LIVIVO - Search results -

Search results

Result 1 - 10 of total 13

Search options

Article ; Online: Wide range thermal and athermal operation of slotted surface grating lasers.

Mickus, Dovydas / Mckenna, Robert / Murphy, Caolan / Donegan, John F

2021 Volume 29, Issue 11, Page(s) 16893–16903

Abstract: Athermalisation is a procedure in which the wavelength of a semiconductor laser remains unchanged even as the temperature is altered. This is achieved by altering the currents that flow through the laser so as to maintain the wavelength and avoid mode ... ...

Abstract	Athermalisation is a procedure in which the wavelength of a semiconductor laser remains unchanged even as the temperature is altered. This is achieved by altering the currents that flow through the laser so as to maintain the wavelength and avoid mode hops. In this study, we demonstrate that lasers operating with a large red-shift with respect to the gain peak yield the best performance in terms of the highest temperature operation and also in terms of the widest athermal operating range. In particular, a device with red detuning of approximately 25 nm yields the best results. This device is athermalised continuously (without mode hops) from 5 to 106
Language	English
Publishing date	2021-06-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.422978
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Blood test shows high accuracy in detecting stage I non-small cell lung cancer.

Goebel, Cherylle / Louden, Christopher L / Mckenna, Robert / Onugha, Osita / Wachtel, Andrew / Long, Thomas

BMC cancer

2020 Volume 20, Issue 1, Page(s) 137

Abstract: Background: In a previous study (Goebel et. al, Cancer Genomics Proteomics 16:229-244, 2019), we identified 33 biomarkers for an early stage (I-II) Non-Small Cell Lung Cancer (NSCLC) test with 90% accuracy, 80.3% sensitivity, and 95.4% specificity. For ... ...

Abstract	Background: In a previous study (Goebel et. al, Cancer Genomics Proteomics 16:229-244, 2019), we identified 33 biomarkers for an early stage (I-II) Non-Small Cell Lung Cancer (NSCLC) test with 90% accuracy, 80.3% sensitivity, and 95.4% specificity. For the current study, we used a narrowed ensemble of 21 biomarkers while retaining similar accuracy in detecting early stage lung cancer. Methods: A multiplex platform, 486 human plasma samples, and 21 biomarkers were used to develop and validate our algorithm which detects early stage NSCLC. The training set consisted of 258 human plasma with 79 Stage I-II NSCLC samples. The 21 biomarkers with the statistical model (Lung Cancer Detector Test 1, LCDT1) was then validated using 228 novel samples which included 55 Stage I NSCLC. Results: The LCDT1 exhibited 95.6% accuracy, 89.1% sensitivity, and 97.7% specificity in detecting Stage I NSCLC on the blind set. When only NSCLC cancers were analyzed, the specificity increased to 99.1%. Conclusions: Compared to current approved clinical methods for diagnosing NSCLC, the LCDT1 greatly improves accuracy while being non-invasive; a simple, cost-effective, early diagnostic blood test should result in expanding access and increase survival rate.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/blood ; Carcinoma, Non-Small-Cell Lung/blood ; Carcinoma, Non-Small-Cell Lung/diagnosis ; Case-Control Studies ; Early Detection of Cancer/methods ; Female ; Hematologic Tests/methods ; Humans ; Lung Neoplasms/blood ; Lung Neoplasms/diagnosis ; Male ; Middle Aged ; Neoplasm Staging ; ROC Curve ; Young Adult
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2020-02-21
Publishing country	England
Document type	Journal Article
ISSN	1471-2407
ISSN (online)	1471-2407
DOI	10.1186/s12885-020-6625-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Tuning behaviour of slotted vernier widely tunable lasers.

Wallace, M J / Jain, Gaurav / Mckenna, Robert / Bello, Frank / Donegan, J F

Optics express

2019 Volume 27, Issue 12, Page(s) 17122–17137

Abstract: A detailed thermo-optic model combining the 1D transfer matrix method and a 3D finite element method is developed and used to simulate a widely tunable vernier laser based on surface etched slots. The model is used to investigate the experimentally ... ...

