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  1. Article ; Online: Randomized controlled trial of the effect of 30% versus 80% fraction of inspired oxygen on cesarean delivery surgical site infection.

    Williams, Ned L / Glover, Melanie M / Crisp, Catrina / Acton, Angus L / Mckenna, David S

    American journal of perinatology

    2013  Volume 30, Issue 9, Page(s) 781–786

    Abstract: Objective: To determine if supplemental perioperative oxygen will reduce surgical site infection (SSI) following cesarean delivery.: Methods: This is a randomized, controlled trial evaluating SSI following either 30% or 80% fraction of inspired ... ...

    Abstract Objective: To determine if supplemental perioperative oxygen will reduce surgical site infection (SSI) following cesarean delivery.
    Methods: This is a randomized, controlled trial evaluating SSI following either 30% or 80% fraction of inspired oxygen (FIO2) during and 2 hours after cesarean delivery. Anesthesia providers administered FIO2 via a high-flow oxygen blender. Subjects, surgeons, and wound evaluation teams were blinded. Serial wound evaluations were performed. Data were analyzed using logistic regression models, Fisher exact test, and t test.
    Results: In all, 179 women were randomized, and 160 subjects were included in the analysis. There were 12/83 (14.5%) SSIs in the control group versus 10/77 (13.0%) in the investigational group (p = 0.82). Caucasian race, increased body mass index, and longer operative time were identified as significant risk factors for infection (p = 0.026, odds ratio 0.283; p = 0.05, odds ratio = 1.058; p = 0.037, odds ratio = 1.038, respectively).
    Conclusion: Perioperative oxygenation with 80% Fio2 is not effective in reducing SSI following cesarean delivery.
    MeSH term(s) Adult ; Body Mass Index ; Cesarean Section/adverse effects ; Double-Blind Method ; European Continental Ancestry Group ; Female ; Humans ; Operative Time ; Oxygen/administration & dosage ; Oxygen Inhalation Therapy ; Postoperative Care ; Pregnancy ; Surgical Wound Infection/etiology ; Surgical Wound Infection/prevention & control ; Young Adult
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2013-10
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 605671-4
    ISSN 1098-8785 ; 0735-1631
    ISSN (online) 1098-8785
    ISSN 0735-1631
    DOI 10.1055/s-0032-1333405
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1929: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Effect of Tocolytics on Surfactant Secretion When Administered with Betamethasone: An in Vitro Study.

    Haidar, Ziad A / Sibai, Baha M / Sonek, Jiri D / Sammohi, Shamili / Mckenna, David S / Grunwald, William C / Cool, David R

    American journal of perinatology

    2015  Volume 32, Issue 14, Page(s) 1351–1358

    Abstract: Objective: To analyze the amount of surfactant protein (SP)-B and lecithin/sphingomyelin (L/S) ratio in response to betamethasone (BMS) alone as compared with magnesium sulfate (Mg(2+)), indomethacin (Indo), and nifedipine (Nif) with or without BMS.: ... ...

    Abstract Objective: To analyze the amount of surfactant protein (SP)-B and lecithin/sphingomyelin (L/S) ratio in response to betamethasone (BMS) alone as compared with magnesium sulfate (Mg(2+)), indomethacin (Indo), and nifedipine (Nif) with or without BMS.
    Study design: NCI-H441 human lung cells were grown and distributed into eight plates. BMS and tocolytics were added and the final plates were: control, BMS only, and each tocolytic ± BMS. Cells were stained with SP-B antibodies and relative fluorescence was measured. Lipids were also extracted, identified, and examined for relative densities. The L/S ratio was calculated.
    Results: Nine independent measurements were obtained for each plate. The protein analysis revealed that among all eight plates, SP-B levels were highest among BMS only. There was a nonsignificant decrease in SP-B in each of the combinations of tocolytics + BMS as compared with BMS only. Compared with BMS only, L/S ratio was decreased in Mg(2+) + BMS (p = 0.041), Indo + BMS (p = 0.042), and Nif + BMS (p = 0.025).
    Conclusion: In our in vitro human lung cell model, SP-B and L/S ratio increased in response to BMS administration alone. The addition of tocolytics to BMS resulted in no increase in L/S ratio and no changes seen in SP-B production compared with BMS alone.
    MeSH term(s) Betamethasone/pharmacology ; Cell Line ; Glucocorticoids/pharmacology ; Humans ; Indomethacin/pharmacology ; Lecithins/metabolism ; Lung/cytology ; Magnesium Sulfate/pharmacology ; Nifedipine/pharmacology ; Pulmonary Surfactant-Associated Protein B/drug effects ; Pulmonary Surfactant-Associated Protein B/secretion ; Sphingomyelins/metabolism ; Tocolytic Agents/pharmacology
    Chemical Substances Glucocorticoids ; Lecithins ; Pulmonary Surfactant-Associated Protein B ; Sphingomyelins ; Tocolytic Agents ; Magnesium Sulfate (7487-88-9) ; Betamethasone (9842X06Q6M) ; Nifedipine (I9ZF7L6G2L) ; Indomethacin (XXE1CET956)
    Language English
    Publishing date 2015-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605671-4
    ISSN 1098-8785 ; 0735-1631
    ISSN (online) 1098-8785
    ISSN 0735-1631
    DOI 10.1055/s-0035-1566306
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1929: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Randomized Controlled Trial of the Effect of 30% versus 80% Fraction of Inspired Oxygen on Cesarean Delivery Surgical Site Infection

    Williams, Ned L. / Glover, Melanie M. / Crisp, Catrina / Acton, Angus L. / Mckenna, David S.

