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  1. Conference proceedings: Females are poorly represented at the biannual meetings of the Society of British Neurological Surgeons

    Lawson Mclean, Aaron / Lawson Mclean, Anna

    2017  , Page(s) Mi.24.03

    Event/congress 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS); Magdeburg; ; Society of British Neurological Surgeons; 2017
    Keywords Medizin, Gesundheit
    Publishing date 2017-06-09
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/17dgnc529
    Database German Medical Science

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  2. Article ; Online: Rodent models and imaging techniques to study liver regeneration.

    Wei, Weiwei / Dirsch, Olaf / Mclean, Anna Lawson / Zafarnia, Sara / Schwier, Michael / Dahmen, Uta

    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes

    2015  Volume 54, Issue 3-4, Page(s) 97–113

    Abstract: The liver has the unique capability of regeneration from various injuries. Different animal models and in vitro methods are used for studying the processes and mechanisms of liver regeneration. Animal models were established either by administration of ... ...

    Abstract The liver has the unique capability of regeneration from various injuries. Different animal models and in vitro methods are used for studying the processes and mechanisms of liver regeneration. Animal models were established either by administration of hepatotoxic chemicals or by surgical approach. The administration of hepatotoxic chemicals results in the death of liver cells and in subsequent hepatic regeneration and tissue repair. Surgery includes partial hepatectomy and portal vein occlusion or diversion: hepatectomy leads to compensatory regeneration of the remnant liver lobe, whereas portal vein occlusion leads to atrophy of the ipsilateral lobe and to compensatory regeneration of the contralateral lobe. Adaptation of modern radiological imaging technologies to the small size of rodents made the visualization of rodent intrahepatic vascular anatomy possible. Advanced knowledge of the detailed intrahepatic 3D anatomy enabled the establishment of refined surgical techniques. The same technology allows the visualization of hepatic vascular regeneration. The development of modern histological image analysis tools improved the quantitative assessment of hepatic regeneration. Novel image analysis tools enable us to quantify reliably and reproducibly the proliferative rate of hepatocytes using whole-slide scans, thus reducing the sampling error. In this review, the refined rodent models and the newly developed imaging technology to study liver regeneration are summarized. This summary helps to integrate the current knowledge of liver regeneration and promises an enormous increase in hepatological knowledge in the near future.
    MeSH term(s) Animals ; Chemical and Drug Induced Liver Injury ; Liver/anatomy & histology ; Liver/surgery ; Liver Regeneration ; Mice ; Models, Animal ; Rats
    Language English
    Publishing date 2015
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 205700-1
    ISSN 1421-9921 ; 0014-312X
    ISSN (online) 1421-9921
    ISSN 0014-312X
    DOI 10.1159/000368573
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 745: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Severe systemic lupus erythematosus induced by antiviral treatment for hepatitis C.

    Ho, Vincent / Mclean, Anna / Terry, Shaughan

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

    2008  Volume 14, Issue 3, Page(s) 166–168

    Abstract: We report the case of a 43-year-old man who developed systemic lupus erythematosus (SLE) after receiving pegylated alpha-interferon and ribavirin for chronic hepatitis C. He displayed 8 features of the American College of Rheumatology criteria for SLE: ... ...

    Abstract We report the case of a 43-year-old man who developed systemic lupus erythematosus (SLE) after receiving pegylated alpha-interferon and ribavirin for chronic hepatitis C. He displayed 8 features of the American College of Rheumatology criteria for SLE: glomerulonephritis, arthritis, serositis, a florid discoid rash, lymphopenia, oral ulcers, the development of high titers of antinuclear antibodies, and antidouble stranded DNA antibodies. Furthermore, his admission was complicated by the development of life threatening myopericarditis and vasculitis. This case is notable for the clinical severity and nature of multiorgan lupus involvement from hepatitis C antiviral therapy. Clinical signs of SLE have resolved and anti DS DNA has normalized.
    MeSH term(s) Adult ; Antibodies, Antinuclear/analysis ; Antiviral Agents/adverse effects ; Cyclophosphamide/therapeutic use ; Hepatitis C, Chronic/drug therapy ; Humans ; Interferon-alpha/adverse effects ; Lupus Erythematosus, Systemic/chemically induced ; Lupus Erythematosus, Systemic/drug therapy ; Male ; Polyethylene Glycols ; Recombinant Proteins
    Chemical Substances Antibodies, Antinuclear ; Antiviral Agents ; Interferon-alpha ; Recombinant Proteins ; Polyethylene Glycols (30IQX730WE) ; interferon alfa-2b (43K1W2T1M6) ; Cyclophosphamide (8N3DW7272P) ; peginterferon alfa-2b (G8RGG88B68)
    Language English
    Publishing date 2008-06
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1283266-2
    ISSN 1536-7355 ; 1076-1608
    ISSN (online) 1536-7355
    ISSN 1076-1608
    DOI 10.1097/RHU.0b013e3181775e80
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4815: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Rodent Models and Imaging Techniques to Study Liver Regeneration

    Wei, Weiwei / Dirsch, Olaf / Lawson Mclean, Anna / Zafarnia, Sara / Schwier, Michael / Dahmen, Uta

    European Surgical Research - Clinical and Experimental Surgery

    2015  Volume 54, Issue 3-4, Page(s) 113–197

    Abstract: The liver has the unique capability of regeneration from various injuries. Different animal models and in vitro methods are used for studying the processes and mechanisms of liver regeneration. Animal models were established either by administration of ... ...

