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  1. Article: Strategies for the production of high solids acrylic/methacrylic core-shell latices

    Udagama, R / Mckenna, T.F.L

    Journal of applied polymer science. 2010 Mar. 05, v. 115, no. 5

    2010  

    Abstract: Well-defined poly(butyl acrylate)/poly(methyl methacrylate) (PBA/PMMA) core shell particles with a moderately high solid content (49%) and particle diameters of less than 200 nm were prepared via seeded emulsion polymerization with a redox initiator and ... ...

    Abstract Well-defined poly(butyl acrylate)/poly(methyl methacrylate) (PBA/PMMA) core shell particles with a moderately high solid content (49%) and particle diameters of less than 200 nm were prepared via seeded emulsion polymerization with a redox initiator and an anionic surfactant. Low-viscosity (less than 150 cps at 20 s⁻¹) latex products were obtained by controlling the particle size distribution to within certain limits. Polymerization conversion and kinetics were followed gravimetrically and were adjusted so as to obtain recipes that could be scaled-up for industrial production.
    Language English
    Dates of publication 2010-0305
    Size p. 2668-2676.
    Publishing place Wiley Subscription Services, Inc., A Wiley Company
    Document type Article
    ZDB-ID 1491105-x
    ISSN 1097-4628 ; 0021-8995
    ISSN (online) 1097-4628
    ISSN 0021-8995
    DOI 10.1002/app.30342
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: Evaluation of a live-attenuated foot-and-mouth disease virus as a vaccine candidate.

    Mason, P W / Piccone, M E / Mckenna, T S / Chinsangaram, J / Grubman, M J

    Virology

    1997  Volume 227, Issue 1, Page(s) 96–102

    Abstract: A variant of foot-and-mouth disease virus (FMDV) lacking the leader (L) coding region (A12-LLV2) was previously constructed and shown to be less virulent in cattle than its wild-type parent (A12-IC). In this study, cattle were tested for their clinical ... ...

    Abstract A variant of foot-and-mouth disease virus (FMDV) lacking the leader (L) coding region (A12-LLV2) was previously constructed and shown to be less virulent in cattle than its wild-type parent (A12-IC). In this study, cattle were tested for their clinical and immunological responses to subcutaneous inoculation with A12-LLV2 or A12-IC or to intramuscular vaccination with chemically inactivated A12-IC. Five weeks postinoculation animals were challenged by intradermal inoculation in the tongue with a virulent cattle-passaged virus. A12-LLV2-inoculated animals showed no clinical signs of disease and developed a neutralizing antibody response by 4 days postinoculation, whereas a companion control bovine did not seroconvert. After challenge, two of three inoculated animals did not develop lesions, but showed mild signs of infection. The third inoculated animal developed some lesions, but these were less severe than in the uninoculated control animal, which showed classical FMD. All animals inoculated with A12-IC developed a fever, two showed typical FMD lesions, and the companion control seroconverted, indicating that it had acquired infection by contact. The A12-IC-inoculated animals and the control were protected from challenge. Animals vaccinated with inactivated virus showed no clinical signs of disease and developed a neutralizing antibody response, and the control did not seroconvert. Upon challenge none of the vaccinated animals developed lesions, one developed a fever, and the control developed FMD. These experiments demonstrate the potential of a rationally designed live-attenuated FMDV vaccine.
    MeSH term(s) Animals ; Antibodies, Viral/biosynthesis ; Aphthovirus/drug effects ; Aphthovirus/genetics ; Aphthovirus/immunology ; Aphthovirus/pathogenicity ; Aziridines/pharmacology ; Cattle ; Cattle Diseases/prevention & control ; Cattle Diseases/virology ; Cell Line ; Endopeptidases/genetics ; Evaluation Studies as Topic ; Foot-and-Mouth Disease/prevention & control ; Injections, Intradermal ; Injections, Subcutaneous ; Male ; Mutation ; Vaccines, Attenuated/administration & dosage ; Vaccines, Attenuated/adverse effects ; Vaccines, Attenuated/immunology ; Vaccines, Inactivated/administration & dosage ; Vaccines, Inactivated/adverse effects ; Vaccines, Inactivated/immunology ; Viral Vaccines/administration & dosage ; Viral Vaccines/adverse effects ; Viral Vaccines/genetics ; Viral Vaccines/immunology ; Virulence/genetics
    Chemical Substances Antibodies, Viral ; Aziridines ; Vaccines, Attenuated ; Vaccines, Inactivated ; Viral Vaccines ; aziridine (54P5FEX9FH) ; Endopeptidases (EC 3.4.-) ; leader proteinase, foot-and-mouth disease virus (EC 3.4.99.-)
    Language English
    Publishing date 1997-01-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 200425-2
    ISSN 1096-0341 ; 0042-6822
    ISSN (online) 1096-0341
    ISSN 0042-6822
    DOI 10.1006/viro.1996.8309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.172: Show issues Location:
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  3. Article: Surgical experience with Cushing's disease.

    Scott, H W / Liddle, G W / Mulherin, J L / Mckenna, T J / Stroup, S L / Rhamy, R K

    Annals of surgery

    1977  Volume 185, Issue 5, Page(s) 524–534

    Abstract: During the period 1952 to 1976 at Vanderbilt University Hospital 119 patients with pituitary-dependent hypercortisolism or Cushing's disease were studied. The less severe cases, which constitute a majority, were treated by pituitary irradiation with ... ...

    Abstract During the period 1952 to 1976 at Vanderbilt University Hospital 119 patients with pituitary-dependent hypercortisolism or Cushing's disease were studied. The less severe cases, which constitute a majority, were treated by pituitary irradiation with endocrinologic cure or improvement in two-thirds of the treated patients. Bilateral total adrenalectomy was reserved for the most severe cases and for failures of pituitary irradiation. In 29 patients with total bilateral adrenalectomy there was one postoperative death. Two of 28 survivors had incomplete relief of hypercortisolism and required additional therapy for its control. One patient with recent operation is improved and another with early improvement died suddenly at home three months after operation. The 24 other adrenalectomized patients, followed 6 months to 20 years, were considered endocrinologic cures of Cushing's disease. One patient in the group who had not received pituitary irradiation developed signs of expanding pituitary tumor after adrenalectomy (Nelson's syndrome) with satisfactory response to radiation therapy.
    MeSH term(s) Adolescent ; Adrenal Cortex Function Tests ; Adrenalectomy ; Adrenocortical Hyperfunction/etiology ; Adult ; Aged ; Child ; Cushing Syndrome/diagnosis ; Cushing Syndrome/radiotherapy ; Cushing Syndrome/surgery ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Pituitary Irradiation ; Pituitary-Adrenal Function Tests ; Postoperative Complications ; Remission, Spontaneous ; Sex Factors
    Language English
    Publishing date 1977-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/00000658-197705000-00004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.35/1: Show issues Location:
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