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Resting EEG Measures of Brain Arousal in a Multisite Study of Major Depression.

    Ulke, Christine / Tenke, Craig E / Kayser, Jürgen / Sander, Christian / Böttger, Daniel / Wong, Lidia Y X / Alvarenga, Jorge E / Fava, Maurizio / McGrath, Patrick J / Deldin, Patricia J / Mcinnis, Melvin G / Trivedi, Madhukar H / Weissman, Myrna M / Pizzagalli, Diego A / Hegerl, Ulrich / Bruder, Gerard E

    Clinical EEG and neuroscience

    2018  Volume 50, Issue 1, Page(s) 3–12

    Abstract: Several studies have found upregulated brain arousal during 15-minute EEG recordings at rest in depressed patients. However, studies based on shorter EEG recording intervals are lacking. Here we aimed to compare measures of brain arousal obtained from 2- ... ...

    Abstract Several studies have found upregulated brain arousal during 15-minute EEG recordings at rest in depressed patients. However, studies based on shorter EEG recording intervals are lacking. Here we aimed to compare measures of brain arousal obtained from 2-minute EEGs at rest under eyes-closed condition in depressed patients and healthy controls in a multisite project-Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care (EMBARC). We expected that depressed patients would show stable and elevated brain arousal relative to controls. Eighty-seven depressed patients and 36 healthy controls from four research sites in the United States were included in the analyses. The Vigilance Algorithm Leipzig (VIGALL) was used for the fully automatic classification of EEG-vigilance stages (indicating arousal states) of 1-second EEG segments; VIGALL-derived measures of brain arousal were calculated. We found that depressed patients scored higher on arousal stability ( Z = -2.163, P = .015) and A stages (dominant alpha activity; P = .027) but lower on B1 stages (low-voltage non-alpha activity, P = .008) compared with healthy controls. No significant group differences were observed in Stage B2/3. In summary, we were able to demonstrate stable and elevated brain arousal during brief 2-minute recordings at rest in depressed patients. Results set the stage for examining the value of these measures for predicting clinical response to antidepressants in the entire EMBARC sample and evaluating whether an upregulated brain arousal is particularly characteristic for responders to antidepressants.
    MeSH term(s) Adolescent ; Adult ; Aged ; Algorithms ; Arousal ; Brain/physiopathology ; Depressive Disorder, Major/physiopathology ; Electroencephalography ; Female ; Humans ; Male ; Middle Aged ; Signal Processing, Computer-Assisted ; Young Adult
    Language English
    Publishing date 2018-09-05
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2140201-2
    ISSN 2169-5202 ; 0009-9155 ; 1550-0594
    ISSN (online) 2169-5202
    ISSN 0009-9155 ; 1550-0594
    DOI 10.1177/1550059418795578
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 833: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Resting EEG measures of brain arousal in a multisite study of major depression

    Ulke, Christine / Tenke, Craig E. / Kayser, Jürgen / Sander, Christian / Böttger, Daniel / Wong, Lidia Y. X. / Alvarenga, Jorge E. / Fava, Maurizio / McGrath, Patrick J. / Deldin, Patricia J. / Mcinnis, Melvin G. / Trivedi, Madhukar H. / Weissman, Myrna M. / Pizzagalli, Diego A. / Hegerl, Ulrich / Bruder, Gerard E.

    Clinical EEG and Neuroscience

    2019  Volume 50, Issue 1, Page(s) 3–12

    Abstract: Several studies have found upregulated brain arousal during 15-minute EEG recordings at rest in depressed patients. However, studies based on shorter EEG recording intervals are lacking. Here we aimed to compare measures of brain arousal obtained from 2- ... ...

    Abstract Several studies have found upregulated brain arousal during 15-minute EEG recordings at rest in depressed patients. However, studies based on shorter EEG recording intervals are lacking. Here we aimed to compare measures of brain arousal obtained from 2-minute EEGs at rest under eyes-closed condition in depressed patients and healthy controls in a multisite project-Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care (EMBARC). We expected that depressed patients would show stable and elevated brain arousal relative to controls. Eighty-seven depressed patients and 36 healthy controls from four research sites in the United States were included in the analyses. The Vigilance Algorithm Leipzig (VIGALL) was used for the fully automatic classification of EEG-vigilance stages (indicating arousal states) of 1-second EEG segments; VIGALL-derived measures of brain arousal were calculated. We found that depressed patients scored higher on arousal stability (Z = -2.163, P = .015) and A stages (dominant alpha activity; P = .027) but lower on B1 stages (low-voltage non-alpha activity, P = .008) compared with healthy controls. No significant group differences were observed in Stage B2/3. In summary, we were able to demonstrate stable and elevated brain arousal during brief 2-minute recordings at rest in depressed patients. Results set the stage for examining the value of these measures for predicting clinical response to antidepressants in the entire EMBARC sample and evaluating whether an upregulated brain arousal is particularly characteristic for responders to antidepressants.
    Keywords Brain ; Electrical Activity ; Electroencephalography ; Elektrische Aktivität ; Elektroenzephalographie ; Gehirn ; Major Depression
    Language English
    Document type Article
    ZDB-ID 2140201-2
    ISSN 1550-0594
    ISSN 1550-0594
    DOI 10.1177/1550059418795578
    Database PSYNDEX

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 833: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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