Abstract	A detailed thermo-optic model combining the 1D transfer matrix method and a 3D finite element method is developed and used to simulate a widely tunable vernier laser based on surface etched slots. The model is used to investigate the experimentally observed tuning patterns. At low injection currents, carrier tuning dominates, while at high currents, thermal tuning is the dominant mechanism. These lasers are very simple to fabricate and have a wide tuning over 50 nm, but SMSR and linewidth performance is not yet optimised. Simulations give an insight into the observed tuning efficiency and linewidth performance of the lasers, with high carrier densities in the grating regions being identified as a key area, which is presently limiting these parameters.
Language	English
Publishing date	2019-06-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.27.017122
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Primary pulmonary myxoid sarcoma, a potential mimic of metastatic extraskeletal myxoid chondrosarcoma.

Yanagida, Roh / Balzer, Bonnie L / Mckenna, Robert J / Fuller, Clark B

Pathology

2017 Volume 49, Issue 7, Page(s) 792–794

MeSH term(s)	Adult ; Chondrosarcoma/diagnostic imaging ; Chondrosarcoma/pathology ; Diagnosis, Differential ; Female ; Humans ; Lung/diagnostic imaging ; Lung/pathology ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology ; Lung Neoplasms/surgery ; Neoplasms, Connective and Soft Tissue/diagnostic imaging ; Neoplasms, Connective and Soft Tissue/pathology ; Sarcoma/diagnostic imaging ; Sarcoma/pathology ; Sarcoma/surgery ; Tomography, X-Ray Computed
Language	English
Publishing date	2017-10-27
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	7085-3
ISSN	1465-3931 ; 0031-3025
ISSN (online)	1465-3931
ISSN	0031-3025
DOI	10.1016/j.pathol.2017.08.015
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 723: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Book: Medical management of the thoracic surgery patient

Lewis, Michael I / Mckenna, Robert J

2010

Author's details	[edited by] Michael I. Lewis, Robert J. McKenna Jr. ; associate editors, Jeremy A. Falk, George E. Chaux
MeSH term(s)	Thoracic Diseases/surgery ; Thoracic Surgery/methods ; Thoracic Surgical Procedures/methods ; Perioperative Care/methods ; Patient Care/methods
Language	English
Size	xix, 540 p. :, ill.
Edition	1st ed.
Publisher	Saunders/Elsevier
Publishing place	Philadelphia, PA
Document type	Book
ISBN	9781416039938 ; 1416039937
Database	Catalogue of the US National Library of Medicine (NLM)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: One-Pot Procedure for the Synthesis of Asymmetric Substituted Ureido Benzene Sulfonamides as Effective Inhibitors of Carbonic Anhydrase Enzymes.

Vannozzi, Gioele / Vullo, Daniela / Angeli, Andrea / Ferraroni, Marta / Combs, Jacob / Lomelino, Carrie / Andring, Jacob / Mckenna, Robert / Bartolucci, Gianluca / Pallecchi, Marco / Lucarini, Laura / Sgambellone, Silvia / Masini, Emanuela / Carta, Fabrizio / Supuran, Claudiu T

Journal of medicinal chemistry

2021 Volume 65, Issue 1, Page(s) 824–837

Abstract: We report a one-pot procedure for the synthesis of asymmetrical ureido-containing benzenesulfonamides based on in situ generation of the corresponding isocyanatobenezenesulfonamide species, which were trapped with the appropriate amines. A library of new ...

Abstract	We report a one-pot procedure for the synthesis of asymmetrical ureido-containing benzenesulfonamides based on in situ generation of the corresponding isocyanatobenezenesulfonamide species, which were trapped with the appropriate amines. A library of new compounds was generated and evaluated in vitro for their inhibition properties against a representative panel of the human (h) metalloenzymes carbonic anhydrases (EC 4.2.1.1), and the best performing compounds on the isozyme II (i.e.,
MeSH term(s)	Animals ; Carbonic Anhydrase II/antagonists & inhibitors ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/pharmacology ; Crystallography, X-Ray ; Drug Design ; Glaucoma/drug therapy ; Intraocular Pressure/drug effects ; Male ; Models, Molecular ; Protein Binding ; Rabbits ; Structure-Activity Relationship ; Sulfonamides/chemical synthesis ; Sulfonamides/pharmacology ; Benzenesulfonamides
Chemical Substances	Carbonic Anhydrase Inhibitors ; Sulfonamides ; Carbonic Anhydrase II (EC 4.2.1.-)
Language	English
Publishing date	2021-12-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.1c01906
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 151: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MB 1: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Next Generation Sequencing of the Pig αβ TCR Repertoire Identifies the Porcine Invariant NKT Cell Receptor.

