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  1. Article: Combined Heart and Liver Transplant: Indication, Patient Selection, and Allocation Policy.

    Zhao, Kai / Mclean, Rhondalyn C / Hoteit, Maarouf A / Olthoff, Kim M

    Clinical liver disease

    2019  Volume 13, Issue 6, Page(s) 170–175

    Language English
    Publishing date 2019-07-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2657644-2
    ISSN 2046-2484
    ISSN 2046-2484
    DOI 10.1002/cld.812
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pulmonary arterial hypertension in adults with systemic right ventricles referred for cardiac transplantation.

    Kim, Yuli Y / Awh, Katherine / Acker, Michael / Atluri, Pavan / Bermudez, Christian / Crespo, Maria / Diamond, Joshua M / Drajpuch, David / Forde-Mclean, Rhondalyn / Fuller, Stephanie / Goldberg, Lee / Mazurek, Jeremy / Mascio, Christopher / Menachem, Jonathan N / Rame, Eduardo / Ruckdeschel, Emily / Tobin, Lynda / Wald, Joyce

    Clinical transplantation

    2019  Volume 33, Issue 4, Page(s) e13496

    Abstract: Background: Systemic right ventricular (RV) failure may progress necessitating referral for orthotropic heart transplantation (OHT). Pulmonary hypertension (PH) frequently coexists in adult congenital heart disease and can complicate the assessment for ... ...

    Abstract Background: Systemic right ventricular (RV) failure may progress necessitating referral for orthotropic heart transplantation (OHT). Pulmonary hypertension (PH) frequently coexists in adult congenital heart disease and can complicate the assessment for OHT.
    Methods: Single-center case series of six patients (median age 34.9 years [IQR, 31.9-42.4]) with systemic RV physiology with PH referred for OHT evaluation from 2008 to 2017.
    Results: One-third (n = 6) of 18 patients with systemic RV physiology referred for OHT evaluation had pulmonary arterial hypertension (PAH) defined as mean pulmonary artery pressure (mPAP) > 25 mm Hg and pulmonary vascular resistance (PVR) > 3 Wood Units. Two of the six patients were considered OHT-ineligible due to PH and comorbidities. Of the remaining four, two had pre-capillary PH and underwent heart-lung transplant (HLTx). The other two demonstrated reversibility of PVR with vasodilator testing and underwent OHT alone, one of whom died post-transplant from PH crisis.
    Conclusions: Pulmonary arterial hypertension is common in systemic RV patients referred for OHT. Systemic RV dysfunction places these patients at risk for post-capillary PH but pre-capillary PH can exist. Despite management with selective pulmonary vasodilators and afterload reduction, criteria for listing patients for HLTx vs OHT are not known and need further elucidation.
    MeSH term(s) Adult ; Child, Preschool ; Follow-Up Studies ; Heart Defects, Congenital/complications ; Heart Defects, Congenital/surgery ; Heart Transplantation/methods ; Humans ; Infant ; Male ; Prognosis ; Pulmonary Arterial Hypertension/complications ; Pulmonary Arterial Hypertension/surgery ; Retrospective Studies ; Ventricular Dysfunction, Right/physiopathology
    Language English
    Publishing date 2019-03-05
    Publishing country Denmark
    Document type Case Reports ; Journal Article
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.13496
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2204: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  3. Article ; Online: Coronavirus disease 2019 in heart transplant recipients: Risk factors, immunosuppression, and outcomes.

    Genuardi, Michael V / Moss, Noah / Najjar, Samer S / Houston, Brian A / Shore, Supriya / Vorovich, Esther / Atluri, Pavan / Molina, Maria / Chambers, Susan / Sharkoski, Tiffany / Hsich, Eileen / Estep, Jerry D / Owens, Anjali T / Alexander, Kevin M / Chaudhry, Sunit-Preet / Garcia-Cortes, Rafael / Molina, Ezequiel / Rodrigo, Maria / Wald, MDc Joyce /
    Margulies, Kenneth B / Hanff, Thomas C / Zimmer, Ross / Kilic, Arman / Mclean, Rhondalyn / Vidula, Himabindu / Dodd, Katherine / Blumberg, Emily A / Mazurek, Jeremy A / Goldberg, Lee R / Alvarez-Garcia, Jesus / Mancini, Donna / Teuteberg, Jeffrey J / Tedford, Ryan J / Birati, Edo Y

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

    2021  Volume 40, Issue 9, Page(s) 926–935

    Abstract: Background: COVID-19 continues to inflict significant morbidity and mortality, particularly on patients with preexisting health conditions. The clinical course, outcomes, and significance of immunosuppression regimen in heart transplant recipients with ... ...