    Abstract The liver has the unique capability of regeneration from various injuries. Different animal models and in vitro methods are used for studying the processes and mechanisms of liver regeneration. Animal models were established either by administration of hepatotoxic chemicals or by surgical approach. The administration of hepatotoxic chemicals results in the death of liver cells and in subsequent hepatic regeneration and tissue repair. Surgery includes partial hepatectomy and portal vein occlusion or diversion: hepatectomy leads to compensatory regeneration of the remnant liver lobe, whereas portal vein occlusion leads to atrophy of the ipsilateral lobe and to compensatory regeneration of the contralateral lobe. Adaptation of modern radiological imaging technologies to the small size of rodents made the visualization of rodent intrahepatic vascular anatomy possible. Advanced knowledge of the detailed intrahepatic 3D anatomy enabled the establishment of refined surgical techniques. The same technology allows the visualization of hepatic vascular regeneration. The development of modern histological image analysis tools improved the quantitative assessment of hepatic regeneration. Novel image analysis tools enable us to quantify reliably and reproducibly the proliferative rate of hepatocytes using whole-slide scans, thus reducing the sampling error. In this review, the refined rodent models and the newly developed imaging technology to study liver regeneration are summarized. This summary helps to integrate the current knowledge of liver regeneration and promises an enormous increase in hepatological knowledge in the near future.© 2014 S. Karger AG, Basel
    Keywords Liver regeneration ; Surgical model ; Toxic model ; Imaging techniques
    Language English
    Publisher S. Karger AG
    Publishing place Basel
    Publishing country Switzerland
    Document type Article ; Online
    ZDB-ID 205700-1
    ISSN 1421-9921 ; 0014-312X ; 0014-312X
    ISSN (online) 1421-9921
    ISSN 0014-312X
    DOI 10.1159/000368573
    Database Karger publisher's database

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 745: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Rodent Models and Imaging Techniques to Study Liver Regeneration

    Wei, Weiwei / Dirsch, Olaf / Lawson Mclean, Anna / Zafarnia, Sara / Schwier, Michael / Dahmen, Uta

    European Surgical Research

    2014  Volume 54, Issue 3-4, Page(s) 97–113

    Abstract: The liver has the unique capability of regeneration from various injuries. Different animal models and in vitro methods are used for studying the processes and mechanisms of liver regeneration. Animal models were established either by administration of ... ...

    Institution Department of General, Visceral and Vascular Surgery, and Institute of Pathology, Jena University Hospital, and Faculty of Medicine, Friedrich Schiller University, Jena Department of Experimental Molecular Imaging, Medical Faculty, RWTH Aachen University, Aachen, and Fraunhofer Institute for Medical Image Computing MEVIS, Bremen, Germany
    Abstract The liver has the unique capability of regeneration from various injuries. Different animal models and in vitro methods are used for studying the processes and mechanisms of liver regeneration. Animal models were established either by administration of hepatotoxic chemicals or by surgical approach. The administration of hepatotoxic chemicals results in the death of liver cells and in subsequent hepatic regeneration and tissue repair. Surgery includes partial hepatectomy and portal vein occlusion or diversion: hepatectomy leads to compensatory regeneration of the remnant liver lobe, whereas portal vein occlusion leads to atrophy of the ipsilateral lobe and to compensatory regeneration of the contralateral lobe. Adaptation of modern radiological imaging technologies to the small size of rodents made the visualization of rodent intrahepatic vascular anatomy possible. Advanced knowledge of the detailed intrahepatic 3D anatomy enabled the establishment of refined surgical techniques. The same technology allows the visualization of hepatic vascular regeneration. The development of modern histological image analysis tools improved the quantitative assessment of hepatic regeneration. Novel image analysis tools enable us to quantify reliably and reproducibly the proliferative rate of hepatocytes using whole-slide scans, thus reducing the sampling error. In this review, the refined rodent models and the newly developed imaging technology to study liver regeneration are summarized. This summary helps to integrate the current knowledge of liver regeneration and promises an enormous increase in hepatological knowledge in the near future. © 2014 S. Karger AG, Basel
    Keywords Liver regeneration ; Surgical model ; Toxic model ; Imaging techniques
    Language English
    Publishing date 2014-11-12
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Invited Review
    ZDB-ID 205700-1
    ISSN 1421-9921 ; 0014-312X
    ISSN (online) 1421-9921
    ISSN 0014-312X
    DOI 10.1159/000368573
    Database Karger publisher's database

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 745: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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