Yang, Guan / Artiaga, Bianca L / Lomelino, Carrie L / Jayaprakash, Anitha D / Sachidanandam, Ravi / Mckenna, Robert / Driver, John P

Journal of immunology (Baltimore, Md. : 1950)

2019 Volume 202, Issue 7, Page(s) 1981–1991

Abstract: Swine represent the only livestock with an established invariant NKT (iNKT) cell-CD1d system. In this study, we exploited the fact that pig iNKT cells can be purified using a mouse CD1d tetramer reagent to establish their TCR repertoire by next ... ...

Abstract	Swine represent the only livestock with an established invariant NKT (iNKT) cell-CD1d system. In this study, we exploited the fact that pig iNKT cells can be purified using a mouse CD1d tetramer reagent to establish their TCR repertoire by next generation sequencing. CD1d tetramer-positive pig cells predominantly expressed an invariant Vα-Jα rearrangement, without nontemplate nucleotide diversity, homologous to the Vα24-Jα18 and Vα14-Jα18 rearrangements of human and murine iNKT cells. The coexpressed β-chain used a Vβ segment homologous to the semivariant Vβ11 and Vβ8.2 segments of human and murine iNKT cell receptors. Molecular modeling found that contacts within CD1d and CDR1α that underlie fine specificity differences between mouse and human iNKT cells are conserved between pigs and humans, indicating that the response of porcine and human iNKT cells to CD1d-restricted Ags may be similar. Accordingly, pigs, which are an important species for diverse fields of biomedical research, may be useful for developing human-based iNKT cell therapies for cancer, infectious diseases, and other disorders. Our study also sequenced the expressed TCR repertoire of conventional porcine αβ T cells, which identified 48 Vα, 50 Jα, 18 Vβ, and 18 Jβ sequences, most of which correspond to human gene segments. These findings provide information on the αβ TCR usage of pigs, which is understudied and deserves further attention.
MeSH term(s)	Animals ; Female ; High-Throughput Nucleotide Sequencing ; Male ; Natural Killer T-Cells/microbiology ; Receptors, Antigen, T-Cell, alpha-beta/immunology ; Swine/immunology
Chemical Substances	Receptors, Antigen, T-Cell, alpha-beta
Language	English
Publishing date	2019-02-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1801171
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 28: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Book: Atlas of minimally invasive thoracic surgery (VATS)

Mckenna, Robert J / Mahtabifard, Ali / Swanson, Scott J

2011

Author's details	Robert J. McKenna Jr, Ali Mahtabifard, Scott J. Swanson
MeSH term(s)	Thoracic Surgery, Video-Assisted/methods ; Minimally Invasive Surgical Procedures/methods ; Thoracic Surgical Procedures/methods
Language	English
Size	xiv, 318 p. :, ill. +
Edition	1st ed.
Publisher	Elsevier/Saunders
Publishing place	Philadelphia
Document type	Book
Note	"Expert consult"--Cover.
Accompanying material	1 DVD (4 3/4 in.).
ISBN	9781416062639 ; 1416062637
Database	Catalogue of the US National Library of Medicine (NLM)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Atomic Resolution Structure of the Oncolytic Parvovirus LuIII by Electron Microscopy and 3D Image Reconstruction.

Pittman, Nikéa / Misseldine, Adam / Geilen, Lorena / Halder, Sujata / Smith, J Kennon / Kurian, Justin / Chipman, Paul / Janssen, Mandy / Mckenna, Robert / Baker, Timothy S / D'Abramo, Anthony / Cotmore, Susan / Tattersall, Peter / Agbandje-McKenna, Mavis

Viruses

2017 Volume 9, Issue 11

Abstract: LuIII, a protoparvovirus pathogenic to rodents, replicates in human mitotic cells, making it applicable for use to kill cancer cells. This virus group includes H-1 parvovirus (H-1PV) and minute virus of mice (MVM). However, LuIII displays enhanced ... ...