    Abstract Background: COVID-19 continues to inflict significant morbidity and mortality, particularly on patients with preexisting health conditions. The clinical course, outcomes, and significance of immunosuppression regimen in heart transplant recipients with COVID-19 remains unclear.
    Methods: We included the first 99 heart transplant recipients at participating centers with COVID-19 and followed patients until resolution. We collected baseline information, symptoms, laboratory studies, vital signs, and outcomes for included patients. The association of immunosuppression regimens at baseline with severe disease were compared using logistic regression, adjusting for age and time since transplant.
    Results: The median age was 60 years, 25% were female, and 44% were white. The median time post-transplant to infection was 5.6 years. Overall, 15% died, 64% required hospital admission, and 7% remained asymptomatic. During the course of illness, only 57% of patients had a fever, and gastrointestinal symptoms were common. Tachypnea, oxygen requirement, elevated creatinine and inflammatory markers were predictive of severe course. Age ≥ 60 was associated with higher risk of death and the use of the combination of calcineurin inhibitor, antimetabolite, and prednisone was associated with more severe disease compared to the combination of calcineurin inhibitor and antimetabolite alone (adjusted OR = 7.3, 95% CI 1.8-36.2). Among hospitalized patients, 30% were treated for secondary infection, acute kidney injury was common and 17% required new renal replacement therapy.
    Conclusions: We present the largest study to date of heart transplant patients with COVID-19 showing common atypical presentations and a high case fatality rate of 24% among hospitalized patients and 16% among symptomatic patients.
    MeSH term(s) Aged ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/therapy ; Female ; Heart Failure/complications ; Heart Failure/mortality ; Heart Failure/surgery ; Heart Transplantation ; Hospitalization ; Humans ; Immunosuppressive Agents/therapeutic use ; Logistic Models ; Male ; Middle Aged ; Risk Factors ; Survival Rate ; Treatment Outcome
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2021-05-19
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1062522-7
    ISSN 1557-3117 ; 1053-2498
    ISSN (online) 1557-3117
    ISSN 1053-2498
    DOI 10.1016/j.healun.2021.05.006
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2056: Show issues Location:
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  4. Article ; Online: Impact of Socioeconomic Factors on Patient Desire for Early LVAD Therapy Prior to Inotrope Dependence.

    Tchoukina, Inna / Shah, Keyur B / Thibodeau, Jennifer T / Estep, Jerry D / Lala, Anuradha / Lanfear, David E / Gilotra, Nisha A / Pamboukian, Salpy V / Horstmanshof, Douglas A / Mcnamara, Dennis M / Haas, Donald C / Jorde, Ulrich P / Mclean, Rhondalyn C / Cascino, Thomas M / Khalatbari, Shokoufeh / Richards, Blair / Yosef, Matheos / Spino, Cathie / Baldwin, J Timothy /
    Mann, Douglas L / Aaronson, Keith D / Stewart, Garrick C

    Journal of cardiac failure

    2019  Volume 26, Issue 4, Page(s) 316–323

    Abstract: Background: Worsening heart failure (HF) and health-related quality of life (HRQOL) have been shown to impact the decision to proceed with left ventricular assist device (LVAD) implantation, but little is known about how socioeconomic factors influence ... ...

    Abstract Background: Worsening heart failure (HF) and health-related quality of life (HRQOL) have been shown to impact the decision to proceed with left ventricular assist device (LVAD) implantation, but little is known about how socioeconomic factors influence expressed patient preference for LVAD.
    Methods and results: Ambulatory patients with advanced systolic HF (n=353) reviewed written information about LVAD therapy and completed a brief survey to indicate whether they would want an LVAD to treat their current level of HF. Ordinal logistic regression analyses identified clinical and demographic predictors of LVAD preference. Higher New York Heart Association (NYHA) class, worse HRQOL measured by Kansas City Cardiomyopathy Questionnaire, lower education level, and lower income were significant univariable predictors of patients wanting an LVAD. In the multivariable model, higher NYHA class (OR [odds ratio]: 1.43, CI [confidence interval]: 1.08-1.90, P = .013) and lower income level (OR: 2.10, CI: 1.18 - 3.76, P = .012 for <$40,000 vs >$80,000) remained significantly associated with wanting an LVAD.
    Conclusion: Among ambulatory patients with advanced systolic HF, treatment preference for LVAD was influenced by level of income independent of HF severity. Understanding the impact of socioeconomic factors on willingness to consider LVAD therapy may help tailor counseling towards individual needs.
    MeSH term(s) Heart Failure/therapy ; Heart-Assist Devices ; Humans ; Prospective Studies ; Quality of Life ; Socioeconomic Factors ; Treatment Outcome
    Language English
    Publishing date 2019-12-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1016/j.cardfail.2019.11.026
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    Zs.A 4340: Show issues Location:
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