    American Journal of Perinatology

    2013  Volume 30, Issue 09, Page(s) 781–786

    Abstract: Objective: To determine if supplemental perioperative oxygen will reduce surgical site infection (SSI) following cesarean delivery.: Methods: This is a randomized, controlled trial evaluating SSI following either 30% or 80% fraction of inspired ... ...

    Abstract Objective: To determine if supplemental perioperative oxygen will reduce surgical site infection (SSI) following cesarean delivery.
    Methods: This is a randomized, controlled trial evaluating SSI following either 30% or 80% fraction of inspired oxygen (F io 2 ) during and 2 hours after cesarean delivery. Anesthesia providers administered F io 2 via a high-flow oxygen blender. Subjects, surgeons, and wound evaluation teams were blinded. Serial wound evaluations were performed. Data were analyzed using logistic regression models, Fisher exact test, and t test.
    Results: In all, 179 women were randomized, and 160 subjects were included in the analysis. There were 12/83 (14.5%) SSIs in the control group versus 10/77 (13.0%) in the investigational group ( p  = 0.82). Caucasian race, increased body mass index, and longer operative time were identified as significant risk factors for infection ( p  = 0.026, odds ratio 0.283; p  = 0.05, odds ratio = 1.058; p  = 0.037, odds ratio = 1.038, respectively).
    Conclusion: Perioperative oxygenation with 80% F io 2 is not effective in reducing SSI following cesarean delivery.
    Keywords cesarean ; F ; infection ; surgical ; oxygen
    Language English
    Publishing date 2013-01-28
    Publisher Thieme Medical Publishers
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 605671-4
    ISSN 1098-8785 ; 0735-1631
    ISSN (online) 1098-8785
    ISSN 0735-1631
    DOI 10.1055/s-0032-1333405
    Database Thieme publisher's database

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1929: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Effect of Tocolytics on Surfactant Secretion When Administered with Betamethasone: An in Vitro Study

    Haidar, Ziad A. / Sibai, Baha M. / Sonek, Jiri D. / Sammohi, Shamili / Mckenna, David S. / Grunwald, William C. / Cool, David R.

    American Journal of Perinatology

    (Presentations from the 35 ; Annual Meeting of the Society for Maternal-Fetal Medicine – The Pregnancy Meeting™)

    2015  Volume 32, Issue 14, Page(s) 1351–1358

    Abstract: Objective: To analyze the amount of surfactant protein (SP)-B and lecithin/sphingomyelin (L/S) ratio in response to betamethasone (BMS) alone as compared with magnesium sulfate (Mg 2+ ), indomethacin (Indo), and nifedipine (Nif) with or without BMS.: ... ...

    Series title Presentations from the 35
    Annual Meeting of the Society for Maternal-Fetal Medicine – The Pregnancy Meeting™
    Abstract Objective: To analyze the amount of surfactant protein (SP)-B and lecithin/sphingomyelin (L/S) ratio in response to betamethasone (BMS) alone as compared with magnesium sulfate (Mg 2+ ), indomethacin (Indo), and nifedipine (Nif) with or without BMS.
    Study design: NCI-H441 human lung cells were grown and distributed into eight plates. BMS and tocolytics were added and the final plates were: control, BMS only, and each tocolytic ± BMS. Cells were stained with SP-B antibodies and relative fluorescence was measured. Lipids were also extracted, identified, and examined for relative densities. The L/S ratio was calculated.
    Results: Nine independent measurements were obtained for each plate. The protein analysis revealed that among all eight plates, SP-B levels were highest among BMS only. There was a nonsignificant decrease in SP-B in each of the combinations of tocolytics + BMS as compared with BMS only. Compared with BMS only, L/S ratio was decreased in Mg 2+ + BMS ( p  = 0.041), Indo + BMS ( p  = 0.042), and Nif + BMS ( p  = 0.025).
    Conclusion: In our in vitro human lung cell model, SP-B and L/S ratio increased in response to BMS administration alone. The addition of tocolytics to BMS resulted in no increase in L/S ratio and no changes seen in SP-B production compared with BMS alone.
    Keywords tocolytics ; surfactant ; lecithin ; betamethasone ; NCI-H441 cell line
    Language English
    Publishing date 2015-11-03
    Publisher Thieme Medical Publishers
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 605671-4
    ISSN 1098-8785 ; 0735-1631
    ISSN (online) 1098-8785
    ISSN 0735-1631
    DOI 10.1055/s-0035-1566306
    Database Thieme publisher's database

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1929: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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