Abstract	LuIII, a protoparvovirus pathogenic to rodents, replicates in human mitotic cells, making it applicable for use to kill cancer cells. This virus group includes H-1 parvovirus (H-1PV) and minute virus of mice (MVM). However, LuIII displays enhanced oncolysis compared to H-1PV and MVM, a phenotype mapped to the major capsid viral protein 2 (VP2). This suggests that within LuIII VP2 are determinants for improved tumor lysis. To investigate this, the structure of the LuIII virus-like-particle was determined using single particle cryo-electron microscopy and image reconstruction to 3.17 Å resolution, and compared to the H-1PV and MVM structures. The LuIII VP2 structure, ordered from residue 37 to 587 (C-terminal), had the conserved VP topology and capsid morphology previously reported for other protoparvoviruses. This includes a core β-barrel and α-helix A, a depression at the icosahedral 2-fold and surrounding the 5-fold axes, and a single protrusion at the 3-fold axes. Comparative analysis identified surface loop differences among LuIII, H-1PV, and MVM at or close to the capsid 2- and 5-fold symmetry axes, and the shoulder of the 3-fold protrusions. The 2-fold differences cluster near the previously identified MVM sialic acid receptor binding pocket, and revealed potential determinants of protoparvovirus tumor tropism.
MeSH term(s)	Animals ; Capsid/chemistry ; Capsid/ultrastructure ; Capsid Proteins/chemistry ; Cryoelectron Microscopy/methods ; H-1 parvovirus/chemistry ; H-1 parvovirus/ultrastructure ; Humans ; Image Processing, Computer-Assisted ; Imaging, Three-Dimensional ; Mice ; Minute Virus of Mice/chemistry ; Minute Virus of Mice/ultrastructure ; Models, Molecular ; Oncolytic Viruses/chemistry ; Oncolytic Viruses/ultrastructure ; Parvovirus/chemistry ; Parvovirus/ultrastructure
Chemical Substances	Capsid Proteins
Language	English
Publishing date	2017-10-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v9110321
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The role of select subtype polymorphisms on HIV-1 protease conformational sampling and dynamics.

Huang, Xi / Britto, Manuel D / Kear-Scott, Jamie L / Boone, Christopher D / Rocca, James R / Simmerling, Carlos / Mckenna, Robert / Bieri, Michael / Gooley, Paul R / Dunn, Ben M / Fanucci, Gail E

The Journal of biological chemistry

2014 Volume 289, Issue 24, Page(s) 17203–17214

Abstract: HIV-1 protease is an essential enzyme for viral particle maturation and is a target in the fight against HIV-1 infection worldwide. Several natural polymorphisms are also associated with drug resistance. Here, we utilized both pulsed electron double ... ...

Abstract	HIV-1 protease is an essential enzyme for viral particle maturation and is a target in the fight against HIV-1 infection worldwide. Several natural polymorphisms are also associated with drug resistance. Here, we utilized both pulsed electron double resonance, also called double electron-electron resonance, and NMR (15)N relaxation measurements to characterize equilibrium conformational sampling and backbone dynamics of an HIV-1 protease construct containing four specific natural polymorphisms commonly found in subtypes A, F, and CRF_01 A/E. Results show enhanced backbone dynamics, particularly in the flap region, and the persistence of a novel conformational ensemble that we hypothesize is an alternative flap orientation of a curled open state or an asymmetric configuration when interacting with inhibitors.
MeSH term(s)	Amino Acid Sequence ; Catalytic Domain ; HIV Protease/chemistry ; HIV Protease/genetics ; Molecular Dynamics Simulation ; Molecular Sequence Data ; Mutation, Missense ; Polymorphism, Single Nucleotide
Chemical Substances	HIV Protease (EC 3.4.23.-)
Language	English
Publishing date	2014-04-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.M114.571836
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.108: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito